Semisynthesis of triptolide analogues: Effect of B-ring substituents on cytotoxic activities

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5671-5674

  Xu, Hongtao ^a   Chen, Yi ^a   Tang, Huanyu ^a   Feng, Huijin ^a   Li, Yuanchao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytotoxic; Diterpenoid; Structure cytotoxic activity relationships; Synthesis; Triptolide

Indexed keywords

EPOXIDE; HALOGEN; HYDROXYL GROUP; TRIPTOLIDE; TRIPTOLIDE ANALOGUE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DITERPENE; ORGANIC COMPOUND; PHENANTHRENE DERIVATIVE;

ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; TUMOR CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GLIOMA; MALE; PROSTATIC NEOPLASMS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; GLIOMA; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANIC CHEMICALS; PHENANTHRENES; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84911945204     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.10.069     Document Type: Article

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