Lecithin (Phosphatidylcholine): Healthy dietary supplement or dangerous toxin?

Natural Products Journal

Volumn 6, Issue 4, 2016, Pages 242-249

  Smith, Robert E ^a   Rouchotas, Philip ^b   Fritz, Heidi ^b  

^a PARK UNIVERSITY   (United States)

^b CANADIAN COLLEGE OF NATUROPATHIC MEDICINE   (Canada)

Author keywords

Choline; Citicoline; Lecithin; Phosphatidylcholine; TMAO; Trimethylamine oxide

Indexed keywords

CHOLINE; CITICOLINE; HOMOCYSTEINE; METHIONINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; TRIMETHYLAMINE OXIDE;

BRAIN FUNCTION; CARDIOVASCULAR DISEASE; CHRONIC STRESS; COGNITION; COGNITIVE DEFECT; DIET SUPPLEMENTATION; FOOD INTAKE; FRACTURE; HUMAN; INTESTINE FLORA; KIDNEY DISEASE; LACTATION; MILD COGNITIVE IMPAIRMENT; NEOPLASM; PREGNANCY; PRIORITY JOURNAL; RED MEAT; REVIEW; VERBAL MEMORY;

EID: 85006998955     PISSN: 22103155     EISSN: 22103163     Source Type: Journal    
DOI: 10.2174/2210315506666160923150904     Document Type: Review

References (52)

