Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

Cell Metabolism

Volumn 25, Issue 1, 2017, Pages 166-181

  Berry, Daniel C ^a   Jiang, Yuwei ^a   Arpke, Robert W ^b,c   Close, Elizabeth L ^a   Uchida, Aki ^a   Reading, David ^a   Berglund, Eric D ^a   Kyba, Michael ^b,c   Graff, Jonathan M ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

adipose; beige adipocytes; cellular aging; cold exposure; Ink4a Arf; mural cells; senescence; thermogenesis

Indexed keywords

BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; PALBOCICLIB; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P21; TAMOXIFEN; UNCOUPLING PROTEIN 1; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE;

ADIPOGENESIS; ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEIGE ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL AGING; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; ENERGY EXPENDITURE; FAT CONTENT; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM TEMPERATURE; ROOM TEMPERATURE; SENESCENCE; AGING; ANIMAL; C57BL MOUSE; COLD; CYTOLOGY; METABOLISM; PHENOTYPE; PHYSIOLOGY; STEM CELL;

ACTINS; ADIPOCYTES, BEIGE; AGING; ANIMALS; CELL AGING; COLD TEMPERATURE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; MALE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; STEM CELLS;

EID: 85007200895     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.10.023     Document Type: Article

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