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Volumn 8, Issue 12, 2016, Pages

Hypoglycemic effect of Opuntia ficus-indica var. saboten is due to enhanced peripheral glucose uptake through activation of AMPK/p38 MAPK pathway

Author keywords

AMPK; db db mice; Glucose uptake; GLUT4; L6 myoblasts; Opuntia ficus indica var. saboten; p38 MAPK

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA GLUCOSIDASE; GLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OPUNTIA FICUS-INDICA EXTRACT; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; INSULIN; PLANT EXTRACT; SLC2A4 PROTEIN, RAT;

EID: 85006132412     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8120800     Document Type: Article
Times cited : (43)

References (48)
  • 2
    • 0025938160 scopus 로고
    • Altered glucose carrier expression: Mechanism of intestinal adaptation during streptozocin-induced diabetes in rats
    • Fedorak, R.N.; Cheesemani, C.I.; Thomson, A.B.; Porter, V.M. Altered glucose carrier expression: Mechanism of intestinal adaptation during streptozocin-induced diabetes in rats. Am. J. Physiol. 1991, 261, G585-G591.
    • (1991) Am. J. Physiol. , vol.261 , pp. G585-G591
    • Fedorak, R.N.1    Cheesemani, C.I.2    Thomson, A.B.3    Porter, V.M.4
  • 3
    • 0036080516 scopus 로고    scopus 로고
    • Expression of monosaccharide transporters in intestine of diabetic humans
    • Dyer, J.; Wood, I.S.; Palejwala, A.; Ellis, A.; Shirazi-Beechey, S.P. Expression of monosaccharide transporters in intestine of diabetic humans. Am. J. Physiol. 2002, 282, G241-G248.
    • (2002) Am. J. Physiol , vol.282 , pp. G241-G248
    • Dyer, J.1    Wood, I.S.2    Palejwala, A.3    Ellis, A.4    Shirazi-Beechey, S.P.5
  • 4
    • 0033515429 scopus 로고    scopus 로고
    • Deconstructing type 2 diabetes
    • Taylor, S.I. Deconstructing type 2 diabetes. Cell 1999, 97, 9-12.
    • (1999) Cell , vol.97 , pp. 9-12
    • Taylor, S.I.1
  • 5
    • 84926320134 scopus 로고    scopus 로고
    • Pancreatic β-cell glucose toxicity in type 2 diabetes mellitus
    • Kaneto, H. Pancreatic β-cell glucose toxicity in type 2 diabetes mellitus. Curr. Diabetes Rev. 2015, 11, 2-6.
    • (2015) Curr. Diabetes Rev , vol.11 , pp. 2-6
    • Kaneto, H.1
  • 6
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A.R.; Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 8
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo, R.A. Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988, 37, 667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • Defronzo, R.A.1
  • 9
    • 77954652820 scopus 로고    scopus 로고
    • Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea
    • Eid, H.M.; Martineau, L.C.; Saleem, A.; Muhammad, A.; Vallerand, D.; Benhaddou-Andaloussi, A.; Nistor, L.; Afshar, A.; Arnason, J.T.; Haddad, P.S. Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea. Mol. Nutr. Food Res. 2010, 54, 991-1003.
    • (2010) Mol. Nutr. Food Res , vol.54 , pp. 991-1003
    • Eid, H.M.1    Martineau, L.C.2    Saleem, A.3    Muhammad, A.4    Vallerand, D.5    Benhaddou-Andaloussi, A.6    Nistor, L.7    Afshar, A.8    Arnason, J.T.9    Haddad, P.S.10
  • 10
    • 79952137209 scopus 로고    scopus 로고
    • Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation
    • Kawabata, K.; Sawada, K.; Ikeda, K.; Fukuda, I.; Kawasaki, K.; Yamamoto, N.; Ashida, H. Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation. Mol. Nutr. Food Res. 2011, 55, 467-475.
    • (2011) Mol. Nutr. Food Res , vol.55 , pp. 467-475
    • Kawabata, K.1    Sawada, K.2    Ikeda, K.3    Fukuda, I.4    Kawasaki, K.5    Yamamoto, N.6    Ashida, H.7
  • 11
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 glucose transporter
    • Huang, S.; Czech, M.P. The GLUT4 glucose transporter. Cell Metab. 2007, 5, 237-252.
