Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing

Journal of Molecular Diagnostics

Volumn 19, Issue 1, 2017, Pages 84-91

  Nowak, Jonathan A ^a   Yurgelun, Matthew B ^b   Bruce, Jacqueline L ^a   Rojas Rudilla, Vanesa ^a   Hall, Dimity L ^a   Shivdasani, Priyanka ^a   Garcia, Elizabeth P ^a   Agoston, Agoston T ^a   Srivastava, Amitabh ^a   Ogino, Shuji ^a,b,c   Kuo, Frank C ^a   Lindeman, Neal I ^a   Dong, Fei ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MISMATCH REPAIR PROTEIN; MICROSATELLITE DNA;

ARTICLE; CANCER PATIENT; CARCINOGENESIS; DNA REPAIR; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDEL MUTATION; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; NEXT GENERATION SEQUENCING; POLE GENE; POLYMERASE CHAIN REACTION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; ADENOCARCINOMA; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; GENETICS; HIGH THROUGHPUT SEQUENCING; MISMATCH REPAIR; MUTATION; NUCLEOTIDE SEQUENCE; TUMOR GENE;

ADENOCARCINOMA; BASE SEQUENCE; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; DNA MUTATIONAL ANALYSIS; GENES, NEOPLASM; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICROSATELLITE INSTABILITY; MICROSATELLITE REPEATS; MUTATION;

EID: 85006364972     PISSN: 15251578     EISSN: 19437811     Source Type: Journal    
DOI: 10.1016/j.jmoldx.2016.07.010     Document Type: Article

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