메뉴 건너뛰기




Volumn 37, Issue , 2017, Pages 33-39

Novel targets for hepatitis B virus therapy

Author keywords

hepatitis B virus; immunotherapy; viral targets

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIVIRUS AGENT; CD39 INHIBITOR; CD73 INHIBITOR; CELLULAR INHIBITORS OF APOPTOSIS PROTEIN INHIBITOR; CHECKPOINT KINASE INHIBITOR; COVALENTLY CLOSED CIRCULAR DNA; CYTOKINE; DNA; HEPATITIS B VACCINE; INTERFERON; MESSENGER RNA; NUCLEOTIDYLTRANSFERASE; PATTERN RECOGNITION RECEPTOR AGONIST; POLYMERASE; PREGENOMIC RNA; PROTEIN INHIBITOR; RELAXED CIRCULAR DNA; RNA; SODIUM BILE ACID COTRANSPORTER; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENZYME; VIRUS RNA; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN;

EID: 85007603250     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.13307     Document Type: Review
Times cited : (59)

References (73)
  • 2
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • e1
    • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012;142:1264–1273.e1.
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 3
    • 84939956694 scopus 로고    scopus 로고
    • Molecular biology of hepatitis B virus infection
    • Seeger C, Mason WS. Molecular biology of hepatitis B virus infection. Virology. 2015;479–480C:672–686.
    • (2015) Virology , vol.479–480C , pp. 672-686
    • Seeger, C.1    Mason, W.S.2
  • 4
    • 84940172646 scopus 로고    scopus 로고
    • HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
    • Nassal M. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Gut. 2015;64:1972–1984.
    • (2015) Gut , vol.64 , pp. 1972-1984
    • Nassal, M.1
  • 5
    • 84923769732 scopus 로고    scopus 로고
    • Antiviral therapies and prospects for a cure of chronic hepatitis B
    • a021501
    • Zoulim F, Durantel D. Antiviral therapies and prospects for a cure of chronic hepatitis B. Cold Spring Harb Perspect Med. 2015;5: a021501
    • (2015) Cold Spring Harb Perspect Med , vol.5
    • Zoulim, F.1    Durantel, D.2
  • 6
    • 84940195264 scopus 로고    scopus 로고
    • Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities
    • Gish RG, Given BD, Lai C-L, et al. Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities. Antiviral Res. 2015;121:47–58.
    • (2015) Antiviral Res , vol.121 , pp. 47-58
    • Gish, R.G.1    Given, B.D.2    Lai, C.-L.3
  • 7
    • 84929737391 scopus 로고    scopus 로고
    • Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues
    • Rapti I, Hadziyannis S. Risk for hepatocellular carcinoma in the course of chronic hepatitis B virus infection and the protective effect of therapy with nucleos(t)ide analogues. World J Hepatol. 2015;7:1064–1073.
    • (2015) World J Hepatol , vol.7 , pp. 1064-1073
    • Rapti, I.1    Hadziyannis, S.2
  • 8
    • 84926407117 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy
    • Papatheodoridis GV, Chan HLY, Hansen BE, Janssen HLA, Lampertico P. Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy. J Hepatol. 2015;62:956–967.
    • (2015) J Hepatol , vol.62 , pp. 956-967
    • Papatheodoridis, G.V.1    Chan, H.L.Y.2    Hansen, B.E.3    Janssen, H.L.A.4    Lampertico, P.5
  • 9
    • 84919848147 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Trépo C, Chan HLY, Lok A. Hepatitis B virus infection. Lancet. 2014;384:2053–2063.
    • (2014) Lancet , vol.384 , pp. 2053-2063
    • Trépo, C.1    Chan, H.L.Y.2    Lok, A.3
  • 10
    • 70350095437 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to nucleos(t)ide analogues
    • 2
    • Zoulim F, Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology. 2009;137:1593–1608-2.
    • (2009) Gastroenterology , vol.137 , pp. 1593-1608
    • Zoulim, F.1    Locarnini, S.2
  • 11
    • 84940459494 scopus 로고    scopus 로고
    • Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure
    • Zeisel MB, Lucifora J, Mason WS, et al. Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure. Gut. 2015;64:1314–1326.
    • (2015) Gut , vol.64 , pp. 1314-1326
    • Zeisel, M.B.1    Lucifora, J.2    Mason, W.S.3
  • 12
    • 84879327902 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. ELife. 2012;1:e00049.
