Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats

Phytotherapy Research

Volumn 25, Issue 3, 2011, Pages 370-375

  Butterweck, Veronika ^a   Semlin, Lydia ^a   Feistel, Bjoern ^b   Pischel, Ivo ^c   Bauer, Katrin ^d   Verspohl, Eugen J ^d  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b Plantextrakt GmbH and Co KG   (Germany)

^c PhytoLab GmbH   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Antidiabetic; Blood sugar lowering; Cactaceae; Insulin; Insulinomimetic; Opuntia ficus indica; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN; OPUNTIA EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FRUIT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN BLOOD LEVEL; LOW DRUG DOSE; MALE; NONHUMAN; OPUNTIA; OPUNTIA FICUS INDICA; PANCREAS ISLET BETA CELL; PLANT STEM; RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; FRUIT; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; MALE; OPUNTIA; PLANT EXTRACTS; PLANT STEMS; RATS; RATS, WISTAR;

CACTACEAE; OPUNTIA FICUS-INDICA; RATTUS;

EID: 79952211652     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3271     Document Type: Article

References (37)

1. Abramovitch RA, Coutts RT, Knaus EE. 1968. Identification of constituents of Opuntia fragilis. Planta Med 16: 147-157.
2. Achari A, Marshall SE, Muirhead H et al. 1981. Glucose-6-phosphate isomerase. Philos Trans R Soc Lond B Biol Sci 293: 145-157.
3. Alarcon-Aguilar FJ, Valdes-Arzate A, Xolalpa-Molina S et al. 2003. Hypoglycemic activity of two polysaccharides isolated from Opuntia ficus-indica and O. streptacantha. Proc West Pharmacol Soc 46: 139-142. (Pubitemid 37463456)
4. Andrade-Cetto A, Heinrich M. 2005. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol 99: 325-348. (Pubitemid 40861709)
5. Bwititi P, Musabayane CT, Nhachi CF. 2000. Effects of Opuntia megacantha on blood glucose and kidney function in streptozotocin diabetic rats. J Ethnopharmacol 69: 247-252. (Pubitemid 30089797)
6. Callahan ST, Mansfield MJ. 2000. Type 2 diabetes mellitus in adolescents. Curr Opin Pediatr 12: 310-315. (Pubitemid 30470119)
7. Cardenas Medellin ML, Serna Saldivar SO, Velazco de la Garza J. 1998. Effect of raw and cooked nopal (Opuntia ficusindica) ingestion on growth and profile of total cholesterol, lipoproteins, and blood glucose in rats. Arch Latinoam Nutr 48: 316-323. (Pubitemid 128383686)
8. De La Cruz M, Badiano J. 1991. Libellus Medicinalibus Indorum Herbis (original 1552). Fondo de la Cultura Economica. Mexico City.
9. Enigbokan MA, Felder TB, Thompson JO. 1996. Hypoglycaemic effects of Opuntia ficus-indica Mill., Opuntia lindheimeri Engelm and Opuntia robusta Wendl. in streptozotocin-induced diabetic rats. Phytother Res 10: 379-382. (Pubitemid 26252782)
10. Ennouri M, Fetoui H, Bourret E et al. 2006. Evaluation of some biological parameters of Opuntia ficus-indica. 1. Influence of a seed oil supplemented diet on rats. Bioresour Technol 97: 1382-1386.
11. Fernandez ML, Lin EC, Trejo A et al. 1992. Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J Nutr 122: 2330-2340. (Pubitemid 23004629)
12. Fernandez ML, Lin EC, Trejo A et al. 1994. Prickly pear (Opuntia sp.) pectin alters hepatic cholesterol metabolism without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet. J Nutr 124: 817-824. (Pubitemid 24200586)
13. Feugang JM, Konarski P, Zou D et al. 2006. Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Front Biosci 11: 2574-2589. (Pubitemid 43806566)
14. Frati AC, Gordillo BE, Altamirano P et al. 1990. Acute hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 13: 455-456. (Pubitemid 20109491)
