-
2
-
-
84860287080
-
Epidemiology of viral hepatitis and hepatocellular carcinoma
-
e1
-
El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012;142:1264–1273.e1.
-
(2012)
Gastroenterology
, vol.142
, pp. 1264-1273
-
-
El-Serag, H.B.1
-
3
-
-
84939956694
-
Molecular biology of hepatitis B virus infection
-
Seeger C, Mason WS. Molecular biology of hepatitis B virus infection. Virology. 2015;479–480C:672–686.
-
(2015)
Virology
, vol.479–480C
, pp. 672-686
-
-
Seeger, C.1
Mason, W.S.2
-
4
-
-
84940172646
-
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
-
Nassal M. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Gut. 2015;64:1972–1984.
-
(2015)
Gut
, vol.64
, pp. 1972-1984
-
-
Nassal, M.1
-
5
-
-
84923769732
-
Antiviral therapies and prospects for a cure of chronic hepatitis B
-
a021501
-
Zoulim F, Durantel D. Antiviral therapies and prospects for a cure of chronic hepatitis B. Cold Spring Harb Perspect Med. 2015;5: a021501
-
(2015)
Cold Spring Harb Perspect Med
, vol.5
-
-
Zoulim, F.1
Durantel, D.2
-
6
-
-
84940195264
-
Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities
-
Gish RG, Given BD, Lai C-L, et al. Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities. Antiviral Res. 2015;121:47–58.
-
(2015)
Antiviral Res
, vol.121
, pp. 47-58
-
-
Gish, R.G.1
Given, B.D.2
Lai, C.-L.3
-
7
-
-
84929737391
-
Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues
-
Rapti I, Hadziyannis S. Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues. World J Hepatol. 2015;7:1064–1073.
-
(2015)
World J Hepatol
, vol.7
, pp. 1064-1073
-
-
Rapti, I.1
Hadziyannis, S.2
-
8
-
-
84926407117
-
Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy
-
Papatheodoridis GV, Chan HLY, Hansen BE, Janssen HLA, Lampertico P. Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy. J Hepatol. 2015;62:956–967.
-
(2015)
J Hepatol
, vol.62
, pp. 956-967
-
-
Papatheodoridis, G.V.1
Chan, H.L.Y.2
Hansen, B.E.3
Janssen, H.L.A.4
Lampertico, P.5
-
9
-
-
84919848147
-
Hepatitis B virus infection
-
Trépo C, Chan HLY, Lok A. Hepatitis B virus infection. Lancet. 2014;384:2053–2063.
-
(2014)
Lancet
, vol.384
, pp. 2053-2063
-
-
Trépo, C.1
Chan, H.L.Y.2
Lok, A.3
-
10
-
-
70350095437
-
Hepatitis B virus resistance to nucleos(t)ide analogues
-
2
-
Zoulim F, Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology. 2009;137:1593–1608-2.
-
(2009)
Gastroenterology
, vol.137
, pp. 1593-1608
-
-
Zoulim, F.1
Locarnini, S.2
-
11
-
-
84940459494
-
Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure
-
Zeisel MB, Lucifora J, Mason WS, et al. Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure. Gut. 2015;64:1314–1326.
-
(2015)
Gut
, vol.64
, pp. 1314-1326
-
-
Zeisel, M.B.1
Lucifora, J.2
Mason, W.S.3
-
12
-
-
84879327902
-
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
-
Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. ELife. 2012;1:e00049.
-
(2012)
ELife
, vol.1
-
-
Yan, H.1
Zhong, G.2
Xu, G.3
-
14
-
-
84857442747
-
Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
-
Lütgehetmann M, Mancke LV, Volz T, et al. Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation. Hepatology. 2012;55:685–694.
-
(2012)
Hepatology
, vol.55
, pp. 685-694
-
-
Lütgehetmann, M.1
Mancke, L.V.2
Volz, T.3
-
15
-
-
84920764736
-
Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
-
Königer C, Wingert I, Marsmann M, Rösler C, Beck J, Nassal M. Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci USA. 2014;111:E4244–E4253.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. E4244-E4253
-
-
Königer, C.1
Wingert, I.2
Marsmann, M.3
Rösler, C.4
Beck, J.5
Nassal, M.6
-
16
-
-
84937889320
-
Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
-
Cui X, McAllister R, Boregowda R, et al. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair? PLoS One. 2015;10:e0128401.
