Staphylococcal pathogenicity island DNA packaging system involving cos-site packaging and phage-encoded HNH endonucleases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 16, 2014, Pages 6016-6021

  Quiles Puchalt, Nuria ^a,b   Carpena, Nuria ^a,b   Alonso, Juan C ^c   Novick, Richard P ^d   Marina, Alberto ^b   Penadés, José R ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Horizontal gene transfer; Interference; Molecular parasitism; PICIs

Indexed keywords

BACTERIOPHAGE DNA; ENDONUCLEASE; HISTIDINE; TERMINASE SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIOPHAGE; CONTROLLED STUDY; DNA PACKAGING; DNA TRANSFER; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; PATHOGENICITY ISLAND; PLASMID; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; STAPHYLOCOCCAL PATHOGENICITY ISLAND; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS PHAGE;

HORIZONTAL GENE TRANSFER; INTERFERENCE; MOLECULAR PARASITISM; PICIS;

ATTACHMENT SITES, MICROBIOLOGICAL; DNA PACKAGING; DNA REPLICATION; ENDONUCLEASES; GENOMIC ISLANDS; MUTATION; STAPHYLOCOCCUS; STAPHYLOCOCCUS PHAGES; VIRAL PROTEINS; VIRUS ASSEMBLY;

EID: 84899088004     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320538111     Document Type: Article

References (30)

1. Ram G, et al. (2012) Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism. Proc Natl Acad Sci USA 109(40):16300-16305.
2. Ubeda C, et al. (2007) SaPI operon I is required for SaPI packaging and is controlled by LexA. Mol Microbiol 65(1):41-50. (Pubitemid 46934482)
3. Viana D, et al. (2010) Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein. Mol Microbiol 77(6):1583-1594.
4. Ubeda C, et al. (2008) SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage. Mol Microbiol 67(3):493-503.
5. Tormo-Más MÁ, et al. (2010) Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature 465(7299):779-782.
6. Tormo-Más MÁ, et al. (2013) Phage dUTPases control transfer of virulence genes by a proto-oncogenic G protein-like mechanism. Mol Cell 49(5):947-958.
7. Tormo MA, et al. (2008) Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins. J Bacteriol 190(7):2434-2440. (Pubitemid 351466338)
8. Quiles-Puchalt N, Martínez-Rubio R, Ram G, Lasa I, Penadés JR (2014) Unravelling bacteriophage φ11 requirements for packaging and transfer of mobile genetic elements in Staphylococcus aureus. Mol Microbiol 91(3):423- 437.
9. García P, et al. (2009) Functional genomic analysis of two Staphylococcus aureus phages isolated from the dairy environment. Appl Environ Microbiol 75(24):7663-7673.
10. Augustin J, et al. (1992) Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis. Eur J Biochem 204(3):1149-1154.
11. Ferrer MD, et al. (2011) RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria. Nucleic Acids Res 39(14):5866-5878.
12. Quiles-Puchalt N, et al. (2013) A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria. Nucleic Acids Res 41(15):7260-7275.
13. Roy A, Kucukural A, Zhang Y (2010) I-TASSER: A unified platform for automated protein structure and function prediction. Nat Protoc 5(4):725-738.
14. Xu S-Y, et al. (2013) Structure determination and biochemical characterization of a putative HNH endonuclease from Geobacter metallireducens GS-15. PLoS ONE 8(9):e72114.
15. Shen BW, et al. (2010) Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure 18(6):734-743.
16. Moodley S, Maxwell KL, Kanelis V (2012) The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease. Protein Sci 21(6):809-818.
17. Smits C, et al. (2009) Structural basis for the nuclease activity of a bacteriophage large terminase. EMBO Rep 10(6):592-598.
18. Sippy J, Feiss M (2004) Initial cos cleavage of bacteriophage lambda concatemers requires proheads and gpFI in vivo. Mol Microbiol 52(2):501-513. (Pubitemid 38520718)
19. Chai S, et al. (1992) Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6. The products of gene 1 and gene 2 are required for pac cleavage. J Mol Biol 224(1):87-102.
20. Xu S-Y, Gupta YK (2013) Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res 41(1):378-390.
21. Muniesa M, Recktenwald J, Bielaszewska M, Karch H, Schmidt H (2000) Characterization of a shiga toxin 2e-converting bacteriophage from an Escherichia coli strain of human origin. Infect Immun 68(9):4850-4855.
22. Lindqvist BH, Dehò G, Calendar R (1993) Mechanisms of genome propagation and helper exploitation by satellite phage P4. Microbiol Rev 57(3):683-702. (Pubitemid 23262514)
23. Huang H, Yuan HS (2007) The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases. J Mol Biol 368(3):812-821. (Pubitemid 46527620)
24. Yang Q, Catalano CE (1997) Kinetic characterization of the strand separation ("helicase") activity of the DNA packaging enzyme from bacteriophage lambda. Biochemistry 36(35):10638-10645. (Pubitemid 27382553)
25. Cornilleau C, et al. (2013) The nuclease domain of the SPP1 packaging motor coordinates DNA cleavage and encapsidation. Nucleic Acids Res 41(1):340-354.
26. Lindsay JA, Ruzin A, Ross HF, Kurepina N, Novick RP (1998) The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus. Mol Microbiol 29(2):527-543. (Pubitemid 28330786)
27. Charpentier E, et al. (2004) Novel cassette-based shuttle vector system for Grampositive bacteria. Appl Environ Microbiol 70(10):6076-6085. (Pubitemid 39471856)
28. Guzman LM, Belin D, Carson MJ, Beckwith J (1995) Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 177(14):4121-4130.
29. Winn MD, et al. (2011) Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 67(Pt 4):235-242.
30. Emsley P, Lohkamp B, Scott WG, Cowtan K (2010) Features and development of Coot. Acta Crystallogr D Biol Crystallogr 66(Pt 4):486-501.