Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi

Phytochemistry

Volumn 134, Issue , 2017, Pages 46-53

  Zhang, De Huai ^a   Li, Na ^a   Yu, Xuya ^a   Zhao, Peng ^a   Li, Tao ^a   Xu, Jun Wei ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Fermentation; Ganoderma lucidum; Genetic engineering; Medicinal mushroom

Indexed keywords

ERGOSTEROL; GANODERIC ACID; GANODERIC ACID MF; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LANOSTEROL; LANOSTEROL SYNTHASE; MUTASE; TRITERPENE;

CHEMISTRY; ENZYMOLOGY; GANODERMA; GANODERMA LUCIDUM; GENETICS; METABOLISM; TRANSGENIC PLANT;

ERGOSTEROL; GANODERMA; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); INTRAMOLECULAR TRANSFERASES; LANOSTEROL; PLANTS, GENETICALLY MODIFIED; REISHI; TRITERPENES;

EID: 85006265719     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2016.11.006     Document Type: Article

References (39)

1. Bisho, K.S., Kao, C.H.J., Xu, Y., Glucina, M.P., Paterson, R.R.M., Ferguson, L.R., From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 114 (2015), 56–65.
2. Chen, S.L., Xu, J., Liu, C., Zhu, Y.J., Nelson, D.R., Zhou, S.G., Li, C.F., Wang, L.Z., Guo, X., Sun, Y.Z., Luo, H.M., Li, Y., Song, J.Y., Henrissat, B., Levasseur, A., Qian, J., Li, J.Q., Luo, X., Shi, L.C., He, L., Xiang, L., Xu, X.L., Niu, Y.Y., Li, Q.S., Han, M.V., Yan, H.X., Zhang, J., Chen, H.M., Lv, A.P., Wang, Z., Liu, M.Z., Schwartz, D.C., Sun, C., Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat. Commun., 3, 2012, 913.
3. Confalonieri, M., Cammareri, M., Biazzi, E., Pecchia, P., Salema Fevereiro, M.P., Balestrazzi, A., Tava, A., Conicella, C., Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene. Plant Biotechnol. J. 7 (2009), 172–182.
4. Gas-Pascual, E., Berna, A., Bach, T.J., Schaller, H., Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. Plos One, 9, 2014, e109156.
5. Godio, R.P., Martin, J.F., Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. Fungal Genet. Biol. 46 (2009), 232–242.
6. Han, J.Y., Kwon, Y.S., Yang, D.C., Jung, Y.R., Choi, Y.E., Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. Plant Cell Physiol. 47 (2006), 1653–1662.
7. Hayashi, H., Huang, P.Y., Inoue, K., Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant Cell Physiol. 44 (2003), 404–411.
8. Li, H.J., He, Y.L., Zhang, D.H., Yue, T.H., Jiang, L.X., Li, N., Xu, J.W., Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. J. Biotechnol. 227 (2016), 35–40.
9. Li, H.J., Zhang, D.H., Han, L.L., Yu, X., Zhao, P., Li, T., Zhong, J.J., Xu, J.W., Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition. Bioproc. Biosys. Eng. 39 (2016), 75–80.
10. Li, H.J., Zhang, D.H., Yue, T.H., Jiang, L.X., Yu, X., Zhao, P., Li, T., Xu, J.W., Improved polysaccharide production in a submerged culture of Ganoderma lucidum by the heterologous expression of Vitreoscilla hemoglobin gene. J. Biotechnol. 217 (2016), 132–137.
11. Liang, C.X., Li, Y.B., Xu, J.W., Wang, J.L., Miao, X.L., Tang, Y.J., Gu, T.Y., Zhong, J.J., Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. Appl. Microbiol. Biotechnol. 86 (2010), 1367–1374.
12. Lin, Y.L., Lee, Y.R., Tsao, N.W., Wang, S.Y., Shaw, J.F., Chu, F.H., Characterization of the 2, 3-oxidosqualene cyclase gene from Antrodia cinnamomea and enhancement of cytotoxic triterpenoid compound production. J. Nat. Prod. 78 (2015), 1556–1562.
13. Liu, R.M., Li, Y.B., Zhong, J.J., Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells. Lat. Am. J. Pharm. 31 (2012), 43–50.
14. Liu, R.M., Zhong, J.J., Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine 18 (2011), 349–355.
15. Nasrollahi, V., Mirzaie-asl, A., Piri, K., Nazeri, S., Mehrabi, R., The effect of drought stress on the expression of key genes involved in the biosynthesis of triterpenoid saponins in liquorice (Glycyrrhiza glabra). Phytochemistry 103 (2014), 32–37.
16. Paterson, R.R., Ganoderma – a therapeutic fungal biofactory. Phytochemistry 67 (2006), 1985–2001.
17. Qin, H., Xu, J.W., Xiao, J.H., Tang, Y.J., Xiao, H., Zhong, J.J., Cell factories of higher fungi for useful metabolite production. Adv. Biochem. Eng. Biotechnol. 155 (2016), 199–235.
