Altered glucose metabolism rather than naive type 2 diabetes mellitus (T2DM) is related to vitamin D status in severe obesity

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  Bellan, Mattia ^a   Guzzaloni, Gabriele ^b   Rinaldi, Maura ^b   Merlotti, Elena ^a   Ferrari, Carlotta ^a   Tagliaferri, Antonella ^b   Pirisi, Mario ^a   Aimaretti, Gianluca ^a   Scacchi, Massimo ^b,c   Marzullo, Paolo ^a,b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; C REACTIVE PROTEIN; CALCIFEDIOL; CALCIUM; ELECTROLYTE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PARATHYROID HORMONE; PHOSPHORUS; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE SEVERITY; FAT MASS; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREVALENCE; SECONDARY HYPERPARATHYROIDISM; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

ADULT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; SEVERITY OF ILLNESS INDEX; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84899499015     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-57     Document Type: Article

References (67)

1. Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Rheum Dis Clin North Am 2012, 38:1-1. 10.1016/j.rdc.2012.03.003, 22525839.
2. Jurutka PW, Whitfield GK, Hsieh JC, Thompson PD, Haussler CA, Haussler MR. Molecular nature of the vitamin D receptor and its role in regulation of gene expression. Rev Endocr Metab Disord 2001, 2:203-216. 10.1023/A:1010062929140, 11705326.
3. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010, 20:1352-1360. 10.1101/gr.107920.110, 2945184, 20736230.
4. Verhave G, Siegert CE. Role of vitamin D in cardiovascular disease. Neth J Med 2010, 68:113-118.
5. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010, 39:365-379. 10.1016/j.ecl.2010.02.010, 2879394, 20511058.
6. Herr C, Greulich T, Koczulla RA, Meyer S, Zakharkina T, Branscheidt M, Eschmann R, Bals R. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res 2011, 12:31. 10.1186/1465-9921-12-31, 3071319, 21418564.
7. Zittermann A, Gummert JF. Nonclassical vitamin D action. Nutrients 2010, 2:408-425. 10.3390/nu2040408, 3257656, 22254030.
8. Zerwekh JE. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008, 87:1087-1091.
9. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997, 7:439-443. 10.1007/s001980050030, 9425501.
10. Bischoff-Ferrari H. Vitamin D: what is an adequate vitamin D level and how much supplementation is necessary?. Best Pract Res Clin Rheumatol 2009, 23:789-795. 10.1016/j.berh.2009.09.005, 19945690.
11. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011, 96:1911-1930. 10.1210/jc.2011-0385, 21646368, Endocrine Society.
12. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Manson JE, Mayne ST, Ross AC, Shapses SA, Taylor CL. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 2012, 97:1146-1152. 10.1210/jc.2011-2218, 22442278.
13. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006, 81:353-373. 10.4065/81.3.353, 16529140.
14. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, IOF Committee of Scientific Advisors (CSA) Nutrition Working Group Global vitamin D status and determinants of Hypovitaminosis D. Osteoporos Int 2009, 20:1807-1820. 10.1007/s00198-009-0954-6, 19543765, IOF Committee of Scientific Advisors (CSA) Nutrition Working Group.
15. Isaia G, Giorgino R, Rini GB, Bevilacqua M, Maugeri D, Adami S. Prevalence of Hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int 2003, 14:577-582. 10.1007/s00198-003-1390-7, 12856111.
16. Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet 1989, 2:1104-1105.
17. Zgaga L, Theodoratou E, Farrington SM, Agakov F, Tenesa A, Walker M, Knox S, Wallace AM, Cetnarskyj R, McNeill G, Kyle J, Porteous ME, Dunlop MG, Campbell H. Diet, environmental factors, and lifestyle underlie the high prevalence of vitamin D deficiency in healthy adults in Scotland, and supplementation reduces the proportion that are severely deficient. J Nutr 2011, 141:1535-1542. 10.3945/jn.111.140012, 3361015, 21697298.
18. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013, 10:e1001383. 10.1371/journal.pmed.1001383, 3564800, 23393431.
19. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985, 76:370-373. 10.1172/JCI111971, 423785, 2991340.
20. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 2005, 90:4119-4123. 10.1210/jc.2005-0216, 15855256.
21. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care 2006, 29:2244-2246. 10.2337/dc06-0946, 17003300.
22. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72:690-693.
23. Farouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European prospective investigation into cancer (EPIC)-Norfolk color and updated meta-analysis of prospective studies. Diabetologia 2012, 55:2173-2182. 10.1007/s00125-012-2544-y, 22526608.
24. Maestro B, Molero S, Bajo S, Dávila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Funct 2002, 20:227-232. 10.1002/cbf.951, 12125099.
25. Alvarez JA, Ashraf AP, Hunter GR, Gower BA. Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. Am J Clin Nutr 2010, 92:1344-1349. 10.3945/ajcn.110.000976, 2980959, 20861177.
26. Huang Y, Li X, Wang M, Ning H, L A, Li Y, Sun C. Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study. Cardiovasc Diabetol 2013, 12:17. 10.1186/1475-2840-12-17, 3570389, 23320821.
27. Lind L, Hänni A, Lithell H, Hvarfner A, Sörensen OH, Ljunghall S. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens 1995, 8:894-901. 10.1016/0895-7061(95)00154-H, 8541004.
28. Tai K, Need AG, Horowitz M, Chapman IM. Vitamin D, glucose, insulin, and insulin sensitivity. Nutrition 2008, 24:279-285. 10.1016/j.nut.2007.11.006, 18187309.
29. Muscogiuri G, Sorice GP, Prioletta A, Policola C, Della Casa S, Pontecorvi A, Giaccari A. 25-hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity. Obesity 2010, 18:1906-1910. 10.1038/oby.2010.11, 20150902.
30. American Diabetes Association Standards of medical care in diabetes - 2012. Diabetes Care 2012, 35(Suppl 1):S11-S63. 3632172, 22187469, American Diabetes Association.
31. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc 2011, 86:50-60. 10.4065/mcp.2010.0567, 3012634, 21193656.
32. Reis JP, von Mühlen D, Miller ER, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 2009, 124:e371-e379. 10.1542/peds.2009-0213, 19661053.
33. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 2012, 97:1953-1961. 10.1210/jc.2011-3187, 22442263.
34. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004, 79:820-825.
35. Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, Rissanen H, Montonen J, Reunanen A. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology 2008, 1:666-671.
36. Barceló A, Esquinas C, Piérola J, De la Peña M, Sánchez-de-la-Torre M, Montserrat JM, Marín JM, Duran J, Arqué M, Bauça JM, Barbé F. Vitamin D status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration 2013, 86:295-301. 10.1159/000342748, 23154407.
37. Tahrani AA, Ball A, Shepherd L, Rahim A, Jones AF, Bates A. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J Clin Pract 2010, 64:351-355. 10.1111/j.1742-1241.2009.02221.x, 19863680.
38. Brock KE, Huang WY, Fraser DR, Ke L, Tseng M, Mason RS, Stolzenberg-Solomon RZ, Freedman DM, Ahn J, Peters U, McCarty C, Hollis BW, Ziegler RG, Purdue MP, Graubard BI. Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the prostate, lung, colorectal and ovarian cancer screening trial. Br J Nutr 2011, 106:339-344. 10.1017/S0007114511001590, 3515777, 21736838.
39. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008, 57:2619-2625. 10.2337/db08-0593, 2551670, 18591391.
40. Salum E, Kampus P, Zilmer M, Eha J, Butlin M, Avolio AP, Põdramägi T, Arend A, Aunapuu M, Kals J. Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes. Cardiovasc Diabet 2012, 11:58.
41. Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008, 57:183-191. 10.1016/j.metabol.2007.08.023, 18191047.
42. Suzuki A, Kotake M, Ono Y, Kato T, Oda N, Hayakawa N, Hashimoto S, Itoh M. Hypovitaminosis D in type 2 diabetes mellitus: association with microvascular complications and type of treatment. Endocr J 2006, 53:503-510. 10.1507/endocrj.K06-001, 16829706.
43. Tsur A, Feldman BS, Feldhammer I, Hoshen MB, Leibowitz G, Balicer RD. Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care 2013, 36:1361-1367. 10.2337/dc12-1050, 23393216.
44. Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013, 36:1422-1428. 10.2337/dc12-0962, 23613602.
45. Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, Gerstein HC, Perkins BA, Harris SB, Zinman B, Hanley AJ. Association of vitamin D with insulin resistance and b-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010, 33:1379-1381. 10.2337/dc09-2321, 2875459, 20215450.
46. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995, 38:1239-1245. 10.1007/BF00422375, 8690178.