    • (2012) ELife , vol.1
    • Yan, H.1    Zhong, G.2    Xu, G.3
  • 14
    • 84857442747 scopus 로고    scopus 로고
    • Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
    • Lütgehetmann M, Mancke LV, Volz T, et al. Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation. Hepatology. 2012;55:685–694.
    • (2012) Hepatology , vol.55 , pp. 685-694
    • Lütgehetmann, M.1    Mancke, L.V.2    Volz, T.3
  • 15
    • 84920764736 scopus 로고    scopus 로고
    • Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
    • Königer C, Wingert I, Marsmann M, Rösler C, Beck J, Nassal M. Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci USA. 2014;111:E4244–E4253.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E4244-E4253
    • Königer, C.1    Wingert, I.2    Marsmann, M.3    Rösler, C.4    Beck, J.5    Nassal, M.6
  • 16
    • 84937889320 scopus 로고    scopus 로고
    • Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
    • Cui X, McAllister R, Boregowda R, et al. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair? PLoS One. 2015;10:e0128401.
    • (2015) PLoS One , vol.10
    • Cui, X.1    McAllister, R.2    Boregowda, R.3
  • 17
    • 84864378861 scopus 로고    scopus 로고
    • Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation
    • Cai D, Mills C, Yu W, et al. Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation. Antimicrob Agents Chemother. 2012;56:4277–4288.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4277-4288
    • Cai, D.1    Mills, C.2    Yu, W.3
  • 18
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora J, Xia Y, Reisinger F, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014;343:1221–1228.
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3
  • 19
    • 84952684286 scopus 로고    scopus 로고
    • Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis
    • Xia Y, Stadler D, Lucifora J, et al. Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis. Gastroenterology. 2016;150:194–205.
    • (2016) Gastroenterology , vol.150 , pp. 194-205
    • Xia, Y.1    Stadler, D.2    Lucifora, J.3
  • 20
    • 84927935415 scopus 로고    scopus 로고
    • Targeting hepatitis B virus with CRISPR/Cas9
    • Seeger C, Sohn JA. Targeting hepatitis B virus with CRISPR/Cas9. Mol Ther Nucleic Acids. 2014;3:e216.
    • (2014) Mol Ther Nucleic Acids , vol.3
    • Seeger, C.1    Sohn, J.A.2
  • 21
    • 84981499570 scopus 로고    scopus 로고
    • Targeting hepatitis B virus cccDNA using CRISPR/Cas9
    • Kennedy EM, Kornepati AVR, Cullen BR. Targeting hepatitis B virus cccDNA using CRISPR/Cas9. Antiviral Res. 2015;123:188–192.
    • (2015) Antiviral Res , vol.123 , pp. 188-192
    • Kennedy, E.M.1    Kornepati, A.V.R.2    Cullen, B.R.3
  • 22
    • 84975298412 scopus 로고    scopus 로고
    • Complete spectrum of CRISPR/Cas9-induced mutations on HBV cccDNA
    • Seeger C, Sohn JA. Complete spectrum of CRISPR/Cas9-induced mutations on HBV cccDNA. Mol Ther. 2016;24:1258–1266.
    • (2016) Mol Ther , vol.24 , pp. 1258-1266
    • Seeger, C.1    Sohn, J.A.2
  • 23
    • 84856514985 scopus 로고    scopus 로고
    • IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • Belloni L, Allweiss L, Guerrieri F, et al. IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest. 2012;122:529–537.
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3
  • 24
    • 84947466102 scopus 로고    scopus 로고
    • Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation
    • Tropberger P, Mercier A, Robinson M, Zhong W, Ganem DE, Holdorf M. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation. Proc Natl Acad Sci USA. 2015;112:E5715–E5724.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E5715-E5724
    • Tropberger, P.1    Mercier, A.2    Robinson, M.3    Zhong, W.4    Ganem, D.E.5    Holdorf, M.6
  • 25
    • 79957614798 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
    • Lucifora J, Arzberger S, Durantel D, et al. Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. J Hepatol. 2011;55:996–1003.
    • (2011) J Hepatol , vol.55 , pp. 996-1003
    • Lucifora, J.1    Arzberger, S.2    Durantel, D.3
  • 26
    • 84982154746 scopus 로고    scopus 로고
    • Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
    • Decorsière A, Mueller H, van Breugel PC, et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386–389.
