Identification and characterization of novel compounds blocking Shiga toxin expression in Escherichia coli O157:H7

Frontiers in Microbiology

Volumn 7, Issue NOV, 2016, Pages

  Huerta Uribe, Alejandro ^a   Marjenberg, Zoe R ^a   Yamaguchi, Nao ^b   Fitzgerald, Stephen ^b   Connolly, James P R ^a   Carpena, Nuria ^a   Uvell, Hanna ^c   Douce, Gillian ^a   Elofsson, Michael ^c   Byron, Olwyn ^a   Marquez, Rudi ^d   Gally, David L ^b   Roe, Andrew J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UMEÅ UNIVERSITY   (Sweden)

^d XI AN JIAOTONG LIVERPOOL UNIVERSITY   (China)

Author keywords

E. coli; Expression; Phage; RecA; Shiga toxin

Indexed keywords

ANTIINFECTIVE AGENT; DICHLOROMETHANE; PHENYL PYRROLEDIONE; SHIGA TOXIN; TETRAHYDROFURAN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; ATPASE ACTIVITY ASSAY; BACTERIAL CHROMOSOME; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DNA REPAIR; DRUG IDENTIFICATION; ELECTROPORATION; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE SPECTROSCOPY; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; HIGH THROUGHPUT SCREENING; MOLECULAR LIBRARY; NONHUMAN; OLIGOMERIZATION; PROTEIN EXPRESSION; RECA GENE; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; TRANSACTIVATION ASSAY; ULTRACENTRIFUGATION;

EID: 85006795688     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.01930     Document Type: Article

References (29)

