Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease

Journal of the American Chemical Society

Volumn 136, Issue 34, 2014, Pages 11956-11963

  Ragland, Debra A ^a   Nalivaika, Ellen A ^a   Nalam, Madhavi N L ^a   Prachanronarong, Kristina L ^a   Cao, Hong ^a   Bandaranayake, Rajintha M ^a   Cai, Yufeng ^a   Kurt Yilmaz, Nese ^a   Schiffer, Celia A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; COMPLEX NETWORKS;

BINDING AFFINITIES; DRUG RESISTANCE; HIGHLY ACTIVE ANTI-RETROVIRAL THERAPIES; HIV-1 PROTEASE INHIBITORS; INHIBITION ASSAYS; MOLECULAR DYNAMICS SIMULATIONS; PROTEASE COMPLEX; STRUCTURE AND DYNAMICS;

COMPLEX NETWORKS; DRUG THERAPY;

DARUNAVIR; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; PROTEIN BINDING; SULFONAMIDE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR DYNAMICS; ANTIVIRAL RESISTANCE; DRUG BINDING; ENZYME STRUCTURE; MUTATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PROTEIN CONFORMATION;

BINDING SITES; DARUNAVIR; DRUG RESISTANCE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SULFONAMIDES;

EID: 84906751080     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja504096m     Document Type: Article

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