U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 6, 2017, Pages 1797-1807

  Lefaudeux, Diane ^a   De Meulder, Bertrand ^a   Loza, Matthew J ^b   Peffer, Nancy ^b   Rowe, Anthony ^b   Baribaud, Frédéric ^b   Bansal, Aruna T ^c   Lutter, Rene ^d   Sousa, Ana R ^e   Corfield, Julie ^f   Pandis, Ioannis ^g   Bakke, Per S ^h   Caruso, Massimo ⁱ   Chanez, Pascal ^j   Dahlén, Sven Erik ^k   Fleming, Louise J ^l   Fowler, Stephen J ^m   Horvath, Ildiko ⁿ   Krug, Norbert ^o   Montuschi, Paolo ^p   Sanak, Marek ^q   Sandstrom, Thomas ^r   Shaw, Dominic E ^s   Singer, Florian ^t   Sterk, Peter J ^u   Roberts, Graham ^v   Adcock, Ian M ^l   Djukanovic, Ratko ^v   Auffray, Charles ^a   Chung, Kian Fan ^l   Adriaens, Nora ^w   Ahmed, Hassan ^w   Aliprantis, Antonios ^w   Alving, Kjell ^w   Badorek, Philipp ^w   Balgoma, David ^w   Barber, Clair ^w   Bautmans, An ^w   Behndig, Annelie F ^w   Bel, Elisabeth ^w   Beleta, Jorge ^w   Berglind, Ann ^w   Berton, Alix ^w   Bigler, Jeanette ^w   Bisgaard, Hans ^w   Bochenek, Grazyna ^w   Boedigheimer, Michael J ^w   Bøonnelykke, Klaus ^w   Brandsma, Joost ^w   Braun, Armin ^w   Brinkman, Paul ^w   Burg, Dominic ^w   Campagna, Davide ^w   Carayannopoulos, Leon ^w   Carvalho da Purfição Rocha, João P ^w   Chaiboonchoe, Amphun ^w   Chaleckis, Romanas ^w   Coleman, Courtney ^w   Compton, Chris ^w   D'Amico, Arnaldo ^w   Dahlén, Barbro ^w   De Alba, Jorge ^w   de Boer, Pim ^w   De Lepeleire, Inge ^w   Dekker, Tamara ^w   Delin, Ingrid ^w   Dennison, Patrick ^w   Dijkhuis, Annemiek ^w   Draper, Aleksandra ^w   Edwards, Jessica ^w   Emma, Rosalia ^w   Ericsson, Magnus ^w   Erpenbeck, Veit ^w   Erzen, Damijan ^w   Faulenbach, Cornelia ^w   Fichtner, Klaus ^w   Fitch, Neil ^w   Flood, Breda ^w   Frey, Urs ^w   Gahlemann, Martina ^w   Galffy, Gabriella ^w   Gallart, Hector ^w   Garret, Trevor ^w   Geiser, Thomas ^w   Gent, Jilaiha ^w   Gerhardsson de Verdier, Maria ^w   Gibeon, David ^w   Gomez, Cristina ^w   Gove, Kerry ^w   Gozzard, Neil ^w   Guo, Yi Ke ^w   Hashimoto, Simone ^w   Haughney, John ^w   Hedlin, Gunilla ^w   Hekking, Pieter Paul ^w   Henriksson, Elisabeth ^w   Hewitt, Lorraine ^w   Higgenbottam, Tim ^w   Hoda, Uruj ^w   Hohlfeld, Jans ^w   Holweg, Cecile ^w   Howarth, Peter ^w   Hu, Richard ^w   Hu, Sile ^w   Hu, Xugang ^w   Hudson, Val ^w   James, Anna J ^w   Kamphuis, Juliette ^w   Kennington, Erika J ^w   Kerry, Dyson ^w   Klüglich, Matthias ^w   Knobel, Hugo ^w   Knowles, Richard ^w   Knox, Alan ^w   Kolmert, Johan ^w   Konradsen, Jon ^w   Kots, Maxim ^w   Krueger, Linn ^w   Kuo, Scott ^w   Kupczyk, Maciej ^w   Lambrecht, Bart ^w   Lantz, Ann Sofie ^w   Larsson, Lars ^w   Lazarinis, Nikos ^w   Lone Satif, Saeeda ^w   Marouzet, Lisa ^w   Martin, Jane ^w   Masefield, Sarah ^w   Mathon, Caroline ^w   Matthews, John G ^w   Mazein, Alexander ^w   Meah, Sally ^w   Maiser, Andrea ^w   Menzies Gow, Andrew ^w   Metcalf, Leanne ^w   Middelveld, Roelinde ^w   Mikus, Maria ^w   Miralpeix, Montse ^w   Monk, Philips ^w   Mores, Nadia ^w   Murray, Clare S ^w   Musial, Jacek ^w   Myles, David ^w   Naz, Shama ^w   Nething, Katja ^w   Nicholas, Ben ^w   Nihlen, Ulf ^w   Nilsson, Peter ^w   Nordlund, Björn ^w   Östling, Jörgen ^w   Pacino, Antonio ^w   Pahus, Laurie ^w   Palkonnen, Susanna ^w   Pavlidis, Stelios ^w   Pennazza, Giorgio ^w   Petrén, Anne ^w   Pink, Sandy ^w   Postle, Anthony ^w   Powel, Pippa ^w   Rahman Amin, Malayka ^w   Rao, Navin ^w   Ravanetti, Lara ^w   Ray, Emma ^w   Reinke, Stacey ^w   Reynolds, Leanne ^w   Riemann, Kathrin ^w   Riley, John ^w   Robberechts, Martine ^w   Roberts, Amanda ^w   Rossios, Christos ^w   Russell, Kirsty ^w   Rutgers, Michael ^w   Santini, Giuseppe ^w   Sentoninco, Marco ^w   Schoelch, Corinna ^w   Schofield, James P R ^w   Seibold, Wolfgang ^w   Sigmund, Ralf ^w   Sjödin, Marcus ^w   Skipp, Paul J ^w   Smids, Barbara ^w   Smith, Caroline ^w   Smith, Jessica ^w   Smith, Katherine M ^w   Söderman, Päivi ^w   Sogbesan, Adesimbo ^w   Staykova, Doroteya ^w   Strandberg, Karin ^w   Sun, Kai ^w   Supple, David ^w   Szentkereszty, Marton ^w   Tamasi, Lilla ^w   Tariq, Kamran ^w   Thörngren, John Olof ^w   Thornton, Bob ^w   Thorsen, Jonathan ^w   Valente, Salvatore ^w   van Aalderenm, Wim ^w   van de Pol, Marianne ^w   van Drunen, Kees ^w   van Geest, Marleen ^w   Versnel, Jenny ^w   Vestbo, Jorgen ^w   Vink, Anton ^w   Vissing, Nadja ^w   von Garnier, Christophe ^w   Wagerner, Arianne ^w   Wagers, Scott ^w   Wald, Frans ^w   Walker, Samantha ^w   Ward, Jonathan ^w   Weiszhart, Zsoka ^w   Wetzel, Kristiane ^w   Wheelock, Craig E ^w   Wiegman, Coen ^w   Williams, Siân ^w   Wilson, Susan J ^w   Woosdcock, Ashley ^w   Yang, Xian ^w   Yeyashingham, Elizabeth ^w   Yu, Wen ^w   Zetterquist, Wilhelm ^w   Zwinderman, Koos ^w   more..

