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Volumn 21, Issue 22, 2015, Pages 5030-5036

Promises and challenges of Smac mimetics as cancer therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BIRC2 PROTEIN, HUMAN; BIRC3 PROTEIN, HUMAN; DIABLO PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MITOCHONDRIAL PROTEIN; SIGNAL PEPTIDE; UBIQUITIN PROTEIN LIGASE; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84954110027     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0365     Document Type: Article
Times cited : (160)

References (73)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006;25:4798-811.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 3
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012;11:109-24.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 4
    • 79959539790 scopus 로고    scopus 로고
    • Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death
    • Vucic D, Dixit VM, Wertz IE. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat Rev Mol Cell Biol 2011;12:439-52.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 439-452
    • Vucic, D.1    Dixit, V.M.2    Wertz, I.E.3
  • 5
    • 33750443289 scopus 로고    scopus 로고
    • IκB kinase complexes: Gateways to NF-κB activation and transcription
    • Scheidereit C. IκB kinase complexes: gateways to NF-κB activation and transcription. Oncogene 2006;25:6685-705.
    • (2006) Oncogene , vol.25 , pp. 6685-6705
    • Scheidereit, C.1
  • 6
    • 84870383878 scopus 로고    scopus 로고
    • Tumor necrosis factor
    • Chu WM. Tumor necrosis factor. Cancer Lett 2013;328:222-5.
    • (2013) Cancer Lett , vol.328 , pp. 222-225
    • Chu, W.M.1
  • 7
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIKdependent alternative NF-kappaB signaling
    • Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIKdependent alternative NF-kappaB signaling. Nat Immunol 2008;9: 1364-70.
    • (2008) Nat Immunol , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1    Matsuzawa, A.2    Zhang, W.3    Tseng, P.H.4    Keats, J.J.5    Wang, H.6
  • 8
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008;9:1371-8.
    • (2008) Nat Immunol , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6
  • 9
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-kappaB signaling pathway
    • Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res 2011; 21:71-85.
    • (2011) Cell Res , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 10
    • 84858627919 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation bymembers of the TNF family of receptors
    • Varfolomeev E, Goncharov T, Maecker H, Zobel K, Komuves LG, Deshayes K, et al. Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation bymembers of the TNF family of receptors. Sci Signal 2012;5:ra22.
    • (2012) Sci Signal , vol.5 , pp. ra22
    • Varfolomeev, E.1    Goncharov, T.2    Maecker, H.3    Zobel, K.4    Komuves, L.G.5    Deshayes, K.6
  • 11
    • 0035854738 scopus 로고    scopus 로고
    • Xlinked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling
    • Birkey Reffey S, Wurthner JU, Parks WT, Roberts AB, Duckett CS. Xlinked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. J Biol Chem 2001;276: 26542-9.
    • (2001) J Biol Chem , vol.276 , pp. 26542-26549
    • Birkey Reffey, S.1    Wurthner, J.U.2    Parks, W.T.3    Roberts, A.B.4    Duckett, C.S.5
  • 12
    • 0034698053 scopus 로고    scopus 로고
    • Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
    • Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R. Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J Biol Chem 2000; 275:22064-8.
    • (2000) J Biol Chem , vol.275 , pp. 22064-22068
    • Hofer-Warbinek, R.1    Schmid, J.A.2    Stehlik, C.3    Binder, B.R.4    Lipp, J.5    De Martin, R.6
  • 14
    • 78649635741 scopus 로고    scopus 로고
    • To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death
    • Lopez J, Meier P. To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death. Curr Opin Cell Biol 2010; 22:872-81.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 872-881
    • Lopez, J.1    Meier, P.2
  • 15
    • 84954117316 scopus 로고    scopus 로고
    • BCL-2 antagonism to target the intrinsic mitochondrial pathway of apoptosis
    • Gibson CJ, Davids MS. BCL-2 antagonism to target the intrinsic mitochondrial pathway of apoptosis. Clin Cancer Res 2015;21:5021-9.
