Chemo-genetic interactions between histone modification and the antiproliferation drug AICAR are conserved in yeast and humans

Genetics

Volumn 204, Issue 4, 2016, Pages 1447-1460

  Albrecht, Delphine ^a,b   Ceschin, Johanna ^a,b   Dompierre, Jim ^a,b   Gueniot, Florian ^a,b   Pinson, Benoît ^a,b   Daignan Fornier, Bertrand ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Institut de Biochimie et Genetique Cellulaires   (France)

Author keywords

Cancer cells; Cell cycle; Histone modification; Synthetic lethality; Yeast

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYCLIN G1; HISTONE; HISTONE H2B; HISTONE H3; LYSINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTINEOPLASTIC AGENT; BRE1 PROTEIN, S CEREVISIAE; CLN1 PROTEIN, S CEREVISIAE; CYCLINE; DNA BINDING PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; MLL2 PROTEIN, HUMAN; PROTEIN BINDING; RIBONUCLEOTIDE; SACCHAROMYCES CEREVISIAE PROTEIN; SET1 PROTEIN, S CEREVISIAE; TUMOR PROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEATH; FLUORESCENCE ACTIVATED CELL SORTING; GENE DELETION; GENE INTERACTION; GENE SILENCING; GENETIC CONSERVATION; GROWTH INHIBITION; HCT116 CELL LINE; HISTONE METHYLATION; HISTONE MODIFICATION; HISTONE UBIQUITINATION; HUMAN; LETHALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENETICS; HCT 116 CELL LINE; METABOLISM; MOLECULAR EVOLUTION; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE;

AMINOIMIDAZOLE CARBOXAMIDE; ANTINEOPLASTIC AGENTS; CYCLINS; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; HCT116 CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBONUCLEOTIDES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 85006060315     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.116.192518     Document Type: Article

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