    • (2007) Cell Metab , vol.5 , pp. 237-252
    • Huang, S.1    Czech, M.P.2
  • 12
    • 0032881635 scopus 로고    scopus 로고
    • Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
    • Russell, R.R., 3rd; Bergeron, R.; Shulman, G.I.; Young, L.H. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am. J. Physiol. 1999, 277, H643-H649.
    • (1999) Am. J. Physiol. , vol.277 , pp. H643-H649
    • Russell, R.R.1    Bergeron, R.2    Shulman, G.I.3    Young, L.H.4
  • 14
    • 0035798668 scopus 로고    scopus 로고
    • Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase
    • Xi, X.; Han, J.; Zhang, J.Z. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J. Biol. Chem. 2001, 276, 41029-41034.
    • (2001) J. Biol. Chem , vol.276 , pp. 41029-41034
    • Xi, X.1    Han, J.2    Zhang, J.Z.3
  • 15
    • 0034987312 scopus 로고    scopus 로고
    • The antihyperglycemic drug a-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: Potential role of p38 mitogen-activated protein kinase in GLUT4 activation
    • Konrad, D.; Somwar, R.; Sweeney, G.; Yaworsky, K.; Hayashi, M.; Ramlal, T.; Klip, A. The antihyperglycemic drug a-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: Potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 2001, 50, 1464-1471.
    • (2001) Diabetes , vol.50 , pp. 1464-1471
    • Konrad, D.1    Somwar, R.2    Sweeney, G.3    Yaworsky, K.4    Hayashi, M.5    Ramlal, T.6    Klip, A.7
  • 16
    • 17444434110 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: Potential role in the stimulation of glucose transport
    • Somwar, R.; Perreault, M.; Kapur, S.; Taha, C.; Sweeney, G.; Ramlal, T.; Kim, D.Y.; Keen, J.; Côte, C.H.; Klip, A. Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: Potential role in the stimulation of glucose transport. Diabetes 2000, 49, 1794-1800.
    • (2000) Diabetes , vol.49 , pp. 1794-1800
    • Somwar, R.1    Perreault, M.2    Kapur, S.3    Taha, C.4    Sweeney, G.5    Ramlal, T.6    Kim, D.Y.7    Keen, J.8    Côte, C.H.9    Klip, A.10
  • 18
    • 84942806778 scopus 로고    scopus 로고
    • Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2+ -dependent AMPK-p38 MAPK pathway in C2C12 skeletal muscle cells
    • Lee, J.O.; Kim, N.; Lee, H.J.; Lee, Y.W.; Kim, J.K.; Kim, H.I.; Lee, S.K.; Kim, S.J.; Park, S.H.; Kim, H.S. Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2+ -dependent AMPK-p38 MAPK pathway in C2C12 skeletal muscle cells. J. Mol. Endocrinol. 2015, 54, 251-262.
    • (2015) J. Mol. Endocrinol , vol.54 , pp. 251-262
    • Lee, J.O.1    Kim, N.2    Lee, H.J.3    Lee, Y.W.4    Kim, J.K.5    Kim, H.I.6    Lee, S.K.7    Kim, S.J.8    Park, S.H.9    Kim, H.S.10
  • 19
    • 0041075518 scopus 로고
    • Review: Use of the fruits and stems of the prickly pear cactus (Opuntia spp.) into human food
    • Lopez, D. Review: Use of the fruits and stems of the prickly pear cactus (Opuntia spp.) into human food. Food Sci. Tech. Int. 1995, 1, 65-74.
    • (1995) Food Sci. Tech. Int , vol.1 , pp. 65-74
    • Lopez, D.1
  • 22
    • 77954960196 scopus 로고    scopus 로고
    • Nopal (Opuntia spp.) and other traditional Mexican plants
    • Pasupuleti, V.K., Anderson, J.W., Eds.;Wiley-Blackwell: Ames, LA, USA
    • Reynoso-Camacho, R.; Gonzalez de Mejia, E. Nopal (Opuntia spp.) and other traditional Mexican plants. In Nutraceuticals, Glycemic Health & Type 2 Diabetes; Pasupuleti, V.K., Anderson, J.W., Eds.;Wiley-Blackwell: Ames, LA, USA, 2008; pp. 379-399.
