-
1
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila ML, Riviere I, Wang X et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6(224), 224ra225 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, Issue.224
, pp. 224ra225
-
-
Davila, M.L.1
Riviere, I.2
Wang, X.3
-
2
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371(16), 1507-1517 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, Issue.16
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
-
3
-
-
85007206434
-
Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: An early Phase IIa trial report
-
Zhang W-Y, Wang Y, Guo Y-L et al. Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early Phase IIa trial report. Signal Transduction And Targeted Therapy 1, 16002 (2016).
-
(2016)
Signal Transduction and Targeted Therapy
, vol.1
, pp. 16002
-
-
Zhang, W.-Y.1
Wang, Y.2
Guo, Y.-L.3
-
4
-
-
84940881287
-
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
-
Porter DL, Hwang WT, Frey NV et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci. Transl. Med. 7(303), 303ra139 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, Issue.303
, pp. 303ra139
-
-
Porter, D.L.1
Hwang, W.T.2
Frey, N.V.3
-
5
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
-
Kochenderfer JN, Dudley ME, Feldman SA et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119(12), 2709-2720 (2012).
-
(2012)
Blood
, vol.119
, Issue.12
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Feldman, S.A.3
-
6
-
-
82955207691
-
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
-
Louis CU, Savoldo B, Dotti G et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 118(23), 6050-6056 (2011).
-
(2011)
Blood
, vol.118
, Issue.23
, pp. 6050-6056
-
-
Louis, C.U.1
Savoldo, B.2
Dotti, G.3
-
7
-
-
84897484486
-
CAR T cells for solid tumors: Armed and ready to go?
-
Kakarla S, Gottschalk S. CAR T cells for solid tumors: armed and ready to go? Cancer J. 20(2), 151-155 (2014).
-
(2014)
Cancer J.
, vol.20
, Issue.2
, pp. 151-155
-
-
Kakarla, S.1
Gottschalk, S.2
-
8
-
-
84954236800
-
Prospects for gene-engineered T cell immunotherapy for solid cancers
-
Klebanoff CA, Rosenberg SA, Restifo NP. Prospects for gene-engineered T cell immunotherapy for solid cancers. Nat. Med. 22(1), 26-36 (2016).
-
(2016)
Nat. Med.
, vol.22
, Issue.1
, pp. 26-36
-
-
Klebanoff, C.A.1
Rosenberg, S.A.2
Restifo, N.P.3
-
9
-
-
84989172165
-
Ionic immune suppression within the tumour microenvironment limits T cell effector function
-
Eil R, Vodnala SK, Clever D et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537(7621), 539-543 (2016).
-
(2016)
Nature
, vol.537
, Issue.7621
, pp. 539-543
-
-
Eil, R.1
Vodnala, S.K.2
Clever, D.3
-
10
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5), 405-413 (1994).
-
(1994)
Immunity
, vol.1
, Issue.5
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
11
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192(7), 1027-1034 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, Issue.7
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
12
-
-
84945451852
-
Immunological hallmarks of stromal cells in the tumour microenvironment
-
Turley SJ, Cremasco V, Astarita JL. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat. Rev. Immunol. 15(11), 669-682 (2015).
-
(2015)
Nat. Rev. Immunol.
, vol.15
, Issue.11
, pp. 669-682
-
-
Turley, S.J.1
Cremasco, V.2
Astarita, J.L.3
-
14
-
-
84882636722
-
Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
-
Schuberth PC, Hagedorn C, Jensen SM et al. Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells. J. Transl. Med. 11, 187 (2013).
-
(2013)
J. Transl. Med.
, vol.11
, pp. 187
-
-
Schuberth, P.C.1
Hagedorn, C.2
Jensen, S.M.3
-
15
-
-
0032710319
-
Clinical applications of angiogenic growth factors and their inhibitors
-
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat. Med. 5(12), 1359-1364 (1999).
-
(1999)
Nat. Med.
