You Are What You Eat: Metabolites of Gut Microbiota Provide Novel Insights into Diagnosis and Development of Chronic Kidney Disease

Transplantation

Volumn 99, Issue 7, 2015, Pages 1306-1307

  Quante, Markus ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; PHOSPHATIDYLCHOLINE; SMAD3 PROTEIN; TRIMETHYLAMINE OXIDE; BIOLOGICAL MARKER; METHYLAMINE; TRIMETHYLOXAMINE;

ANGIOCARDIOGRAPHY; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHRONIC ALLOGRAFT NEPHROPATHY; CHRONIC KIDNEY DISEASE; DIET SUPPLEMENTATION; HUMAN; IMMUNE RESPONSE; INTESTINE FLORA; KIDNEY FIBROSIS; KIDNEY GRAFT; METABOLITE; METABOLOMICS; MORTALITY; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; ADVERSE EFFECTS; ANIMAL; BACTERIUM; DIET; INTESTINE; METABOLISM; MICROBIOLOGY; MICROFLORA; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTOR;

ANIMALS; BACTERIA; BIOMARKERS; DIET; HUMANS; INTESTINES; METABOLOMICS; METHYLAMINES; MICROBIOTA; PHOSPHATIDYLCHOLINES; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS;

EID: 84940647852     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000793     Document Type: Note

References (10)

1. Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108:2154-2169.
2. Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature. 2012;489:242-249.
3. Rhee EP, Clish CB, Ghorbani A, et al. A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol. 2013;24:1330-1338.
4. Tang WH, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368: 1575-1584.
5. Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576-585.
6. Tang WH, Wang Z, Kennedy DJ, et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res. 2015;116:448-455.
7. Schulman G, Agarwal R, Acharya M, et al. Amulticenter, randomized, doubleblind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD. Am J Kidney Dis. 2006;47: 565-577.
8. Ito S, Higuchi Y, Yagi Y, et al. Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease. J Leukoc Biol. 2013;93:837-845.
9. Heemann U, Lutz J. Pathophysiology and treatment options of chronic renal allograft damage. Nephrol Dial Transplant. 2013;28:2438-2446.
10. Bohra R, Klepacki J, Klawitter J, et al. Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int. 2013;26:225-241.