Additive insulinogenic action of Opuntia ficus-indica cladode and fruit skin extract and leucine after exercise in healthy males

Journal of the International Society of Sports Nutrition

Volumn 10, Issue , 2013, Pages

  Deldicque, Louise ^a   Van Proeyen, Karen ^a   Ramaekers, Monique ^a   Pischel, Ivo ^b   Sievers, Hartwig ^b   Hespel, Peter ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b PhytoLab GmbH   (Germany)

Author keywords

Amino acids; Endurance athletes; Glucose clearance; Glycogen resynthesis; Nutritional supplements; Post exercise recovery

Indexed keywords

OPUNTIA; OPUNTIA FICUS-INDICA;

EID: 84885824554     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-10-45     Document Type: Article

References (27)

1. Bergstrom J, Hultman E. Muscle glycogen synthesis after exercise: an enhancing factor localized to the muscle cells in man. Nature 1966, 210:309-310. 10.1038/210309a0, 5954569.
2. Ivy JL, Lee MC, Brozinick JT, Reed MJ. Muscle glycogen storage after different amounts of carbohydrate ingestion. J Appl Physiol 1988, 65:2018-2023.
3. Price TB, Rothman DL, Taylor R, Avison MJ, Shulman GI, Shulman RG. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. J Appl Physiol 1994, 76:104-111. 10.1063/1.357116, 7909795.
4. Richter EA, Derave W, Wojtaszewski JF. Glucose, exercise and insulin: emerging concepts. J Physiol 2001, 535:313-322. 10.1111/j.1469-7793.2001.t01-2-00313.x, 2278791, 11533125.
5. Srivastava AK, Pandey SK. Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin. Mol Cell Biochem 1998, 182:135-141. 10.1023/A:1006857527588, 9609122.
6. Cartee GD, Young DA, Sleeper MD, Zierath J, Wallberg-Henriksson H, Holloszy JO. Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. Am J Physiol 1989, 256:E494-E499.
7. van Loon LJ, Saris WH, Kruijshoop M, Wagenmakers AJ. Maximizing postexercise muscle glycogen synthesis: carbohydrate supplementation and the application of amino acid or protein hydrolysate mixtures. Am J Clin Nutr 2000, 72:106-111.
8. van Loon LJ, Kruijshoop M, Verhagen H, Saris WH, Wagenmakers AJ. Ingestion of protein hydrolysate and amino acid-carbohydrate mixtures increases postexercise plasma insulin responses in men. J Nutr 2000, 130:2508-2513.
9. Butterweck V, Semlin L, Feistel B, Pischel I, Bauer K, Verspohl EJ. Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats. Phytother Res 2011, 25:370-375.
10. Van Proeyen K, Ramaekers M, Pischel I, Hespel P. Opuntia ficus-indica ingestion stimulates peripheral disposal of oral glucose before and after exercise in healthy men. Int J Sport Nutr Exerc Metab 2012, 22:284-291.
11. Feugang JM, Konarski P, Zou D, Stintzing FC, Zou C. Nutritional and medicinal use of Cactus pear (Opuntia spp.) cladodes and fruits. Front Biosci 2006, 11:2574-2589. 10.2741/1992, 16720335.
12. Ennouri M, Fetoui H, Bourret E, Zeghal N, Guermazi F, Attia H. Evaluation of some biological parameters of Opuntia ficus indica. 2. Influence of seed supplemented diet on rats. Bioresour Technol 2006, 97:2136-2140. 10.1016/j.biortech.2005.09.031, 16290138.
13. Frati-Munari AC, de LC, Ariza-Andraca R, Banales-Ham MB, Lopez-Ledesma R, Lozoya X. [Effect of a dehydrated extract of nopal (Opuntia ficus indica Mill.) on blood glucose]. Arch Invest Med (Mex) 1989, 20:211-216.
14. Godard MP, Ewing BA, Pischel I, Ziegler A, Benedek B, Feistel B. Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females. J Ethnopharmacol 2010, 130:631-634. 10.1016/j.jep.2010.05.047, 20621660.
15. Kaastra B, Manders RJ, Van BE, Kies A, Jeukendrup AE, Keizer HA, Kuipers H, van Loon LJ. Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc 2006, 38:268-275. 10.1249/01.mss.0000183875.86476.bd, 16531895.
16. Bunch R. New developments in breeding and cactus pear products at D'Arrigo Bros. J Prof Assoc Cactus Dev 2013, 1:100-102.
17. Wolever TM, Jenkins DJ. The use of the glycemic index in predicting the blood glucose response to mixed meals. Am J Clin Nutr 1986, 43:167-172.
18. Wolever TM, Jenkins DJ, Jenkins AL, Josse RG. The glycemic index: methodology and clinical implications. Am J Clin Nutr 1991, 54:846-854.
19. Burke LM, Hawley JA, Wong SH, Jeukendrup AE. Carbohydrates for training and competition. J Sports Sci 2011, 29(Suppl 1):S17-S27.
20. Richter EA, Mikines KJ, Galbo H, Kiens B. Effect of exercise on insulin action in human skeletal muscle. J Appl Physiol 1989, 66:876-885.
21. Jensen TE, Richter EA. Regulation of glucose and glycogen metabolism during and after exercise. J Physiol 2012, 590:1069-1076. 3381815, 22199166.
22. Beelen M, Burke LM, Gibala MJ, van Loon LJ. Nutritional strategies to promote postexercise recovery. Int J Sport Nutr Exerc Metab 2010, 20:515-532.
23. Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, et al. Effects of Leucine and its metabolite, beta-hydroxy-beta-methylbutyrate (HMB) on human skeletal muscle protein metabolism. J Physiol 2013, 591:2911-2923. 3690694,3690694, 23551944.
24. Manders RJ, Little JP, Forbes SC, Candow DG. Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia. Nutrients 2012, 4:1664-1678. 10.3390/nu4111664, 3509512, 23201839.
25. Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond) 2005, 108:185-194. 10.1042/CS20040290, 15544573.
26. Sener A, Malaisse WJ. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 1980, 288:187-189. 10.1038/288187a0, 7001252.
27. Panten U, Kriegstein E, Poser W, Schonborn J, Hasselblatt A. Effects of L-leucine and alpha-ketoisocaproic acid upon insulin secretion and metabolism of isolated pancreatic islets. FEBS Lett 1972, 20:225-228. 10.1016/0014-5793(72)80801-9, 11946423.