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Volumn 10, Issue , 2015, Pages 1421-1429

The role of citicoline in cognitive impairment: Pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives

Author keywords

Citicoline; Cognitive impairment; Elderly; Neurodegeneration; Neuroprotective effects; Sirtuins

Indexed keywords

ALPHA SYNUCLEIN; CHOLINE; CITICOLINE; CYTIDINE; PLACEBO; PROTEIN KINASE; SIRTUIN 1; NOOTROPIC AGENT;

EID: 84940979687     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S87886     Document Type: Review
Times cited : (76)

References (46)
  • 2
    • 84921431963 scopus 로고    scopus 로고
    • Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly
    • Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2005;18(2):CD000269.
    • (2005) Cochrane Database Syst Rev , vol.18 , Issue.2
    • Fioravanti, M.1    Yanagi, M.2
  • 3
    • 79952118481 scopus 로고    scopus 로고
    • Neuroprotection and recovery: Recent data at the bench on citicoline
    • Hurtado O, Lizasoain I, Moro MÁ. Neuroprotection and recovery: recent data at the bench on citicoline. Stroke. 2011;42(suppl1):S33-S35.
    • (2011) Stroke , vol.42 , pp. S33-S35
    • Hurtado, O.1    Lizasoain, I.2    Moro, M.3
  • 4
    • 84896724702 scopus 로고    scopus 로고
    • Neuroprotective properties of citicoline: Facts, doubts and unresolved issues
    • Grieb P. Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS Drugs. 2014;28(3):185-193.
    • (2014) CNS Drugs , vol.28 , Issue.3 , pp. 185-193
    • Grieb, P.1
  • 5
    • 84873605697 scopus 로고    scopus 로고
    • Long-term treatment with citicoline may improve poststroke vascular cognitive impairment
    • Alvarez-Sabín J, Ortega G, Jacas C, et al. Long-term treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovasc Dis. 2013;35(2):146-154.
    • (2013) Cerebrovasc Dis , vol.35 , Issue.2 , pp. 146-154
    • Alvarez-Sabín, J.1    Ortega, G.2    Jacas, C.3
  • 6
    • 79957673012 scopus 로고    scopus 로고
    • Citicoline: Pharmacological and clinical review, 2010 update
    • Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol. 2011;52(suppl 2):S1-S62.
    • (2011) Rev Neurol , vol.52 , pp. SS1-S62
    • Secades, J.J.1
  • 7
    • 84856806411 scopus 로고    scopus 로고
    • Citicoline in vascular cognitive impairment and vascular dementia after stroke
    • Alvarez-Sabin J, Roman GC. Citicoline in vascular cognitive impairment and vascular dementia after stroke. Stroke. 2011;42:S40-S43.
    • (2011) Stroke , vol.42 , pp. S40-S43
    • Alvarez-Sabin, J.1    Roman, G.C.2
  • 9
    • 38449104026 scopus 로고    scopus 로고
    • Citicoline (Cognizin) in the treatment of cognitive impairment
    • Fioravanti M, Buckley AE. Citicoline (Cognizin) in the treatment of cognitive impairment. Clin Interv Aging. 2006;1(3):247-251.
    • (2006) Clin Interv Aging , vol.1 , Issue.3 , pp. 247-251
    • Fioravanti, M.1    Buckley, A.E.2
  • 10
    • 84867609173 scopus 로고    scopus 로고
    • Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome
    • Putignano S, Gareri P, Castagna A, et al. Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome. Clin Interv Aging. 2012;7:113-118.
    • (2012) Clin Interv Aging , vol.7 , pp. 113-118
    • Putignano, S.1    Gareri, P.2    Castagna, A.3
  • 11
    • 84873673270 scopus 로고    scopus 로고
    • Effectiveness and safety of citicoline in mild vascular cognitive impairment: The IDEALE study
    • Cotroneo AM, Castagna A, Putignano S, et al. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. Clin Interv Aging. 2013;8:131-137.
    • (2013) Clin Interv Aging , vol.8 , pp. 131-137
    • Cotroneo, A.M.1    Castagna, A.2    Putignano, S.3
  • 12
    • 33750003900 scopus 로고    scopus 로고
    • Citicoline: Pharmacological and clinical review, 2006 update
    • Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol. 2006;28(suppl B):1-56.
    • (2006) Methods Find Exp Clin Pharmacol , vol.28 , pp. 1-56
