메뉴 건너뛰기




Volumn 3, Issue 3, 2015, Pages

Moderate alcohol consumption does not impair overloadinduced muscle hypertrophy and protein synthesis

Author keywords

Ethanol; Hypertrophy; mTORC1; Overload; Protein synthesis

Indexed keywords

LIGHT CHAIN 3; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDES AND PROTEINS; PRAS40 PROTEIN; PROTEIN KINASE B; PROTEIN P62; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSE 1; UNC 51 LIKE AUTOPHAGY ACTIVATING KINASE 1; UNCLASSIFIED DRUG;

EID: 85006172606     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12333     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • Anjum, R., and J. Blenis. 2008. The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. 9:747-758
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 2
    • 84895488953 scopus 로고    scopus 로고
    • Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression
    • Baehr, L. M., M. Tunzi, and S. C. Bodine. 2014. Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression. Front. Physiol. 5:69.
    • (2014) Front. Physiol , vol.5 , pp. 69
    • Baehr, L.M.1    Tunzi, M.2    Bodine, S.C.3
  • 3
    • 84555188361 scopus 로고    scopus 로고
    • Analysis of skeletal muscle hypertrophy in models of increased loading
    • Bodine, S. C., and K. Baar. 2012. Analysis of skeletal muscle hypertrophy in models of increased loading. Methods Mol. Biol. 798:213-229
    • (2012) Methods Mol. Biol , vol.798 , pp. 213-229
    • Bodine, S.C.1    Baar, K.2
  • 4
    • 0035736260 scopus 로고    scopus 로고
    • Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    • Bodine, S. C., T. N. Stitt, M. Gonzalez, W. O. Kline, G. L. Stover, R. Bauerlein, et al. 2001. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:1014-1019
    • (2001) Nat. Cell Biol , vol.3 , pp. 1014-1019
    • Bodine, S.C.1    Stitt, T.N.2    Gonzalez, M.3    Kline, W.O.4    Stover, G.L.5    Bauerlein, R.6
  • 5
    • 0036438894 scopus 로고    scopus 로고
    • Regulation of peptidechain elongation in mammalian cells
    • Browne, G. J., and C. G. Proud. 2002. Regulation of peptidechain elongation in mammalian cells. Eur. J. Biochem. 269:5360-5368
    • (2002) Eur. J. Biochem , vol.269 , pp. 5360-5368
    • Browne, G.J.1    Proud, C.G.2
  • 6
    • 0027449323 scopus 로고
    • Relationship between ethanolrelated diseases and nutritional status in chronically alcoholic men
    • Estruch, R., J. M. Nicol_as, E. Villegas, A. Junqu_e, and A. Urbano-M_arquez. 1993. Relationship between ethanolrelated diseases and nutritional status in chronically alcoholic men. Alcohol Alcohol. 28:543-550
    • (1993) Alcohol Alcohol , vol.28 , pp. 543-550
    • Estruch, R.1    Nicol-As, J.M.2    Villegas, E.3    Junqu-E, A.4    Urbano-Marquez, A.5
  • 7
    • 84881532404 scopus 로고    scopus 로고
    • Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus
    • Filiano, A. N., T. Millender-Swain, R. Johnson, M. E. Young, K. L. Gamble, and S. M. Bailey. 2013. Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. PLoS ONE 8:e71684.
    • (2013) Plos ONE , vol.8 , pp. 71684
    • Filiano, A.N.1    Millender-Swain, T.2    Johnson, R.3    Young, M.E.4    Gamble, K.L.5    Bailey, S.M.6
  • 8
    • 0014709194 scopus 로고
    • Alcohol consumption and its circadian distribution in mice
    • Freund, G. 1970. Alcohol consumption and its circadian distribution in mice. J. Nutr. 100:30-36
    • (1970) J. Nutr , vol.100 , pp. 30-36
    • Freund, G.1
  • 10
    • 84876130455 scopus 로고    scopus 로고
    • Measuring protein synthesis with SUnSET: A valid alternative to traditional techniques
    • Goodman, C. A., and T. A. Hornberger. 2013. Measuring protein synthesis with SUnSET: a valid alternative to traditional techniques? Exerc. Sport Sci. Rev. 41:107-115
    • (2013) Exerc. Sport Sci. Rev , vol.41 , pp. 107-115
