Antimalarial activity of novel 4-aminoquinolines active against drug resistant strains

Bioorganic Chemistry

Volumn 70, Issue , 2017, Pages 74-85

  Kondaparla, Srinivasarao ^a   Soni, Awakash ^a   Manhas, Ashan ^a   Srivastava, Kumkum ^a   Puri, Sunil K ^a   Katti, S B ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

4 Aminoquinoline; Antimalarial; Heam binding; Plasmodium falciparum

Indexed keywords

2 (7 CHLOROQUINOLIN 4 YLAMINO)ETHYL METHANESULFONATE; 2 [7 (TRIFLUOROMETHYL)QUINOLIN 4 YLAMINO]ETHYL METHANESULFONATE; 3 (7 CHLOROQUINOLIN 4 YLAMINO)PROPYL METHANESULFONATE; 3 [7 (TRIFLUOROMETHYL)QUINOLIN 4 YLAMINO]PROPYL; 3 [7 (TRIFLUOROMETHYL)QUINOLIN 4 YLAMINO]PROPYL METHANESULFONATE; 4 (7 CHLOROQUINOLIN 4 YLAMINO)BUTAN 1 OL; 4 (7 CHLOROQUINOLIN 4 YLAMINO)BUTYL METHANESULFONATE; 4 AMINOQUINOLINE DERIVATIVE; 4 [7 (TRIFLUOROMETHYL)QUINOLIN 4 YLAMINO]BUTAN 1 OL; 4 [7 (TRIFLUOROMETHYL)QUINOLIN 4 YLAMINO]BUTYL METHANESULFONATE; 7 CHLORO N [2 (4 ETHYLPIPERAZIN 1 YL)ETHYL]QUINOLIN 4 AMINE; 7 CHLORO N [2 (4 PHENYLPIPERAZIN 1 YL)ETHYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (4 ETHYLPIPERAZIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [4 (4 ETHYLPIPERAZIN 1 YL)BUTYL]QUINOLIN 4 AMINE; 7 CHLORO N [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]QUINOLIN 4 AMINE; ANTIMALARIAL AGENT; ARTEETHER; CHLOROQUINE; N [2 (4 ETHYLPIPERAZIN 1 YL)ETHYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [2 (4 PHENYLPIPERAZIN 1 YL)ETHYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [3 (4 BENZYLPIPERAZIN 1 YL)PROPYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [3 (4 ETHYLPIPERAZIN 1 YL)PROPYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 (4 BENZYLPIPERAZIN 1 YL) BUTYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 (4 BENZYLPIPERAZIN 1 YL)BUTYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 (4 BENZYLPIPERAZIN 1 YL)BUTYL] 7 CHLOROQUINOLIN 4 AMINE; N [4 (4 ETHYLPIPERAZIN 1 YL)BUTYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; N [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL] 7 (TRIFLUOROMETHYL)QUINOLIN 4 AMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4-AMINOQUINOLINE; AMINOQUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MOUSE; MOUSE MODEL; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VERO CELL LINE; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG RESISTANCE; DRUG SENSITIVITY; MALARIA; MALARIA, FALCIPARUM;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; CERCOPITHECUS AETHIOPS; DRUG DISCOVERY; DRUG RESISTANCE; HUMANS; MALARIA; MALARIA, FALCIPARUM; MICE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; VERO CELLS;

EID: 85007363508     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2016.11.010     Document Type: Article

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