    • (2015) Clin Cancer Res , vol.21 , pp. 5021-5029
    • Gibson, C.J.1    Davids, M.S.2
  • 16
    • 84876071466 scopus 로고    scopus 로고
    • Pulling the plug on a cancer cell by eliminating XIAP with AEG35156
    • LaCasse EC. Pulling the plug on a cancer cell by eliminating XIAP with AEG35156. Cancer Lett 2013;332:215-24.
    • (2013) Cancer Lett , vol.332 , pp. 215-224
    • LaCasse, E.C.1
  • 17
    • 78650959291 scopus 로고    scopus 로고
    • Targeting IAPs as an approach to anti-cancer therapy
    • Straub CS. Targeting IAPs as an approach to anti-cancer therapy. Curr Top Med Chem 2011;11:291-316.
    • (2011) Curr Top Med Chem , vol.11 , pp. 291-316
    • Straub, C.S.1
  • 18
    • 35648961848 scopus 로고    scopus 로고
    • A dimeric smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo
    • Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM, et al. A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. J Biol Chem 2007; 282:30718-27.
    • (2007) J Biol Chem , vol.282 , pp. 30718-30727
    • Gao, Z.1    Tian, Y.2    Wang, J.3    Yin, Q.4    Wu, H.5    Li, Y.M.6
  • 19
    • 71749083634 scopus 로고    scopus 로고
    • X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists
    • Varfolomeev E, Alicke B, Elliott JM, Zobel K, West K, Wong H, et al. X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem 2009;284:34553-60.
    • (2009) J Biol Chem , vol.284 , pp. 34553-34560
    • Varfolomeev, E.1    Alicke, B.2    Elliott, J.M.3    Zobel, K.4    West, K.5    Wong, H.6
  • 20
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs, NFkappaB activation, and TNFalpha-dependent apoptosis
    • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, et al. IAP antagonists induce autoubiquitination of c-IAPs, NFkappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131:669-81.
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1    Blankenship, J.W.2    Wayson, S.M.3    Fedorova, A.V.4    Kayagaki, N.5    Garg, P.6
  • 21
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007;131:682-93.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 22
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha signaling renders human cancer cells susceptible to smacmimetic-induced apoptosis
    • Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smacmimetic-induced apoptosis. Cancer Cell 2007;12:445-56.
    • (2007) Cancer Cell , vol.12 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6
  • 23
    • 44949240664 scopus 로고    scopus 로고
    • CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008;30:689-700.
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 25
    • 67650787318 scopus 로고    scopus 로고
    • Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists
    • Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, et al. Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. ACS Chem Biol 2009;4: 557-66.
    • (2009) ACS Chem Biol , vol.4 , pp. 557-566
    • Ndubaku, C.1    Varfolomeev, E.2    Wang, L.3    Zobel, K.4    Lau, K.5    Elliott, L.O.6
  • 26
    • 84907883684 scopus 로고    scopus 로고
    • Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors
    • Infante JR, Dees EC, Olszanski AJ, Dhuria SV, Sen S, Cameron S, et al. Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors. J Clin Oncol 2014;32: 3103-10.
    • (2014) J Clin Oncol , vol.32 , pp. 3103-3110
    • Infante, J.R.1    Dees, E.C.2    Olszanski, A.J.3    Dhuria, S.V.4    Sen, S.5    Cameron, S.6
  • 27
    • 84901490248 scopus 로고    scopus 로고
    • Phase I study of safety and pharmacokinetics (PK) of GDC-0917, an antagonist of inhibitor of apoptosis (IAP) proteins in patients (Pts) with refractory solid tumors or lymphoma
    • (suppl; abstr 2503)
    • Tolcher A, Papadopoulos K, Patnaik A, Fairbrother W, Wong H, Budha N, et al. Phase I study of safety and pharmacokinetics (PK) of GDC-0917, an antagonist of inhibitor of apoptosis (IAP) proteins in patients (Pts) with refractory solid tumors or lymphoma. J Clin Oncol 31, 2013 (suppl; abstr 2503).