^a CNRS   (France)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c Acclarogen Ltd   (United Kingdom)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e GLAXOSMITHKLINE   (United Kingdom)

^f ASTRAZENECA   (United Kingdom)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF BERGEN   (Norway)

ⁱ UNIVERSITY OF CATANIA   (Italy)

^j AIX MARSEILLE UNIVERSITY   (France)

^k KAROLINSKA INSTITUTE   (Sweden)

^l ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^m UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁿ SEMMELWEIS UNIVERSITY   (Hungary)

^o FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^p CATHOLIC UNIVERSITY   (Italy)

^q JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^r UMEÅ UNIVERSITY   (Sweden)

^s UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^t UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^u Southampton NIHR Respiratory Biomedical Research Unit   (United Kingdom)

^v UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^w University of Southampton ^*

more..

Author keywords

clustering; partition around medoids algorithm; Severe asthma; sputum eosinophilia

Indexed keywords

ALPHA ACTININ 2; BETA THROMBOGLOBULIN; CATHEPSIN G; CHEMOKINE; CXCL7 CHEMOKINE; DIAPH2 PROTEIN; F2R PROTEIN; FN1 PROTEIN; FUCOSYL TRANSFERASE 5; FUCOSYLTRANSFERASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1; IMMUNOGLOBULIN E; INTERLEUKIN 16; ITGB1 PROTEIN; ITGB8 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; N ACETYLGALACTOSAMINE 4 SULFATASE; NITRIC OXIDE; OAS3 PROTEIN; OASL PROTEIN; PROTEIN; PROTEIN KINASE LYN; SPRY2 PROTEIN; TRANSCRIPTION FACTOR E2F1; TRIM14 PROTEIN; TRYPSIN; TRYPSIN 2; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ACTIN FILAMENT; ADULT; ANTIGEN PRESENTATION; ARTICLE; ASTHMA; CELL DIFFERENTIATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLUSTER ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; EOSINOPHILIA; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; SMOKING; SPUTUM; TRANSCRIPTOMICS; AGED; ALGORITHM; CLASSIFICATION; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; LEUKOCYTE COUNT; METABOLISM; SEVERITY OF ILLNESS INDEX;

ADULT; AGED; ALGORITHMS; ASTHMA; BIOMARKERS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEOMICS; SEVERITY OF ILLNESS INDEX; SPUTUM;

EID: 85007464360     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.08.048     Document Type: Article

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