47. Inomata S, Kadowaki S, Yamatani T, Fukase M, Fujita T. Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner 1986, 1:187-192.
48. Palomer X, González-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 2008, 10:185-197. 10.1111/j.1463-1326.2007.00710.x, 18269634.
49. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209:823-882. 10.1126/science.6250216, 6250216.
50. Orwoll E, Riddle M, Prince M. Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1994, 59:1083-1087.
51. Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab 2012, 14:789-794. 10.1111/j.1463-1326.2012.01605.x, 22486948.
52. Guasch A, Bulló M, Rabassa A, Bonada A, Del Castillo D, Sabench F, Salas-Salvadó J. Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study. Cardiovasc Diabetol 2012, 11:149. 10.1186/1475-2840-11-149, 3541071, 23228198.
53. Alkharfy KM, Al-Daghri NM, Sabico SB, Al-Othman A, Moharram O, Alokail MS, Al-Saleh Y, Kumar S, Chrousos GP. Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective study. Cardiovasc Diabetol 2013, 12(1):113. 10.1186/1475-2840-12-113, 3750473, 23924389.
54. Karhapaa P, Pihlajamaki J, Porsti I, Kastarinen M, Mustonen J, Niemela O, Kuusisto J. Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias. J Intern Med 2010, 268:604-610. 10.1111/j.1365-2796.2010.02279.x, 20831628.
55. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the united states: data from the third national health and nutrition examination survey. Arch Intern Med 2007, 167:1159-1165. 10.1001/archinte.167.11.1159, 17563024.
56. Yanoff LB, Parikh SJ, Spitalnik A, Denkinger B, Sebring NG, Slaughter P, McHugh T, Remaley AT, Yanovski JA. The prevalence of Hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf) 2006, 64:523-529. 10.1111/j.1365-2265.2006.02502.x, 1863008, 16649971.
57. Khor GL, Chee WS, Shariff ZM, Poh BK, Arumugam M, Rahman JA, Theobald HE. High prevalence of vitamin D insufficiency and its association with BMI-for-age among primary school children in Kuala Lumpur, Malaysia. BMC Public Health 2011, 11:95. 10.1186/1471-2458-11-95, 3045951, 21310082.
58. Çizmecioǧlu FM, Etiler N, Görmüş U, Hamzaoǧlu O, Hatun T. Hypovitaminosis D in obese and overweight schoolchildren. J Clin Res Pediatr Endocrinol 2008, 1:89-96. 3005643, 21318069.
59. Goldner WS, Stoner JA, Thompson J, Taylor K, Larson L, Erickson J, McBride C. Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg 2008, 18:145-150. 10.1007/s11695-007-9315-8, 18175194.
60. Rosenstreich SJ, Rich C, Volwiler W. Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest 1971, 50:679-687. 10.1172/JCI106538, 291976, 4322721.
61. Mawer EB, Backhouse J, Holman CA, Lumb GA, Stanbury SW. The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 1972, 43:413-431.
62. Vilarrasa N, Maravall J, Estepa A, Sánchez R, Masdevall C, Navarro MA, Alía P, Soler J, Gómez JM. Low 25-hydroxyvitamin D concentrations in obese women: their clinical significance and relationship with anthropometric and body composition variables. J Endocrinol Invest 2007, 30:653-658.
63. Moizé V, Deulofeu R, Torres F, de Osaba JM, Vidal J. Nutritional intake and prevalence of nutritional deficiencies prior to surgery in a Spanish morbidly obese population. Obes Surg 2011, 21:1382-1388. 10.1007/s11695-011-0360-y, 21298509.
64. Reis JP, von Muhlen D, Miller ER. Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol 2008, 159:41-48. 10.1530/EJE-08-0072, 18426812.
65. Lee DM, Rutter MK, O'Neill TW, Boonen S, Vanderschueren D, Bouillon R, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Wu FC, European Male Ageing Study Group Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. Eur J Endocrinol 2009, 161:947-954. 10.1530/EJE-09-0496, 19773367, European Male Ageing Study Group.
66. Røislien J, Van Calster B, Hjelmesæth J. Parathyroid hormone is a plausible mediator for the metabolic syndrome in the morbidly obese: a cross-sectional study. Cardiovasc Diabetol 2011, 10:17. 10.1186/1475-2840-10-17, 3042378, 21306649.
67. Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013, 97:774-781. 10.3945/ajcn.112.050013, 23407306.