    • (2013) J Clin Oncol , vol.31
    • Tolcher, A.1    Papadopoulos, K.2    Patnaik, A.3    Fairbrother, W.4    Wong, H.5    Budha, N.6
  • 28
    • 84856455103 scopus 로고    scopus 로고
    • Safety, pharmocokinetics (PK), and pharmacodynamics (PD) of HGS1029, an inhibitor of apoptosis protein (IAP), in patients (Pts.) with advanced solid tumors: Results of a phase I study
    • (suppl; abstr 3008)
    • Sikic BI, Eckhardt SG, Gallant G, Burris HA, Camidge DR, Covelas AD, et al. Safety, pharmocokinetics (PK), and pharmacodynamics (PD) of HGS1029, an inhibitor of apoptosis protein (IAP), in patients (Pts.) with advanced solid tumors: results of a phase I study. J Clin Oncol 29, 2011 (suppl; abstr 3008).
    • (2011) J Clin Oncol , vol.29
    • Sikic, B.I.1    Eckhardt, S.G.2    Gallant, G.3    Burris, H.A.4    Camidge, D.R.5    Covelas, A.D.6
  • 29
    • 84901487898 scopus 로고    scopus 로고
    • A phase I study of birinapant (TL32711) combined with multiple chemotherapies evaluating tolerability and clinical activity for solid tumor patients
    • (suppl; abstr 2504)
    • Amaravadi R, NN S, LP M, Schilder R, LoRusso P, Papadopoulos K, et al. A phase I study of birinapant (TL32711) combined with multiple chemotherapies evaluating tolerability and clinical activity for solid tumor patients. J Clin Oncol 31, 2013 (suppl; abstr 2504).
    • (2013) J Clin Oncol , vol.31
    • Amaravadi, R.1    Nn, S.2    Lp, M.3    Schilder, R.4    LoRusso, P.5    Papadopoulos, K.6
  • 30
    • 84899917603 scopus 로고    scopus 로고
    • Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer
    • (suppl; abstr 3621)
    • Senzer N, LoRusso P, Martin L, Schilder R, Amaravadi R, Papadopoulos K, et al. Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer. J Clin Oncol 31, 2013 (suppl; abstr 3621).
    • (2013) J Clin Oncol , vol.31
    • Senzer, N.1    LoRusso, P.2    Martin, L.3    Schilder, R.4    Amaravadi, R.5    Papadopoulos, K.6
  • 31
    • 84934907317 scopus 로고    scopus 로고
    • First-inhuman, pharmacokinetic (PK), and pharmacodynamics (PD) phase I study of debio1143 (AT-406) in patients with advanced cancer: Final results
    • (suppl; abstr 2532)
    • Hurwitz H, Pitot H, Smith D, Brill J, Vuagniaux G, Rouits E, et al. First-inhuman, pharmacokinetic (PK), and pharmacodynamics (PD) phase I study of Debio1143 (AT-406) in patients with advanced cancer: Final results. J Clin Oncol 32:5s, 2014 (suppl; abstr 2532).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Hurwitz, H.1    Pitot, H.2    Smith, D.3    Brill, J.4    Vuagniaux, G.5    Rouits, E.6
  • 32
    • 84902048280 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of the smac-mimetic birinapant (TL32711) as a single agent and in combination with multiple chemotherapy regimens
    • (suppl; abstr 3029)
    • Fetterly G, Liu B, Senzer N, Amaravadi R, Schilder R, Martin L, et al. Clinical pharmacokinetics of the Smac-mimetic birinapant (TL32711) as a single agent and in combination with multiple chemotherapy regimens. J Clin Oncol 30, 2012 (suppl; abstr 3029).