    • (2016) Nature , vol.531 , pp. 386-389
    • Decorsière, A.1    Mueller, H.2    van Breugel, P.C.3
  • 27
    • 84991690879 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes degradation of SMC5/6 to enhance HBV replication
    • Murphy CM, Xu Y, Li F, et al. Hepatitis B virus X protein promotes degradation of SMC5/6 to enhance HBV replication. Cell Rep. 2016;16:2846–2854.
    • (2016) Cell Rep , vol.16 , pp. 2846-2854
    • Murphy, C.M.1    Xu, Y.2    Li, F.3
  • 28
    • 84936972906 scopus 로고    scopus 로고
    • Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent
    • Gish RG, Yuen M-F, Chan HLY, et al. Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent. Antiviral Res. 2015;121:97–108.
    • (2015) Antiviral Res , vol.121 , pp. 97-108
    • Gish, R.G.1    Yuen, M.-F.2    Chan, H.L.Y.3
  • 29
    • 84968743695 scopus 로고    scopus 로고
    • ARC-520 produces deep and durable knockdown of viral antigens and DNA in a phase II study in patients with chronic hepatitis B
    • Yuen M-F, Chan HL-Y, Liu SHK, et al. ARC-520 produces deep and durable knockdown of viral antigens and DNA in a phase II study in patients with chronic hepatitis B. Hepatology. 2015;62:1385A.
    • (2015) Hepatology , vol.62 , pp. 1385A
    • Yuen, M.-F.1    Chan, H.L.-Y.2    Liu, S.H.K.3
  • 31
    • 80054867708 scopus 로고    scopus 로고
    • The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication
    • Billioud G, Pichoud C, Puerstinger G, Neyts J, Zoulim F. The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication. Antiviral Res. 2011;92:271–276.
    • (2011) Antiviral Res , vol.92 , pp. 271-276
    • Billioud, G.1    Pichoud, C.2    Puerstinger, G.3    Neyts, J.4    Zoulim, F.5
  • 32
    • 84865773658 scopus 로고    scopus 로고
    • In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations
    • Wang X-Y, Wei Z-M, Wu G-Y, et al. In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. Antivir Ther. 2012;17:793–803.
    • (2012) Antivir Ther , vol.17 , pp. 793-803
    • Wang, X.-Y.1    Wei, Z.-M.2    Wu, G.-Y.3
  • 33
    • 84983678700 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by the HBV core inhibitor NVR 3-778
    • Lam A, Ren S, Vogel R, et al. Inhibition of hepatitis B virus replication by the HBV core inhibitor NVR 3-778. Hepatology. 2015;62:223A.
    • (2015) Hepatology , vol.62 , pp. 223A
    • Lam, A.1    Ren, S.2    Vogel, R.3
  • 34
    • 79958761596 scopus 로고    scopus 로고
    • HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state
    • Guo Y-H, Li Y-N, Zhao J-R, Zhang J, Yan Z. HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state. Epigenetics. 2011;6:720–726.
    • (2011) Epigenetics , vol.6 , pp. 720-726
    • Guo, Y.-H.1    Li, Y.-N.2    Zhao, J.-R.3    Zhang, J.4    Yan, Z.5
  • 35
    • 84926312344 scopus 로고    scopus 로고
    • The nuclear function of Hepatitis B capsid (HBc) protein is to inhibit IFN response very early after infection of hepatocytes
    • Gruffaz M, Testoni B, Luangsay S, et al. The nuclear function of Hepatitis B capsid (HBc) protein is to inhibit IFN response very early after infection of hepatocytes. Hepatology. 2013;58:276A.
    • (2013) Hepatology , vol.58 , pp. 276A
    • Gruffaz, M.1    Testoni, B.2    Luangsay, S.3
  • 36
    • 85000432888 scopus 로고    scopus 로고
    • HAPs hepatitis B virus (HBV) capsid inhibitors block core protein interaction with the viral minichromosome and host cell genes and affect cccDNA transcription and stability
    • Belloni L, Li L, Palumbo GA, et al. HAPs hepatitis B virus (HBV) capsid inhibitors block core protein interaction with the viral minichromosome and host cell genes and affect cccDNA transcription and stability. Hepatology. 2013;58:277A.
    • (2013) Hepatology , vol.58 , pp. 277A
    • Belloni, L.1    Li, L.2    Palumbo, G.A.3
  • 37
    • 84943403551 scopus 로고    scopus 로고
    • Hepatitis B virus reverse transcriptase—target of current antiviral therapy and future drug development
    • Clark DN, Hu J. Hepatitis B virus reverse transcriptase—target of current antiviral therapy and future drug development. Antiviral Res. 2015;123:132–137.
