Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection

mBio

Volumn 7, Issue 6, 2016, Pages

  Diner, Benjamin A ^a   Lum, Krystal K ^a   Toettcher, Jared E ^a   Cristea, Ileana M ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP AMP SYNTHASE; GAMMA INTERFERON INDUCIBLE PROTEIN IFI16; PROTEIN; PYRIN; SYNTHETASE; UNCLASSIFIED DRUG; VIRUS DNA; CYTOKINE; IFI16 PROTEIN, HUMAN; MB21D1 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUCLEOTIDYLTRANSFERASE; PHOSPHOPROTEIN;

APOPTOSIS; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DNA VIRUS; GENE EXPRESSION REGULATION; HERPES SIMPLEX VIRUS 1; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNITY; MAMMAL CELL; MASS SPECTROMETRY; OLIGOMERIZATION; OPTOGENETICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; VIRUS GENE; VIRUS GENOME; VIRUS REPLICATION; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CRISPR CAS SYSTEM; CYTOMEGALOVIRUS; ENERGY FILTERED TRANSMISSION ELECTRON MICROSCOPY; FIBROBLAST; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; PYRIN DOMAIN; SIGNAL TRANSDUCTION; ULTRASTRUCTURE; VIROLOGY;

APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; CRISPR-CAS SYSTEMS; CYTOKINES; CYTOMEGALOVIRUS; DNA, VIRAL; FIBROBLASTS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 1, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROSCOPY, ENERGY-FILTERING TRANSMISSION ELECTRON; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES; PHOSPHOPROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOMICS; PYRIN DOMAIN; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

EID: 85007554197     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01553-16     Document Type: Article

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