18. Ren, A., Li, M.J., Shi, L., Mu, D.S., Jiang, A.L., Han, Q., Zhao, M.W., Profiling and quantifying differential gene transcription provide insights into ganoderic acid biosynthesis in Ganoderma lucidum in response to methyl jasmonate. Plos One, 2013, e65027.
19. Ren, A., Li, X.B., Miao, Z.G., Shi, L., Jaing, A.L., Zhao, M.W., Transcript and metabolite alterations increase ganoderic acid content in Ganoderma lucidum using acetic acid as an inducer. Biotechnol. Lett. 36 (2014), 2529–2536.
20. Ren, A., Qin, L., Shi, L., Dong, X., Mu, D.S., Li, Y.X., Zhao, M.W., Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum. Bioresour. Technol. 101 (2010), 6785–6790.
21. Shang, C.H., Shi, L., Ren, A., Qin, L., Zhao, M.W., Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum. Biosci. Biotech. Biochem. 74 (2010), 974–978.
22. Shi, L., Ren, A., Mu, D.S., Zhao, M.W., Current progress in the study on biosynthesis and regulation of ganoderic acids. Appl. Microbiol. Biotechnol. 88 (2010), 1243–1251.
23. Takagi, K., Nishizawa, K., Hirose, A., Kita, A., Ishimoto, M., Manipulation of saponin biosynthesis by RNA interference-mediated silencing of beta-amyrin synthase gene expression in soybean. Plant Cell Rep. 30 (2011), 1835–1846.
24. Tang, W., Liu, J.W., Zhao, W.M., Wei, D.Z., Zhong, J.J., Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci. 80 (2006), 205–211.
25. Upadhyay, M., Shrivastava, B., Jain, A., Kidwai, M., Kumar, S., Gomes, J., Goswami, D.G., Panda, A.K., Kuhad, R.C., Production of ganoderic acid by Ganoderma lucidum RCKB-2010 and its therapeutic potential. Ann. Microbiol. 64 (2014), 839–846.
26. Wang, G., Zhao, J., Liu, J.W., Huang, Y.P., Zhong, J.J., Tang, W., Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int. Immunopharmacol. 7 (2007), 864–870.
27. Wang, J.L., Li, Y.B., Liu, R.M., Zhong, J.J., A new ganoderic acid from Ganoderma lucidum mycelia. J. Asian. Nat. Prod. Res. 12 (2010), 727–730.
28. Xu, J.W., Ji, S.L., Li, H.J., Ren, M.F., Duan, Y.Q., Dang, L.Z., Mo, M.H., Increased polysaccharide production and biosynthetic gene expressions in a submerged culture of Ganoderma lucidum by the overexpression of the homologous alpha-phosphoglucomutase gene. Bioproc. Biosys. Eng. 38 (2015), 399–405.
29. Xu, J.W., Xu, Y.N., Zhong, J.J., Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Appl. Microbiol. Biotechnol. 85 (2010), 941–948.
30. Xu, J.W., Xu, Y.N., Zhong, J.J., Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum. Appl. Enviorn. Microbiol. 78 (2012), 7968–7976.
31. Xu, J.W., Zhong, J.J., Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids. Bioengineered 6 (2015), 357–360.
32. Xu, J.W., Zhao, W., Zhong, J.J., Biotechnological production and application of ganoderic acids. Appl. Microbiol. Biotechnol. 87 (2010), 457–466.
33. Xu, K., Liang, X., Gao, F., Zhong, J.J., Liu, J.W., Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem. 45 (2010), 1261–1267.
34. Xu, Y.N., Zhong, J.J., Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum. Biotechnol. Adv. 30 (2012), 1301–1308.
35. Yu, X., Ji, S.L., He, Y.L., Ren, M.F., Xu, J.W., Development of an expression plasmid and its use in genetic manipulation of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). Int. J. Med. Mushrooms 16 (2014), 161–168.
36. Zhang, W.X., Tang, Y.J., Zhong, J.J., Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum. Bioproc. Biosys. Eng. 33 (2010), 683–690.
37. Zhao, W., Xu, J.W., Zhong, J.J., Enhanced production of ganoderic acids in static liquid culture of Ganoderma lucidum under nitrogen-limiting conditions. Bioresour. Technol. 102 (2011), 8185–8190.
38. Zhou, L.W., Cao, Y., Wu, S.H., Vlasak, J., Li, D.W., Li, M.J., Dai, Y.C., Global diversity of the Ganoderma lucidum complex (Ganodermataceae, Polyporales) inferred from morphology and multilocus phylogeny. Phytochemistry 114 (2015), 7–15.
39. Zhou, J.S., Ji, S.L., Ren, M.F., He, Y.L., Jing, X.R., Xu, J.W., Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochem. Eng. J. 90 (2014), 178–183.