Lyn regulates cytotoxicity in respiratory epithelial cells challenged by cigarette smoke extracts

Current Molecular Medicine

Volumn 14, Issue 5, 2014, Pages 663-672

  Wang, W ^a,b   Ye, Y ^a   Li, J ^a   Li, X ^a   Zhou, X ^a   Tan, D ^b   Jin, Y ^c   Wu, E ^d   Cui, Q ^b   Wu, M ^a  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

^b YUNNAN UNIVERSITY   (China)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Cancer risk; Cigarette smoke extract (CSE); COPD; Cytotoxicity; JAK2; STAT1

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; JANUS KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE LYN; STAT1 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; JAK2 PROTEIN, HUMAN; LYN PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE; SMOKE; STAT1 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; LUNG ALVEOLUS MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PROTEIN EXPRESSION; SMOKING; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; HUMAN; METABOLISM; SMOKE; TOBACCO;

ANIMALS; CELL LINE; EPITHELIAL CELLS; HUMANS; JANUS KINASE 2; MICE; PHAGOCYTOSIS; SMOKE; SMOKING; SRC-FAMILY KINASES; STAT1 TRANSCRIPTION FACTOR; TOBACCO;

EID: 84904065391     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524014666140603095027     Document Type: Article

References (65)

1. Bauer CM, Morissette MC, Stampfli MR. The influence of cigarette smoking on viral infections: Translating bench science to impact copd pathogenesis and acute exacerbations of copd clinically. Chest 2013; 143(1): 196-206.
2. Houghton AM. Mechanistic links between copd and lung cancer. Nat Rev Cancer 2013; 13(4): 233-245.
3. Ferry H, Crockford TL, Silver K, Rust N, Goodnow CC, Cornall RJ. Analysis of lyn/cd22 double-deficient b cells in vivo demonstrates lyn-and cd22-independent pathways affecting bcr regulation and b cell survival. Eur J Immunol 2005; 35(12): 3655-3663.
4. Ghosh AK, Secreto C, Boysen J, et al. The novel receptor tyrosine kinase axl is constitutively active in b-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: Implications for therapy. Blood 2011; 117(6): 1928-1937.
5. De Toni EN, Kuntzen C, Gerbes AL, et al. P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes. J Hepatol 2007; 46(4): 682-691.
6. Hibbs ML, Tarlinton DM, Armes J, et al. Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease. Cell 1995; 83(2): 301-311.
7. Harder KW, Parsons LM, Armes J, et al. Gain-and loss-offunction lyn mutant mice define a critical inhibitory role for lyn in the myeloid lineage. Immunity 2001; 15(4): 603-615.
8. Verhagen AM, Wallace ME, Goradia A, et al. A kinase-dead allele of lyn attenuates autoimmune disease normally associated with lyn deficiency. J Immunol 2009; 182(4): 2020-2029.
9. Barouch-Bentov R, Che J, Lee CC, et al. A conserved salt bridge in the g loop of multiple protein kinases is important for catalysis and for in vivo lyn function. Mol Cell 2009; 33(1): 43-52.
10. Yew KH, Harrison CJ. Blockade of lyn kinase upregulates both canonical and non-canonical tlr-3 pathways in thp-1 monocytes exposed to human cytomegalovirus. Acta Virol 2011; 55(3): 243-253.
11. Scapini P, Lamagna C, Hu Y, et al. B cell-derived il-10 suppresses inflammatory disease in lyn-deficient mice. Proc Natl Acad Sci U S A 2011; 108(41): E823-832.
12. Tilbrook PA, Palmer GA, Bittorf T, et al. Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of lyn. Cancer Res 2001; 61(6): 2453-2458.
13. Hayakawa F, Naoe T. Sfk-stat pathway: An alternative and important way to malignancies. Ann N Y Acad Sci 2006; 1086: 213-222.
14. Shuh M, Morse BA, Heidecker G, Derse D. Association of src-related kinase lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of jak/stat in human t-cell leukemia virus type 1-transformed t cells. J Virol 2011; 85(9): 4623-4627.
15. Pazdrak K, Justement L, Alam R. Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of lyn, map, jak2 kinases and stat1 nuclear factor. J Immunol 1995; 155(9): 4454-4458.
