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Volumn 19, Issue 8, 2014, Pages 1131-1136

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DEVELOPMENT; HUMAN; PHYSICAL CHEMISTRY; REVIEW; RISK ASSESSMENT; RISK FACTOR; TOXICOLOGY; ADVERSE DRUG REACTION; ANIMAL; DRUG DESIGN; DRUG SCREENING; PROCEDURES; SAFETY;

EID: 84906317424     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.12.008     Document Type: Review
Times cited : (90)

References (28)
  • 1
    • 78951480503 scopus 로고    scopus 로고
    • Pharmaceutical innovation in the 21st century: New drug approvals in the first decade, 2000-2009
    • K.I. Kaitin, and J.A. Dimasi Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009 Clin. Pharmacol. Ther. 89 2011 183 188
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 183-188
    • Kaitin, K.I.1    Dimasi, J.A.2
  • 2
    • 79952587191 scopus 로고    scopus 로고
    • The cost of drug development: A systematic review
    • S. Morgan et al. The cost of drug development: a systematic review Health Policy 100 2011 4 17
    • (2011) Health Policy , vol.100 , pp. 4-17
    • Morgan, S.1
  • 3
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: The pharmaceutical industry's grand challenge
    • S.M. Paul et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 203-214
    • Paul, S.M.1
  • 4
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 715
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 5
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: Phase II failures: 2008-2010
    • J. Arrowsmith Trial watch: phase II failures: 2008-2010 Nat. Rev. Drug Discov. 10 2011 328 329
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 6
    • 79551575056 scopus 로고    scopus 로고
    • Trial watch: Phase III and submission failures: 2007-2010
    • J. Arrowsmith Trial watch: phase III and submission failures: 2007-2010 Nat. Rev. Drug Discov. 10 2011 87
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 87
    • Arrowsmith, J.1
  • 7
    • 33750106228 scopus 로고    scopus 로고
    • National surveillance of emergency department visits for outpatient adverse drug events
    • D.S. Budnitz et al. National surveillance of emergency department visits for outpatient adverse drug events JAMA 296 2006 1858 1866
    • (2006) JAMA , vol.296 , pp. 1858-1866
    • Budnitz, D.S.1
  • 8
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
    • J. Lazarou et al. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies JAMA 279 1998 1200 1205
    • (1998) JAMA , vol.279 , pp. 1200-1205
    • Lazarou, J.1
  • 9
    • 34547656228 scopus 로고    scopus 로고
    • The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
    • J.A. Kramer et al. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates Nat. Rev. Drug Discov. 6 2007 636 649
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 636-649
    • Kramer, J.A.1
  • 10
    • 7444226416 scopus 로고    scopus 로고
    • Testing paradigm for prediction of development-limiting barriers and human drug toxicity
    • V.G. Sasseville et al. Testing paradigm for prediction of development-limiting barriers and human drug toxicity Chem. Biol. Interact. 150 2004 9 25
    • (2004) Chem. Biol. Interact. , vol.150 , pp. 9-25
    • Sasseville, V.G.1
  • 11
    • 84856375492 scopus 로고    scopus 로고
    • The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery
    • C.E. Thomas, and Y. Will The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery Expert Opin. Drug Discov. 7 2012 109 122
    • (2012) Expert Opin. Drug Discov. , vol.7 , pp. 109-122
    • Thomas, C.E.1    Will, Y.2
  • 13
    • 79958260793 scopus 로고    scopus 로고
    • Drug targets for cognitive enhancement in neuropsychiatric disorders
    • T.L. Wallace et al. Drug targets for cognitive enhancement in neuropsychiatric disorders Pharmacol. Biochem. Behav. 99 2011 130 145
    • (2011) Pharmacol. Biochem. Behav. , vol.99 , pp. 130-145
    • Wallace, T.L.1
  • 14
    • 77957229824 scopus 로고    scopus 로고
    • Challenges and opportunities for drug discovery in psychiatric disorders: The drug hunters' perspective
    • E.H.F. Wong et al. Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective Int. J. Neuropsychopharmacol. 13 2010 1269 1284
    • (2010) Int. J. Neuropsychopharmacol. , vol.13 , pp. 1269-1284
    • Wong, E.H.F.1
  • 15
    • 84889241089 scopus 로고    scopus 로고
    • Simple drugs do not cure complex diseases: The need for multi-targeted drugs in designing multi-target drugs
    • J.R. Morphy, J.C. Harris, The Royal Society of Chemistry
    • J.J. Hornberg Simple drugs do not cure complex diseases: the need for multi-targeted drugs in designing multi-target drugs J.R. Morphy, J.C. Harris, Designing Multi-target Drugs 2012 The Royal Society of Chemistry 1 13
