A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

Lab on a Chip

Volumn 17, Issue 1, 2017, Pages 134-144

  Coppeta, J R ^a   Mescher, M J ^a   Isenberg, B C ^a   Spencer, A J ^a   Kim, E S ^a   Lever, A R ^a   Mulhern, T J ^a   Prantil Baun, R ^a   Comolli, J C ^a   Borenstein, J T ^a  

^a Draper 555 Technology Square   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; CYTOCHROME P450 3A;

ARTICLE; CELL ADHESION; CELL CULTURE; DRUG DEVELOPMENT; DRUG RESPONSE; ELECTROMAGNETISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW RATE; HUMAN; LIVER CELL; LIVER FUNCTION; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; MORPHOLOGY; ORGAN PERFUSION; OXYGENATION; PHARMACOKINETICS; PRIORITY JOURNAL; TISSUE INTERACTION; TRANSEPITHELIAL RESISTANCE; BRONCHUS; COCULTURE; CYTOLOGY; DEVICES; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; MAGNETIC FIELD; METABOLISM; PROCEDURES;

BRONCHI; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOCHROME P-450 CYP3A; DRUG DISCOVERY; EPITHELIAL CELLS; HEPATOCYTES; HUMANS; MAGNETIC FIELDS; MICROFLUIDICS; MICROSCOPY, FLUORESCENCE;

EID: 85006886583     PISSN: 14730197     EISSN: 14730189     Source Type: Journal    
DOI: 10.1039/C6LC01236A     Document Type: Article

References (47)

