메뉴 건너뛰기




Volumn 4, Issue 14, 2016, Pages

Neoantigen-based cancer immunotherapy

Author keywords

Immunopeptidome; Immunotherapy; Mutanome; Neoantigens (neoAgs)

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; TUMOR ANTIGEN;

EID: 85006192515     PISSN: 23055839     EISSN: 23055847     Source Type: Journal    
DOI: 10.21037/atm.2016.06.17     Document Type: Review
Times cited : (67)

References (46)
  • 1
    • 84894559188 scopus 로고    scopus 로고
    • Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
    • Coulie PG, Van den Eynde BJ, et al. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nat Rev Cancer 2014;14:135-46.
    • (2014) Nat Rev Cancer , vol.14 , pp. 135-146
    • Coulie, P.G.1    den Eynde, V.B.J.2
  • 2
    • 84857725402 scopus 로고    scopus 로고
    • Exploiting the mutanome for tumor vaccination
    • Castle JC, Kreiter S, Diekmann J, et al. Exploiting the mutanome for tumor vaccination. Cancer Res 2012;72:1081-91.
    • (2012) Cancer Res , vol.72 , pp. 1081-1091
    • Castle, J.C.1    Kreiter, S.2    Diekmann, J.3
  • 3
    • 84862776855 scopus 로고    scopus 로고
    • Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
    • Matsushita H, Vesely MD, Koboldt DC, et al. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 2012;48:400-4.
    • (2012) Nature , vol.48 , pp. 400-404
    • Matsushita, H.1    Vesely, M.D.2    Koboldt, D.C.3
  • 4
    • 84920956731 scopus 로고    scopus 로고
    • Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
    • Yadav M, Jhunjhunwala S, Phung QT, et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 2014;515:572-6.
    • (2014) Nature , vol.515 , pp. 572-576
    • Yadav, M.1    Jhunjhunwala, S.2    Phung, Q.T.3
  • 5
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins PF, Lu YC, El-Gamil M, et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med 2013;19:747-52.
    • (2013) Nat Med , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3
  • 6
    • 84872841412 scopus 로고    scopus 로고
    • Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
    • van Rooij N, van Buuren MM, Philips D, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol 2013;31:e439-42.
    • (2013) J Clin Oncol , vol.31
    • van Rooij, N.1    van Buuren, M.M.2    Philips, D.3
  • 7
    • 84895835410 scopus 로고    scopus 로고
    • Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer
    • Wick DA, Webb JR, Nielsen JS, et al. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res 2014;20:1125-34.
    • (2014) Clin Cancer Res , vol.20 , pp. 1125-1134
    • Wick, D.A.1    Webb, J.R.2    Nielsen, J.S.3
  • 8
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2189-99.
    • (2014) N Engl J Med , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 9
    • 84928811341 scopus 로고    scopus 로고
    • Mutant MHC class II epitopes drive therapeutic immune responses to cancer
    • Kreiter S, Vormehr M, van de Roemer N, et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 2015;520:692-6.
    • (2015) Nature , vol.520 , pp. 692-696
    • Kreiter, S.1    Vormehr, M.2    van de Roemer, N.3
  • 10
    • 84961323160 scopus 로고    scopus 로고
    • Highthroughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
    • Linnemann C, van Buuren MM, Bies L, et al. Highthroughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Nat Med 2015;21:81-5.
    • (2015) Nat Med , vol.21 , pp. 81-85
    • Linnemann, C.1    van Buuren, M.M.2    Bies, L.3
  • 11
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
    • Tran E, Turcotte S, Gros A, et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 2014;344:641-5.
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1    Turcotte, S.2    Gros, A.3
  • 12
    • 27644534576 scopus 로고    scopus 로고
    • The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
    • Lennerz V, Fatho M, Gentilini C, et al. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Proc Natl Acad Sci U S A. 2005;102:16013-8.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , pp. 16013-16018
    • Lennerz, V.1    Fatho, M.2    Gentilini, C.3
  • 14
    • 84904472602 scopus 로고    scopus 로고
    • Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
    • Rajasagi M, Shukla SA, Fritsch EF, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood 2014;124:453-62.
    • (2014) Blood , vol.124 , pp. 453-462
    • Rajasagi, M.1    Shukla, S.A.2    Fritsch, E.F.3
  • 16
    • 84883251918 scopus 로고    scopus 로고