    • (2008) Nutraceuticals, Glycemic Health & Type 2 Diabetes , pp. 379-399
    • Reynoso-Camacho, R.1    Gonzalez De Mejia, E.2
  • 23
    • 0035064410 scopus 로고    scopus 로고
    • An anti-inflammatory principle from cactus
    • Park, E.-H.; Kahng, J.H.; Lee, S.H.; Shin, K.H. An anti-inflammatory principle from cactus. Fitoterapia 2001, 72, 288-290.
    • (2001) Fitoterapia , vol.72 , pp. 288-290
    • Park, E.-H.1    Kahng, J.H.2    Lee, S.H.3    Shin, K.H.4
  • 24
    • 77954955670 scopus 로고    scopus 로고
    • Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females
    • Godard, M.P.; Ewing, B.A.; Pischel, I.; Ziegler, A.; Benedek, B.; Feistel, B. Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females. J. Ethnopharmacol. 2010, 130, 631-634.
    • (2010) J. Ethnopharmacol , vol.130 , pp. 631-634
    • Godard, M.P.1    Ewing, B.A.2    Pischel, I.3    Ziegler, A.4    Benedek, B.5    Feistel, B.6
  • 25
    • 79952211652 scopus 로고    scopus 로고
    • Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats
    • Butterweck, V.; Semlin, L.; Feistel, B.; Pischel, I.; Bauer, K.; Verspohl, E.J. Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats. Phytother. Res. 2011, 25, 370-375.
    • (2011) Phytother. Res , vol.25 , pp. 370-375
    • Butterweck, V.1    Semlin, L.2    Feistel, B.3    Pischel, I.4    Bauer, K.5    Verspohl, E.J.6
  • 27
    • 84885824554 scopus 로고    scopus 로고
    • Additive insulinogenic action of Opuntia ficus-indica cladode and fruit skin extract and leucine after exercise in healthy males
    • Deldicque, L.; Van Proeyen, K.; Ramaekers, M.; Pischel, I.; Sievers, H.; Hespel, P. Additive insulinogenic action of Opuntia ficus-indica cladode and fruit skin extract and leucine after exercise in healthy males. J. Int. Soc. Sports Nutr. 2013, 10, 45.
    • (2013) J. Int. Soc. Sports Nutr , vol.10 , pp. 45
    • Deldicque, L.1    Van Proeyen, K.2    Ramaekers, M.3    Pischel, I.4    Sievers, H.5    Hespel, P.6
  • 28
    • 84908375880 scopus 로고    scopus 로고
    • The effect of nopal (Opuntiaficus indica) on postprandial blood glucose, incretins, and antioxidant activityin Mexican patients with type 2 diabetes after consumption of two different composition breakfasts
    • López-Romero, P.; Pichardo-Ontiveros, E.; Avila-Nava, A.; Vázquez-Manjarrez, N.; Tovar, A.R.; Pedraza-Chaverri, J.; Torres, N. The effect of nopal (Opuntiaficus indica) on postprandial blood glucose, incretins, and antioxidant activityin Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J. Acad. Nutr. Diet. 2014, 114, 1811-1818.
    • (2014) J. Acad. Nutr. Diet , vol.114 , pp. 1811-1818
    • López-Romero, P.1    Pichardo-Ontiveros, E.2    Avila-Nava, A.3    Vázquez-Manjarrez, N.4    Tovar, A.R.5    Pedraza-Chaverri, J.6    Torres, N.7
  • 29
    • 0027210828 scopus 로고
    • Acute and chronic effects of pancreatic glucagon on sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes
    • Debnam, E.S.; Sharp, P.A. Acute and chronic effects of pancreatic glucagon on sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes. Exp. Physiol. 1993, 78, 197-207.
    • (1993) Exp. Physiol , vol.78 , pp. 197-207
    • Debnam, E.S.1    Sharp, P.A.2
  • 30
    • 0025134198 scopus 로고
    • Simple in vito cytotoxicity test using theMTT (3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric assay: Analysis of eugenol toxicity on dental pulp cells (RPC-C2A)
    • Kasugai, S.; Hasegawa, N.; Ogura, H. A simple in vito cytotoxicity test using theMTT (3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric assay: Analysis of eugenol toxicity on dental pulp cells (RPC-C2A). Jpn. J. Pharmacol. 1990, 52, 95-100.