    • Goodman, C.A.1    Hornberger, T.A.2
  • 11
    • 79954618679 scopus 로고    scopus 로고
    • Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique
    • Goodman, C. A., D. M. Mabrey, J. W. Frey, M. H. Miu, E. K. Schmidt, P. Pierre, et al. 2011. Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique. FASEB J. 25:1028-1039
    • (2011) FASEB J , vol.25 , pp. 1028-1039
    • Goodman, C.A.1    Mabrey, D.M.2    Frey, J.W.3    Miu, M.H.4    Schmidt, E.K.5    Pierre, P.6
  • 12
    • 33947530921 scopus 로고    scopus 로고
    • Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinasedependent mechanism in C2C12 skeletal myocytes
    • Hong-Brown, L. Q., C. R. Brown, D. S. Huber, and C. H. Lang. 2007. Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinasedependent mechanism in C2C12 skeletal myocytes. J. Biol. Chem. 282:3702-3712
    • (2007) J. Biol. Chem , vol.282 , pp. 3702-3712
    • Hong-Brown, L.Q.1    Brown, C.R.2    Huber, D.S.3    Lang, C.H.4
  • 13
    • 0031824699 scopus 로고    scopus 로고
    • Diurnal variation in plasma ethanol levels of TO and CBA mice on chronic ethanol drinking or ethanol liquid diet schedules
    • Jelic, P., M. F. Shih, and P. V. Taberner. 1998. Diurnal variation in plasma ethanol levels of TO and CBA mice on chronic ethanol drinking or ethanol liquid diet schedules. Psychopharmacology 138:143-150
    • (1998) Psychopharmacology , vol.138 , pp. 143-150
    • Jelic, P.1    Shih, M.F.2    Taberner, P.V.3
  • 14
    • 84892396956 scopus 로고    scopus 로고
    • Binge drinking-United States, 2011
    • Kanny, D., Y. Liu, R. D. Brewer, H. Lu, and (CDC), C. F. D. C. A. P. 2013. Binge drinking-United States, 2011. MMWR Surveill. Summ. 62(Suppl 3):77-80
    • (2013) MMWR Surveill. Summ , vol.62 , pp. 77-80
    • Kanny, D.1    Liu, Y.2    Brewer, R.D.3    Lu, H.4
  • 15
    • 84872369332 scopus 로고    scopus 로고
    • The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb
    • Kelleher, A. R., S. R. Kimball, M. D. Dennis, R. J. Schilder, and L. S. Jefferson. 2013. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am. J. Physiol. Endocrinol. Metab. 304:E229-E236
    • (2013) Am. J. Physiol. Endocrinol. Metab , vol.304 , pp. E229-E236
    • Kelleher, A.R.1    Kimball, S.R.2    Dennis, M.D.3    Schilder, R.J.4    Jefferson, L.S.5
  • 16
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim, J., M. Kundu, B. Viollet, and K. L. Guan. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13:132-141
    • (2011) Nat. Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 18
    • 0036838513 scopus 로고    scopus 로고
    • Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle
    • Kumar, V., R. A. Frost, and C. H. Lang. 2002. Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 283: E917-E928
    • (2002) Am. J. Physiol. Endocrinol. Metab , vol.283 , pp. E917-E928
    • Kumar, V.1    Frost, R.A.2    Lang, C.H.3
  • 19
    • 0035025348 scopus 로고    scopus 로고
    • Alcohol myopathy: Impairment of protein synthesis and translation initiation
    • Lang, C. H., S. R. Kimball, R. A. Frost, and T. C. Vary. 2001. Alcohol myopathy: impairment of protein synthesis and translation initiation. Int. J. Biochem. Cell Biol. 33:457-473
    • (2001) Int. J. Biochem. Cell Biol , vol.33 , pp. 457-473
    • Lang, C.H.1    Kimball, S.R.2    Frost, R.A.3    Vary, T.C.4
  • 21
    • 9244257375 scopus 로고    scopus 로고
    • Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism
    • Lang, C. H., A. M. Pruznak, N. Deshpande, M. M. Palopoli, R. A. Frost, and T. C. Vary. 2004. Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Alcohol. Clin. Exp. Res. 28:1758-1767
    • (2004) Alcohol. Clin. Exp. Res , vol.28 , pp. 1758-1767
    • Lang, C.H.1    Pruznak, A.M.2    Deshpande, N.3    Palopoli, M.M.4    Frost, R.A.5    Vary, T.C.6
  • 22