15. Frati AC, Xilotl Diaz N, Altamirano P et al. 1991. The effect of two sequential doses of Opuntia streptacantha upon glycemia. Arch Invest Med (Mex) 22: 333-336. (Pubitemid 23000021)
16. Frati-Munari AC, de Leon C, Ariza-Andraca R et al. 1989. Effect of a dehydrated extract of nopal (Opuntia ficus indica Mill.) on blood glucose. Arch Invest Med (Mex) 20: 211-216. (Pubitemid 20122137)
17. Frati-Munari AC, Fernandez-Harp JA, Banales-Ham M et al. 1983. Decreased blood glucose and insulin by nopal (Opuntia sp.). Arch Invest Med (Mex) 14: 269-274.
18. Frati-Munari AC, Gordillo BE, Altamirano P et al. 1988. Hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 11: 63-66.
19. Frati-Munari AC, Licona-Quesada R, Araiza-Andraca CR et al. 1990. Activity of Opuntia streptacantha in healthy individuals with induced hyperglycemia. Arch Invest Med (Mex) 21: 99-102.
20. Frati Munari AC, Quiroz Lazaro JL, Altamirano Bustamante P et al. 1988. The effect of various doses of nopal (Opuntia streptacantha Lemaire) on the glucose tolerance test in healthy individuals. Arch Invest Med (Mex) 19: 143-148.
21. Frati-Munari AC, Yever-Garces A, Islas-Andrade S et al. 1987. Studies on the mechanism of 'hypoglycemic' effect of nopal (Opuntia sp.). Arch Invest Med (Mex) 18: 7-12.
22. Gillies CL, Abrams KR, Lambert PC et al. 2007. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis. Br Med J 334: 299.
23. Hannan JM, Ali L, Rokeya B et al. 2007. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr 97: 514-521. (Pubitemid 46662041)
24. Hannan JM, Marenah L, Ali L et al. 2006. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells. J Endocrinol 189: 127-136. (Pubitemid 43670707)
25. Hasse C, Feistel B, Felker P et al. 2008. Opuntia - A cactus crop and its many health benefits. Nutracos 9/10: 17-22.
26. Ibanez-Camacho R, Meckes-Lozoya M. 1983. Effect of a semipurified product obtained from Opuntia streptacantha L. (a cactus) on glycemia and triglyceridemia of rabbit. Arch Invest Med (Mex) 14: 437-443.
27. Ibanez-Camacho R, Meckes-Lozoya M, Mellado-Campos V. 1983. The hypoglucemic effect of Opuntia streptacantha studied in different animal experimental models. J Ethnopharmacol 7: 175-181.
28. Laurenz JC, Collier CC, Kuti JO. 2003. Hypoglycaemic effect of Opuntia lindheimeri Englem in a diabetic pig model. Phytother Res 17: 26-29.
29. Martinez M. 1933. Las Plantas Medicinales de México. Ediciones Botas, Mexico City.
30. Meckes-Lozoya M, Ibanez-Camacho R. 1989. Hypoglucaemic activity of Opuntia streptacantha throughout its annual cycle. Am J Chin Med 17: 221-224. (Pubitemid 20108986)
31. Meckes-Lozyoa M, Roman-Ramos R. 1986. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 14: 116-118.
32. Stintzing FC, Carle R. 2005. Cactus stems (Opuntia spp.): a review on their chemistry, technology, and uses. Mol Nutr Food Res 49: 175-194. (Pubitemid 40379814)
33. Trejo-Gonzalez A, Gabriel-Ortiz G, Puebla-Perez AM et al. 1996. A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. J Ethnopharmacol 55: 27-33. (Pubitemid 27051178)
34. Verspohl EJ. 2002. Recommended testing in diabetes research. Planta Med 68: 581-590. (Pubitemid 34827921)
35. Wild S, Roglic G, Green A et al. 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053. (Pubitemid 38579764)
36. Wolfram RM, Kritz H, Efthimiou Y et al. 2002. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia - a pilot study. Wien Klin Wochenschr 114: 840-846. (Pubitemid 35356122)
37. World Health Organization. 2003. Screening for Type 2 Diabetes. WHO/NMH/MNC/03.1. WHO: Geneva.