1. J. A. DiMasi L. Feldman A. Seckler A. Wilson Trends in risks associated with new drug development: success rates for investigational drugs Clin. Pharmacol. Ther. 2010 87 3 272-277
2. M. Hay D. W. Thomas J. L. Craighead C. Economides J. Rosenthal Clinical development success rates for investigational drugs Nat. Biotechnol. 2014 32 1 40-51
3. W. Kerns et al., Drug-induced vascular injury--a quest for biomarkers Toxicol. Appl. Pharmacol. 2005 203 1 62-87
4. J. J. Hornberg et al., Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how Drug Discovery Today 2014 19 8 1131-1136
5. C. Tamaki et al., Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan J. Toxicol. Sci. 2013 38 4 581-598
6. J. H. Sung et al., Microfabricated mammalian organ systems and their integration into models of whole animals and humans Lab Chip 2013 13 7 1201-1212
7. A. Polini et al., Organs-on-a-chip: a new tool for drug discovery Expert Opin. Drug Discovery 2014 9 4 335-352
8. T. S. Chan et al., Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac Drug Metab. Dispos. 2013 41 12 2024-2032
9. D. Huh et al., A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice Sci. Transl. Med. 2012 4 159 159ra147
10. K.-H. Nam A. S. T. Smith S. Lone S. Kwon D.-H. Kim Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening J. Lab. Autom. 2015 20 3 201-215
11. J. P. Wikswo et al., Scaling and systems biology for integrating multiple organs-on-a-chip Lab Chip 2013 13 18 3496-3511
12. M. B. Esch et al., How multi-organ microdevices can help foster drug development Adv. Drug Delivery Rev. 2014 69-70 158-169
13. C. Moraes et al., On being the right size: scaling effects in designing a human-on-a-chip Integr. Biol. 2013 5 9 1149-1161
14. J. P. Wikswo et al., Engineering challenges for instrumenting and controlling integrated organ-on-chip systems IEEE Trans. Biomed. Eng. 2013 60 3 682-690
15. S. Li J. Nickels A. F. Palmer Liposome-encapsulated actin-hemoglobin (LEAcHb) artificial blood substitutes Biomaterials 2005 26 17 3759-3769
16. F. Trietsch R. J. Snijder C. Kloosterziel D. A. F. van den Heuvel Pulmonary artery embolization for refractory hypoxemia caused by invasive mucinous adenocarcinoma J. Thorac. Oncol. 2013 8 2 e15-e16
17. J. H. Sung C. Kam M. L. Shuler A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip Lab Chip 2010 10 4 446-455
18. P. J. Lee T. A. Gaige N. Ghorashian P. J. Hung Microfluidic tissue model for live cell screening Biotechnol. Prog. 2007 23 4 946-951
19. W. Inman et al., Design, modeling and fabrication of a constant flow pneumatic micropump J. Micromech. Microeng. 2007 17 5 891-899
20. I. Wagner et al., A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture Lab Chip 2013 13 18 3538-3547
21. D. E. Ingber, D.Levner, I.Thompson, J.Fernandez-Alcon and C. D.Hinojosa, Systems and Methods for Cell Culture Device Interconnection and Fluidic Device Interconnection, 2015, Available at: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015006751, [Accessed February 16, 2016]
22. M. Mescher, J.Fiering and C.Dube, Electromagnetically-actuated microfluidic flow regulators and related applications, 2005, Available at: http://www.google.com/patents/US20050238506, [Accessed February 16, 2016]
23. V. Tandon et al., Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing Lab Chip 2016 16 5 829-846
24. M. J. Mescher et al., Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System J. Microelectromech. Syst. 2009 18 3 501-510
25. L. M. Fulcher, et al., Well-differentiated human airway epithelial cell cultures, in Human Cell Culture Protocols, ed. J. Picot, Springer, Available at: http://www.springer.com/us/book/9781588292223, pp. 183-206, [Accessed March 7, 2016]
26. A. R. Lever et al., Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model Physiol. Rep. 2015 3 4 e12334
27. D. K. Spracklin D. C. Hankins J. M. Fisher K. E. Thummel E. D. Kharasch Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro J. Pharmacol. Exp. Ther. 1997 281 1 400-411
28. A. M. Siore Endotoxin-induced acute lung injury requires interaction with the liver Am. J. Physiol. 2005 289 5 L769-L776
29. G. M. Matuschak K. A. Henry C. A. Johanns A. J. Lechner Liver-lung interactions following Escherichia coli bacteremic sepsis and secondary hepatic ischemia/reperfusion injury Am. J. Respir. Crit. Care Med. 2001 163 4 1002-1009
30. F. Broeckaert A. Bernard Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker Clin. Exp. Allergy 2000 30 4 469-475
31. G. Singh S. L. Katyal Clara Cells and Clara Cell 10 kD Protein (CC10) Am. J. Respir. Cell Mol. Biol. 1997 17 2 141-143
32. L. A. Sachs W. E. Finkbeiner J. H. Widdicombe Effects of media on differentiation of cultured human tracheal epithelium In Vitro Cell. Dev. Biol.: Anim. 2003 39 1-2 56-62
33. J. C. Willey M. A. Laveck I. A. McClendon J. F. Lechner Relationship of ornithine decarboxylase activity and cAMP metabolism to proliferation of normal human bronchial epithelial cells J. Cell. Physiol. 1985 124 2 207-212
34. C. Aninat et al., Catecholamines induce an inflammatory response in human hepatocytes Crit. Care Med. 2008 36 3 848-854
35. K. Domansky et al., Perfused multiwell plate for 3D liver tissue engineering Lab Chip 2010 10 1 51-58
36. A. Vivares et al., Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device Xenobiotica 2015 45 1 29-44
37. M. C. Rose J. A. Voynow Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease Physiol. Rev. 2006 86 1 245-278
38. M. Vareille E. Kieninger M. R. Edwards N. Regamey The Airway Epithelium: Soldier in the Fight against Respiratory Viruses Clin. Microbiol. Rev. 2011 24 1 210-229
39. J. R. Rock S. H. Randell B. L. M. Hogan Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling Dis. Models & Mech. 2010 3 9-10 545-556
40. F. Broeckaert A. Clippe B. Knoops C. Hermans A. Bernard Clara cell secretory protein (CC16): features as a peripheral lung biomarker Ann. N. Y. Acad. Sci. 2000 923 68-77
41. Y. Kono S. Yang E. A. Roberts Extended primary culture of human hepatocytes in a collagen gel sandwich system In Vitro Cell. Dev. Biol.: Anim. 1997 33 6 467-472
42. D. Roymans et al., Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes Biochem. Pharmacol. 2004 67 3 427-437
43. J. P. Nicholson M. R. Wolmarans G. R. Park The role of albumin in critical illness Br. J. Anaesth. 2000 85 4 599-610
44. B. Clement et al., Long-Term Co-Cultures of Adult Human Hepatocytes with Rat Liver Epithelial Cells: Modulation of Albumin Secretion and Accumulation of Extracellular Material Hepatology 1984 4 3 373-380
45. Wiley: Drug-Drug Interactions in Pharmaceutical Development, ed. A. P. Li and B. Wang, Available at: http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471794414.html, [Accessed February 16, 2016]
46. Q. Yang U. Doshi N. Li A. P. Li Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin-6: implications for experimental design for the evaluation of downregulatory effects of biotherapeutics Curr. Drug Metab. 2012 13 7 938-946
47. M.-H. Wu S.-B. Huang Z. Cui Z. Cui G.-B. Lee A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture Biomed. Microdevices 2008 10 2 309-319