, vol.5
, Issue.12
, pp. 1359-1364
-
-
Ferrara, N.1
Alitalo, K.2
-
16
-
-
78049436238
-
Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
-
Chinnasamy D, Yu Z, Theoret MR et al. Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice. J. Clin. Invest. 120(11), 3953-3968 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, Issue.11
, pp. 3953-3968
-
-
Chinnasamy, D.1
Yu, Z.2
Theoret, M.R.3
-
17
-
-
0028900690
-
Persistent oxidative stress in cancer
-
Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 358(1), 1-3 (1995).
-
(1995)
FEBS Lett.
, vol.358
, Issue.1
, pp. 1-3
-
-
Toyokuni, S.1
Okamoto, K.2
Yodoi, J.3
Hiai, H.4
-
18
-
-
84954164946
-
Coexpressed catalase protects chimeric antigen receptorredirected T cells as well as bystander cells from oxidative stress-induced loss of antitumor activity
-
Ligtenberg MA, Mougiakakos D, Mukhopadhyay M et al. Coexpressed catalase protects chimeric antigen receptorredirected T cells as well as bystander cells from oxidative stress-induced loss of antitumor activity. J. Immunol. 196(2), 759-766 (2016).
-
(2016)
J. Immunol.
, vol.196
, Issue.2
, pp. 759-766
-
-
Ligtenberg, M.A.1
Mougiakakos, D.2
Mukhopadhyay, M.3
-
19
-
-
0035575701
-
Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
-
Liu K, Rosenberg SA. Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity. J. Immunol. 167(11), 6356-6365 (2001).
-
(2001)
J. Immunol.
, vol.167
, Issue.11
, pp. 6356-6365
-
-
Liu, K.1
Rosenberg, S.A.2
-
20
-
-
0038176105
-
Interleukin-2-independent proliferation of human melanoma-reactive T lymphocytes transduced with an exogenous IL-2 gene is stimulation dependent
-
Liu K, Rosenberg SA. Interleukin-2-independent proliferation of human melanoma-reactive T lymphocytes transduced with an exogenous IL-2 gene is stimulation dependent. J. Immunother. 26(3), 190-201 (2003).
-
(2003)
J. Immunother.
, vol.26
, Issue.3
, pp. 190-201
-
-
Liu, K.1
Rosenberg, S.A.2
-
21
-
-
44349117909
-
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2
-
Heemskerk B, Liu K, Dudley ME et al. Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2. Hum. Gene Ther. 19(5), 496-510 (2008).
-
(2008)
Hum. Gene Ther.
, vol.19
, Issue.5
, pp. 496-510
-
-
Heemskerk, B.1
Liu, K.2
Dudley, M.E.3
-
22
-
-
28244460980
-
Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawalinduced apoptosis and persist long-term in the absence of exogenous cytokine
-
Hsu C, Hughes MS, Zheng Z, Bray RB, Rosenberg SA, Morgan RA. Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawalinduced apoptosis and persist long-term in the absence of exogenous cytokine. J. Immunol. 175(11), 7226-7234 (2005).
-
(2005)
J. Immunol.
, vol.175
, Issue.11
, pp. 7226-7234
-
-
Hsu, C.1
Hughes, M.S.2
Zheng, Z.3
Bray, R.B.4
Rosenberg, S.A.5
Morgan, R.A.6
-
23
-
-
34250023777
-
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
-
Hsu C, Jones SA, Cohen CJ et al. Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood 109(12), 5168-5177 (2007).
-
(2007)
Blood
, vol.109
, Issue.12
, pp. 5168-5177
-
-
Hsu, C.1
Jones, S.A.2
Cohen, C.J.3
-
24
-
-
77954590000
-
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
-
Hoyos V, Savoldo B, Quintarelli C et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia 24(6), 1160-1170 (2010).