1. Smith, R.E. Medicinal Chemistry-Fusion of Traditional and Western Medicine, 2nd ed., Bentham Science, Sharjah, U.A.E, 2014, pp. 27, 82, 84, 90, 139, 231, 237, 358-360, 418, 436, 441, 442.
2. Zeisel, S.H.; da Costa, K.A. Choline: An essential nutrient for public health. Nutr. Rev., 2009, 67, 615-623.
3. Grieb, P. Citicoline: A food that may improve memory. Med. Sci. Rev., 2015, 2, 67-72.
4. Leermakers, E.T.M.; Moreira, E.M.; Kiefte-de Jong, J.C.; Darweesh, S.K.L.; Visser, T.; Voortman, T.; Bautista, P.K.; Chowdhury, R.; Gorman, D.; Bramer, W.N. Effects of choline on health across the life course: A systematic review. Nutr. Rev., 2015, 73(8), 500-522.
5. Li, Z.; Vance, D.E. Phosphatidylcholine and choline homeostasis. J. Lipid Res. 2008, 49, 1187-1194.
6. Bradley, R.M.; Marvyn, P.M.; Henao, J.J.A.; Mardian, E.B.; George, G.; Aucoin, M.G.; Stark, K.D.; Duncan, R.E. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Biochim. Biophys. Acta, 2015, 1851, 1566-1576.
7. Smith, R.E. Medicinal Chemistry-Fusion of Traditional and Western Medicine, 3rd ed., Bentham Science, Sharjah, U.A.E, 2015, pp. 55-66, 72-81, 97, 111, 113, 125, 372, 376, 385, 407.
8. Ozarda, I.; Uncu, G.; Ulus, I. Free and phospholipid-bound choline concentrations in serum during pregnancy, after deliver and in newborns. Arch. Physiol. Biochem. 2002, 110, 393-399.
9. McNamara, D.J. The fifty year rehabilitation of the egg. Nutrients, 2015, 7, 8716-8722.
10. Tang, W.H.W.; Wang, Z.; Levison, B.S.; Koeth, R.A.; Britt, E.B.; Fu, X.; Wu, Y.; Hazen, S.L. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med., 2013, 368, 1575-1584.
11. Janket, S.-J.; Javaheri, H.; Ackerson, L.K.; Ayilavarapu, S.; Meurman, J.H. Oral infections, metabolic inflammation, genetics, and cardiometabolic diseases. J. Dent. Res. Clin. Res., 2015, 94(Suppl 9), 119S-127S.
12. Ross, R.G.; Hunter, S.K.; Hoffman, M.C.; McCarthy, L.; Chambers, B.M.; Law, A.J.; Leonard, S.L.; Zerbe, G.O.; Freedman, R. Perinatal phosphatidylcholine supplementation and early childhood behavior problems: Evidence for CHRNA7 moderation. Am. J. Psychiat., 2015, 12, 128.
13. Betsholz, C. Lipid transport and human brain development. Nat. Genet., 2015, 47, 699-701.
14. Stremmel, W.; Ehehalt, R.; Autschbach, F.; Karner, M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: A randomized trial. Ann. Intern. Med., 2007, 147, 603-610.
15. Stremmel, W.; Merle, U.; Zahn, A.; Autschbach, F.; Hinz, U.; Ehehalt, R. Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis. Gut., 2005, 54, 966-971.
16. Ferrucci, F.; Zucca, E.; Croci, C.; Di Fabio, V.; Ferro, E. Treatment of gastric ulceration in 10 standard bred race horses with a pectinlecithin complex. Vet. Rec., 2003, 152, 679-681.
17. Anand, B.S.; Romero, J.J.; Sanduja, S.K.; Lichtenberger, L.M. Phospholipid association reduces the gastric mucosal toxicity of aspirin in human subjects. Am. J. Gastroenterol., 1999, 94, 1818-1822.
18. Oliveira, T.G.; Chan, R.B.; Bravo, F.V.; Miranda, A.; Silva, R.R.; Zhou, B.; Marques, F.; Pinto, V.; Cerqueira, J.J.; Di Paolo, G.; Sousa, N. The impact of chronic stress on the rat brain lipidome. Mol. Psychiat., 2016, 21, 80-88.
19. Chung, S.-Y.; Moriyama, T.; Uezu E.; Uezu, K.; Hirata, R.; Yohena, N.; Masuda, Y.; Kokubo, T.; Yamamoto, S. Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. J. Nutr., 1995, 125, 1484-1489.
20. Simpson, B.N.; Kim, M.; Chuang, Y.-F.; Beason-Held, L.; Kitner-Triolo, M.; Michael Kraut, M.; Seth T Lirette, S.T.; Windham, B.G.; Griswold, M.E.; Legido-Quigley, C.; Thambisetty, M. Blood metabolite markers of cognitive performance and brain function in aging. J. Cereb. Blood Flow Metab., 2015, 15(08), 1-12.
21. Visentin, C.E.; Masih, S.; Plumptre, L.; Malysheva, O.; Nielsen, D.E.; Sohn, K.-J.; Ly, A.; Lausman, A.Y.; Berger, H.; Croxford, R. Maternal choline status, but not fetal genotype, influences cord plasma choline metabolite concentrations. J. Nutr., 2015, 145, 1491-1497.
22. Cho, E.; Zeisel, S.; Jacques, P. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham offspring study. Am. J. Clin. Nutr., 2008, 83, 905-911.
23. Fargnoli, J.L.; Fung, T.T.; Olencauk, D.M.; Chamberland, J.P.; Hu, F.B.; Mantzoros, C.S. Adherence to healthy eating patterns is associated with higher circulating total and high-molecular-weight adiponectin and lower resistin concentrations in women from the Nurses’ Health Study. Am. J. Clin. Nutr., 2008, 88, 1213-1324.
24. Cohen, B.M.; Renshaw, P.F.; Stoll, A.L.; Wurtman, R.J.; Yurgelun-Todd, D.; Babb, S.M. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. J. Am. Med. Assoc., 1995, 274, 902-907.
25. Babb, S.M.; Appelmans, K.E.; Renshaw, P.F.; Wurtman, R.J.; Cohen, B.M. Differential effect of CDP-choline on brain cytosolic choline levels in younger and older subjects as measured by proton magnetic resonance spectroscopy. Psychopharmacology (Berl)., 1996, 127, 88-94.
26. Babb, S.M.; Wald, L.L.; Cohen, B.M.; Villafuerte, R.A.; Gruber, S.A.; Yurgelun-Todd, D.A. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl)., 2002, 161(3), 248-254.
