P11 and its role in depression and therapeutic responses to antidepressants

Nature Reviews Neuroscience

Volumn 14, Issue 10, 2013, Pages 673-680

  Svenningsson, Per ^a,b   Kim, Yong ^a   Warner Schmidt, Jennifer ^a   Oh, Yong Seok ^a   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOKINE; GLUCOCORTICOID; GROWTH FACTOR; LIPOCORTIN 2; MESSENGER RNA; NEUROTRANSMITTER; PEPTIDES AND PROTEINS; PROTEIN P11; PROTEIN SMARCA3; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

BEHAVIOR; BRAIN REGION; DEPRESSION; GENETIC TRANSCRIPTION; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANNEXIN A2; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; S100 PROTEINS;

EID: 84884586454     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3564     Document Type: Review

References (49)

1. Belmaker, R. H. & Agam, G. N. Major depressive disorder. N. Engl. J. Med. 358, 55-68 (2008).
2. Svenningsson, P. et al. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311, 77-80 (2006). (Pubitemid 43063061)
3. Warner-Schmidt, J. L. et al. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J. Neurosci. 29, 1937-1946 (2009).
4. Marenholz, I., Heizmann, C. W. & Fritz, G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem. Biophys. Res. Commun. 322, 1111-1122 (2004). (Pubitemid 39164640)
5. Gerke, V. & Weber, K. The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells. EMBO J. 4, 2917-2920 (1985).
6. Svenningsson, P. & Greengard, P. p11 (S100A10)-an inducible adaptor protein that modulates neuronal functions. Curr. Opin. Pharmacol. 7, 27-32 (2007).
7. Rescher, U. & Gerke, V. S100A10/p11: family, friends and functions. Pflugers Arch. 455, 575-582 (2008). (Pubitemid 350160469)
8. Warner-Schmidt, J. L. et al. Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proc. Natl Acad. Sci. USA 109, 11360-11365 (2012).
9. Egeland, M., Warner-Schmidt, J., Greengard, P. & Svenningsson, P. Co-expression of serotonin 5-HT1B and 5-HT4 receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology 61, 442-450 (2011).
10. Schmidt, E. F. et al. Identification of the cortical neurons that mediate antidepressant responses. Cell 149, 1152-1163 (2012).
11. Oh, Y. S. et al. SMARCA3, a chromatin remodeling factor, is required for p11-dependent antidepressant action. Cell 152, 831-843 (2013).
12. Alexander, B. et al. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci. Transl. Med. 2, 54ra76 (2010).
13. Anisman, H. et al. Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. J. Psychiatry Neurosci. 33, 131-141 (2008). (Pubitemid 351441383)
14. Warner-Schmidt, J. L. et al. A role for p11 in the antidepressant action of brain-derived neurotrophic factor. Biol. Psychiatry 68, 528-535 (2010).
15. Zhang, X., Andren, P. E., Greengard, P. & Svenningsson, P. Evidence for a role of the 5-HT1B receptor and its adaptor protein, 11, in L-DOPA treatment of an animal model of Parkinsonism. Proc. Natl Acad. Sci. USA 105, 2163-2168 (2008). (Pubitemid 351439482)
16. Saarelainen, T. et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J. Neurosci. 23, 349-357 (2003). (Pubitemid 36050437)
17. Okuse, K. et al. Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature 417, 653-656 (2002). (Pubitemid 34614824)
18. Masiakowski, P. & Shooter, E. M. Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells. Proc. Natl Acad. Sci. USA 85, 1277-1281 (1988). (Pubitemid 18073992)
19. Warner-Schmidt, J. L. et al. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc. Natl Acad. Sci. USA 108, 9262-9267 (2011).
20. Anisman, H., Gibb, J. & Hayley, S. Influence of continuous infusion of interleukin-1? on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression. Psychopharmacology 199, 231-244 (2008).
21. Raison, C. L. & Miller, A. H. Is depression an inflammatory disorder? Curr. Psychiatry Rep. 13, 467-475 (2011).
22. Song, C., Zhang, Y. & Dong, Y. Acute and subacute IL-1? administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration. J. Neuroinflammation 10, 59-74 (2013).