    • Targeting the tumor mutanome for personalized vaccination therapy
    • Kreiter S, Castle JC, Türeci O, et al. Targeting the tumor mutanome for personalized vaccination therapy. Oncoimmunology 2012;1:768-9.
    • (2012) Oncoimmunology , vol.1 , pp. 768-769
    • Kreiter, S.1    Castle, J.C.2    Türeci, O.3
  • 17
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature 2013;500:415-21.
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 18
    • 84949294045 scopus 로고    scopus 로고
    • Cancer immunotherapy targeting neoantigens
    • Lu YC, Robbins PF. Cancer immunotherapy targeting neoantigens. Semin Immunol 2016;28:22-7.
    • (2016) Semin Immunol , vol.28 , pp. 22-27
    • Lu, Y.C.1    Robbins, P.F.2
  • 19
    • 84964334411 scopus 로고    scopus 로고
    • Cancer Neoantigens and Applications for Immunotherapy
    • Desrichard A, Snyder A, Chan TA. Cancer Neoantigens and Applications for Immunotherapy. Clin Cancer Res 2016;22:807-12.
    • (2016) Clin Cancer Res , vol.22 , pp. 807-812
    • Desrichard, A.1    Snyder, A.2    Chan, T.A.3
  • 20
    • 84950280845 scopus 로고    scopus 로고
    • Mutanome directed cancer immunotherapy
    • Vormehr M, Diken M, Boegel S, et al. Mutanome directed cancer immunotherapy. Curr Opin Immunol 2016;39:14-22.
    • (2016) Curr Opin Immunol , vol.39 , pp. 14-22
    • Vormehr, M.1    Diken, M.2    Boegel, S.3
  • 21
    • 81255198783 scopus 로고    scopus 로고
    • Prediction of epitopes using neural network based methods
    • Lundegaard C, Lund O, Nielsen M. Prediction of epitopes using neural network based methods. J Immunol Methods 2011;374:26-34.
    • (2011) J Immunol Methods , vol.374 , pp. 26-34
    • Lundegaard, C.1    Lund, O.2    Nielsen, M.3
  • 22
    • 77953520516 scopus 로고    scopus 로고
    • MHC class II epitope predictive algorithms
    • Nielsen M, Lund O, Buus S, et al. MHC class II epitope predictive algorithms. Immunology 2010;130:319-28.
    • (2010) Immunology , vol.130 , pp. 319-328
    • Nielsen, M.1    Lund, O.2    Buus, S.3
  • 23
    • 84949730499 scopus 로고    scopus 로고
    • Immunogenicity of somatic mutations in human gastrointestinal cancers
    • Tran E, Ahmadzadeh M, Lu YC, et al. Immunogenicity of somatic mutations in human gastrointestinal cancers. Science 2015;350:1387-90.
    • (2015) Science , vol.350 , pp. 1387-1390
    • Tran, E.1    Ahmadzadeh, M.2    Lu, Y.C.3
  • 24
    • 84859399304 scopus 로고    scopus 로고
    • Dissection of T-cell antigen specificity in human melanoma
    • Andersen RS, Thrue CA, Junker N, et al. Dissection of T-cell antigen specificity in human melanoma. Cancer Res 2012;72:1642-50.
    • (2012) Cancer Res , vol.72 , pp. 1642-1650
    • Andersen, R.S.1    Thrue, C.A.2    Junker, N.3
  • 25
    • 84920921528 scopus 로고    scopus 로고
    • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
    • Gubin MM, Zhang X, Schuster H, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 2014;515:577-81.
    • (2014) Nature , vol.515 , pp. 577-581
    • Gubin, M.M.1    Zhang, X.2    Schuster, H.3
  • 26
    • 84943329717 scopus 로고    scopus 로고
    • Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
    • Cohen CJ, Gartner JJ, Horovitz-Fried M, et al. Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes. J Clin Invest 2015;125:3981-91.
    • (2015) J Clin Invest , vol.125 , pp. 3981-3991
    • Cohen, C.J.1    Gartner, J.J.2    Horovitz-Fried, M.3
  • 28
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012;366:883-92.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 29
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010;467:1114-7.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 30
    • 84923092072 scopus 로고    scopus 로고
    • Tertiary lymphoid structures in cancer and beyond
    • Dieu-Nosjean MC, Goc J, Giraldo NA, et al. Tertiary lymphoid structures in cancer and beyond. Trends Immunol 2014;35:571-80.
    • (2014) Trends Immunol , vol.35 , pp. 571-580
    • Dieu-Nosjean, M.C.1    Goc, J.2    Giraldo, N.A.3
  • 31
    • 84857118418 scopus 로고    scopus 로고
    • Expression of tumour-specific antigens underlies cancer immunoediting
    • DuPage M, Mazumdar C, Schmidt LM, et al. Expression of tumour-specific antigens underlies cancer immunoediting. Nature 2012;482:405-9.
    • (2012) Nature , vol.482 , pp. 405-409
    • Du Page, M.1    Mazumdar, C.2    Schmidt, L.M.3
  • 32