    • (2012) Designing Multi-target Drugs , pp. 1-13
    • Hornberg, J.J.1
  • 16
    • 84860455486 scopus 로고    scopus 로고
    • Discovery of small molecule cancer drugs: Successes, challenges and opportunities
    • S. Hoelder et al. Discovery of small molecule cancer drugs: successes, challenges and opportunities Mol. Oncol. 6 2012 155 176
    • (2012) Mol. Oncol. , vol.6 , pp. 155-176
    • Hoelder, S.1
  • 17
    • 84872857932 scopus 로고    scopus 로고
    • Cutaneous side effects of inhibitors of the RAS/RAF/MEK/ERK signalling pathway and their management
    • I. Manousaridis et al. Cutaneous side effects of inhibitors of the RAS/RAF/MEK/ERK signalling pathway and their management J. Eur. Acad. Dermatol. Venereol. 27 2012 11 18
    • (2012) J. Eur. Acad. Dermatol. Venereol. , vol.27 , pp. 11-18
    • Manousaridis, I.1
  • 18
    • 84863424046 scopus 로고    scopus 로고
    • Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors
    • L. Peuvrel et al. Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors Support. Care Cancer 20 2012 909 921
    • (2012) Support. Care Cancer , vol.20 , pp. 909-921
    • Peuvrel, L.1
  • 19
    • 80052974259 scopus 로고    scopus 로고
    • Improving drug candidates by design: A focus on physicochemical properties as a means of improving compound disposition and safety
    • N.A. Meanwell Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety Chem. Res. Toxicol. 24 2011 1420 1456
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 1420-1456
    • Meanwell, N.A.1
  • 20
    • 77953680038 scopus 로고    scopus 로고
    • Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes
    • T.T. Wager et al. Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes ACS Chem. Neurosci. 1 2010 420 434
    • (2010) ACS Chem. Neurosci. , vol.1 , pp. 420-434
    • Wager, T.T.1
  • 21
    • 84867027478 scopus 로고    scopus 로고
    • The determination and interpretation of the therapeutic index in drug development
    • P.Y. Muller, and M.N. Milton The determination and interpretation of the therapeutic index in drug development Nat. Rev. Drug Discov. 11 2012 751 761
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 751-761
    • Muller, P.Y.1    Milton, M.N.2
  • 22
    • 0035092543 scopus 로고    scopus 로고
    • Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets - 1960 to 1999
    • M. Fung et al. Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets - 1960 to 1999 Drug Inf. J. 35 2001 293 317
    • (2001) Drug Inf. J. , vol.35 , pp. 293-317
    • Fung, M.1
  • 23
    • 58849132807 scopus 로고    scopus 로고
    • The future of drug safety testing: Expanding the view and narrowing the focus
    • J.L. Stevens, and T.K. Baker The future of drug safety testing: expanding the view and narrowing the focus Drug Discov. Today. 14 2009 162 167
    • (2009) Drug Discov. Today. , vol.14 , pp. 162-167
    • Stevens, J.L.1    Baker, T.K.2
  • 24
    • 84906304409 scopus 로고    scopus 로고
    • Postmarketing safety evaluation: Monitoring, assessing, and reporting of adverse drug responses
    • John Wiley & Sons
    • S.C. Gad Postmarketing safety evaluation: monitoring, assessing, and reporting of adverse drug responses Pharmaceutical Sciences Encyclopedia 2010 John Wiley & Sons
    • (2010) Pharmaceutical Sciences Encyclopedia
    • Gad, S.C.1
  • 25
    • 0033771951 scopus 로고    scopus 로고
    • Concordance of the toxicity of pharmaceuticals in humans and in animals
    • H. Olson et al. Concordance of the toxicity of pharmaceuticals in humans and in animals Regul. Toxicol. Pharmacol. 32 2000 56 67
    • (2000) Regul. Toxicol. Pharmacol. , vol.32 , pp. 56-67
    • Olson, H.1
  • 26
    • 67649185786 scopus 로고    scopus 로고
    • Toxicity testing in the 21st century: A view from the pharmaceutical industry
    • J.S. MacDonald, and R.T. Robertson Toxicity testing in the 21st century: a view from the pharmaceutical industry Toxicol. Sci. 110 2009 40 46
    • (2009) Toxicol. Sci. , vol.110 , pp. 40-46
    • Macdonald, J.S.1    Robertson, R.T.2
  • 27
    • 79958067466 scopus 로고    scopus 로고
    • Impact and frequency of different toxicities throughout the pharmaceutical life cycle
    • W.S. Redfern et al. Impact and frequency of different toxicities throughout the pharmaceutical life cycle Toxicologist 114 2010 1081
    • (2010) Toxicologist , vol.114 , pp. 1081
    • Redfern, W.S.1
  • 28
    • 84906250752 scopus 로고    scopus 로고
    • Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies
    • http://dx.doi.org/10.1016/j.drudis.2013.12.009
    • J.J. Hornberg et al. Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies Drug Discov. Today 2013 http://dx.doi.org/10.1016/j.drudis.2013.12.009
    • (2013) Drug Discov. Today
    • Hornberg, J.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.