Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum

Journal of Biotechnology

Volumn 227, Issue , 2016, Pages 35-40

  Li, Huan Jun ^a   He, Yi Long ^a   Zhang, De Huai ^a   Yue, Tong Hui ^a   Jiang, Lu Xi ^a   Li, Na ^a   Xu, Jun Wei ^a  

^a KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Biosynthetic genes; Ganoderic acid productions; Medicinal mushroom fermentation; Vitreoscilla hemoglobin

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; DRUG PRODUCTS; FERMENTATION; GENE EXPRESSION; GENES; HEMOGLOBIN;

3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; BIOSYNTHETIC GENE; FERMENTATION PROCESS; GANODERIC ACID PRODUCTIONS; MAXIMUM CONCENTRATIONS; MEDICINAL MUSHROOM FERMENTATIONS; VITREOSCILLA HEMOGLOBIN; VITREOSCILLA HEMOGLOBIN GENE;

TRANSCRIPTION;

GANODERIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL; LANOSTEROL SYNTHASE; NATURAL PRODUCT; SQUALENE SYNTHASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; HEMOGLOBIN PROTEIN, VITREOSCILLA; TRITERPENE; TRUNCATED HEMOGLOBIN;

ARTICLE; FERMENTATION; GANODERMA LUCIDUM; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HMGR GENE; LS GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SQS GENE; UPREGULATION; VITREOSCILLA HEMOGLOBIN GENE; WILD TYPE; BIOMASS; BIOSYNTHESIS; BIOTECHNOLOGY; GENE EXPRESSION; GENETIC TRANSFORMATION; GENETICS; METABOLISM; PROCEDURES; TIME FACTOR;

BACTERIAL PROTEINS; BIOMASS; BIOSYNTHETIC PATHWAYS; BIOTECHNOLOGY; GENE EXPRESSION; LANOSTEROL; REISHI; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMATION, GENETIC; TRITERPENES; TRUNCATED HEMOGLOBINS;

EID: 84962808546     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.04.017     Document Type: Article

References (42)