    • Secades, J.J.1    Lorenzo, J.L.2
  • 13
    • 0028558634 scopus 로고
    • Brain mapping activity and mental performance after chronic treatment with CDP-choline in Alzheimer’s disease
    • Franco-Maside A, Caamaño J, Gómez MJ, Cacabelos R. Brain mapping activity and mental performance after chronic treatment with CDP-choline in Alzheimer’s disease. Methods Find Exp Clin Pharmacol. 1994;16(8):597-607.
    • (1994) Methods Find Exp Clin Pharmacol , vol.16 , Issue.8 , pp. 597-607
    • Franco-Maside, A.1    Caamaño, J.2    Gómez, M.J.3    Cacabelos, R.4
  • 14
    • 0028351522 scopus 로고
    • Effects of CDP-choline on cognition and cerebral hemodynamics in patients with Alzheimer’s disease
    • Caamaño J, Gómez MJ, Franco A, Cacabelos R. Effects of CDP-choline on cognition and cerebral hemodynamics in patients with Alzheimer’s disease. Methods Find Exp Clin Pharmacol. 1994;16(3):211-218.
    • (1994) Methods Find Exp Clin Pharmacol , vol.16 , Issue.3 , pp. 211-218
    • Caamaño, J.1    Gómez, M.J.2    Franco, A.3    Cacabelos, R.4
  • 16
    • 0027364283 scopus 로고
    • Effect of CDP-choline on cognition and immune function in Alzheimer’s disease and multi-infarct dementia
    • Cacabelos R, Alvarez XA, Franco-Maside A, Fernández-Novoa L, Caamaño J. Effect of CDP-choline on cognition and immune function in Alzheimer’s disease and multi-infarct dementia. Ann N Y Acad Sci. 1993;695:321-323.
    • (1993) Ann N Y Acad Sci , vol.695 , pp. 321-323
    • Cacabelos, R.1    Alvarez, X.A.2    Franco-Maside, A.3    Fernández-Novoa, L.4    Caamaño, J.5
  • 17
    • 0033403796 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer’s disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion
    • Alvarez XA, Mouzo R, Pichel V, et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer’s disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods Find Exp Clin Pharmacol. 1999;21(9):633-644.
    • (1999) Methods Find Exp Clin Pharmacol , vol.21 , Issue.9 , pp. 633-644
    • Alvarez, X.A.1    Mouzo, R.2    Pichel, V.3
  • 18
    • 33845208684 scopus 로고    scopus 로고
    • Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13
    • Bellizzi D, Dato S, Cavalcante P, et al. Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13. Genomics. 2007;89(1):143-150.
    • (2007) Genomics , vol.89 , Issue.1 , pp. 143-150
    • Bellizzi, D.1    Dato, S.2    Cavalcante, P.3
  • 19
    • 84878617717 scopus 로고    scopus 로고
    • Sirtuins as possible targets in neurodegenerative diseases
    • Donmez G. Sirtuins as possible targets in neurodegenerative diseases. Curr Drug Targets. 2013;14:644-647.
    • (2013) Curr Drug Targets , vol.14 , pp. 644-647
    • Donmez, G.1
  • 20
    • 77953257025 scopus 로고    scopus 로고
    • Aging and disease: Connections to sirtuins
    • Donmez G, Guarente L. Aging and disease: connections to sirtuins. Aging Cell. 2010;9:285-290.
    • (2010) Aging Cell , vol.9 , pp. 285-290
    • Donmez, G.1    Guarente, L.2
  • 21
    • 84919387678 scopus 로고    scopus 로고
    • SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
    • Ma CY, Yao MJ, Zhai QW, Jiao JW, Yuan XB, Poo MM. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development. 2014;141:4697-4709.
    • (2014) Development , vol.141 , pp. 4697-4709
    • Ma, C.Y.1    Yao, M.J.2    Zhai, Q.W.3    Jiao, J.W.4    Yuan, X.B.5    Poo, M.M.6
  • 22
    • 79952353862 scopus 로고    scopus 로고
    • Neuronal SIRT3 protects against excitotoxic injury in mouse cortical neuron culture
    • Kim SH, Lu HF, Alano CC. Neuronal SIRT3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One. 2011;6:e14731.
    • (2011) Plos One , vol.6
    • Kim, S.H.1    Lu, H.F.2    Alano, C.C.3
  • 23
    • 84858297200 scopus 로고    scopus 로고
    • SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress
    • D’Aquila P, Rose G, Panno ML, Passarino G, Bellizzi D. SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress. Gene. 2012;497(2):323-329.
    • (2012) Gene , vol.497 , Issue.2 , pp. 323-329
    • D’Aquila, P.1    Rose, G.2    Panno, M.L.3    Passarino, G.4    Bellizzi, D.5
  • 24
    • 80054123174 scopus 로고    scopus 로고
    • Protective effects and mechanisms of sirtuins in the nervous system
    • Zhang F, Wang S, Gan L, et al. Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol. 2011;95:373-395.
    • (2011) Prog Neurobiol , vol.95 , pp. 373-395
    • Zhang, F.1    Wang, S.2    Gan, L.3
  • 25
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • Donmez G, Wang D, Cohen D, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell. 2010;142:320-332.
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.3    Guarente, L.4
  • 26
    • 84874709843 scopus 로고    scopus 로고
    • SIRT1 and SIRT2: Emerging targets in neurodegeneration
    • Donmez G, Outeiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med. 2013;5:344-352.
    • (2013) EMBO Mol Med , vol.5 , pp. 344-352
    • Donmez, G.1    Outeiro, T.F.2
  • 27
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • Min SW, Cho SH, Zhou Y, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010;67:953-966.
    • (2010) Neuron , vol.67 , pp. 953-966
    • Min, S.W.1    Cho, S.H.2    Zhou, Y.3
  • 28
    • 84865274411 scopus 로고    scopus 로고
    • The neurobiology of sirtuins and their role in neurodegeneration
    • Donmez G. The neurobiology of sirtuins and their role in neurodegeneration. TIPS. 2012;33(9):494-501.
    • (2012) TIPS , vol.33 , Issue.9 , pp. 494-501
    • Donmez, G.1
  • 29
    • 0033989375 scopus 로고    scopus 로고
    • Evidence for the involvement of TNF and NF-kB in hippocampal synaptic plasticity
    • Albensi BC, Mattson MP. Evidence for the involvement of TNF and NF-kB in hippocampal synaptic plasticity. Synapse. 2010;35(2):151-159.
    • (2010) Synapse , vol.35 , Issue.2 , pp. 151-159
    • Albensi, B.C.1    Mattson, M.P.2
  • 30
    • 84855929223 scopus 로고    scopus 로고
    • SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
    • Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci. 2012;32(1):124-132.
    • (2012) J Neurosci , vol.32 , Issue.1 , pp. 124-132
    • Donmez, G.1    Arun, A.2    Chung, C.Y.3    McLean, P.J.4    Lindquist, S.5    Guarente, L.6
  • 31
    • 84881498370 scopus 로고    scopus 로고
    • The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case control cohorts
    • Polito L, Kehoe PG, Davin A, et al. The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case control cohorts. Alzheimers Dement. 2013;9(4):392-399.
    • (2013) Alzheimers Dement , vol.9 , Issue.4 , pp. 392-399
    • Polito, L.1    Kehoe, P.G.2    Davin, A.3
  • 32
    • 84883740105 scopus 로고    scopus 로고
    • Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke
    • Hurtado O, Hernández-Jiménez M, Zarruk JG, et al. Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. J Neurochem. 2013;126:816-819.
    • (2013) J Neurochem , vol.126 , pp. 816-819
    • Hurtado, O.1    Hernández-Jiménez, M.2    Zarruk, J.G.3
  • 33
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family and NAD-dependent deacetylases by phenotypic screening
    • Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family and NAD-dependent deacetylases by phenotypic screening. J Biol Chem. 2001;276:38837-38843.
    • (2001) J Biol Chem , vol.276 , pp. 38837-38843
    • Grozinger, C.M.1    Chao, E.D.2    Blackwell, H.E.3    Moazed, D.4    Schreiber, S.L.5
  • 34
    • 84880790329 scopus 로고    scopus 로고
    • Silent information regulator 1 (SIRT1) protects the brain against cerebral ischemic damage
    • Hernández-Jiménez M, Hurtado O, Cuartero MI, et al. Silent information regulator 1 (SIRT1) protects the brain against cerebral ischemic damage. Stroke. 2013;44(8):2333-2337.
    • (2013) Stroke , vol.44 , Issue.8 , pp. 2333-2337