    • (1990) Jpn. J. Pharmacol , vol.52 , pp. 95-100
    • Kasugai, S.1    Hasegawa, N.2    Ogura, H.A.3
  • 31
    • 0034698030 scopus 로고    scopus 로고
    • Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic beta-cells
    • Yamada, K.; Nakata, M.; Horimoto, N.; Saito, M.; Matsuoka, H.; Inagaki, N. Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic beta-cells. J. Biol. Chem. 2000, 275, 22278-22283.
    • (2000) J. Biol. Chem. , vol.275 , pp. 22278-22283
    • Yamada, K.1    Nakata, M.2    Horimoto, N.3    Saito, M.4    Matsuoka, H.5    Inagaki, N.6
  • 32
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • Katz, A.; Nambi, S.S.; Mather, K.; Baron, A.D.; Follmann, D.A.; Sullivan, G.; Quon, M.J. Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 2000, 85, 2402-2410.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3    Baron, A.D.4    Follmann, D.A.5    Sullivan, G.6    Quon, M.J.7
  • 33
    • 0018905303 scopus 로고
    • Aldehyde Fuchsin staining of pancreatic B cells. Reproducible high-contrast staining of formalin-fixed and paraffin-embedded material
    • Lyon, H.; Prento, P. Aldehyde Fuchsin staining of pancreatic B cells. Reproducible high-contrast staining of formalin-fixed and paraffin-embedded material. Histochem. J. 1980, 12, 97-105.
    • (1980) Histochem. J. , vol.12 , pp. 97-105
    • Lyon, H.1    Prento, P.2
  • 34
    • 58549084978 scopus 로고    scopus 로고
    • Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
    • Fröjdö, S.; Vidal, H.; Pirola, L. Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans. Biochim. Biophys. Acta. 2009, 1792, 83-92.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 83-92
    • Fröjdö, S.1    Vidal, H.2    Pirola, L.3
  • 35
    • 84906075429 scopus 로고    scopus 로고
    • Cellular regulation of glucose uptake by glucose transporter GLUT4
    • Govers, R. Cellular regulation of glucose uptake by glucose transporter GLUT4. Adv. Clin. Chem. 2014, 66, 173-240.
    • (2014) Adv. Clin. Chem , vol.66 , pp. 173-240
    • Govers, R.1
  • 36
    • 0037067666 scopus 로고    scopus 로고
    • The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer, L.G.; Parbu-Patel, A.; Carling, D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 2002, 277, 25226-25232.
    • (2002) J. Biol. Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 37
    • 33646346627 scopus 로고    scopus 로고
    • Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    • Nawrocki, A.R.; Rajala, M.W.; Tomas, E.; Pajvani, U.B.; Saha, A.K.; Trumbauer, M.E.; Pang, Z.; Chen, A.S.; Ruderman, N.B.; Chen, H. et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J. Biol. Chem. 2006, 281, 2654-2660.
    • (2006) J. Biol. Chem , vol.281 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3    Pajvani, U.B.4    Saha, A.K.5    Trumbauer, M.E.6    Pang, Z.7    Chen, A.S.8    Ruderman, N.B.9    Chen, H.10
  • 38
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
    • DeFronzo, R.A.; Tripathy, D. Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes. Diab. Care 2009, 32 (Suppl. S2), S157-S163.
    • (2009) Diab. Care , vol.32 , pp. S157-S163
    • Defronzo, R.A.1    Tripathy, D.2
  • 40
    • 84959104085 scopus 로고    scopus 로고
    • Appropriate therapy for type 2 diabetes mellitus in view of pancreatic -cell glucose toxicity: “The earlier, the better”
    • Kaneto, H.; Matsuoka, T.A.; Kimura, T.; Obata, A.; Shimoda, M.; Kamei, S.; Mune, T.; Kaku, K. Appropriate therapy for type 2 diabetes mellitus in view of pancreatic -cell glucose toxicity: “The earlier, the better”. Diabetes 2016, 8, 183-189.