-
(2015)
PLoS One
, vol.10
-
-
Cui, X.1
McAllister, R.2
Boregowda, R.3
-
17
-
-
84864378861
-
Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation
-
Cai D, Mills C, Yu W, et al. Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation. Antimicrob Agents Chemother. 2012;56:4277–4288.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 4277-4288
-
-
Cai, D.1
Mills, C.2
Yu, W.3
-
18
-
-
84896029673
-
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
-
Lucifora J, Xia Y, Reisinger F, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014;343:1221–1228.
-
(2014)
Science
, vol.343
, pp. 1221-1228
-
-
Lucifora, J.1
Xia, Y.2
Reisinger, F.3
-
19
-
-
84952684286
-
Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis
-
Xia Y, Stadler D, Lucifora J, et al. Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis. Gastroenterology. 2016;150:194–205.
-
(2016)
Gastroenterology
, vol.150
, pp. 194-205
-
-
Xia, Y.1
Stadler, D.2
Lucifora, J.3
-
20
-
-
84927935415
-
Targeting hepatitis B virus with CRISPR/Cas9
-
Seeger C, Sohn JA. Targeting hepatitis B virus with CRISPR/Cas9. Mol Ther Nucleic Acids. 2014;3:e216.
-
(2014)
Mol Ther Nucleic Acids
, vol.3
-
-
Seeger, C.1
Sohn, J.A.2
-
22
-
-
84975298412
-
Complete spectrum of CRISPR/Cas9-induced mutations on HBV cccDNA
-
Seeger C, Sohn JA. Complete spectrum of CRISPR/Cas9-induced mutations on HBV cccDNA. Mol Ther. 2016;24:1258–1266.
-
(2016)
Mol Ther
, vol.24
, pp. 1258-1266
-
-
Seeger, C.1
Sohn, J.A.2
-
23
-
-
84856514985
-
IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
-
Belloni L, Allweiss L, Guerrieri F, et al. IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest. 2012;122:529–537.
-
(2012)
J Clin Invest
, vol.122
, pp. 529-537
-
-
Belloni, L.1
Allweiss, L.2
Guerrieri, F.3
-
24
-
-
84947466102
-
Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation
-
Tropberger P, Mercier A, Robinson M, Zhong W, Ganem DE, Holdorf M. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation. Proc Natl Acad Sci USA. 2015;112:E5715–E5724.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. E5715-E5724
-
-
Tropberger, P.1
Mercier, A.2
Robinson, M.3
Zhong, W.4
Ganem, D.E.5
Holdorf, M.6
-
25
-
-
79957614798
-
Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
-
Lucifora J, Arzberger S, Durantel D, et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J Hepatol. 2011;55:996–1003.
-
(2011)
J Hepatol
, vol.55
, pp. 996-1003
-
-
Lucifora, J.1
Arzberger, S.2
Durantel, D.3
-
26
-
-
84982154746
-
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
-
Decorsière A, Mueller H, van Breugel PC, et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386–389.
-
(2016)
Nature
, vol.531
, pp. 386-389
-
-
Decorsière, A.1
Mueller, H.2
van Breugel, P.C.3
-
27
-
-
84991690879
-
Hepatitis B virus X protein promotes degradation of SMC5/6 to enhance HBV replication
-
Murphy CM, Xu Y, Li F, et al. Hepatitis B virus X protein promotes degradation of SMC5/6 to enhance HBV replication. Cell Rep. 2016;16:2846–2854.
-
(2016)
Cell Rep
, vol.16
, pp. 2846-2854
-
-
Murphy, C.M.1
Xu, Y.2
Li, F.3
-
28
-
-
84936972906
-
Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent
-
Gish RG, Yuen M-F, Chan HLY, et al. Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent. Antiviral Res. 2015;121:97–108.
-
(2015)
Antiviral Res
, vol.121
, pp. 97-108
-
-
Gish, R.G.1
Yuen, M.-F.2
Chan, H.L.Y.3
-
29
-
-
84968743695
-
ARC-520 produces deep and durable knockdown of viral antigens and DNA in a phase II study in patients with chronic hepatitis B
-
Yuen M-F, Chan HL-Y, Liu SHK, et al. ARC-520 produces deep and durable knockdown of viral antigens and DNA in a phase II study in patients with chronic hepatitis B. Hepatology. 2015;62:1385A.