23. Müller, N. et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol. Psychiatry 11, 680-684 (2006). (Pubitemid 43989814)
24. Trivedi, M. H. et al. Non-steroidal anti-inflammatory drug use is associated with lower remission rate with escitalopram but not with other antidepressants. Neuropsychopharmacology 38, S314-S446 (2012).
25. Zhang, L. et al. p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter. Neuroscience 153, 1126-1134 (2008).
26. Eriksson, T. M. et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol. Psychiatry http://dx.doi. org/10.1038/mp.2012.130 (2012).
27. Egeland, M., Warner-Schmidt, J., Greengard, P. & Svenningsson, P. Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biol. Psychiatry 67, 1048-1056 (2010).
28. Réty, S. et al. The crystal structure of a complex of p11 with the annexin II N-terminal peptide. Nature Struct. Biol. 6, 89-95 (1999). (Pubitemid 29232429)
29. Gerke, V., Creutz, C. E. & Moss, S. E. Annexins: linking Ca2+ signalling to membrane dynamics. Nature Rev. Mol. Cell Biol. 6, 449-461 (2005). (Pubitemid 40780557)
30. Gerfen, C. R. & Surmeier, D. J. Modulation of striatal projection systems by dopamine. Annu. Rev. Neurosci. 34, 441-466 (2011).
31. O'Neill, M. F. & Conway, M. W. Role of 5-HT1A and 5-HT1B receptors in the mediation of behavior in the forced swim test in mice. Neuropsychopharmacology 24, 391-398 (2001). (Pubitemid 32157555)
32. Lucas, G. et al. Serotonin4 (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 55, 712-725 (2007). (Pubitemid 47334877)
33. Svenningsson, P. et al. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J. Neurosci. 27, 4201-4209 (2007). (Pubitemid 46597167)
34. Debauve, G., Capouillez, A., Belayew, A. & Saussez, S. The helicase-like transcription factor and its implication in cancer progression. Cell. Mol. Life Sci. 65, 591-604 (2008).
35. Zaidi, S. K. et al. Nuclear microenvironments in biological control and cancer. Nature Rev. Cancer 7, 454-463 (2007). (Pubitemid 46809169)
36. Liu, J. et al. Nuclear annexin II negatively regulates growth of LNCaP cells and substitution of ser 11 and 25 to glu prevents nucleo-cytoplasmic shuttling of annexin II. BMC Biochem. 4, 10-25 (2003).
37. Vishwanatha, J. K., Jindal, H. K. & Davis, R. G. The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells. J. Cell. Sci. 101, 25-34 (1992).
38. Barlow, C. A., Laishram, R. S. & Anderson, R. A. Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum. Trends Cell. Biol. 20, 25-35 (2010).
39. Hargreaves, D. C. & Crabtree, G. R. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 21, 396-420 (2011).
40. Sheridan, P. L., Schorpp, M., Voz, M. L. & Jones, K. A. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter. J. Biol. Chem. 270, 4575-4587 (1995).
41. Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124, 319-335 (1965).
42. Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nature Med. 4, 1313-1317 (1998). (Pubitemid 28512114)
43. Malberg, J. E., Eisch, A. J., Nestler, E. J. & Duman, R. S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110 (2000). (Pubitemid 32042912)
44. Santarelli, L. et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809 (2003). (Pubitemid 36962615)
45. Holtzheimer, P. E. & Mayberg, H. S. Deep brain stimulation for psychiatric disorders. Annu. Rev. Neurosci. 34, 289-307 (2011).
46. Sanacora, G., Zarate, C. A., Krystal, J. H. & Manji, H. K. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Rev. Drug Discov. 7, 426-437 (2008). (Pubitemid 351619114)
47. Tzang, R. F. et al. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. Neurosci. Lett. 447, 92-95 (2008).
48. Perlis, R. H. et al. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR D study. Neuropsychopharmacology 33, 2810-2819 (2008).
49. Ripke, S. et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18, 497-511 (2013).