27. Alvarez, X.A.; Laredo, M.; Corzo, D.; Fernandez-Novoa, L.; Mouzo, R.; Perea, J.E. Citicoline improves memory performance in elderly subjects. Methods Find. Exp. Clin. Pharmacol., 1997, 19, 201-210.
28. Spiers, P.A.; Myers, D.; Hochanadel, G.S.; Lieberman, H.R.; Wurtman, R.J. Citicoline improves verbal memory in aging. Arch. Neurol., 1996, 53, 441-448.
29. Cotroneo, A.M.; Castagna, A.; Putignano, S.; Lacava, R.; Fanto, F.; Monteleone, F. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. Clin. Interv. Aging, 2013, 8, 131-137.
30. Grieb, P. Citicoline: A food that may improve memory. Med. Sci. Rev., 2015, 2, 67-72.
31. Horrocks, L.A.; Dorman, R.V.; Dabrowiecki, Z. CDP choline and CDP ethanolamine prevent the release of free fatty acids during brain ischemia. Prog. Lipid Res., 1981, 20, 531-534.
32. Horrocks, L.A.; Dorman, R.V.; Dabrowiecki, Z.M. Therapeutic agents for preventing phospholipid degradation and free fatty acid proliferation. United States Patent no: 4, 1981, 386, 078.
33. D’Orlando, K.J.; Sandage, B.W. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurol. Res., 1995, 17, 281-284.
34. Conant, R.; Schauss, A. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly; A review of the literature. Alt. Rev. Med., 2004, 9, 17-32.
35. Schauss, A.G.; Somfai-Relle, S.; Financsek, I. Single-and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5’-pyrophosphate) in Sprague-Dawley rats. Int. J. Toxicol., 2009, 28, 479-487.
36. Salehpour, F.; Aghazade, J.; Mirzaee F.; Mahdkhah, A. Citicoline in patients with traumatic brain injuries. EC Neurol., 2015, 2, 87-93.
37. Jacotte-Simancas, A.; Costa-Miserachs, D.; Coll-Andreu, M.; Torras-Garcia, M.; Borlongan, C.V.; Portell-Corte´s, I. Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis, and neuroprotection after traumatic brain injury in rats. J. Neurotrauma, 2015, 32, 739-751.
38. Hutchinson, M. The best basic science paper in multiple sclerosis in 2014: Citicoline, remyelination and neuroprotection: Commentary. Mult. Scler. J., 2015, 21, 374-375.
39. Ghosh, S.; Das, S.K.; Nath, T.; Ghosh, K.C.; Bhattacharyya, R.; Mondal, G.P. The effect of citicoline on stroke: A comparative study from the Eastern part of India. Neurol. India, 2015, 63, 697-701.
40. Silveri, M.M.; Dikan, J.; Ross, A.J.; Jensen, J.E.; Kamiya, T.; Kawada, Y.; Renshaw, P.F.; Yurgelun, D.A. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed., 2008, 21, 1066-1075.
41. Gareri, P.; Castagna, A.; Cotroneo, A.M.; Putignano, S.; de Sarro, G.; Bruni, A.C. The role of citicoline in cognitive impairment: Pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clin. Int. Aging, 2015, 10, 1421-1429.
42. Pramila, B.; Kalaivani, P.; Barathidasan, R.; Babu, C.S. Combination of citicoline and L-NAME restores neurological functions, reverts biochemical alterations and reduces neuronal damage in transient focal cerebral ischemic rats. Ind. J. Sci. Technol., 2015, 8(9), 804-813.
43. Roberti, G.; Tanga, L.; Michelessi, M.; Quaranta, L.; Parisi, V.; Manni, G.; Oddone, F. Cytidine 5’-diphosphocholine (citicoline) in glaucoma: Rationale of its use, current evidence and future perspectives. Int. J. Mol. Sci., 2015, 16, 28401-28417.
44. Parisi, V.; Centofanti, M.; Ziccardi, L.; Tanga, L.; Michelessi, M.; Roberti, G.; Manni, G. Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma. Graefes Arch. Clin. Exp. Ophthalmol., 2015, 253, 1327-1340.
45. Knott, V.; de la Salle, S.; Smith, D.; Choueiry, J.; Impey, D.; Smith, M.; Beaudry, E.; Saghir, S.; Ilivitsky, V.; Labelle, A. Effects of acute CDP-choline treatment on resting state brain oscillations in healthy volunteers. Neurosci. Lett., 2015, 591, 121-125.
46. Wu, A.; Noble, E.E.; Tyagi, E.; Ying, Z.; Zhuang, Y.; Gomez-Pinilla, F. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Biochim. Biophys. Acta, 2015, 1852, 951-961.
47. Morris, M.C.; Tangney, C.C.; Wang, Y.; Sacks, F.M.; Bennett, D.A.; Aggarwal, N.T. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimer’s Dement., 2015, 11, 1007-1014.
48. Morris, M.C.; Tangney, C.C.; Wang, Y.; Sacks, F.M.; Barnes, L.L.; Bennett, D.A.; Aggarwal, N.T. MIND diet slows cognitive decline with aging. Alzheimer’s Dement., 2015, 11, 1015-1022.
49. Tang, W.H.W.; Wang, Z.; Kennedy, D.J.; Wu, Y.; Buffa, J.A.; Agatisa-Boyle, B.; Li, X.S.; Levison, B.S.; Hazen, S.L. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ. Res., 2015, 116, 448-455.
50. Quante, M. You are what you eat: Metabolites of gut microbiota provide novel insights into diagnosis and development of chronic kidney disease. Transplantaion 2015, 99, 1306-1307.
51. Ierardi, E.; Sorrentino, C.; Principe, M.; Giorgio, F.; Losurdo, G.; de Leo, A. Intestinal microbial metabolism of phosphatidylcholine: a novel insight in the cardiovascular risk scenario. Hepato. Biliary Surg. Nutr., 2015, 4(4): 289-292.
52. Koeth, R.A.; Wang, Z.; Levison, B.S.; Buffa, J.A.; Org, E.; Sheehy, B.T.; Britt, E.B.; Fu, X.; Wu, Y. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med., 2013, 19(5), 576-585.