Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 882-888

  Flynn, Paul J ^a   Reece, Richard J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; SACCHAROMYCES CEREVISIAE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0032961173     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.882     Document Type: Article

References (30)

1. Antonelli, R., L. Estevez, and M. Denis-Duphil. 1998. Carbamyl-phosphate synthetase domain of the yeast multifunctional protein Ura2 is necessary for aspartate transcarbamylase inhibition by UTP. FEBS Lett. 422:170-174.
2. de Montigny, J., L. Kern, J. C. Hubert, and F. Lacroute. 1990. Cloning and sequencing af URA10, a second gene encoding orotate phosphoribosyl transferase in Saccharomyces cerevisiae. Curr. Genet. 17:105-111.
3. Denis-Duphil, M. 1989. Pyrimidine biosynthesis in Saccharomyces cerevisiae: the ura2 cluster gene, its multifunctional enzyme product, and other structural or regulatory genes involved in de novo UMP synthesis. Biochem. Cell. Biol. 67:612-631.
4. Flynn, P. J., and R. J. Reece. Unpublished observations.
5. Friden, P., C. Reynolds, and P. Schimmel. 1989. A large internal deletion converts yeast LEU3 to a constitutive transcriptional activator. Mol. Cell. Biol. 9:4056-4060.
6. Friden, P., and P. Schimmel. 1988. LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence. Mol. Cell. Biol. 8:2690-2697.
7. Friden, P., and P. Schimmel. 1987. LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol. Cell. Biol. 7:2708-2717.
8. Jaquet, L., V. Serre, M. Lollier, B. Penverne, G. Herve, J. L. Souciet, and S. Potier. 1995. Allosteric regulation of carbamoylphosphate synthetase-aspartate transcarbamylase multifunctional protein of Saccharomyces cerevisiae: selection, mapping and identification of missense mutations define three regions involved in feedback inhibition by UTP. J. Mol. Biol. 248:639-652.
9. Kammerer, B., A. Guyonvarch, and J. C. Hubert. 1984. Yeast regulatory gene PPR1. I. Nucleotide sequence, restriction map and codon usage. J. Mol. Biol. 180:239-250.
10. Lacroute, F. 1968. Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae. J. Bacteriol. 95:824-842.
11. 6 binuclear cluster proteins recognizes DNA. Mol. Cell. Biol. 16:3773-3780.
12. Liljelund, P., R. Lesson, B. Kammerer, and F. Lacroute. 1984. Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect. J. Mol. Biol. 180:251-265.
13. Lillie, J. W., M. Green, and M. R. Green. 1986. An adenovirus E1a protein region required for transformation and transcriptional repression. Cell 46: 1043-1051.
14. Lin, Y.-S., M. F. Carey, M. Ptashne, and M. R. Green. 1988. GAL4 derivatives function alone and synergistically with mammalian activators in vitro. Cell 54:659-664.
15. Loison, G., R. Jund, M. Nguyen-Juilleret, and F. Lacroute. 1981. Evidence for transcriptional regulation of dihydroorotic acid dehydrogenase in Saccharomyces cerevisiae. Curr. Genet. 3:119-123.
16. Loison, G., R. Losson, and F. Lacroute. 1980. Constitutive mutants for orotidine 5 phosphate decarboxylase and dihydroorotic acid dehydrogenase in Saccharomyces cerevisiae. Curr. Genet. 2:39-44.
17. Losson, R., and F. Lacroute. 1981. Cloning of a eukaryotic regulatory gene. Mol. Gen. Genet. 184:394-399.
18. 6 binuclear cluster. Genes Dev. 8:2504-2512.
19. Nagy, M., F. Lacroute, and D. Thomas. 1992. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Proc. Natl. Acad. Sci. USA 89:8966-8970.
20. Nagy, M., J. Laporte, B. Penverne, and G. Herve. 1982. Nuclear localization of aspartate transcarbamoylase in Saccharomyces cerevisiae. J. Cell Biol. 92: 790-794.
21. Ohashi, Y., J. M. Brickman, E. Furman, B. Middleton, and M. Carey. 1994. Modulating the potency of an activator in a yeast in vitro transcription system. Mol. Cell. Biol. 13:2731-2739.
22. Ponticelli, A. S., and K. Struhl. 1990. Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription. Mol. Cell. Biol. 10:2832-2839.
23. Potier, S., F. Lacroute, J. C. Hubert, and J. L. Souciet. 1990. Studies on transcription of the yeast URA2 gene. FEMS Microbiol. Lett. 60:215-219.
24. Reece, R. J., R. J. Rickles, and M. Ptashne. 1993. Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli. Gene 126:105-107.
25. Roy, A., F. Exinger, and R. Losson. 1990. cis- and trans-acting regulatory elements of the yeast URA3 promoter. Mol. Cell. Biol. 10:5257-5270.
26. Roy, A., and R. Losson. Personal communication.
27. 6 zinc cluster family of transcriptional regulators. Nucleic Acids Res. 24:4599-4607.
28. Sze, J.-Y., M. Woontner, J. A. Jaehning, and G. B. Kohlhaw. 1992. In vitro transcriptional activation by a metabolic derivative: activation of Leu3 depends on α-isopropylmalate. Science 258:1143-1145.
29. Wang, D., Y. Hu, F. Zheng, K. Zhou, and G. B. Kohlhaw. 1997. Evidence that intramolecular interactions are involved in masking the activation domain of the transcriptional activator Leu3p. J. Biol. Chem. 272:19383-19392.
30. Wu, Y., R. J. Reece, and M. Ptashne. 1996. Quantitation of putative activator-target affinities predicts transcriptional activating potentials. EMBO J. 15:3951-3963.