Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

Journal of Chemical Theory and Computation

Volumn 12, Issue 12, 2016, Pages 6098-6108

  Prachanronarong, Kristina L ^a   Özen, Ayşegül ^a   Thayer, Kelly M ^a,b   Yilmaz, L Safak ^a,c   Zeldovich, Konstantin B ^a,b   Bolon, Daniel N ^a   Kowalik, Timothy F ^a   Jensen, Jeffrey D ^a,e   Finberg, Robert W ^d   Wang, Jennifer P ^d   Kurt Yilmaz, Nese ^a   Schiffer, Celia A ^a  

^a Department of Biochemistry and Molecular Pharmacology ^*  (United States)

^b Program in Bioinformatics and Integrative Biology   (United States)

^c Program in Systems Biology   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; OSELTAMIVIR; PROTEIN BINDING; SIALIDASE; ZANAMIVIR;

ANTAGONISTS AND INHIBITORS; ANTIVIRAL RESISTANCE; BINDING SITE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; HYDROGEN BOND; INFLUENZA; INFLUENZA A VIRUS; METABOLISM; MOLECULAR DYNAMICS; PATHOLOGY; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY; THERMODYNAMICS; VIROLOGY;

ANTIVIRAL AGENTS; BINDING SITES; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NEURAMINIDASE; OSELTAMIVIR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; THERMODYNAMICS; ZANAMIVIR;

EID: 85006014437     PISSN: 15499618     EISSN: 15499626     Source Type: Journal    
DOI: 10.1021/acs.jctc.6b00703     Document Type: Article

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