-
(2010)
Leukemia
, vol.24
, Issue.6
, pp. 1160-1170
-
-
Hoyos, V.1
Savoldo, B.2
Quintarelli, C.3
-
25
-
-
79953325686
-
Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment
-
Zhang L, Kerkar SP, Yu Z et al. Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. Mol. Ther. 19(4), 751-759 (2011).
-
(2011)
Mol. Ther.
, vol.19
, Issue.4
, pp. 751-759
-
-
Zhang, L.1
Kerkar, S.P.2
Yu, Z.3
-
26
-
-
84055217292
-
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
-
Kerkar SP, Goldszmid RS, Muranski P et al. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J. Clin. Invest. 121(12), 4746-4757 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, Issue.12
, pp. 4746-4757
-
-
Kerkar, S.P.1
Goldszmid, R.S.2
Muranski, P.3
-
27
-
-
84879696103
-
Collapse of the tumor stroma is triggered by IL-12 induction of Fas
-
Kerkar SP, Leonardi AJ, Van Panhuys N et al. Collapse of the tumor stroma is triggered by IL-12 induction of Fas. Mol. Ther. 21(7), 1369-1377 (2013).
-
(2013)
Mol. Ther.
, vol.21
, Issue.7
, pp. 1369-1377
-
-
Kerkar, S.P.1
Leonardi, A.J.2
Van Panhuys, N.3
-
28
-
-
84858759305
-
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
-
Pegram HJ, Lee JC, Hayman EG et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 119(18), 4133-4141 (2012).
-
(2012)
Blood
, vol.119
, Issue.18
, pp. 4133-4141
-
-
Pegram, H.J.1
Lee, J.C.2
Hayman, E.G.3
-
29
-
-
84936934796
-
TRUCKs: The fourth generation of CARs
-
Chmielewski M, Abken H. TRUCKs: the fourth generation of CARs. Expert Opin. Biol. Ther. 15(8), 1145-1154 (2015).
-
(2015)
Expert Opin. Biol. Ther.
, vol.15
, Issue.8
, pp. 1145-1154
-
-
Chmielewski, M.1
Abken, H.2
-
30
-
-
84958230998
-
Engineering customized cell sensing and response behaviors using synthetic Notch receptors
-
Morsut L, Roybal KT, Xiong X et al. Engineering customized cell sensing and response behaviors using synthetic Notch receptors. Cell 164(4), 780-791 (2016).
-
(2016)
Cell
, vol.164
, Issue.4
, pp. 780-791
-
-
Morsut, L.1
Roybal, K.T.2
Xiong, X.3
-
31
-
-
84990855364
-
Engineering T cells with customized therapeutic response programs using synthetic Notch receptors
-
Roybal KT, Williams JZ, Morsut L et al. Engineering T cells with customized therapeutic response programs using synthetic Notch receptors. Cell 167(2), 419-432 e416 (2016).
-
(2016)
Cell
, vol.167
, Issue.2
, pp. 419e416-432e416
-
-
Roybal, K.T.1
Williams, J.Z.2
Morsut, L.3
-
32
-
-
84990200043
-
Customizing functionality and payload delivery for receptor-engineered T cells
-
Klebanoff CA, Restifo NP. Customizing functionality and payload delivery for receptor-engineered T cells. Cell 167(2), 304-306 (2016).
-
(2016)
Cell
, vol.167
, Issue.2
, pp. 304-306
-
-
Klebanoff, C.A.1
Restifo, N.P.2
-
33
-
-
84902124970
-
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
-
Motz GT, Santoro SP, Wang LP et al. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat. Med. 20(6), 607-615 (2014).
-
(2014)
Nat. Med.
, vol.20
, Issue.6
, pp. 607-615
-
-
Motz, G.T.1
Santoro, S.P.2
Wang, L.P.3
-
34
-
-
67650638846
-
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
-
Di Stasi A, De Angelis B, Rooney CM et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood 113(25), 6392-6402 (2009).