    • (2012) J Clin Oncol , vol.30
    • Fetterly, G.1    Liu, B.2    Senzer, N.3    Amaravadi, R.4    Schilder, R.5    Martin, L.6
  • 33
    • 84954142544 scopus 로고    scopus 로고
    • Clinical pharmacokinetic (PK)/pharmacodynamic (PD) model for debio 1143, a novel antagonist of IAPs in cancer treatment
    • (suppl; abstr 2585)
    • Rouits E, Gisleskog P, Gavillet B, Menetrey A, Sorensen M, Zanna C, et al. Clinical pharmacokinetic (PK)/pharmacodynamic (PD) model for Debio 1143, a novel antagonist of IAPs in cancer treatment. J Clin Oncol 32:5s, 2014 (suppl; abstr 2585).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Rouits, E.1    Gisleskog, P.2    Gavillet, B.3    Menetrey, A.4    Sorensen, M.5    Zanna, C.6
  • 34
    • 84954145699 scopus 로고    scopus 로고
    • Pharmacodynamic biomarkers from phase II study of the SMAC (Second mitochondrial-derived activator of caspases)-mimetic birinapant (TL32711; NSC 756502) in relapsed platinum-resistant epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC) (NCT01681368)
    • (suppl; abstr 5585)
    • Bunch K, Noonan A, Lee J, O'Sullivan CCM, Houston N, Ekwede I, et al. Pharmacodynamic biomarkers from phase II study of the SMAC (Second Mitochondrial-Derived Activator of Caspases)-mimetic birinapant (TL32711; NSC 756502) in relapsed platinum-resistant epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC) (NCT01681368). J Clin Oncol 32:5s, 2014 (suppl; abstr 5585).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Bunch, K.1    Noonan, A.2    Lee, J.3    O'Sullivan, C.C.M.4    Houston, N.5    Ekwede, I.6
  • 35
    • 84855440150 scopus 로고    scopus 로고
    • Requirement of nuclear factor kappaB for smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis
    • Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D, et al. Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. Neoplasia 2011;13:1162-70.
    • (2011) Neoplasia , vol.13 , pp. 1162-1170
    • Stadel, D.1    Cristofanon, S.2    Abhari, B.A.3    Deshayes, K.4    Zobel, K.5    Vucic, D.6
  • 36
    • 84860756390 scopus 로고    scopus 로고
    • RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
    • Loeder S, Fakler M, Schoeneberger H, Cristofanon S, Leibacher J, Vanlangenakker N, et al. RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Leukemia 2012;26:1020-9.
    • (2012) Leukemia , vol.26 , pp. 1020-1029
    • Loeder, S.1    Fakler, M.2    Schoeneberger, H.3    Cristofanon, S.4    Leibacher, J.5    Vanlangenakker, N.6
  • 37
    • 77956712168 scopus 로고    scopus 로고
    • Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-alpha-dependent manner
    • Probst BL, Liu L, Ramesh V, Li L, Sun H, Minna JD, et al. Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-alpha-dependent manner. Cell Death Differ 2010;17:1645-54.
    • (2010) Cell Death Differ , vol.17 , pp. 1645-1654
    • Probst, B.L.1    Liu, L.2    Ramesh, V.3    Li, L.4    Sun, H.5    Minna, J.D.6
  • 38
    • 77950806356 scopus 로고    scopus 로고
    • Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer
    • Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, et al. Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer. Cancer Res 2010;70:2852-61.
    • (2010) Cancer Res , vol.70 , pp. 2852-2861
    • Dineen, S.P.1    Roland, C.L.2    Greer, R.3    Carbon, J.G.4    Toombs, J.E.5    Gupta, P.6
  • 39
    • 84874763808 scopus 로고    scopus 로고
    • Smac mimetic sensitizes glioblastoma cells to temozolomide-induced apoptosis in a RIP1- and NF-kappaB-dependent manner
    • Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, et al. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-kappaB-dependent manner. Oncogene 2013;32:988-97.
    • (2013) Oncogene , vol.32 , pp. 988-997
    • Wagner, L.1    Marschall, V.2    Karl, S.3    Cristofanon, S.4    Zobel, K.5    Deshayes, K.6
  • 40
    • 84893682835 scopus 로고    scopus 로고
    • Smac mimetic primes apoptosisresistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis
    • Chromik J, Safferthal C, Serve H, Fulda S. Smac mimetic primes apoptosisresistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis. Cancer Lett 2014;344:101-9.