    • (2016) Diabetes , vol.8 , pp. 183-189
    • Kaneto, H.1    Matsuoka, T.A.2    Kimura, T.3    Obata, A.4    Shimoda, M.5    Kamei, S.6    Mune, T.7    Kaku, K.8
  • 42
    • 34047254102 scopus 로고    scopus 로고
    • Soluble dietary fibre fraction of Trigonella foenum-graecum (Fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action
    • Hannan, J.M.; Ali, L.; Rokeya, B.; Khaleque, J.; Akhter, M.; Flatt, P.R.; Abdel-Wahab, Y.H. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br. J. Nutr. 2007, 97, 514-521.
    • (2007) Br. J. Nutr , vol.97 , pp. 514-521
    • Hannan, J.M.1    Ali, L.2    Rokeya, B.3    Khaleque, J.4    Akhter, M.5    Flatt, P.R.6    Abdel-Wahab, Y.H.7
  • 43
    • 84887415748 scopus 로고    scopus 로고
    • Antioxidants and diabetes
    • Bajaj, S.; Khan, A. Antioxidants and diabetes. Indian J. Endocrinol. Metab. 2012, 16 (Suppl. S2), S267-S271.
    • (2012) Indian J. Endocrinol. Metab , vol.16 , pp. S267-S271
    • Bajaj, S.1    Khan, A.2
  • 44
    • 0000350540 scopus 로고    scopus 로고
    • Phytochemical and nutritional significance of cactus pear
    • Stintzing, F.C.; Schieber, A.; Carle, R. Phytochemical and nutritional significance of cactus pear. Food Res. Tech. Int. 2001, 212, 396-407.
    • (2001) Food Res. Tech. Int , vol.212 , pp. 396-407
    • Stintzing, F.C.1    Schieber, A.2    Carle, R.3
  • 45
    • 12244283706 scopus 로고    scopus 로고
    • Neuroprotective effects of antioxidative flavonoids, quercetin, (1)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. Saboten
    • Dok-Go, H.; Lee, K.H.; Kim, H.J.; Lee, E.H.; Lee, J.; Song, Y.S.; Lee, Y.; Jin, C.; Lee, Y.S.; Cho, J. Neuroprotective effects of antioxidative flavonoids, quercetin, (1)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003, 965, 130-136.
    • (2003) Brain Res , vol.965 , pp. 130-136
    • Dok-Go, H.1    Lee, K.H.2    Kim, H.J.3    Lee, E.H.4    Lee, J.5    Song, Y.S.6    Lee, Y.7    Jin, C.8    Lee, Y.S.9    Cho, J.10
  • 46
    • 84920035325 scopus 로고    scopus 로고
    • Extract of cactus (Opuntia ficus indica) cladodes scavenges reactive oxygen species in vitro and enhances plasma antioxidant capacity in humans
    • Avila-Nava, A.; Calderón-Oliver, M.; Medina-Campos, O.N.; Zou, T.; Gu, L.; Torres, N.; Tovar, A.R.; Pedraza-Chaverri, J. Extract of cactus (Opuntia ficus indica) cladodes scavenges reactive oxygen species in vitro and enhances plasma antioxidant capacity in humans. J. Funct. Food 2014, 10, 13-24.
    • (2014) J. Funct. Food , vol.10 , pp. 13-24
    • Avila-Nava, A.1    Calderón-Oliver, M.2    Medina-Campos, O.N.3    Zou, T.4    Gu, L.5    Torres, N.6    Tovar, A.R.7    Pedraza-Chaverri, J.8
  • 48
    • 84912071496 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1
    • Yun, H.; Park, S.; Kim, M.J.; Yang, W.K.; Im, D.U.; Yang, K.R.; Hong, J.; Choe, W.; Kang, I.; Kim, S.S. et al. AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. FEBS J. 2014, 281, 4421-4438.
    • (2014) FEBS J , vol.281 , pp. 4421-4438
    • Yun, H.1    Park, S.2    Kim, M.J.3    Yang, W.K.4    Im, D.U.5    Yang, K.R.6    Hong, J.7    Choe, W.8    Kang, I.9    Kim, S.S.10


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