-
(2009)
Blood
, vol.113
, Issue.25
, pp. 6392-6402
-
-
Stasi A, D.I.1
De Angelis, B.2
Rooney, C.M.3
-
35
-
-
77958063691
-
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
-
Craddock JA, Lu A, Bear A et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J. Immunother. 33(8), 780-788 (2010).
-
(2010)
J. Immunother.
, vol.33
, Issue.8
, pp. 780-788
-
-
Craddock, J.A.1
Lu, A.2
Bear, A.3
-
36
-
-
67349252824
-
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7
-
Vera JF, Hoyos V, Savoldo B et al. Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol. Ther. 17(5), 880-888 (2009).
-
(2009)
Mol. Ther.
, vol.17
, Issue.5
, pp. 880-888
-
-
Vera, J.F.1
Hoyos, V.2
Savoldo, B.3
-
37
-
-
55249117972
-
Antitumor activity of EBVspecific T lymphocytes transduced with a dominant negative TGF-beta receptor
-
Foster AE, Dotti G, Lu A et al. Antitumor activity of EBVspecific T lymphocytes transduced with a dominant negative TGF-beta receptor. J. Immunother. 31(5), 500-505 (2008).
-
(2008)
J. Immunother.
, vol.31
, Issue.5
, pp. 500-505
-
-
Foster, A.E.1
Dotti, G.2
Lu, A.3
-
38
-
-
0036566184
-
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
-
Bollard CM, Rossig C, Calonge MJ et al. Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood 99(9), 3179-3187 (2002).
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3179-3187
-
-
Bollard, C.M.1
Rossig, C.2
Calonge, M.J.3
-
39
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto-and transcostimulation, resulting in potent tumor rejection
-
Stephan MT, Ponomarev V, Brentjens RJ et al. T cell-encoded CD80 and 4-1BBL induce auto-and transcostimulation, resulting in potent tumor rejection. Nat. Med. 13(12), 1440-1449 (2007).
-
(2007)
Nat. Med.
, vol.13
, Issue.12
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
-
40
-
-
84962163731
-
A chimeric switchreceptor targeting PD1 augments the efficacy of secondgeneration CAR T cells in advanced solid tumors
-
Liu X, Ranganathan R, Jiang S et al. A chimeric switchreceptor targeting PD1 augments the efficacy of secondgeneration CAR T cells in advanced solid tumors. Cancer Res. 76(6), 1578-1590 (2016).
-
(2016)
Cancer Res.
, vol.76
, Issue.6
, pp. 1578-1590
-
-
Liu, X.1
Ranganathan, R.2
Jiang, S.3
-
41
-
-
84902146901
-
Reversal of tumor immune inhibition using a chimeric cytokine receptor
-
Leen AM, Sukumaran S, Watanabe N et al. Reversal of tumor immune inhibition using a chimeric cytokine receptor. Mol. Ther. 22(6), 1211-1220 (2014).
-
(2014)
Mol. Ther.
, vol.22
, Issue.6
, pp. 1211-1220
-
-
Leen, A.M.1
Sukumaran, S.2
Watanabe, N.3
-
42
-
-
85126608903
-
Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes
-
Lizotte PH, Ivanova EV, Awad MM et al. Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes. JCI Insight 1(14), e89014 (2016).
-
(2016)
JCI Insight
, vol.1
, Issue.14
, pp. e89014
-
-
Lizotte, P.H.1
Ivanova, E.V.2
Awad, M.M.3
-
43
-
-
84955621208
-
Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers
-
Becht E, Giraldo NA, Germain C et al. Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers. Adv. Immunol. 130, 95-190 (2016).
-
(2016)
Adv. Immunol.
, vol.130
, pp. 95-190
-
-
Becht, E.1
Giraldo, N.A.2
Germain, C.3
-
45
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 372(26), 2521-2532 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, Issue.26
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
-
46
-
-
84959040060
-
Importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies
-
Choudhury N, Nakamura Y. Importance of immunopharmacogenomics in cancer treatment: patient selection and monitoring for immune checkpoint antibodies. Cancer Sci. 107(2), 107-115 (2016).