    • (2015) Antiviral Res , vol.123 , pp. 132-137
    • Clark, D.N.1    Hu, J.2
  • 38
    • 84929598387 scopus 로고    scopus 로고
    • Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
    • Murakami E, Wang T, Park Y, et al. Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy. Antimicrob Agents Chemother. 2015;59:3563–3569.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 3563-3569
    • Murakami, E.1    Wang, T.2    Park, Y.3
  • 39
    • 84996538096 scopus 로고    scopus 로고
    • Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial
    • Buti M, Gane E, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:196–206.
    • (2016) Lancet Gastroenterol Hepatol , vol.1 , pp. 196-206
    • Buti, M.1    Gane, E.2    Seto, W.K.3
  • 40
    • 0031940764 scopus 로고    scopus 로고
    • Inhibitory effect of 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyl-Uracil on duck hepatitis B virus replication
    • Aguesse-Germon S, Liu S-H, Chevallier M, et al. Inhibitory effect of 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyl-Uracil on duck hepatitis B virus replication. Antimicrob Agents Chemother. 1998;42:369–376.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 369-376
    • Aguesse-Germon, S.1    Liu, S.-H.2    Chevallier, M.3
  • 41
    • 84927950089 scopus 로고    scopus 로고
    • The hepatitis B virus ribonuclease H as a drug target
    • Tavis JE, Lomonosova E. The hepatitis B virus ribonuclease H as a drug target. Antiviral Res. 2015;118:132–138.
    • (2015) Antiviral Res , vol.118 , pp. 132-138
    • Tavis, J.E.1    Lomonosova, E.2
  • 42
    • 84921925555 scopus 로고    scopus 로고
    • Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity
    • Lu G, Lomonosova E, Cheng X, et al. Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity. Antimicrob Agents Chemother. 2015;59:1070–1079.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 1070-1079
    • Lu, G.1    Lomonosova, E.2    Cheng, X.3
  • 43
    • 84974783000 scopus 로고    scopus 로고
    • Safety and efficacy of nucleic acid polymers in monotherapy and combined with immunotherapy in treatment-naive Bangladeshi patients with HBeAg+ chronic hepatitis B infection
    • Al-Mahtab M, Bazinet M, Vaillant A. Safety and efficacy of nucleic acid polymers in monotherapy and combined with immunotherapy in treatment-naive Bangladeshi patients with HBeAg+ chronic hepatitis B infection. PLoS One. 2016;11:e0156667.
    • (2016) PLoS One , vol.11
    • Al-Mahtab, M.1    Bazinet, M.2    Vaillant, A.3
  • 44
    • 84919698407 scopus 로고    scopus 로고
    • HBV and the immune response
    • Ferrari C. HBV and the immune response. Liver Int. 2015;35(Suppl 1):121–128.
    • (2015) Liver Int , vol.35 , pp. 121-128
    • Ferrari, C.1
  • 45
    • 84869869851 scopus 로고    scopus 로고
    • Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection
    • e8
    • Martinet J, Dufeu-Duchesne T, Bruder Costa J, et al. Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection. Gastroenterology. 2012;143:1586–1596.e8.
    • (2012) Gastroenterology , vol.143 , pp. 1586-1596
    • Martinet, J.1    Dufeu-Duchesne, T.2    Bruder Costa, J.3
  • 46
    • 84905647558 scopus 로고    scopus 로고
    • The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection
    • Schuch A, Hoh A, Thimme R. The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection. Front Immunol. 2014;5:258.
    • (2014) Front Immunol , vol.5 , pp. 258
    • Schuch, A.1    Hoh, A.2    Thimme, R.3
  • 47
    • 84872369702 scopus 로고    scopus 로고
    • Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B?
    • Thimme R, Dandri M. Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B? J Hepatol. 2013;58:205–209.
    • (2013) J Hepatol , vol.58 , pp. 205-209
    • Thimme, R.1    Dandri, M.2
  • 48
    • 84940172833 scopus 로고    scopus 로고
    • Immune-modulators to combat hepatitis B virus infection: from IFN-α to novel investigational immunotherapeutic strategies
    • Isorce N, Lucifora J, Zoulim F, Durantel D. Immune-modulators to combat hepatitis B virus infection: from IFN-α to novel investigational immunotherapeutic strategies. Antiviral Res. 2015;122:69–81.