    • Hernández-Jiménez, M.1    Hurtado, O.2    Cuartero, M.I.3
  • 36
    • 0020630071 scopus 로고
    • Efficacy and safety of oral CDP-choline. Drug surveillance study in 2,817 cases
    • Lozano-Fernandez R. Efficacy and safety of oral CDP-choline. Drug surveillance study in 2,817 cases. Arzneimittelforschung. 1983;33(7A):1073-1080.
    • (1983) Arzneimittelforschung , vol.33 , Issue.7A , pp. 1073-1080
    • Lozano-Fernandez, R.1
  • 37
    • 0042240292 scopus 로고    scopus 로고
    • CDP-choline: Update and review of its pharmacology and clinical use
    • Secades JJ. CDP-choline: update and review of its pharmacology and clinical use. Methods Find Exp Clin Pharmacol. 2002; 24(suppl B):1-53.
    • (2002) Methods Find Exp Clin Pharmacol , vol.24 , pp. 1-53
    • Secades, J.J.1
  • 38
    • 0029961114 scopus 로고    scopus 로고
    • Therapeutic effects of CDP-choline in Alzheimer’s disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors
    • Cacabelos R, Caamaño J, Gómez MJ, Fernández-Novoa L, Franco-Maside A, Alvarez XA. Therapeutic effects of CDP-choline in Alzheimer’s disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors. Ann N Y Acad Sci. 1996; 777:399-403.
    • (1996) Ann N Y Acad Sci , vol.777 , pp. 399-403
    • Cacabelos, R.1    Caamaño, J.2    Gómez, M.J.3    Fernández-Novoa, L.4    Franco-Maside, A.5    Alvarez, X.A.6
  • 40
    • 0027943114 scopus 로고
    • Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group
    • Lyden P, Brott T, Tilley B, et al. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke. 1994;25(11):2220-2226.
    • (1994) Stroke , vol.25 , Issue.11 , pp. 2220-2226
    • Lyden, P.1    Brott, T.2    Tilley, B.3
  • 41
    • 0032771005 scopus 로고    scopus 로고
    • Reliability and validity of estimating the NIH stroke scale score from medical records
    • Kasner SE, Chalela JA, Luciano JM, et al. Reliability and validity of estimating the NIH stroke scale score from medical records. Stroke. 1999;30(8):1534-1537.
    • (1999) Stroke , vol.30 , Issue.8 , pp. 1534-1537
    • Kasner, S.E.1    Chalela, J.A.2    Luciano, J.M.3
  • 42
    • 0032796473 scopus 로고    scopus 로고
    • Use of the Barthel Index and modified Rankin Scale in acute stroke trials
    • Sulter G, Steen C, De Keyser J. Use of the Barthel Index and modified Rankin Scale in acute stroke trials. Stroke. 1999;30(8):1538-1541.
    • (1999) Stroke , vol.30 , Issue.8 , pp. 1538-1541
    • Sulter, G.1    Steen, C.2    De Keyser, J.3
  • 43
    • 84869175006 scopus 로고    scopus 로고
    • Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline brain injury treatment trial (COBRIT)
    • Zafonte RD, Bagiella E, Ansel BM, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: citicoline brain injury treatment trial (COBRIT). JAMA. 2012;308(19):1993-2000.
    • (2012) JAMA , vol.308 , Issue.19 , pp. 1993-2000
    • Zafonte, R.D.1    Bagiella, E.2    Ansel, B.M.3
  • 44
    • 84864277207 scopus 로고    scopus 로고
    • International Citicoline Trial on acUte Stroke (ICTUS) trial investigators. Citicoline in the treatment of acute ischaemic stroke: An international, randomised, multicentre, placebo-controlled study (ICTUS trial)
    • Dávalos A, Alvarez-Sabín J, Castillo J, et al; International Citicoline Trial on acUte Stroke (ICTUS) trial investigators. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet. 2012;380(9839):349-357.
    • (2012) Lancet , vol.380 , Issue.9839 , pp. 349-357
    • Dávalos, A.1    Alvarez-Sabín, J.2    Castillo, J.3
  • 45
    • 0029148448 scopus 로고
    • Citicoline (CDP-choline): Mechanism of action and effects in ischemic brain injury
    • D’Orlando KJ, Sandage BW Jr. Citicoline (CDP-choline): mechanism of action and effects in ischemic brain injury. Neurol Res. 1995;17:281-284.
    • (1995) Neurol Res , vol.17 , pp. 281-284
    • D’Orlando, K.J.1    Sandage, B.W.2


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