-
(2016)
Cancer Sci.
, vol.107
, Issue.2
, pp. 107-115
-
-
Choudhury, N.1
Nakamura, Y.2
-
47
-
-
84942890083
-
IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8+ T cells
-
Sun Z, Fourcade J, Pagliano O et al. IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8+ T cells. Cancer Res. 75(8), 1635-1644 (2015).
-
(2015)
Cancer Res.
, vol.75
, Issue.8
, pp. 1635-1644
-
-
Sun, Z.1
Fourcade, J.2
Pagliano, O.3
-
48
-
-
34250884676
-
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type i signaling
-
Raskovalova T, Lokshin A, Huang X et al. Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling. Cancer Res. 67(12), 5949-5956 (2007).
-
(2007)
Cancer Res.
, vol.67
, Issue.12
, pp. 5949-5956
-
-
Raskovalova, T.1
Lokshin, A.2
Huang, X.3
-
49
-
-
84904254163
-
Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
-
Mittal D, Young A, Stannard K et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res. 74(14), 3652-3658 (2014).
-
(2014)
Cancer Res.
, vol.74
, Issue.14
, pp. 3652-3658
-
-
Mittal, D.1
Young, A.2
Stannard, K.3
-
50
-
-
34248173331
-
Indoleamine 2,3-dioxygenase and tumor-induced tolerance
-
Munn DH, Mellor AL. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117(5), 1147-1154 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, Issue.5
, pp. 1147-1154
-
-
Munn, D.H.1
Mellor, A.L.2
-
51
-
-
84880664259
-
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
-
Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210(7), 1389-1402 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, Issue.7
, pp. 1389-1402
-
-
Holmgaard, R.B.1
Zamarin, D.2
Munn, D.H.3
Wolchok, J.D.4
Allison, J.P.5
-
52
-
-
84977161108
-
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
-
Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J Immunother. Cancer 2, 3 (2014).
-
(2014)
J Immunother. Cancer
, vol.2
, pp. 3
-
-
Spranger, S.1
Koblish, H.K.2
Horton, B.3
Scherle, P.A.4
Newton, R.5
Gajewski, T.F.6
-
53
-
-
84935012050
-
Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
-
Ninomiya S, Narala N, Huye L et al. Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs. Blood 125(25), 3905-3916 (2015).
-
(2015)
Blood
, vol.125
, Issue.25
, pp. 3905-3916
-
-
Ninomiya, S.1
Narala, N.2
Huye, L.3
-
54
-
-
0031573612
-
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells
-
Levine BL, Bernstein WB, Connors M et al. Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J. Immunol. 159(12), 5921-5930 (1997).
-
(1997)
J. Immunol.
, vol.159
, Issue.12
, pp. 5921-5930
-
-
Levine, B.L.1
Bernstein, W.B.2
Connors, M.3
-
55
-
-
0036171757
-
Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB
-
Maus MV, Thomas AK, Leonard DG et al. Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat. Biotechnol. 20(2), 143-148 (2002).
-
(2002)
Nat. Biotechnol.
, vol.20
, Issue.2
, pp. 143-148
-
-
Maus, M.V.1
Thomas, A.K.2
Leonard, D.G.3
-
56
-
-
84898009421
-
Universal artificial antigen presenting cells to selectively propagate T cells expressing chimeric antigen receptor independent of specificity
-
Rushworth D, Jena B, Olivares S et al. Universal artificial antigen presenting cells to selectively propagate T cells expressing chimeric antigen receptor independent of specificity. J. Immunother. 37(4), 204-213 (2014).
-
(2014)
J. Immunother.
, vol.37
, Issue.4
, pp. 204-213
-
-
Rushworth, D.1
Jena, B.2
Olivares, S.3
-
57
-
-
79956149133
-
Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies
-
Singh H, Figliola MJ, Dawson MJ et al. Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies. Cancer Res. 71(10), 3516-3527 (2011).