-
(2015)
Hepatology
, vol.62
, pp. 1385A
-
-
Yuen, M.-F.1
Chan, H.L.-Y.2
Liu, S.H.K.3
-
30
-
-
84936972283
-
Core protein: a pleiotropic keystone in the HBV lifecycle
-
Zlotnick A, Venkatakrishnan B, Tan Z, Lewellyn E, Turner W, Francis S. Core protein: a pleiotropic keystone in the HBV lifecycle. Antiviral Res. 2015;121:82–93.
-
(2015)
Antiviral Res
, vol.121
, pp. 82-93
-
-
Zlotnick, A.1
Venkatakrishnan, B.2
Tan, Z.3
Lewellyn, E.4
Turner, W.5
Francis, S.6
-
31
-
-
80054867708
-
The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication
-
Billioud G, Pichoud C, Puerstinger G, Neyts J, Zoulim F. The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication. Antiviral Res. 2011;92:271–276.
-
(2011)
Antiviral Res
, vol.92
, pp. 271-276
-
-
Billioud, G.1
Pichoud, C.2
Puerstinger, G.3
Neyts, J.4
Zoulim, F.5
-
32
-
-
84865773658
-
In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations
-
Wang X-Y, Wei Z-M, Wu G-Y, et al. In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. Antivir Ther. 2012;17:793–803.
-
(2012)
Antivir Ther
, vol.17
, pp. 793-803
-
-
Wang, X.-Y.1
Wei, Z.-M.2
Wu, G.-Y.3
-
33
-
-
84983678700
-
Inhibition of hepatitis B virus replication by the HBV core inhibitor NVR 3-778
-
Lam A, Ren S, Vogel R, et al. Inhibition of hepatitis B virus replication by the HBV core inhibitor NVR 3-778. Hepatology. 2015;62:223A.
-
(2015)
Hepatology
, vol.62
, pp. 223A
-
-
Lam, A.1
Ren, S.2
Vogel, R.3
-
34
-
-
79958761596
-
HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state
-
Guo Y-H, Li Y-N, Zhao J-R, Zhang J, Yan Z. HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state. Epigenetics. 2011;6:720–726.
-
(2011)
Epigenetics
, vol.6
, pp. 720-726
-
-
Guo, Y.-H.1
Li, Y.-N.2
Zhao, J.-R.3
Zhang, J.4
Yan, Z.5
-
35
-
-
84926312344
-
The nuclear function of Hepatitis B capsid (HBc) protein is to inhibit IFN response very early after infection of hepatocytes
-
Gruffaz M, Testoni B, Luangsay S, et al. The nuclear function of Hepatitis B capsid (HBc) protein is to inhibit IFN response very early after infection of hepatocytes. Hepatology. 2013;58:276A.
-
(2013)
Hepatology
, vol.58
, pp. 276A
-
-
Gruffaz, M.1
Testoni, B.2
Luangsay, S.3
-
36
-
-
85000432888
-
HAPs hepatitis B virus (HBV) capsid inhibitors block core protein interaction with the viral minichromosome and host cell genes and affect cccDNA transcription and stability
-
Belloni L, Li L, Palumbo GA, et al. HAPs hepatitis B virus (HBV) capsid inhibitors block core protein interaction with the viral minichromosome and host cell genes and affect cccDNA transcription and stability. Hepatology. 2013;58:277A.
-
(2013)
Hepatology
, vol.58
, pp. 277A
-
-
Belloni, L.1
Li, L.2
Palumbo, G.A.3
-
37
-
-
84943403551
-
Hepatitis B virus reverse transcriptase—target of current antiviral therapy and future drug development
-
Clark DN, Hu J. Hepatitis B virus reverse transcriptase—target of current antiviral therapy and future drug development. Antiviral Res. 2015;123:132–137.
