A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12

Clinical Nutrition

Volumn 36, Issue 6, 2017, Pages 1509-1515

  Kwok, Timothy ^a   Lee, Jenny ^b   Ma, Ronald C ^a   Wong, Samuel Y ^a   Kung, Kenny ^c   Lam, Augustine ^a   Ho, C S ^a   Lee, Vivian ^d   Harrison, John ^e   Lam, Linda ^d  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Alice Ho Nethersole Hospital   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cognitive disorder; Diabetes mellitus; Elderly; Randomized trial; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; HOMOCYSTEINE; MECOBALAMIN; CHOLESTEROL; CREATININE; METHYLMALONIC ACID; TRIACYLGLYCEROL;

AGED; AGING; AMINO ACID BLOOD LEVEL; ARTICLE; COGNITIVE DEFECT; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DEMENTIA ASSESSMENT; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SMOKING; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD; DIETARY SUPPLEMENT; FOLLOW UP; NEUROPSYCHOLOGICAL TEST; SOCIOECONOMICS;

AGED; CHOLESTEROL; COGNITIVE DYSFUNCTION; CREATININE; DIABETES MELLITUS; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HOMOCYSTEINE; HUMANS; MALE; METHYLMALONIC ACID; NEUROPSYCHOLOGICAL TESTS; SOCIOECONOMIC FACTORS; TRIGLYCERIDES; VITAMIN B 12;

EID: 85006096635     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2016.10.018     Document Type: Article

References (30)

1. Xu, W., Qiu, C., Gatz, M., Pedersen, N.L., Johansson, B., Fratiglioni, L., Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes 58 (2009), 71–77.
2. Neumann, K.F., Rojo, L., Navarrete, L.P., Farias, G., Reyes, P., Maccioni, R.B., Insulin resistance and Alzheimer's disease: molecular links & clinical implications. Curr Alzheimer Res 5 (2008), 438–447.
3. Snowdon, D.A., Greiner, L.H., Mortimer, J.A., Riley, K.P., Greiner, P.A., Markesbery, W.R., Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277 (1997), 813–817.
4. Bruce, D.G., Davis, W.A., Casey, G.P., Starkstein, S.E., Clarnette, R.M., Foster, J.K., et al. Predictors of cognitive impairment and dementia in older people with diabetes. Diabetologia 51 (2008), 241–248.
5. Ting, R.Z., Szeto, C.C., Chan, M.H., Ma, K.K., Chow, K.M., Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med 166 (2006), 1975–1979.
6. Selhub, J., Bagley, L.C., Miller, J., Rosenberg, I.H., B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 71 (2000), 614S–620S.
7. Fuso, A., Seminara, L., Cavallaro, R.A., D'Anselmi, F., Scarpa, S., S- adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 28 (2005), 195–204.
8. Hin, H., Clarke, R., Sherliker, P., Atoyebi, W., Emmens, K., Birks, J., et al. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing 35 (2006), 416–422.
9. Wang, H.X., Wahlin, A., Basun, H., Fastbom, J., Winblad, B., Fratiglioni, L., Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology 56 (2001), 1188–1194.
10. Eussen, S.J., de Groot, L.C., Joosten, L.W., Bloo, R.J., Clarke, R., Ueland, P.M., et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 84 (2006), 361–370.
11. Malouf, R., Areosa Sastre, A., Vitamin B12 for cognition. Cochrane Database Syst Rev, 3, 2003, CD004326.
12. Abyad, A., Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 6 (2002), 254–260.
13. Martin, D.C., Francis, J., Protetch, J., Huff, F.J., Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study. J Am Geriatr Soc 40 (1992), 168–172.
14. Pfeiffer, C.M., Caudill, S.P., Gunter, E.W., Osterloh, J., Sampson, E.J., Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 82 (2005), 442–450.
15. Lam, L.C., Tam, C.W., Lui, V.W., Chan, W.C., Chan, S.S., Ho, K.S., et al. Use of clinical dementia rating in detecting early cognitive deficits in a community-based sample of Chinese older persons in Hong Kong. Alzheimer Dis Assoc Disord 22 (2008), 153–157.
16. Chiu, H.F., Lam, L.C., Chi, I., Leung, T., Li, S.W., Law, W.T., et al. Prevalence of dementia in Chinese elderly in Hong Kong. Neurology 50 (1998), 1002–1009.
17. Lee, H.C.B., Chiu, H.F.K., Wing, Y.K., Kwong, P.K., Leung, C.M., Chung, D.W.S., The GDS short form as a screening test for the Chinese elderly. A preliminary study. Clin Gerontol 14 (1993), 37–41.
18. Shen, J.H., Shen, Q., Yu, H., Lai, J.S., Beaumont, J.L., Zhang, Z., et al. Validation of an Alzheimer's disease assessment battery in Asian participants with mild to moderate Alzheimer's disease. Am J Neurodegener Dis 3 (2014), 158–169.
19. Li, J., Deng, J., Sheng, W., Zuo, Z., Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacol Biochem Behav 101 (2012), 564–574.
20. Ng, T.P., Feng, L., Yap, K.B., Lee, T.S., Tan, C.H., Winblad, B., Long-term metformin usage and cognitive function among older adults with diabetes. J Alzheimers Dis 41 (2014), 61–68.
21. Greibe, E., Trolle, B., Bor, M.V., Lauszus, F.F., Nexo, E., Metformin lowers serum cobalamin without changing other markers of cobalamin status: a study on women with polycystic ovary syndrome. Nutrients 5 (2013), 2475–2482.
22. Wijekoon, E.P., Brosnan, M.E., Brosnan, J.T., Homocysteine metabolism in diabetes. Biochem Soc Trans 35 (2007), 1175–1179.
23. McCampbell, A., Wessner, K., Marlatt, M.W., Wolffe, C., Toolan, D., Podtelezhnikov, A., et al. Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine. J Neurochem 116 (2011), 82–92.
24. Poddar, R., Paul, S., Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death. J Neurochem 124 (2013), 558–570.
25. Zou, C.G., Zhao, Y.S., Gao, S.Y., Li, S.D., Cao, X.Z., Zhang, M., et al. Homocysteine promotes proliferation and activation of microglia. Neurobio Aging 31 (2010), 2069–2079.
26. Aisen, P.S., Schneider, L.S., Sano, M., Diaz-Arrastia, R., van Dyck, C.H., Weiner, M.F., et al. Alzheimer Disease Cooperative Study. High dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300 (2008), 1774–1783.
27. van der Zwaluw, N.L., Dhonukshe-Rutten, R.A., van Wijngaarden, J.P., Brouwer-Brolsma, E.M., van de Rest, O., In't Veld, P.H., et al. Results of 2-year vitamin B treatment on cognitive performance: secondary data from an RCT. Neurology 83 (2014), 2158–2166.
28. Smith, A.D., Smith, S.M., de Jager, C.A., Whitbread, P., Johnston, C., Agacinski, G., et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One, 5, 2010, e12244.
29. de Jager, C.A., Oulhaj, A., Jacoby, R., Refsum, H., Smith, A.D., Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 27 (2012), 592–600.
30. Liu, M.Y., Bian, C., Zhang, J.Q., Wen, F., Apolipoprotein gene polymorphism and Alzheimer disease in Chinese population: a meta-analysis. Sci Rep 4 (2014), 4383–4388.