Novel inhibitors of e. coli reca atpase activity

Current Chemical Genomics

Volumn 4, Issue 1, 2010, Pages 34-42

  Sexton, Jonathan Z ^a   Wigle, Tim J ^b   He, Qingping ^a   Hughes, Mark A ^a   Smith, Ginger R ^a   Singleton, Scott F ^b   Williams, Alfred L ^a   Yeh, Li An ^a  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b University of North Carolina   (United States)

Author keywords

Antibiotic resistance; Atpase inhibition; High throughput screening; Microbial drug resistance; Reca; Sos response

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTIINFECTIVE AGENT; RECA PROTEIN; RECA PROTEIN INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS);

EID: 78249279388     PISSN: None     EISSN: 18753973     Source Type: Journal    
DOI: 10.2174/1875397301004010034     Document Type: Article

References (35)

1. Diekema DJ, BootsMiller BJ, Vaughn TE, et al. Antimicrobial resistance trends and outbreak frequency in United States hospitals. Clin Infect Dis 2004; 38(1): 78-85.
2. Talbot GH, Bradley J, Edwards JE, Jr., Gilbert D, Scheld M, Bartlett JG. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis 2006; 42(5): 657-668.
3. Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48(1): 1-12.
4. Power E. Impact of antibiotic restrictions: the pharmaceutical perspective. Clin Microbiol Infect 2006; 12(Suppl 5): 25-34.
5. Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007; 6(1): 29-40.
6. Lock RL, Harry EJ. Cell-division inhibitors: new insights for future antibiotics. Nat Rev Drug Discov 2008; 7(4): 324-338.
7. Baba T, Ara T, Hasegawa M, et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2006; 2: 2006. 0008.
8. Escaich S. Antivirulence as a new antibacterial approach for chemotherapy. Curr Opin Chem Biol 2008; 12(4): 400-408.
9. Cottarel G, Wierzbowski J. Combination drugs, an emerging option for antibacterial therapy. Trends Biotechnol 2007; 25(12): 547-555.
10. Friedberg EC, Walker GC, Siede W. SOS responses and DNA damage tolerance in prokaryotes. DNA Repair and Mutagenesis. Washington, D.C.: ASM Press 1995; pp. 407-464.
11. Haruta N, Yu X, Yang S, Egelman EH, Cox MM. A DNA pairingenhanced conformation of bacterial RecA proteins. J Biol Chem 2003; 278(52): 52710-52723.
12. VanLoock MS, Yu X, Yang S, et al. ATP-mediated conformational changes in the RecA filament. Structure 2003; 11(2): 187-196.
13. Sassanfar M, Roberts JW. Nature of the SOS-inducing signal in Escherichia coli. The involvement of DNA replication. J Mol Biol 1990; 212(1): 79-96.
14. Kelley WL. Lex marks the spot: the virulent side of SOS and a closer look at the LexA regulon. Mol Microbiol 2006; 62(5): 1228-1238.
15. Hastings PJ, Rosenberg SM, Slack A. Antibiotic-induced lateral transfer of antibiotic resistance. Trends Microbiol 2004; 12(9): 401-404.
16. Schlacher K, Leslie K, Wyman C, Woodgate R, Cox MM, Goodman MF. DNA polymerase V and RecA protein, a minimal mutasome. Mol Cell 2005; 17(4): 561-572.
17. Schlacher K, Pham P, Cox MM, Goodman MF. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation. Chem Rev 2006; 106(2): 406-419.
18. Cox JM, Tsodikov OV, Cox MM. Organized unidirectional waves of ATP hydrolysis within a RecA filament. PLoS Biol 2005; 3(2): e52.
19. Cox MM. The bacterial RecA protein as a motor protein. Annu Rev Microbiol 2003; 57: 551-577.
20. Courcelle J, Ganesan AK, Hanawalt PC. Therefore, what are recombination proteins there for? BioEssays 2001; 23: 463-470.
21. Roca AI, Cox MM. RecA protein: structure, function, and role in recombinational DNA repair. Prog Nucl Acid Res Mol Biol 1997; 56: 129-223.
22. Radman M, Taddei F, Matic I. DNA repair systems and bacterial evolution. Cold Spring Harb Symp Quant Biol 2000; 65: 11-19.
23. Beaber JW, Hochhut B, Waldor MK. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 2004; 427(6969): 72-74.
24. Cirz RT, Jones MB, Gingles NA, et al. Complete and SOSmediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. J Bacteriol 2007; 189(2): 531-539.
25. Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 2007; 130(5): 797-810.
26. Lee AM, Ross CT, Zeng BB, Singleton SF. A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP. J Med Chem 2005; 48(17): 5408-5411.
27. Wigle TJ, Lee AM, Singleton SF. Conformationally selective binding of nucleotide analogues to Escherichia coli RecA: a ligandbased analysis of the RecA ATP binding site. Biochemistry 2006; 45(14): 4502-4513.
28. Wigle TJ, Singleton SF. Directed molecular screening for RecA ATPase inhibitors. Bioorg Med Chem Lett 2007; 17(12): 3249-3253.
29. Cline DJ, Holt SL, Singleton SF. Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix. Org Biomol Chem 2007; 5(10): 1525-1528.
30. Lee AM, Singleton SF. Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates. J Inorg Biochem 2004; 98(11): 1981-1986.
31. Singleton SF, Simonette RA, Sharma NC, Roca AI. Inteinmediated affinity-fusion purification of the Escherichia coli RecA protein. Protein Expr Purif 2002; 26(3): 476-488.
32. Lee AM, Wigle TJ, Singleton SF. A complementary pair of rapid molecular screening assays for RecA activities. Anal Biochem 2007; 367(2): 247-258.
33. Wigle TJ, Sexton JZ, Gromova AV, et al. Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the sos response in Escherichia coli. J Biomol Screen 2009; 14(9): 1092-1101.
34. Mikawa T, Masui R, Kuramitsu S. RecA protein has extremely high cooperativity for substrate in its ATPase activity. J Biochem 1998; 123(3): 450.
35. Register J, Griffith J. The direction of RecA protein assembly onto single strand DNA is the same as the direction of strand assimilation during strand exchange. J Biol Chem 1985; 260(22): 12308-12312.