    • (2014) Cancer Lett , vol.344 , pp. 101-109
    • Chromik, J.1    Safferthal, C.2    Serve, H.3    Fulda, S.4
  • 41
    • 84904104369 scopus 로고    scopus 로고
    • Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly
    • Belz K, Schoeneberger H, Wehner S, Weigert A, Bonig H, Klingebiel T, et al. Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. Blood 2014;124:240-50.
    • (2014) Blood , vol.124 , pp. 240-250
    • Belz, K.1    Schoeneberger, H.2    Wehner, S.3    Weigert, A.4    Bonig, H.5    Klingebiel, T.6
  • 42
    • 67650485853 scopus 로고    scopus 로고
    • Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
    • Vellanki SH, Grabrucker A, Liebau S, Proepper C, Eramo A, Braun V, et al. Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. Neoplasia 2009;11:743-52.
    • (2009) Neoplasia , vol.11 , pp. 743-752
    • Vellanki, S.H.1    Grabrucker, A.2    Liebau, S.3    Proepper, C.4    Eramo, A.5    Braun, V.6
  • 43
    • 35549007260 scopus 로고    scopus 로고
    • Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition
    • Giagkousiklidis S, Vellanki SH, Debatin KM, Fulda S. Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition. Oncogene 2007;26:7006-16.
    • (2007) Oncogene , vol.26 , pp. 7006-7016
    • Giagkousiklidis, S.1    Vellanki, S.H.2    Debatin, K.M.3    Fulda, S.4
  • 44
    • 80053933840 scopus 로고    scopus 로고
    • NF-{kappa}B is required for smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis
    • Berger R, Jennewein C, Marschall V, Karl S, Cristofanon S, Wagner L, et al. NF-{kappa}B is required for Smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis. Mol Cancer Ther 2011;10:1867-75.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1867-1875
    • Berger, R.1    Jennewein, C.2    Marschall, V.3    Karl, S.4    Cristofanon, S.5    Wagner, L.6
  • 45
    • 80052731000 scopus 로고    scopus 로고
    • A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo
    • Ziegler DS, Keating J, Kesari S, Fast EM, Zawel L, Ramakrishna N, et al. A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo. Neuro Oncol 2011;13:820-9.
    • (2011) Neuro Oncol , vol.13 , pp. 820-829
    • Ziegler, D.S.1    Keating, J.2    Kesari, S.3    Fast, E.M.4    Zawel, L.5    Ramakrishna, N.6
  • 46
    • 84861703831 scopus 로고    scopus 로고
    • Inhibitor of apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers
    • Fulda S. Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers. Cancer Treat Rev 2012;38:760-6.
    • (2012) Cancer Treat Rev , vol.38 , pp. 760-766
    • Fulda, S.1
  • 47
    • 78650385933 scopus 로고    scopus 로고
    • TRAILinduced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors
    • Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, et al. TRAILinduced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors. Clin Cancer Res 2010;16:5734-49.
    • (2010) Clin Cancer Res , vol.16 , pp. 5734-5749
    • Stadel, D.1    Mohr, A.2    Ref, C.3    MacFarlane, M.4    Zhou, S.5    Humphreys, R.6
  • 48
    • 65549139431 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma
    • Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M, et al. Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. Cancer Res 2009;69:2425-34.
    • (2009) Cancer Res , vol.69 , pp. 2425-2434
    • Vogler, M.1    Walczak, H.2    Stadel, D.3    Haas, T.L.4    Genze, F.5    Jovanovic, M.6
  • 50
    • 85042587668 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome bcl-2-mediated resistance
    • Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, Debatin KM, et al. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 2009;113:1710-22.
    • (2009) Blood , vol.113 , pp. 1710-1722
    • Fakler, M.1    Loeder, S.2    Vogler, M.3    Schneider, K.4    Jeremias, I.5    Debatin, K.M.6
  • 51
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda S, Wick W, Weller M, Debatin KM. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 2002;8:808-15.
    • (2002) Nat Med , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 52
    • 84989339202 scopus 로고    scopus 로고
    • Identification of RIP1 as a critical mediator of smac mimetic-mediated sensitization of glioblastoma cells for drozitumabinduced apoptosis
    • Cristofanon S, Abhari BA, Krueger M, Tchoghandjian A, Momma S, Calaminus C, et al. Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumabinduced apoptosis. Cell Death Dis 2015;6:e1724.
