Design, synthesis, and in vitro activity of novel 2′- O -substituted 15-membered azalides

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3216-3227

  Pešić, Dijana ^a   Starčević, Kristina ^a   Toplak, Ana ^a   Herreros, Esperanza ^b   Vidal, Jaume ^b   Almela, Maria Jesus ^b   Jelić, Dubravko ^a   Alihodžić, Sulejman ^a   Spaventi, Radan ^a   Perić, Mihaela ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2' O (3 AMINOPROPYL) 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O (3 CARBOXYETHYL) 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [(4 QUINOLINYL)AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [(4 QUINOLINYLMETHYL)AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [(7 CHLORO 4 QUINOLINYL)AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [METHYL(4 QUINOLINYLMETHYL)AMINO]PROPYL]9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [[2 [(4 QUINOLINYL)AMINO]ETHANOYL]AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [[2 [(7 CHLORO 4 QUINOLINYL)AMINO]ETHANOYL]AMINO]PROPYL] 3 O DECLADINOSYL 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [[2 [(7 CHLORO 4 QUINOLINYL)AMINO]ETHANOYL]AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [[2 [(7 CHLORO 4 QUINOLINYL)AMINO]ETHYL]AMINO] 3 OXOPROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O [3 [[4 [(7 CHLORO 4 QUINOLINYL)AMINO]BUTANOYL]AMINO]PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; ANTIMALARIAL AGENT; AZITHROMYCIN; CHLOROQUINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; PARASITE; PLASMODIUM FALCIPARUM;

EID: 84859791683     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201676t     Document Type: Article

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