    • 34447567479 scopus 로고    scopus 로고
    • Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication
    • Lang, C. H., R. A. Frost, and T. C. Vary. 2007. Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Am. J. Physiol. Endocrinol. Metab. 292: E1497-E1506
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.292 , pp. E1497-E1506
    • Lang, C.H.1    Frost, R.A.2    Vary, T.C.3
  • 23
    • 61849111619 scopus 로고    scopus 로고
    • Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats
    • Lang, C. H., A. M. Pruznak, G. J. Nystrom, and T. C. Vary. 2009. Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: comparable effects in young and mature rats. Nutr. Metab. (Lond.) 6:4.
    • (2009) Nutr. Metab. (Lond.) , vol.6 , pp. 4
    • Lang, C.H.1    Pruznak, A.M.2    Nystrom, G.J.3    Vary, T.C.4
  • 25
    • 0021863954 scopus 로고
    • Assessment in vitro and in vivo of muscle degradation in chronic skeletal muscle myopathy of alcoholism
    • Martin, F. C., and T. J. Peters. 1985. Assessment in vitro and in vivo of muscle degradation in chronic skeletal muscle myopathy of alcoholism. Clin. Sci. (Lond.) 68:693-700
    • (1985) Clin. Sci. (Lond.) , vol.68 , pp. 693-700
    • Martin, F.C.1    Peters, T.J.2
  • 26
    • 0021814114 scopus 로고
    • Alcoholic skeletal myopathy, a clinical and pathological study
    • Martin, F., K. Ward, G. Slavin, J. Levi, and T. J. Peters. 1985. Alcoholic skeletal myopathy, a clinical and pathological study. Q. J. Med. 55:233-251
    • (1985) Q. J. Med , vol.55 , pp. 233-251
    • Martin, F.1    Ward, K.2    Slavin, G.3    Levi, J.4    Peters, T.J.5
  • 28
    • 40949146900 scopus 로고    scopus 로고
    • Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    • McGee, S. L., K. J. Mustard, D. G. Hardie, and K. Baar. 2008. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J. Physiol. 586:1731-1741
    • (2008) J. Physiol , vol.586 , pp. 1731-1741
    • McGee, S.L.1    Mustard, K.J.2    Hardie, D.G.3    Baar, K.4
  • 29
    • 79953152152 scopus 로고    scopus 로고
    • Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling
    • Miyazaki, M., J. J. McCarthy, M. J. Fedele, and K. A. Esser. 2011. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J. Physiol. 589:1831-1846
    • (2011) J. Physiol , vol.589 , pp. 1831-1846
    • Miyazaki, M.1    McCarthy, J.J.2    Fedele, M.J.3    Esser, K.A.4
  • 30
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/ LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S., T. H. Clausen, T. Lamark, A. Brech, J. A. Bruun, H. Outzen, et al. 2007. p62/SQSTM1 binds directly to Atg8/ LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131-24145
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 31
    • 84890281516 scopus 로고    scopus 로고
    • The transcriptional coactivator PGC-1a is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling
    • P_erez-Schindler, J., S. Summermatter, G. Santos, F. Zorzato, and C. Handschin. 2013. The transcriptional coactivator PGC-1a is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proc. Natl Acad. Sci. USA 110:20314-20319
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20314-20319
    • Perez-Schindler, J.1    Summermatter, S.2    Santos, G.3    Zorzato, F.4    Handschin, C.5
  • 32
    • 34347242470 scopus 로고    scopus 로고
    • RAS/ERK signaling promotes sitespecific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    • Roux, P. P., D. Shahbazian, H. Vu, M. K. Holz, M. S. Cohen, J. Taunton, et al. 2007. RAS/ERK signaling promotes sitespecific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J. Biol. Chem. 282:14056-14064
    • (2007) J. Biol. Chem , vol.282 , pp. 14056-14064
    • Roux, P.P.1    Shahbazian, D.2    Vu, H.3    Holz, M.K.4    Cohen, M.S.5    Taunton, J.6
  • 34
    • 37749027195 scopus 로고    scopus 로고