    • (2015) Antiviral Res , vol.122 , pp. 69-81
    • Isorce, N.1    Lucifora, J.2    Zoulim, F.3    Durantel, D.4
  • 49
  • 50
    • 84900842537 scopus 로고    scopus 로고
    • Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming
    • Dalod M, Chelbi R, Malissen B, Lawrence T. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J. 2014;33:1104–1116.
    • (2014) EMBO J , vol.33 , pp. 1104-1116
    • Dalod, M.1    Chelbi, R.2    Malissen, B.3    Lawrence, T.4
  • 51
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
    • 1517-10
    • Lanford RE, Guerra B, Chavez D, et al. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology. 2013;144:1508–1517, 1517-10.
    • (2013) Gastroenterology , vol.144 , pp. 1508-1517
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.3
  • 52
    • 84929606985 scopus 로고    scopus 로고
    • Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
    • Menne S, Tumas DB, Liu KH, et al. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. J Hepatol. 2015;62:1237–1245.
    • (2015) J Hepatol , vol.62 , pp. 1237-1245
    • Menne, S.1    Tumas, D.B.2    Liu, K.H.3
  • 53
    • 84935451137 scopus 로고    scopus 로고
    • The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
    • Gane EJ, Lim Y-S, Gordon SC, et al. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. J Hepatol. 2015;63:320–328.
    • (2015) J Hepatol , vol.63 , pp. 320-328
    • Gane, E.J.1    Lim, Y.-S.2    Gordon, S.C.3
  • 54
    • 84921914245 scopus 로고    scopus 로고
    • STING agonists induce an innate antiviral immune response against hepatitis B virus
    • Guo F, Han Y, Zhao X, et al. STING agonists induce an innate antiviral immune response against hepatitis B virus. Antimicrob Agents Chemother. 2015;59:1273–1281.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 1273-1281
    • Guo, F.1    Han, Y.2    Zhao, X.3
  • 55
    • 85007531029 scopus 로고    scopus 로고
    • P0535: direct antiviral effects of various pattern recognition receptor (PRR) agonists in HBV-replicating hepatocytes
    • Lucifora J, Maadadi S, Floriot O, et al. P0535: direct antiviral effects of various pattern recognition receptor (PRR) agonists in HBV-replicating hepatocytes. J Hepatol. 2015;62:S515–S516.
    • (2015) J Hepatol , vol.62 , pp. S515-S516
    • Lucifora, J.1    Maadadi, S.2    Floriot, O.3
  • 56
    • 33846492518 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
    • Visvanathan K, Skinner NA, Thompson AJV, et al. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology. 2007;45:102–110.
    • (2007) Hepatology , vol.45 , pp. 102-110
    • Visvanathan, K.1    Skinner, N.A.2    Thompson, A.J.V.3
  • 57
    • 84865153815 scopus 로고    scopus 로고
    • Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
    • Zhang X, Ma Z, Liu H, et al. Role of Toll-like receptor 2 in the immune response against hepadnaviral infection. J Hepatol. 2012;57:522–528.
    • (2012) J Hepatol , vol.57 , pp. 522-528
    • Zhang, X.1    Ma, Z.2    Liu, H.3
  • 58
    • 84865118780 scopus 로고    scopus 로고
    • Interplay between hepatitis B virus and TLR2-mediated innate immune responses: can restoration of TLR2 functions be a new therapeutic option?
    • Durantel D, Zoulim F. Interplay between hepatitis B virus and TLR2-mediated innate immune responses: can restoration of TLR2 functions be a new therapeutic option? J Hepatol. 2012;57:486–489.
    • (2012) J Hepatol , vol.57 , pp. 486-489
    • Durantel, D.1    Zoulim, F.2
  • 59
    • 84928947363 scopus 로고    scopus 로고
    • Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis
    • Ebert G, Allison C, Preston S, et al. Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc Natl Acad Sci USA. 2015;112:5803–5808.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 5803-5808
    • Ebert, G.1    Allison, C.2    Preston, S.3
  • 60
    • 84954110027 scopus 로고    scopus 로고
    • Promises and challenges of smac mimetics as cancer therapeutics
    • Fulda S. Promises and challenges of smac mimetics as cancer therapeutics. Clin Cancer Res. 2015;21:5030–5036.
