High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men

Cardiovascular Diabetology

Volumn 15, Issue 1, 2016, Pages

  Sung, Ki Chul ^a   Chang, Yoosoo ^b   Ryu, Seungho ^b   Chung, Hye Kyung ^c  

^a School of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Coronary artery calcification; Gender difference; Metabolic diseases; Serum vitamin D

Indexed keywords

VITAMIN D; BIOLOGICAL MARKER;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY CALCIFICATION; FATTY LIVER; FEMALE; HIGH RISK PATIENT; HUMAN; INSULIN RESISTANCE; KOREAN (PEOPLE); LOW RISK PATIENT; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METABOLIC SYNDROME X; RISK ASSESSMENT; SEX DIFFERENCE; VITAMIN BLOOD LEVEL; BLOOD; CHI SQUARE DISTRIBUTION; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDY; HEALTH SURVEY; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PROTECTION; RISK FACTOR; SOUTH KOREA; STATISTICAL MODEL; UPREGULATION; VASCULAR CALCIFICATION;

ADULT; BIOMARKERS; CHI-SQUARE DISTRIBUTION; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HEALTH SURVEYS; HUMANS; INSULIN RESISTANCE; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PROTECTIVE FACTORS; REPUBLIC OF KOREA; RISK FACTORS; SEX FACTORS; UP-REGULATION; VASCULAR CALCIFICATION; VITAMIN D;

EID: 85007452840     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-016-0432-3     Document Type: Article

References (52)

1. Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin D and bone health in the elderly. Am J Clin Nutr. 1982;36:1014-31.
2. Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154(Suppl):S57-73.
3. Cashman KD, Dowling KG, Skrabakova Z, Gonzalez-Gross M, Valtuena J, De Henauw S, Moreno L, Damsgaard CT, Michaelsen KF, Molgaard C, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103:1033-44.
4. Joo NS, Yang SW, Song BC, Yeum KJ. Vitamin A intake, serum vitamin D and bone mineral density: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-2011). Nutrients. 2015;7:1716-27.
5. Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev. 2008;13:6-20.
6. Vitezova A, Voortman T, Zillikens MC, Jansen PW, Hofman A, Uitterlinden AG, Franco OH, Kiefte-de Jong JC. Bidirectional associations between circulating vitamin D and cholesterol levels: the Rotterdam study. Maturitas. 2015;82:411-7.
7. McGreevy C, Williams D. New insights about vitamin D and cardiovascular disease: a narrative review. Ann Intern Med. 2011;155:820-6.
8. Hurskainen AR, Virtanen JK, Tuomainen TP, Nurmi T, Voutilainen S. Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland. Diabetes Metab Res Rev. 2012;28:418-23.
9. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, Mullen KD, Cooper JN, Sheridan MJ. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745-50.
10. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-32.
11. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-5.
12. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9.
13. LeFevre ML, Force USPST. Screening for vitamin D deficiency in adults: US preventive services task force recommendation statement. Ann Intern Med. 2015;162:133-40.
14. Devine A, Wilson SG, Dick IM, Prince RL. Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women. Am J Clin Nutr. 2002;75:283-8.
15. Zhu K, Bruce D, Austin N, Devine A, Ebeling PR, Prince RL. Randomized controlled trial of the effects of calcium with or without vitamin D on bone structure and bone-related chemistry in elderly women with vitamin D insufficiency. J Bone Miner Res. 2008;23:1343-8.
16. Song HR, Park CH. Low serum vitamin D level is associated with high risk of metabolic syndrome in post-menopausal women. J Endocrinol Invest. 2013;36:791-6.
17. Moy FM, Bulgiba A. High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia. BMC Public Health. 2011;11:735.
18. Ju SY, Jeong HS. Kim do H. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab. 2014;99:1053-63.
19. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 2008;57:2619-25.
20. Liu E, Meigs JB, Pittas AG, McKeown NM, Economos CD, Booth SL, Jacques PF. Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. 2009;139:329-34.
21. Bellan M, Guzzaloni G, Rinaldi M, Merlotti E, Ferrari C, Tagliaferri A, Pirisi M, Aimaretti G, Scacchi M, Marzullo P. Altered glucose metabolism rather than naive type 2 diabetes mellitus (T2DM) is related to vitamin D status in severe obesity. Cardiovasc Diabetol. 2014;13:57.
22. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006;29:650-6.
23. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Rheum Dis Clin N Am. 2012;38:179-206.
24. Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin N Am. 2014;43:205-32.
25. de Boer IH, Tinker LF, Connelly S, Curb JD, Howard BV, Kestenbaum B, Larson JC, Manson JE, Margolis KL, Siscovick DS, et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the women's health initiative. Diabetes Care. 2008;31:701-7.
26. Hypp�nen E, L��r� E, Reunanen A, J�rvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birthcohort study. Lancet. 2001;358:1500-3.
27. Stene LC, Joner G. Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr. 2003;78:1128-34.
28. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008;93:512-7.
29. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844-50.
30. Barchetta I, Angelico F, Del Ben M, Baroni MG, Pozzilli P, Morini S, Cavallo MG. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med. 2011;9:85.
31. Lee SM, Jun DW, Cho YK, Jang KS. Vitamin D deficiency in non-alcoholic fatty liver disease: The chicken or the egg? Clin Nutr. 2015. doi:10.1016/j.clnu.2015.10.017.
32. Christakos S, Gabrielides C, Rhoten WB. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology. Endocr Rev. 1989;10:3-26.
33. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000;47:383-91.
34. Sun Q, Shi L, Rimm EB, Giovannucci EL, Hu FB, Manson JE, Rexrode KM. Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nutr. 2011;94:534-42.
35. Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 2006;20:720-2.
36. Nakatani T, Ohnishi M, Razzaque MS. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J. 2009;23:3702-11.
37. Ohnishi M, Nakatani T, Lanske B, Razzaque MS. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin D levels. Circ Cardiovasc Genet. 2009;2:583-90.
38. Brown RB, Haq A, Stanford CF, Razzaque MS. Vitamin D, phosphate, and vasculotoxicity. Can J Physiol Pharmacol. 2015;93:1077-82.
39. Kiani AN, Fang H, Magder LS, Petri M. Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology. 2013;52:2071-6.
40. Sachs MC, Brunzell JD, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Zinman B, de Boer IH, Diabetes C, et al. Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes. Diabetes Care. 2013;36:2423-9.
41. Doherty TM, Tang W, Dascalos S, Watson KE, Demer LL, Shavelle RM, Detrano RC. Ethnic origin and serum levels of 1a, 25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation. 1997;96:1477-81.
42. Ho JS, Cannaday JJ, Barlow CE, Reinhardt DB, Wade WA, Ellis JR. Low 25-OH vitamin D levels are not associated with coronary artery calcium or obstructive stenoses. Coron Artery Dis. 2015;26:521-5.
43. Engelen L, Schalkwijk CG, Eussen SJ, Scheijen JL, Soedamah-Muthu SS, Chaturvedi N, Fuller JH, Stehouwer CD. Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovasc Diabetol. 2015;14:67.
44. Seibert E, Lehmann U, Riedel A, Ulrich C, Hirche F, Brandsch C, Dierkes J, Girndt M, Stangl GI. Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status. Eur J Nutr. 2015;1-14. doi:10.1007/s00394-015-1106-8.
45. Young KA, Snell-Bergeon JK, Naik RG, Hokanson JE, Tarullo D, Gottlieb PA, Garg SK, Rewers M. Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care. 2011;34:454-8.
46. Lee S, Ahuja V, Masaki K, Evans RW, Barinas-Mitchell EJ, Ueshima H, Shin C, Choo J, Hassen L, Edmundowicz D, Kuller LH, Willcox B, Sekikawa A. A significant positive association of vitamin D deficiency with coronary artery calcification among middle-aged men: for the ERA JUMP study. J Am Coll Nutr. 2016;1-7. doi:10.1080/07315724.2015.1118651.
47. Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010;6:550-61.
48. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807-20.
49. Morris ME, Lee HJ, Predko LM. Gender differences in the membrane transport of endogenous and exogenous compounds. Pharmacol Rev. 2003;55:229-40.
50. Al-Daghri NM, Al-Saleh Y, Aljohani N, Alokail M, Al-Attas O, Alnaami AM, Sabico S, Alsulaimani M, Al-Harbi M, Alfawaz H, Chrousos GP. Vitamin D deficiency and cardiometabolic risks: a juxtaposition of Arab adolescents and adults. PLoS One. 2015;17(10):e0131315.
51. Al-Daghri NM, Al-Attas OS, Johnston HE, Singhania A, Alokail MS, Alkharfy KM, Abd-Alrahman SH, Sabico SL, Roumeliotis TI, Manousopoulou-Garbis A, Townsend PA, Woelk CH, Chrousos GP, Garbis SD. Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu int�rieur of overweight and obese adults. J Proteome Res. 2014;13:5094-105.
52. Devries S, Wolfkiel C, Fusman B, Bakdash H, Ahmed A, Levy P, Chomka E, Kondos G, Zajac E, Rich S. Influence of age and gender on the presence of coronary calcium detected by ultrafast computed tomography. J Am Coll Cardiol. 1995;25:76-82.