    • A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
    • Spangenburg, E. E., D. le Roith, C. W. Ward, and S. C. Bodine. 2008. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J. Physiol. 586:283-291
    • (2008) J. Physiol , vol.586 , pp. 283-291
    • Spangenburg, E.E.1    Le Roith, D.2    Ward, C.W.3    Bodine, S.C.4
  • 35
    • 84911935474 scopus 로고    scopus 로고
    • Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a timedependent manner following electrically stimulated muscle contraction
    • Steiner, J. L., and C. H. Lang. 2014. Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a timedependent manner following electrically stimulated muscle contraction. J. Appl. Physiol. (1985), 117:1170-1179
    • (2014) J. Appl. Physiol , vol.117 , pp. 1170-1179
    • Steiner, J.L.1    Lang, C.H.2
  • 36
    • 84921458936 scopus 로고    scopus 로고
    • Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction
    • Steiner, J., and C. Lang. 2015. Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction. Alcohol. Clin. Exp. Res. 39:1-10
    • (2015) Alcohol. Clin. Exp.Res , vol.39 , pp. 1-10
    • Steiner, J.1    Lang, C.2
  • 38
    • 37348998877 scopus 로고    scopus 로고
    • Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy
    • Vargas, R., and C. H. Lang. 2008. Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy. Alcohol. Clin. Exp. Res. 32:128-137
    • (2008) Alcohol. Clin. Exp. Res , vol.32 , pp. 128-137
    • Vargas, R.1    Lang, C.H.2
  • 39
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • Wang, X., and C. G. Proud. 2006. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21:362-369
    • (2006) Physiology (Bethesda) , vol.21 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 40
    • 0035881470 scopus 로고    scopus 로고
    • Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    • Wang, X., W. Li, M. Williams, N. Terada, D. R. Alessi, and C. G. Proud. 2001. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 20:4370-4379
    • (2001) EMBO J , vol.20 , pp. 4370-4379
    • Wang, X.1    Li, W.2    Williams, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 41
    • 80755190061 scopus 로고    scopus 로고
    • Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway
    • Wang, H., Q. Zhang, Q. Wen, Y. Zheng, P. Lazarovici, L. Philip, et al. 2012. Proline-rich Akt substrate of 40 kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. Cell. Signal. 24:17-24
    • (2012) Cell. Signal , vol.24 , pp. 17-24
    • Wang, H.1    Zhang, Q.2    Wen, Q.3    Zheng, Y.4    Lazarovici, P.5    Philip, L.6
  • 42
    • 0035406554 scopus 로고    scopus 로고
    • Mitogenactivated protein kinase signal transduction in skeletal muscle: Effects of exercise and muscle contraction
    • Widegren, U., J. W. Ryder, and J. R. Zierath. 2001. Mitogenactivated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction. Acta Physiol. Scand. 172:227-238
    • (2001) Acta Physiol. Scand , vol.172 , pp. 227-238
    • Widegren, U.1    Ryder, J.W.2    Zierath, J.R.3
  • 43
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    • Zhao, J., J. J. Brault, A. Schild, P. Cao, M. Sandri, S. Schiaffino, et al. 2007. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6:472-483
    • (2007) Cell Metab , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6
  • 44
    • 84910145403 scopus 로고    scopus 로고
    • Current models of mammalian target of rapamycin complex 1 (MTORC1) activation by growth factors and amino acids
    • Zheng, X., Y. Liang, Q. He, R. Yao, W. Bao, L. Bao, et al. 2014. Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids. Int. J. Mol. Sci. 15:20753-20769
    • (2014) Int. J. Mol. Sci , vol.15 , pp. 20753-20769
    • Zheng, X.1    Liang, Y.2    He, Q.3    Yao, R.4    Bao, W.5    Bao, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.