    • (2015) Clin Cancer Res , vol.21 , pp. 5030-5036
    • Fulda, S.1
  • 61
    • 84946018523 scopus 로고    scopus 로고
    • Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the « magic bullet » to kill cccDNA
    • Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M. Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the « magic bullet » to kill cccDNA. Antiviral Res. 2015;123:193–203.
    • (2015) Antiviral Res , vol.123 , pp. 193-203
    • Zhang, E.1    Kosinska, A.2    Lu, M.3    Yan, H.4    Roggendorf, M.5
  • 63
    • 84922268964 scopus 로고    scopus 로고
    • Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
    • Qasim W, Brunetto M, Gehring AJ, et al. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. J Hepatol. 2015;62:486–491.
    • (2015) J Hepatol , vol.62 , pp. 486-491
    • Qasim, W.1    Brunetto, M.2    Gehring, A.J.3
  • 64
    • 84965083364 scopus 로고    scopus 로고
    • T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
    • Ye B, Liu X, Li X, Kong H, Tian L, Chen Y. T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance. Cell Death Dis. 2015;6:e1694.
    • (2015) Cell Death Dis , vol.6
    • Ye, B.1    Liu, X.2    Li, X.3    Kong, H.4    Tian, L.5    Chen, Y.6
  • 65
    • 84921496569 scopus 로고    scopus 로고
    • Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections
    • Rehermann B, Bertoletti A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology. 2015;61:712–721.
    • (2015) Hepatology , vol.61 , pp. 712-721
    • Rehermann, B.1    Bertoletti, A.2
  • 66
    • 84930651350 scopus 로고    scopus 로고
    • Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
    • Pallett LJ, Gill US, Quaglia A, et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med. 2015;21:591–600.
    • (2015) Nat Med , vol.21 , pp. 591-600
    • Pallett, L.J.1    Gill, U.S.2    Quaglia, A.3
  • 67
    • 84983720423 scopus 로고    scopus 로고
    • PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model
    • Tzeng H-T, Tsai H-F, Liao H-J, et al. PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. PLoS One. 2012;7:e39179.
    • (2012) PLoS One , vol.7
    • Tzeng, H.-T.1    Tsai, H.-F.2    Liao, H.-J.3
  • 68
    • 84893805242 scopus 로고    scopus 로고
    • Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
    • Liu J, Zhang E, Ma Z, et al. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog. 2014;10:e1003856.
    • (2014) PLoS Pathog , vol.10
    • Liu, J.1    Zhang, E.2    Ma, Z.3
  • 69
    • 84859482444 scopus 로고    scopus 로고
    • Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection
    • Tang Y, Jiang L, Zheng Y, Ni B, Wu Y. Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection. BMC Immunol. 2012;13:17.
    • (2012) BMC Immunol , vol.13 , pp. 17
    • Tang, Y.1    Jiang, L.2    Zheng, Y.3    Ni, B.4    Wu, Y.5
  • 70
    • 84919773476 scopus 로고    scopus 로고
    • Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial–ANRS HB02 VAC-ADN
    • Fontaine H, Kahi S, Chazallon C, et al. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial–ANRS HB02 VAC-ADN. Gut. 2015;64:139–147.
    • (2015) Gut , vol.64 , pp. 139-147
    • Fontaine, H.1    Kahi, S.2    Chazallon, C.3
  • 71
    • 84991093310 scopus 로고    scopus 로고
    • Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B
    • Lok AS, Pan CQ, Han S-HB, et al. Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B. J Hepatol. 2016;65:509–516.
    • (2016) J Hepatol , vol.65 , pp. 509-516
    • Lok, A.S.1    Pan, C.Q.2    Han, S.-H.B.3
  • 72
    • 84925501250 scopus 로고    scopus 로고
    • Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end?
    • Michel M-L, Bourgine M, Fontaine H, Pol S. Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end? Med Microbiol Immunol. 2015;204:121–129.
    • (2015) Med Microbiol Immunol , vol.204 , pp. 121-129
    • Michel, M.-L.1    Bourgine, M.2    Fontaine, H.3    Pol, S.4
  • 73
    • 84928889426 scopus 로고    scopus 로고
    • The immune tolerant phase of chronic HBV infection: new perspectives on an old concept
    • Bertoletti A, Kennedy PT. The immune tolerant phase of chronic HBV infection: new perspectives on an old concept. Cell Mol Immunol. 2015;12:258–263.
    • (2015) Cell Mol Immunol , vol.12 , pp. 258-263
    • Bertoletti, A.1    Kennedy, P.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.