    • (2015) Cell Death Dis , vol.6 , pp. e1724
    • Cristofanon, S.1    Abhari, B.A.2    Krueger, M.3    Tchoghandjian, A.4    Momma, S.5    Calaminus, C.6
  • 53
    • 84880265865 scopus 로고    scopus 로고
    • RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex
    • Abhari BA, Cristofanon S, Kappler R, von Schweinitz D, Humphreys R, Fulda S. RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex. Oncogene 2013;32:3263-73.
    • (2013) Oncogene , vol.32 , pp. 3263-3273
    • Abhari, B.A.1    Cristofanon, S.2    Kappler, R.3    Von Schweinitz, D.4    Humphreys, R.5    Fulda, S.6
  • 54
    • 84869056283 scopus 로고    scopus 로고
    • RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis
    • Basit F, Humphreys R, Fulda S. RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis. J Biol Chem 2012;287:38767-77.
    • (2012) J Biol Chem , vol.287 , pp. 38767-38777
    • Basit, F.1    Humphreys, R.2    Fulda, S.3
  • 55
    • 84885015530 scopus 로고    scopus 로고
    • Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
    • Steinhart L, Belz K, Fulda S. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis. Cell Death Dis 2013;4:e802.
    • (2013) Cell Death Dis , vol.4 , pp. e802
    • Steinhart, L.1    Belz, K.2    Fulda, S.3
  • 56
    • 84897112174 scopus 로고    scopus 로고
    • Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents
    • Carter BZ, Mak PY, Mak DH, Shi Y, Qiu Y, Bogenberger JM, et al. Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents. J Natl Cancer Inst 2014;106:djt440.
    • (2014) J Natl Cancer Inst , vol.106 , pp. djt440
    • Carter, B.Z.1    Mak, P.Y.2    Mak, D.H.3    Shi, Y.4    Qiu, Y.5    Bogenberger, J.M.6
  • 57
    • 84937519269 scopus 로고    scopus 로고
    • Identification of a novel synergistic induction of cell death by smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
    • Steinwascher S, Nugues AL, Schoeneberger H, Fulda S. Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. Cancer Lett 2015;366: 32-43.
    • (2015) Cancer Lett , vol.366 , pp. 32-43
    • Steinwascher, S.1    Nugues, A.L.2    Schoeneberger, H.3    Fulda, S.4
  • 59
    • 84908217257 scopus 로고    scopus 로고
    • Synergistic interaction of smac mimetic and IFNalpha to trigger apoptosis in acute myeloid leukemia cells
    • Bake V, Roesler S, Eckhardt I, Belz K, Fulda S. Synergistic interaction of Smac mimetic and IFNalpha to trigger apoptosis in acute myeloid leukemia cells. Cancer Lett 2014;355:224-31.
    • (2014) Cancer Lett , vol.355 , pp. 224-231
    • Bake, V.1    Roesler, S.2    Eckhardt, I.3    Belz, K.4    Fulda, S.5
  • 60
    • 84863499007 scopus 로고    scopus 로고
    • Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-alpha but not through TRAIL and fas L
    • Jinesh GG, Chunduru S, Kamat AM. Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-alpha but not through TRAIL and Fas L. J Leukoc Biol 2012;92:233-44.
    • (2012) J Leukoc Biol , vol.92 , pp. 233-244
    • Jinesh, G.G.1    Chunduru, S.2    Kamat, A.M.3
  • 61
    • 84940648522 scopus 로고    scopus 로고
    • SMAC mimetic BV6 enables sensitization of resistant tumor cells but also affects cytokine-induced killer (CIK) cells: A potential challenge for combination therapy
    • Rettinger E, Glatthaar A, Abhari B, Oelsner S, Pfirrmann V, Huenecke S, et al. SMAC mimetic BV6 enables sensitization of resistant tumor cells but also affects cytokine-induced killer (CIK) cells: a potential challenge for combination therapy. Front Pediatr Onc 2014;2:75.