1. Alam, M. K., Alhhazmi, A., DeCoteau, J. F., Luo, Y., and Geyer, C. R. (2016). RecA inhibitors potentiate antibiotic activity and block evolution of antibiotic resistance. Cell Chem. Biol. 23, 381-391. doi: 10.1016/j.chembiol.2016.02.010.
2. Beaber, J. W., Hochhut, B., and Waldor, M. K. (2004). SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427, 72-74. doi: 10.1038/nature02241.
3. Bergan, J., Dyve Lingelem, A. B., Simm, R., Skotland, T., and Sandvig, K. (2012). Shiga toxins. Toxicon 60, 1085-1107. doi: 10.1016/j.toxicon.2012.07.016.
4. Böttcher, T., and Sieber, S. (2010). Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria. J. Am. Chem. Soc. 132, 6964-6972. doi: 10.1021/ja909150y.
5. Brenner, S. L., Zlotnick, A., and Stafford, W. F. (1990). RecA protein self-assembly. II. Analytical equilibrium ultracentrifugation studies of the entropy-driven self-association of RecA. J. Mol. Biol. 216, 949-964. doi: 10.1016/S0022-2836(99)80013-8.
6. Budke, B., Logan, H. L., Kalin, J. H., Zelivianskaia, A. S., Cameron McGuire, W., Miller, L. L., et al. (2012). RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 40, 7347-7357. doi: 10.1093/nar/gks353.
7. Chen, Z., Yang, H., and Pavletich, N. P. (2008). Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature 453, 489-494. doi: 10.1038/nature06971.
8. Fraser, M. E., Fujinaga, M., Cherney, M. M., Melton-Celsa, A. R., Twiddy, E. M., O'Brien, A. D., et al. (2004). Structure of Shiga toxin type 2 (Stx2) from Escherichia coli O157:H7. J. Biol. Chem. 279, 27511-27517. doi: 10.1074/jbc.M401939200.
9. Fuller, C. A., Pellino, C. A., Flagler, M. J., Strasser, J. E., and Weiss, A. A. (2011). Shiga toxin subtypes display dramatic differences in potency. Infect. Immun. 79, 1329-1337. doi: 10.1128/IAI.01182-10.
10. Karmali, M. A., Steele, B. T., Petric, M., and Lim, C. (1983). Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1, 619-620. doi: 10.1016/S0140-6736(83)91795-6.
11. Lim, J. Y., Yoon, J., and Hovde, C. J. (2010). A brief overview of Escherichia coli O157:H7 and its plasmid O157. J. Microbiol. Biotechnol. 20, 5-14.
12. Lucas, E. M. F., de Castro, M. C. M., and Takahashi, J. A. (2007). Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma. Braz. J. Microbiol. 38, 785-789. doi: 10.1590/S1517-83822007000400036.
13. Manley-King, C. I., Terre'Blanche, G., Castagnoli, N., Bergh, J. J., and Petzer, J. P. (2009). Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides. Bioorg. Med. Chem. 17, 3104-3110. doi: 10.1016/j.bmc.2009.03.005.
14. Manning, S. D., Motiwala, A. S., Springman, A. C., Qi, W., Lacher, D. W., Ouellette, L. M., et al. (2008). Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks. Proc. Natl. Acad. Sci. U.S.A. 105, 4868-4873. doi: 10.1073/pnas.0710834105.
15. Mizusawa, S., Court, D., and Gottesman, S. (1983). Transcription of the sulA gene and repression by LexA. J. Mol. Biol. 171, 337-343.
16. Nowak-Sliwinska, P., Storto, M., Cataudella, T., Ballini, J.-P., Gatz, R., Giorgio, M., et al. (2012). Angiogenesis inhibition by the maleimide-based small molecule GNX-686. Microvasc. Res. 83, 105-110. doi: 10.1016/j.mvr.2011.10.004.
17. Paton, J. C., and Paton, A. W. (1998). Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin. Microbiol. Rev. 11, 450-479.
18. Persson, S., Olsen, K. E. P., Ethelberg, S., and Scheutz, F. (2007). Subtyping method for Escherichia coli Shiga toxin (verocytotoxin) 2 variants and correlations to clinical manifestations. J. Clin. Microbiol. 45, 2020-2024. doi: 10.1128/JCM.02591-06.
19. Peterson, E. J. R., Janzen, W. P., Kireev, D., and Singleton, S. F. (2012). High-throughput screening for RecA inhibitors using a transcreener adenosine 5'-O-diphosphate assay. Assay Drug Dev. Technol. 10, 260-268. doi: 10.1089/adt.2011.0409.
20. Putri, S. P., Ishido, K. I., Kinoshita, H., Kitani, S., Ihara, F., Sakihama, Y., et al. (2014). Production of antioomycete compounds active against the phytopathogens Phytophthora sojae and Aphanomyces cochlioides by clavicipitoid entomopathogenic fungi. J. Biosci. Bioeng. 117, 557-562. doi: 10.1016/j.jbiosc.2013.10.014.
21. Quiles-Puchalt, N., Carpena, N., Alonso, J. C., Novick, R. P., Marina, A., and Penadés, J. R. (2014). Staphylococcal pathogenicity island DNA packaging system involving cos-site packaging and phage-encoded HNH endonucleases. Proc. Natl. Acad. Sci. U.S.A. 111, 6016-6021. doi: 10.1073/pnas.1320538111.
22. Riley, L. W., Remis, R. S., Helgerson, S. D., McGee, H. B., Wells, J. G., Davis, B. R., et al. (1983). Hemorrhagic colitis associated with a rare Escherichia coli serotype. N. Engl. J. Med. 308, 681-685. doi: 10.1056/NEJM198303243081203.
23. Sexton, J. Z., Wigle, T. J., He, Q., Hughes, M., Smith, G. R., Singleton, S. F., et al. (2010). Novel inhibitors of E. coli RecA ATPase activity. Curr. Chem. Genomics 4, 34-42. doi: 10.2174/1875397301004010034.
24. Singh, R., Ledesma, K. R., Chang, K.-T., and Tam, V. H. (2010). Impact of RecA on levofloxacin exposure-related resistance development. Antimicrob. Agents Chemother. 54, 4262-4268. doi: 10.1128/AAC.00168-10.
25. Tarr, P. I., Gordon, C. A., and Chandler, W. L. (2005). Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365, 1073-1086. doi: 10.1016/S0140-6736(05)71144-2.
26. Thi, T. D., López, E., Rodríguez-Rojas, A., Rodríguez-Beltrán, J., Couce, A., Guelfo, J. R., et al. (2011). Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials. J. Antimicrob. Chemother. 66, 531-538. doi: 10.1093/jac/dkq496.
27. Vistica, J., Dam, J., Balbo, A., Yikilmaz, E., Mariuzza, R. A., Rouault, T. A., et al. (2004). Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition. Anal. Biochem. 326, 234-256. doi: 10.1016/j.ab.2003.12.014.
28. Wigle, T. J., Sexton, J. Z., Gromova, A. V., Hadimani, M. B., Hughes, M., Smith, G. R., et al. (2009). Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coli. J. Biomol. Screen. 14, 1092-1101. doi: 10.1177/1087057109342126.
29. Wigle, T. J., and Singleton, S. F. (2007). Directed molecular screening for RecA ATPase inhibitors. Bioorg. Med. Chem. Lett. 17, 3249-3253. doi: 10.1016/j.bmcl.2007.04.013.