-
(2015)
Antiviral Res
, vol.123
, pp. 132-137
-
-
Clark, D.N.1
Hu, J.2
-
38
-
-
84929598387
-
Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
-
Murakami E, Wang T, Park Y, et al. Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy. Antimicrob Agents Chemother. 2015;59:3563–3569.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 3563-3569
-
-
Murakami, E.1
Wang, T.2
Park, Y.3
-
39
-
-
84996538096
-
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial
-
Buti M, Gane E, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:196–206.
-
(2016)
Lancet Gastroenterol Hepatol
, vol.1
, pp. 196-206
-
-
Buti, M.1
Gane, E.2
Seto, W.K.3
-
40
-
-
0031940764
-
Inhibitory effect of 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyl-Uracil on duck hepatitis B virus replication
-
Aguesse-Germon S, Liu S-H, Chevallier M, et al. Inhibitory effect of 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyl-Uracil on duck hepatitis B virus replication. Antimicrob Agents Chemother. 1998;42:369–376.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 369-376
-
-
Aguesse-Germon, S.1
Liu, S.-H.2
Chevallier, M.3
-
41
-
-
84927950089
-
The hepatitis B virus ribonuclease H as a drug target
-
Tavis JE, Lomonosova E. The hepatitis B virus ribonuclease H as a drug target. Antiviral Res. 2015;118:132–138.
-
(2015)
Antiviral Res
, vol.118
, pp. 132-138
-
-
Tavis, J.E.1
Lomonosova, E.2
-
42
-
-
84921925555
-
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity
-
Lu G, Lomonosova E, Cheng X, et al. Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity. Antimicrob Agents Chemother. 2015;59:1070–1079.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1070-1079
-
-
Lu, G.1
Lomonosova, E.2
Cheng, X.3
-
43
-
-
84974783000
-
Safety and efficacy of nucleic acid polymers in monotherapy and combined with immunotherapy in treatment-naive Bangladeshi patients with HBeAg+ chronic hepatitis B infection
-
Al-Mahtab M, Bazinet M, Vaillant A. Safety and efficacy of nucleic acid polymers in monotherapy and combined with immunotherapy in treatment-naive Bangladeshi patients with HBeAg+ chronic hepatitis B infection. PLoS One. 2016;11:e0156667.
-
(2016)
PLoS One
, vol.11
-
-
Al-Mahtab, M.1
Bazinet, M.2
Vaillant, A.3
-
44
-
-
84919698407
-
HBV and the immune response
-
Ferrari C. HBV and the immune response. Liver Int. 2015;35(Suppl 1):121–128.
-
(2015)
Liver Int
, vol.35
, pp. 121-128
-
-
Ferrari, C.1
-
45
-
-
84869869851
-
Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection
-
e8
-
Martinet J, Dufeu-Duchesne T, Bruder Costa J, et al. Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection. Gastroenterology. 2012;143:1586–1596.e8.
-
(2012)
Gastroenterology
, vol.143
, pp. 1586-1596
-
-
Martinet, J.1
Dufeu-Duchesne, T.2
Bruder Costa, J.3
-
46
-
-
84905647558
-
The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection
-
Schuch A, Hoh A, Thimme R. The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection. Front Immunol. 2014;5:258.
-
(2014)
Front Immunol
, vol.5
, pp. 258
-
-
Schuch, A.1
Hoh, A.2
Thimme, R.3
-
47
-
-
84872369702
-
Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B?
-
Thimme R, Dandri M. Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B? J Hepatol. 2013;58:205–209.
-
(2013)
J Hepatol
, vol.58
, pp. 205-209
-
-
Thimme, R.1
Dandri, M.2
-
48
-
-
84940172833
-
Immune-modulators to combat hepatitis B virus infection: from IFN-α to novel investigational immunotherapeutic strategies
-
Isorce N, Lucifora J, Zoulim F, Durantel D. Immune-modulators to combat hepatitis B virus infection: from IFN-α to novel investigational immunotherapeutic strategies. Antiviral Res. 2015;122:69–81.
-
(2015)
Antiviral Res
, vol.122
, pp. 69-81
-
-
Isorce, N.1
Lucifora, J.2
Zoulim, F.3
Durantel, D.4
-
50
-
-
84900842537
-
Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming
-
Dalod M, Chelbi R, Malissen B, Lawrence T. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J. 2014;33:1104–1116.
