Engagement of the S1, S1′ and S2′ subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 183, Issue 1, 2012, Pages 70-77

  Dalal, Seema ^a   Ragheb, Daniel R T ^a   Klemba, Michael ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Enzyme kinetics; Hemoglobin; Malaria; Peptidase; Vacuole

Indexed keywords

AMINOPEPTIDASE; HEMOGLOBIN;

ARTICLE; CATALYSIS; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; HYDROPHOBICITY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMINOPEPTIDASES; CATALYTIC DOMAIN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; OLIGOPEPTIDES; PLASMODIUM FALCIPARUM; PROTEOLYSIS; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; ZINC;

PLASMODIUM FALCIPARUM;

EID: 84858702136     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2012.02.003     Document Type: Article

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