1. Anand A., Duk B.T., Singh S., Akbas M.Y., Webster D.A., Stark B.C., Dikshit K.L. Redox mediated interactions of Vitreoscilla hemoglobin [VHb] with OxyR: novel regulation of VHb biosynthesis under oxidative stress. Biochem. J. 2010, 426:271-280.
2. Antonini E., Brunori M. The derivatives of ferrous hemoglobin and myoglobin. In Hemoglobin and Myoglobin in Their Reactions with Ligands 1971, 13-52. North-Holland Publishing Company, Amsterdam, Holland. A. Neuberger, E.L. Tatum (Eds.).
3. Bishop K.S., Kao C.H.J., Xu Y., Glucina M.P., Paterson R.R.M., Ferguson L.R. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 2015, 114:56-65.
4. Chen N.H., Liu J.W., Zhong J.J. Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J. Pharm. Sci. 2008, 108:212-216.
5. Chen S., Xu J., Liu C., Zhu Y., Nelson D.R., Zhou S., Li C., Wang L., Guo X., Sun Y., Luo H., Li Y., Song J., Henrissat B., Levasseur A., Qian J., Li J., Luo X., Shi L., He L., Xiang L., Xu X., Niu Y., Li Q., Han M.V., Yan H., Zhang J., Chen H., Lv A., Wang Z., Liu M., Schwartz D.C., Sun C. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat. Commun. 2012, 3:913.
6. Frey A.D., Kallio P.T. Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology. FEMS Microbiol. Rev. 2003, 27:525-545.
7. Li H.J., Zhang D.H., Han L.L., Yu X., Zhao P., Li T., Zhong J.J., Xu J.W. Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition. Bioprocess Biosyst. Eng. 2016, 39:75-80.
8. Li H.J., Zhang D.H., Yue T.H., Jiang L.X., Yu X., Zhao P., Li T., Xu J.W. Improved polysaccharide production in a submerged culture of Ganoderma lucidum by the heterologous expression of Vitreoscilla hemoglobin gene. J. Biotechnol. 2016, 217:132-137.
9. Liang C.X., Li Y.B., Xu J.W., Wang J.L., Miao X.L., Tang Y.J., Gu T., Zhong J.J. Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. Appl. Microbiol. Biotechnol. 2010, 86:1367-1374.
10. Liu R.M., Li Y.B., Zhong J.J. Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells. Lat. Am. J. Pharm. 2012, 31:43-50.
11. Liu S.C., Liu Y.X., Webster D.A., Stark B.C. Sequence of the region downstream of th: vitreoscilla hemoglobin gene: vgb is not part of a multigene operon. Appl. Microbiol. Biotechnol. 1994, 42:304-308.
12. Ren A., Qin L., Shi L., Dong X., Mu D.S., Li Y.X., Zhao M.W. Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum. Bioresour. Technol. 2010, 101:6785-6790.
13. Ren A., Li X.B., Miao Z.G., Shi L., Jaing A.L., Zhao M.W. Transcript and metabolite alterations increase ganoderic acid content in Ganoderma lucidum using acetic acid as an inducer. Biotechnol. Lett. 2014, 36:2529-2536.
14. Saghai-Maroof M.A., Soliman K.M., Jorgensen R.A., Allard R.W. Ribosomal DNA spacer-length polymorphisms in barley Mendelian inheritance, chromosomal location, and population dynamics. Proc. Natl. Acad. Sci. U. S. A. 1984, 81:8104-8108.
15. Sanodiya B.S., Thakur G.S., Baghel R.K., Prasad G.B.K.S., Bisen P.S. Ganoderma lucidum: a potent pharmacological macrofungus. Curr. Pharm. Biotechnol. 2009, 10:717-742.
16. Shi L., Ren A., Mu D., Zhao M. Current progress in the study on biosynthesis and regulation of ganoderic acids. Appl. Microbiol. Biotechnol. 2010, 88:1243-1251.
17. Shi L., Fang X., Li M., Mu D., Ren A., Tan Q., Zhao M. Development of a simple and efficient transformation system for the basidiomycetous medicinal fungus Ganoderma lucidum. World J. Microbiol. Biotechnol. 2012, 28:283-291.
18. Stark B.C., Pagilla K.R., Dikshit K.L. Recent applications of Vitreoscilla hemoglobin technology in bioproduct synthesis and bioremediation. Appl. Microbiol. Biotechnol. 2015, 99:1627-1636.
19. Suen Y.L., Tang H., Huang J., Chen F. Enhanced production of fatty acids and astaxanthin in Aurantiochytrium sp. by the expression of Vitreoscilla hemoglobin. J. Agric. Food. Chem. 2014, 62:12392-12398.
20. Tang W., Liu J.W., Zhao W.M., Wei D.Z., Zhong J.J. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci. 2006, 80:205-211.
21. Tang Y.J., Zhong J.J. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme Microb. Technol. 2003, 32:478-484.
22. Tang Y.J., Zhang W., Zhong J.J. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresour. Technol. 2009, 100:1852-1859.
23. Upadhyay M., Shrivastava B., Jain A., Kidwai M., Kumar S., Gomes J., Goswami D.G., Panda A.K., Kuhad R.C. Production of ganoderic acid by Ganoderma lucidum RCKB-2010 and its therapeutic potential. Ann. Microbiol. 2014, 64:839-846.
24. Wang C.N., Chen J.C., Shiao M.S., Wang C.T. The aggregation of human platelet induced by ganodermic acid S. Biochim. Biophyst. Acta 1989, 986:151-160.
25. Wang S., Liu F., Hou Z., Zong G., Zhu X., Ling P. Enhancement of natamycin production on Streptomyces gilvosporeus by chromosomal integration of the Vitreoscilla hemoglobin gene (vgb). World J. Microbiol. Biotechnol 2014, 30:1369-1376.
26. Wei Z.H., Duan Y.Y., Qian Y.Q., Guo X.F., Li Y.J., Jin S.H., Zhou Z.X., Shan S.Y., Wang C.R., Chen X.J., Zheng Y., Zhong J.J. Screening of Ganoderma strains with high polysaccharides and ganoderic acid contents and optimization of the fermentation medium by statistical methods. Bioprocess Biosyst. Eng. 2014, 37:1789-1797.
27. Xu J.W., Xu Y.N., Zhong J.J. Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Appl. Microbiol. Biotechnol. 2010, 85:941-948.
28. Xu J.W., Zhao W., Zhong J.J. Biotechnological production and application of ganoderic acids. Appl. Microbiol. Biotechnol. 2010, 87:457-466.
29. Xu J.W., Xu Y.N., Zhong J.J. Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum. Appl. Environ. Microbiol. 2012, 78:7968-7976.
30. Xu Y.N., Zhong J.J. Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum. Biotechnol. Adv. 2012, 30:1301-1308.
31. Xu Y.N., Xia X.X., Zhong J.J. Induced effect of Na plus on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction. Biotechnol. Bioeng. 2013, 110:1913-1923.
32. You B.J., Lee M.H., Tien N., Lee M.S., Hsieh H.C., Tseng L.H., Chung Y.L., Lee H.Z. A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. PLoS One 2013, 8:e53616.
33. Yu X., Ji S.L., He Y.L., Ren M.F., Xu J.W. Development of an expression plasmid and its use in genetic manipulation of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). Int. J. Med. Mushrooms 2014, 16:161-168.
34. Zhang L., Li Y., Wang Z., Xia Y., Chen W., Tang K. Recent developments and future prospects of Vitreoscilla hemoglobin application in metabolic engineering. Biotechnol. Adv. 2007, 25:123-136.
35. Zhang W., Xie H., He Y., Feng J., Gao W., Gu Y., Wang S., Song C. Chromosome integration of the Vitreoscilla hemoglobin gene (vgb) mediated by temperature-sensitive plasmid enhances γ-PGA production in Bacillus amyloliquefaciens. FEMS Microbiol. Lett. 2013, 343:127-134.
36. Zhang J.M., Zhong J.J., Geng A.L. Improvement of ganoderic acid production by fermentation of Ganoderma lucidum with cellulase as an elicitor. Process Biochem. 2014, 49:1580-1586.
37. Zhang S., Wang J., Wei Y., Tang Q., Kanwal M., He J. Heterologous expression of VHb can improve the yield and quality of biocontrol fungus Paecilomyces lilacinus, during submerged fermentation. J. Biotechnol. 2014, 187:147-153.
38. Zhang W.X., Tang Y.J., Zhong J.J. Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum. Bioprocess Biosyst. Eng. 2010, 33:683-690.
39. Zhong J.J., Tang Y.J. Submerged cultivation of medicinal mushrooms for production of valuable bioactive metabolites. Adv. Biochem. Eng. Biotechnol. 2004, 87:25-59.
40. Zhou J.S., Ji S.L., Ren M.F., He Y.L., Jing X.R., Xu J.W. Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochem. Eng. J. 2014, 90:178-183.
41. Zhu L.W., Zhong J.J., Tang Y.J. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum. Process Biochem. 2010, 15:1904-1911.
42. Zhu H., Sun S., Zhang S. Enhanced production of total flavones and exopolysaccharides via Vitreoscilla hemoglobin biosynthesis in Phellinus igniarius. Bioresour. Technol. 2011, 102:1747-1751.