-
(2014)
EMBO J
, vol.33
, pp. 1104-1116
-
-
Dalod, M.1
Chelbi, R.2
Malissen, B.3
Lawrence, T.4
-
51
-
-
84878276077
-
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
-
1517-10
-
Lanford RE, Guerra B, Chavez D, et al. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology. 2013;144:1508–1517, 1517-10.
-
(2013)
Gastroenterology
, vol.144
, pp. 1508-1517
-
-
Lanford, R.E.1
Guerra, B.2
Chavez, D.3
-
52
-
-
84929606985
-
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
-
Menne S, Tumas DB, Liu KH, et al. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. J Hepatol. 2015;62:1237–1245.
-
(2015)
J Hepatol
, vol.62
, pp. 1237-1245
-
-
Menne, S.1
Tumas, D.B.2
Liu, K.H.3
-
53
-
-
84935451137
-
The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
-
Gane EJ, Lim Y-S, Gordon SC, et al. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. J Hepatol. 2015;63:320–328.
-
(2015)
J Hepatol
, vol.63
, pp. 320-328
-
-
Gane, E.J.1
Lim, Y.-S.2
Gordon, S.C.3
-
54
-
-
84921914245
-
STING agonists induce an innate antiviral immune response against hepatitis B virus
-
Guo F, Han Y, Zhao X, et al. STING agonists induce an innate antiviral immune response against hepatitis B virus. Antimicrob Agents Chemother. 2015;59:1273–1281.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1273-1281
-
-
Guo, F.1
Han, Y.2
Zhao, X.3
-
55
-
-
85007531029
-
P0535: direct antiviral effects of various pattern recognition receptor (PRR) agonists in HBV-replicating hepatocytes
-
Lucifora J, Maadadi S, Floriot O, et al. P0535: direct antiviral effects of various pattern recognition receptor (PRR) agonists in HBV-replicating hepatocytes. J Hepatol. 2015;62:S515–S516.
-
(2015)
J Hepatol
, vol.62
, pp. S515-S516
-
-
Lucifora, J.1
Maadadi, S.2
Floriot, O.3
-
56
-
-
33846492518
-
Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
-
Visvanathan K, Skinner NA, Thompson AJV, et al. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology. 2007;45:102–110.
-
(2007)
Hepatology
, vol.45
, pp. 102-110
-
-
Visvanathan, K.1
Skinner, N.A.2
Thompson, A.J.V.3
-
57
-
-
84865153815
-
Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
-
Zhang X, Ma Z, Liu H, et al. Role of Toll-like receptor 2 in the immune response against hepadnaviral infection. J Hepatol. 2012;57:522–528.
-
(2012)
J Hepatol
, vol.57
, pp. 522-528
-
-
Zhang, X.1
Ma, Z.2
Liu, H.3
-
58
-
-
84865118780
-
Interplay between hepatitis B virus and TLR2-mediated innate immune responses: can restoration of TLR2 functions be a new therapeutic option?
-
Durantel D, Zoulim F. Interplay between hepatitis B virus and TLR2-mediated innate immune responses: can restoration of TLR2 functions be a new therapeutic option? J Hepatol. 2012;57:486–489.
-
(2012)
J Hepatol
, vol.57
, pp. 486-489
-
-
Durantel, D.1
Zoulim, F.2
-
59
-
-
84928947363
-
Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis
-
Ebert G, Allison C, Preston S, et al. Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc Natl Acad Sci USA. 2015;112:5803–5808.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 5803-5808
-
-
Ebert, G.1
Allison, C.2
Preston, S.3
-
60
-
-
84954110027
-
Promises and challenges of smac mimetics as cancer therapeutics
-
Fulda S. Promises and challenges of smac mimetics as cancer therapeutics. Clin Cancer Res. 2015;21:5030–5036.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 5030-5036
-
-
Fulda, S.1
-
61
-
-
84946018523
-
Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the « magic bullet » to kill cccDNA
-
Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M. Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the « magic bullet » to kill cccDNA. Antiviral Res. 2015;123:193–203.
