The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

Phytomedicine

Volumn 22, Issue 11, 2015, Pages 1009-1016

  Burmistrova, Olga ^a   Perdomo, Juan ^a   Simões, M Fátima ^b   Rijo, Patricia ^b,c   Quintana, José ^a   Estévez, Francisco ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIAS   (Portugal)

Author keywords

Abietane diterpenes; Apoptosis; Cytotoxicity; Parvifloron D; Plectranthus ecklonii

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CYTOCHROME C; DITERPENOID; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIDRUG RESISTANCE PROTEIN; PARVIFLORON D; PLANT EXTRACT; PLECTRANTHUS ECKLONII EXTRACT; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 2-(4-HYDROXY)-BENZOYLOXY-11-HYDROXY-5,7,9(11),13-ABIETATETRAEN-12-ONE; ABIETANE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; COLORIMETRY; CYTOTOXICITY; DNA FRAGMENTATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PERIPHERAL BLOOD MONONUCLEAR CELL; PLECTRANTHUS; PLECTRANTHUS ECKLONII; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HL 60 CELL LINE; K562 CELL LINE; METABOLISM; MONONUCLEAR CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; DITERPENES, ABIETANE; HL-60 CELLS; HUMANS; K562 CELLS; LEUKOCYTES, MONONUCLEAR; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; PLECTRANTHUS; REACTIVE OXYGEN SPECIES;

EID: 84941565035     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.06.013     Document Type: Article

References (23)

1. Adams J.M.; Cory S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential Curr. Opin. Immunol. 19 2007 488 496
2. Burmistrova O.; Simões M.F.; Rijo P.; Quintana J.; Bermejo J.; Estévez F. Antiproliferative activity of abietane diterpenoids against human tumor cells J. Nat. Prod. 76 2013 1413 1423
3. Cragg G.M.; Newman D.J. Natural products: a continuing source of novel drug leads Biochim. Biophys. Acta 1830 2013 3670 3695
4. Dubrez L.; Goldwasser F.; Genne P.; Pommier Y.; Solary E. The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors Leukemia 9 1995 1013 1024
5. Fronza M.; Lamy E.; Günther S.; Heinzmann B.; Laufer S.; Merfort I. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action Phytochemistry 78 2012 107 119
6. Gangemi R.M.; Tiso M.; Marchetti C.; Severi A.B.; Fabbi M. Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death Cancer Chemother. Pharmacol. 36 1995 385 392
7. Guerrero I.C.; Andrés L.S.; León L.G.; Machín R.P.; Padrón J.M.; Luis J.G.; Delgadillo J. Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines J. Nat. Prod. 69 2006 1803 1805
8. Hueso-Rodríguez J.A.; Jimeno M.L.; Rodríguez B.; Savona G.; Bruno M. Abietane diterpenoids from the root of Salvia phlomoides Phytochemistry 22 1983 2005 2009
9. Kaufmann S.H.; Desnoyers S.; Ottaviano Y.; Davidson N.E.; Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis Cancer Res. 53 1993 3976 3985
10. Li J.; Yuan J. Caspases in apoptosis and beyond Oncogene 27 2008 6194 6206
11. Lukhoba C.W.; Simmonds M.S.; Paton A.J. Plectranthus: a review of ethnobotanical uses J. Ethnopharmacol. 103 2006 1 24
12. McCubrey J.A.; Lahair M.M.; Franklin R.A. Reactive oxygen species-induced activation of the MAP kinase signaling pathway Antioxid. Redox Signal. 8 2006 1775 1789
13. McGahon A.; Bissonnette R.; Schmitt M.; Cotter K.M.; Green D.R.; Cotter T.G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death Blood 83 1994 1179 1187
14. Ray S.; Bullock G.; Nuñez G.; Tang C.; Ibrado A.M.; Huang Y.; Bhalla K. Enforced expression of Bcl-XS induces differentiation and sensitizes chronic myelogenous leukemia-blast crisis K-562 cells to 1-β-D-arabinofuranosylcytosine-mediated differentiation and apoptosis Cell Growth Differ. 7 1996 1617 1623
15. Rubio S.; Quintana J.; Eiroa J.L.; Triana J.; Estévez F. Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK Carcinogenesis 28 2007 2105 2113
16. 2-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells Mol. Carcinog. 49 2010 32 43
17. Simões M.F.; Rijo P.; Duarte A.; Matias D.; Rodríguez B. An easy and stereoselective rearrangement of an abietane diterpenoid into a bioactive microstegiol derivative Phytochem. Lett. 3 2010 234 237
18. Tewari M.; Quan L.T.; O'Rourke K.; Desnoyers S.; Zeng Z.; Beidler D.R.; Poirier G.G.; Salvesen G.S.; Dixit V.M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase Cell 81 1995 801 809
19. Torres F.; Quintana J.; Estévez F. 5,7,3trihydroxy-3,4-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway Mol. Carcinog. 49 2010 464 475
20. Wang X.; Morris-Natschke S.L.; Lee K.H. New developments in the chemistry and biology of the bioactive constituents of Tanshen Med. Res. Rev. 27 2007 133 148
21. Yang J.; Liu X.; Bhalla K.; Kim C.N.; Ibrado A.M.; Cai J.; Peng T.I.; Jones D.P.; Wang X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked Science 275 1997 1129 1132
22. Youle R.J.; Strasser A. The BCL-2 protein family: opposing activities that mediate cell death Nat. Rev. Mol. Cell Biol. 9 2008 47 59
23. Zhuang S.; Demirs J.T.; Kochevar I.E. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide J. Biol. Chem. 275 2000 25939 25948