-
(2011)
Cancer Res.
, vol.71
, Issue.10
, pp. 3516-3527
-
-
Singh, H.1
Figliola, M.J.2
Dawson, M.J.3
-
58
-
-
17944379652
-
Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma
-
Dudley ME, Wunderlich J, Nishimura MI et al. Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma. J. Immunother. 24(4), 363-373 (2001).
-
(2001)
J. Immunother.
, vol.24
, Issue.4
, pp. 363-373
-
-
Dudley, M.E.1
Wunderlich, J.2
Nishimura, M.I.3
-
59
-
-
0021334789
-
Rapid expansion of human cytotoxic T cell clones: Growth promotion by a heat-labile serum component and by various types of feeder cells
-
Van De Griend RJ, Van Krimpen BA, Bol SJ, Thompson A, Bolhuis RL. Rapid expansion of human cytotoxic T cell clones: growth promotion by a heat-labile serum component and by various types of feeder cells. J. Immunol. Methods 66(2), 285-298 (1984).
-
(1984)
J. Immunol. Methods
, vol.66
, Issue.2
, pp. 285-298
-
-
Van De Griend, R.J.1
Van Krimpen, B.A.2
Bol, S.J.3
Thompson, A.4
Bolhuis, R.L.5
-
60
-
-
20444499355
-
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
-
Gattinoni L, Klebanoff CA, Palmer DC et al. Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J. Clin. Invest. 115(6), 1616-1626 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.6
, pp. 1616-1626
-
-
Gattinoni, L.1
Klebanoff, C.A.2
Palmer, D.C.3
-
61
-
-
84873050511
-
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
-
Cieri N, Camisa B, Cocchiarella F et al. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood 121(4), 573-584 (2013).
-
(2013)
Blood
, vol.121
, Issue.4
, pp. 573-584
-
-
Cieri, N.1
Camisa, B.2
Cocchiarella, F.3
-
62
-
-
85015703065
-
Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors
-
Jin C, Yu D, Hillerdal V, Wallgren A, Karlsson-Parra A, Essand M. Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors. Molecular Therapy. Methods & Clinical Development 1, 14001 (2014).
-
(2014)
Molecular Therapy. Methods & Clinical Development
, vol.1
, pp. 14001
-
-
Jin, C.1
Yu, D.2
Hillerdal, V.3
Wallgren, A.4
Karlsson-Parra, A.5
Essand, M.6
-
63
-
-
84897557033
-
Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition
-
Riddell SR, Sommermeyer D, Berger C et al. Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition. Cancer J. 20(2), 141-144 (2014).
-
(2014)
Cancer J.
, vol.20
, Issue.2
, pp. 141-144
-
-
Riddell, S.R.1
Sommermeyer, D.2
Berger, C.3
-
64
-
-
84868221578
-
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale
-
Wang X, Naranjo A, Brown CE et al. Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale. J. Immunother. 35(9), 689-701 (2012).
-
(2012)
J. Immunother.
, vol.35
, Issue.9
, pp. 689-701
-
-
Wang, X.1
Naranjo, A.2
Brown, C.E.3
-
65
-
-
80053997259
-
A human memory T cell subset with stem cell-like properties
-
Gattinoni L, Lugli E, Ji Y et al. A human memory T cell subset with stem cell-like properties. Nat. Med. 17(10), 1290-1297 (2011).
-
(2011)
Nat. Med.
, vol.17
, Issue.10
, pp. 1290-1297
-
-
Gattinoni, L.1
Lugli, E.2
Ji, Y.3
-
66
-
-
84988805188
-
Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells
-
Turtle CJ, Hanafi LA, Berger C et al. Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells. Sci. Transl. Med. 8(355), 355ra116 (2016).
-
(2016)
Sci. Transl. Med.
, vol.8
, Issue.355
, pp. 355ra116
-
-
Turtle, C.J.1
Hanafi, L.A.2
Berger, C.3
|