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565-70.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 33
    • 84899836282 scopus 로고    scopus 로고
    • Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
    • Brown SD, Warren RL, Gibb EA, et al. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res 2014;24:743-50.
    • (2014) Genome Res , vol.24 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3
  • 34
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney MS, Shukla SA, Wu CJ, et al. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 2015;160:48-61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3
  • 35
    • 84943516465 scopus 로고    scopus 로고
    • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
    • Van Allen EM, Miao D, Schilling B, et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 2015;350:207-11.
    • (2015) Science , vol.350 , pp. 207-211
    • Van Allen, E.M.1    Miao, D.2    Schilling, B.3
  • 36
    • 84931426001 scopus 로고    scopus 로고
    • Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
    • Angelova M, Charoentong P, Hackl H, et al. Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Genome Biol 2015;16:64.
    • (2015) Genome Biol , vol.16 , pp. 64
    • Angelova, M.1    Charoentong, P.2    Hackl, H.3
  • 37
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
    • Le DT, Uram JN, Wang H, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015;372:2509-20.
    • (2015) N Engl J Med , vol.372 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 38
    • 84949937538 scopus 로고    scopus 로고
    • Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era
    • Martin SD, Coukos G, Holt RA, et al. Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era. Ann Oncol 2015;26:2367-74.
    • (2015) Ann Oncol , vol.26 , pp. 2367-2374
    • Martin, S.D.1    Coukos, G.2    Holt, R.A.3
  • 39
    • 84955621208 scopus 로고    scopus 로고
    • Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers
    • Becht E, Giraldo NA, Germain C, et al. Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers. Adv Immunol 2016;130:95-190.
    • (2016) Adv Immunol , vol.130 , pp. 95-190
    • Becht, E.1    Giraldo, N.A.2    Germain, C.3
  • 40
    • 84998865518 scopus 로고    scopus 로고
    • Novel technologies and emerging biomarkers for personalized cancer immunotherapy
    • Yuan J, Hegde PS, Clynes R, et al. Novel technologies and emerging biomarkers for personalized cancer immunotherapy. J Immunother Cancer 2016;4:3.
    • (2016) J Immunother Cancer , vol.4 , pp. 3
    • Yuan, J.1    Hegde, P.S.2    Clynes, R.3
  • 41
    • 0025369899 scopus 로고
    • Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide
    • Sibille C, Chomez P, Wildmann C, et al. Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide. J Exp Med 1990;172:35-45.
    • (1990) J Exp Med , vol.172 , pp. 35-45
    • Sibille, C.1    Chomez, P.2    Wildmann, C.3
  • 42
    • 0028978274 scopus 로고
    • A p16INK4ainsensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
    • Wölfel T, Hauer M, Schneider J, et al. A p16INK4ainsensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995;269:1281-4.
    • (1995) Science , vol.269 , pp. 1281-1284
    • Wölfel, T.1    Hauer, M.2    Schneider, J.3
  • 43
    • 0033591429 scopus 로고    scopus 로고
    • Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen
    • Wang RF, Wang X, Atwood AC, et al. Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Science 1999;284:1351-4.
    • (1999) Science , vol.284 , pp. 1351-1354
    • Wang, R.F.1    Wang, X.2    Atwood, A.C.3
  • 44
    • 0028856743 scopus 로고
    • Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation
    • Gjertsen MK, Bakka A, Breivik J, et al. Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation. Lancet 1995;346:1399-400.
    • (1995) Lancet , vol.346 , pp. 1399-1400
    • Gjertsen, M.K.1    Bakka, A.2    Breivik, J.3
  • 45
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: progress and promise
    • Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science 2011;331:1553-8.
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 46
    • 84943555630 scopus 로고    scopus 로고
    • CANCER. The odds of immunotherapy success
    • Gubin MM, Schreiber RD. CANCER. The odds of immunotherapy success. Science 2015;350:158-9.
    • (2015) Science , vol.350 , pp. 158-159
    • Gubin, M.M.1    Schreiber, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.