-
(2015)
Antiviral Res
, vol.123
, pp. 193-203
-
-
Zhang, E.1
Kosinska, A.2
Lu, M.3
Yan, H.4
Roggendorf, M.5
-
62
-
-
84944445841
-
T cell receptor-therapy in HBV-related hepatocellularcarcinoma
-
Bertoletti A, Brunetto M, Maini MK, Bonino F, Qasim W, Stauss H. T cell receptor-therapy in HBV-related hepatocellularcarcinoma. Oncoimmunology. 2015;4:e1008354.
-
(2015)
Oncoimmunology
, vol.4
-
-
Bertoletti, A.1
Brunetto, M.2
Maini, M.K.3
Bonino, F.4
Qasim, W.5
Stauss, H.6
-
63
-
-
84922268964
-
Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
-
Qasim W, Brunetto M, Gehring AJ, et al. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. J Hepatol. 2015;62:486–491.
-
(2015)
J Hepatol
, vol.62
, pp. 486-491
-
-
Qasim, W.1
Brunetto, M.2
Gehring, A.J.3
-
64
-
-
84965083364
-
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
-
Ye B, Liu X, Li X, Kong H, Tian L, Chen Y. T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance. Cell Death Dis. 2015;6:e1694.
-
(2015)
Cell Death Dis
, vol.6
-
-
Ye, B.1
Liu, X.2
Li, X.3
Kong, H.4
Tian, L.5
Chen, Y.6
-
65
-
-
84921496569
-
Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections
-
Rehermann B, Bertoletti A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology. 2015;61:712–721.
-
(2015)
Hepatology
, vol.61
, pp. 712-721
-
-
Rehermann, B.1
Bertoletti, A.2
-
66
-
-
84930651350
-
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
-
Pallett LJ, Gill US, Quaglia A, et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med. 2015;21:591–600.
-
(2015)
Nat Med
, vol.21
, pp. 591-600
-
-
Pallett, L.J.1
Gill, U.S.2
Quaglia, A.3
-
67
-
-
84983720423
-
PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model
-
Tzeng H-T, Tsai H-F, Liao H-J, et al. PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. PLoS One. 2012;7:e39179.
-
(2012)
PLoS One
, vol.7
-
-
Tzeng, H.-T.1
Tsai, H.-F.2
Liao, H.-J.3
-
68
-
-
84893805242
-
Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
-
Liu J, Zhang E, Ma Z, et al. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog. 2014;10:e1003856.
-
(2014)
PLoS Pathog
, vol.10
-
-
Liu, J.1
Zhang, E.2
Ma, Z.3
-
69
-
-
84859482444
-
Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection
-
Tang Y, Jiang L, Zheng Y, Ni B, Wu Y. Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection. BMC Immunol. 2012;13:17.
-
(2012)
BMC Immunol
, vol.13
, pp. 17
-
-
Tang, Y.1
Jiang, L.2
Zheng, Y.3
Ni, B.4
Wu, Y.5
-
70
-
-
84919773476
-
Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial–ANRS HB02 VAC-ADN
-
Fontaine H, Kahi S, Chazallon C, et al. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial–ANRS HB02 VAC-ADN. Gut. 2015;64:139–147.
-
(2015)
Gut
, vol.64
, pp. 139-147
-
-
Fontaine, H.1
Kahi, S.2
Chazallon, C.3
-
71
-
-
84991093310
-
Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B
-
Lok AS, Pan CQ, Han S-HB, et al. Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B. J Hepatol. 2016;65:509–516.
-
(2016)
J Hepatol
, vol.65
, pp. 509-516
-
-
Lok, A.S.1
Pan, C.Q.2
Han, S.-H.B.3
-
72
-
-
84925501250
-
Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end?
-
Michel M-L, Bourgine M, Fontaine H, Pol S. Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end? Med Microbiol Immunol. 2015;204:121–129.
-
(2015)
Med Microbiol Immunol
, vol.204
, pp. 121-129
-
-
Michel, M.-L.1
Bourgine, M.2
Fontaine, H.3
Pol, S.4
-
73
-
-
84928889426
-
The immune tolerant phase of chronic HBV infection: new perspectives on an old concept
-
Bertoletti A, Kennedy PT. The immune tolerant phase of chronic HBV infection: new perspectives on an old concept. Cell Mol Immunol. 2015;12:258–263.
-
(2015)
Cell Mol Immunol
, vol.12
, pp. 258-263
-
-
Bertoletti, A.1
Kennedy, P.T.2
|