16. Takai T. Tslp expression: Cellular sources, triggers, and regulatory mechanisms. Allergol Int 2012; 61(1): 3-17.
17. Smelter DF, Sathish V, Thompson MA, Pabelick CM, Vassallo R, Prakash YS. Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle. J Immunol 2010; 185(5): 3035-3040.
18. Nakamura Y, Miyata M, Ohba T, et al. Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to t(h)2-type immune responses and airway inflammation. J Allergy Clin Immunol 2008; 122(6): 1208-1214.
19. Li G, Fox J, 3rd, Liu Z, et al. Lyn mitigates mouse airway remodeling by downregulating the tgf-beta3 isoform in house dust mite models. J Immunol 2013; 191(11): 5359-5370.
20. Kannan S, Audet A, Huang H, Chen LJ, Wu M. Cholesterolrich membrane rafts and lyn are involved in phagocytosis during pseudomonas aeruginosa infection. J Immunol 2008; 180(4): 2396-2408.
21. Li X, Zhou X, Ye Y, et al. Lyn regulates inflammatory responses in klebsiella pneumoniae infection via the p38/nf-κb pathway. Eur J Immunol 2014; 44(3): 763-73.
22. Kannan S, Audet A, Knittel J, Mullegama S, Gao GF, Wu M. Src kinase lyn is crucial for pseudomonas aeruginosa internalization into lung cells. Eur J Immunol 2006; 36(7): 1739-1752.
23. Yuan K, Huang C, Fox J, et al. Autophagy plays an essential role in the clearance of pseudomonas aeruginosa by alveolar macrophages. J Cell Sci 2012; 125(Pt 2): 507-515.
24. Kannan S, Pang H, Foster DC, Rao Z, Wu M. Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered mapk activity. Cell Death Differ 2006; 13(2): 311-323.
25. Wu M, Huang H, Zhang W, et al. Host DNA repair proteins in response to pseudomonas aeruginosa in lung epithelial cells and in mice. Infect Immun 2011; 79(1): 75-87.
26. He YH, Wu M, Kobune M, Xu Y, Kelley MR, Martin WJ 2nd. Expression of yeast apurinic/apyrimidinic endonuclease (apn1) protects lung epithelial cells from bleomycin toxicity. Am J Respir Cell Mol Biol 2001; 25(6): 692-698.
27. Sethi JM, Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med 2000; 21(1): 67-86, viii.
28. Li G, Yuan K, Yan C, et al. 8-oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating stat6 and il-4 in cells and in mice. Free Radic Biol Med 2012; 52(2): 392-401.
29. Guo Q, Shen N, Yuan K, et al. Caveolin-1 plays a critical role in host immunity against klebsiella pneumoniae by regulating stat5 and akt activity. Eur J Immunol 2012; 42(6): 1500-1511.
30. Kode A, Yang SR, Rahman I. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res 2006; 7: 132.
31. Serikov VB, Leutenegger C, Krutilina R, et al. Cigarette smoke extract inhibits expression of peroxiredoxin v and increases airway epithelial permeability. Inhal Toxicol 2006; 18(1): 79-92.
32. Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM. Lyn tyrosine kinase: Accentuating the positive and the negative. Immunity 2005; 22(1): 9-18.
33. Holowka D, Gosse JA, Hammond AT, et al. Lipid segregation and ige receptor signaling: A decade of progress. Biochim Biophys Acta 2005; 1746(3): 252-259.
34. Kannan S, Huang H, Seeger D, et al. Alveolar epithelial type ii cells activate alveolar macrophages and mitigate P. aeruginosa infection. PLoS One 2009; 4(3): e4891.
35. Wang L, Kurosaki T, Corey SJ. Engagement of the b-cell antigen receptor activates stat through lyn in a jakindependent pathway. Oncogene 2007; 26(20): 2851-2859.
36. Gorina R, Petegnief V, Chamorro A, Planas AM. Ag490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: Involvement of the jak2/stat pathway. J Neurochem 2005; 92(3): 505-518.
37. Rojas M, Olivier M, Garcia LF. Activation of jak2/stat1-alphadependent signaling events during mycobacterium tuberculosis-induced macrophage apoptosis. Cell Immunol 2002; 217(1-2): 58-66.
38. Marti-Lliteras P, Regueiro V, Morey P, et al. Nontypeable haemophilus influenzae clearance by alveolar macrophages is impaired by exposure to cigarette smoke. Infect Immun 2009; 77(10): 4232-4242.
39. Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S. Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke. Biochem Biophys Res Commun 2012; 426(2): 253-259.
40. Phipps JC, Aronoff DM, Curtis JL, Goel D, O'Brien E, Mancuso P. Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complementmediated phagocytosis of streptococcus pneumoniae. Infect Immun 2010; 78(3): 1214-1220.
41. Wang Y, Zeigler MM, Lam GK, et al. The role of the nadph oxidase complex, p38 mapk, and akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol 2007; 36(1): 68-77.
42. Zheng T, Zhu Z, Wang Z, et al. Inducible targeting of il-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema. J Clin Invest 2000; 106(9): 1081-1093.
43. Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis 2005; 26(7): 1263-1271.
44. McGrath M, Wong JY, Michaud D, Hunter DJ, De Vivo I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev 2007; 16(4): 815-819.
45. Kogevinas M, Trichopoulos D. In: Urinary bladder cancer. In: Adami H-O, Hunter DJ, Trichopoulos D, (eds). Textbook of Cancer Epidemiology New York Oxford University Press; 2002. p. 446-466.
46. Wynder EL, Graham EA, Croninger AB. Experimental production of carcinoma with cigarette tar. Cancer Res 1953; 13(12): 855-864.
47. Mannino DM, Buist AS. Global burden of copd: Risk factors, prevalence, and future trends. Lancet 2007; 370(9589): 765-773.
48. Adcock IM, Caramori G, Barnes PJ. Chronic obstructive pulmonary disease and lung cancer: New molecular insights. Respiration 2011; 81(4): 265-284.
49. Wu M. DNA repair proteins as molecular therapeutics for oxidative and alkylating lung injury. Curr Gene Ther 2005; 5(2): 225-236.
50. Kannan S, Wu M. Respiratory stem cells and progenitors: Overview, derivation, differentiation, carcinogenesis, regeneration and therapeutic application. Curr Stem Cell Res Ther 2006; 1(1): 37-46.
51. Chang YP, Tsai CC, Huang WC, et al. Autophagy facilitates ifn-gamma-induced jak2-stat1 activation and cellular inflammation. J Biol Chem 2010; 285(37): 28715-28722.
52. Yao H, Edirisinghe I, Rajendrasozhan S, et al. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol 2008; 294(6): L1174-1186.
53. Guerassimov A, Hoshino Y, Takubo Y, et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med 2004; 170(9): 974-980.
54. Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C. Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent. Am J Physiol Lung Cell Mol Physiol 2010; 298(5): L704-713.
55. Bartalesi B, Cavarra E, Fineschi S, et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 2005; 25(1): 15-22.
56. Cavarra E, Bartalesi B, Lucattelli M, et al. Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants. Am J Respir Crit Care Med 2001; 164(5): 886-890.
57. Martorana PA, Cavarra E, Lucattelli M, Lungarella G. Models for copd involving cigarette smoke. Drug Discov Today Dis Models 2006; 3(3): 225-230.
58. Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
59. Stone KK, Bermudez E, Pryor WA. Aqueous extracts of cigarette tar containing the tar free radical cause DNA nicks in mammalian cells. Environ Health Perspect 1994; 102 Suppl 10: 173-178.
60. Thorne D, Wilson J, Kumaravel TS, Massey ED, McEwan M. Measurement of oxidative DNA damage induced by mainstream cigarette smoke in cultured nci-h292 human pulmonary carcinoma cells. Mutat Res 2009; 673(1): 3-8.
61. Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol 2011; 254(2): 72-85.
62. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in copd. Eur Respir J 2006; 28(1): 219-242.
63. Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for copd. Biochim Biophys Acta 2012; 1822(5): 714-728.
64. Zhou X, Li X, Ye Y, et al. MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to the TLR/IRAK4 circuit. Nat Commun 2014; 5: 3619.
65. Yuan K, Xie K, Fox J III, et al. Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Colorectal Tumor Growth and Metastasis in Mice. Gastroenterology 2013; 145(4): 853-864.