    • (2014) Front Pediatr Onc , vol.2 , pp. 75
    • Rettinger, E.1    Glatthaar, A.2    Abhari, B.3    Oelsner, S.4    Pfirrmann, V.5    Huenecke, S.6
  • 62
    • 85015338574 scopus 로고    scopus 로고
    • Phase I study of debio1143 (AT406) in combination with daunorubicin (D) and cytarabine (C) in patients with poor-risk acute myeloid leukemia (AML)
    • (suppl; abstr 7029)
    • DiPersio J, Erba H, Larson R, Luger S, Mangan K, Tallman M, et al. Phase I study of Debio1143 (AT406) in combination with daunorubicin (D) and cytarabine (C) in patients with poor-risk acute myeloid leukemia (AML). J Clin Oncol 32:5s, 2014 (suppl; abstr 7029).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • DiPersio, J.1    Erba, H.2    Larson, R.3    Luger, S.4    Mangan, K.5    Tallman, M.6
  • 63
    • 34447308516 scopus 로고    scopus 로고
    • Potentiation of antileukemic therapies by smac mimetic, LBW242: Effects on mutant FLT3-expressing cells
    • Weisberg E, Kung AL, Wright RD, Moreno D, Catley L, Ray A, et al. Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol Cancer Ther 2007;6:1951-61.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1951-1961
    • Weisberg, E.1    Kung, A.L.2    Wright, R.D.3    Moreno, D.4    Catley, L.5    Ray, A.6
  • 64
    • 84954137885 scopus 로고    scopus 로고
    • A drug combination screen identifies taxanes as synergistic agents with the oral IAP inhibitor debio 1143 in non-small cell lung cancer cells [abstract]
    • Oct 19-23; Boston (MA) and Philadelphia (PA): AACR; 2013: Abstract nr A16
    • Langdon CG, Wiedemann N, Held MA, Platt JT, Lévy F, Zanna C, et al., et al. A drug combination screen identifies taxanes as synergistic agents with the oral IAP inhibitor Debio 1143 in non-small cell lung cancer cells [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston (MA) and Philadelphia (PA): AACR; 2013: Abstract nr A16.
    • (2013) Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
    • Langdon, C.G.1    Wiedemann, N.2    Held, M.A.3    Platt, J.T.4    Lévy, F.5    Zanna, C.6
  • 65
    • 84954160956 scopus 로고    scopus 로고
    • Preclinical rationale for combining the smac-mimetic debio 1143 with concurrent chemio-radiotherapy in La-SCCHN [abstract]
    • 2013 Feb 7-9, Barcelona, Spain. Brussels (Belgium): European Society for Radiotherapy&Oncology; Radiother Oncol. Abstract nr OC-019
    • Viertl D, Perillo-Adamer F, Rigotti S, Maby El Hajjami H, Vaslin A, Vuagniaux G, et al. Preclinical rationale for combining the Smac-mimetic Debio 1143 with concurrent chemio-radiotherapy in La-SCCHN [abstract]. In: Proceedings of the 4th International Conference on Innovative Approaches in Head & Neck Oncology; 2013 Feb 7-9, Barcelona, Spain. Brussels (Belgium): European Society for Radiotherapy&Oncology; Radiother Oncol. 2013;106:S6-7. Abstract nr OC-019.
    • (2013) Proceedings of the 4th International Conference on Innovative Approaches in Head & Neck Oncology , vol.106 , pp. S6-7
    • Viertl, D.1    Perillo-Adamer, F.2    Rigotti, S.3    Maby El-Hajjami, H.4    Vaslin, A.5    Vuagniaux, G.6
  • 66
    • 84954152045 scopus 로고    scopus 로고
    • A phase I/II randomized study of debio1143 combined with concurrent chemoradiation therapy (CCRT) in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN)
    • (suppl; abstr TPS6097)
    • Le Tourneau C, Tao Y, Delord J, Brienza S, Vuagniaux G, Sablin M, et al. A phase I/II randomized study of Debio1143 combined with concurrent chemoradiation therapy (CCRT) in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). J Clin Oncol 32:5s, 2014 (suppl; abstr TPS6097).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Le Tourneau, C.1    Tao, Y.2    Delord, J.3    Brienza, S.4    Vuagniaux, G.5    Sablin, M.6
  • 67
    • 84905441719 scopus 로고    scopus 로고
    • Molecular pathways: Targeting death receptors and smac mimetics
    • Fulda S. Molecular pathways: targeting death receptors and smac mimetics. Clin Cancer Res 2014;20:3915-20.
    • (2014) Clin Cancer Res , vol.20 , pp. 3915-3920
    • Fulda, S.1
  • 68
    • 34247163603 scopus 로고    scopus 로고
    • A small molecule smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells
    • Petrucci E, Pasquini L, Petronelli A, Saulle E, Mariani G, Riccioni R, et al. A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells. Gynecol Oncol 2007;105:481-92.
    • (2007) Gynecol Oncol , vol.105 , pp. 481-492
    • Petrucci, E.1    Pasquini, L.2    Petronelli, A.3    Saulle, E.4    Mariani, G.5    Riccioni, R.6
  • 69
    • 84872790310 scopus 로고    scopus 로고
    • Smac peptide potentiates TRAIL-or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo
    • Mao HL, Pang Y, Zhang X, Yang F, Zheng J, Wang Y, et al. Smac peptide potentiates TRAIL-or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo. Oncol Rep 2013;29:515-22.
    • (2013) Oncol Rep , vol.29 , pp. 515-522
    • Mao, H.L.1    Pang, Y.2    Zhang, X.3    Yang, F.4    Zheng, J.5    Wang, Y.6
  • 70
    • 84954159417 scopus 로고    scopus 로고
    • A phase 1b/2a study of birinapant in combination with 5-azacitadine in patients with myelodysplastic syndrome who are naïve, refractory to or have relapsed on 5-azacitadine: A preliminary analysis [abstract]
    • 2014 Dec 6-9; San Francisco, CA and Washington, DC: American Society of Hematology; Abstract nr 3263
    • Borthakur G, Foran J, Wang E, Rakkar A, Hager S, Frey N, et al. A phase 1b/2a study of birinapant in combination with 5-azacitadine in patients with myelodysplastic syndrome who are naïve, refractory to or have relapsed on 5-azacitadine: a preliminary analysis [abstract]. In: Proceedings of the 56th ASH Annual Meeting and Exposition; 2014 Dec 6-9; San Francisco, CA and Washington, DC: American Society of Hematology; 2014. Abstract nr 3263.
    • (2014) Proceedings of the 56th ASH Annual Meeting and Exposition
    • Borthakur, G.1    Foran, J.2    Wang, E.3    Rakkar, A.4    Hager, S.5    Frey, N.6
  • 71
    • 84875877848 scopus 로고    scopus 로고
    • Identification of non-canonical NF-kappaB signaling as a critical mediator of smac mimetic-stimulated migration and invasion of glioblastoma cells
    • Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S. Identification of non-canonical NF-kappaB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. Cell Death Dis 2013;4:e564.
    • (2013) Cell Death Dis , vol.4 , pp. e564
    • Tchoghandjian, A.1    Jennewein, C.2    Eckhardt, I.3    Rajalingam, K.4    Fulda, S.5
  • 73
    • 84907447355 scopus 로고    scopus 로고
    • Correlation between TNFα and LCL161 anti-tumor activity in patient derived xenograft models of human cancer [abstract]
    • Firestone B, Conway C, Yang G, Gao H, Porter D, Slisz J, et al. Correlation between TNFα and LCL161 anti-tumor activity in patient derived xenograft models of human cancer [abstract]. Mol Cancer Ther 2009;8(12 Suppl): B27.
    • (2009) Mol Cancer Ther , vol.8 , Issue.12 , pp. B27
    • Firestone, B.1    Conway, C.2    Yang, G.3    Gao, H.4    Porter, D.5    Slisz, J.6


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