메뉴 건너뛰기




Volumn 71, Issue 1, 2012, Pages 66-72

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549: BRAF fusion variants

Author keywords

BRAF; Brain tumor; Glioneuronal; MAPK; Pilocytic astrocytoma

Indexed keywords

B RAF KINASE; MEMBRANE PROTEIN; PROTEIN KIAA1549; UNCLASSIFIED DRUG;

EID: 84655167688     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31823f2cb0     Document Type: Article
Times cited : (139)

References (30)
  • 1
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 2005;64:479-89 (Pubitemid 40781150)
    • (2005) Journal of Neuropathology and Experimental Neurology , vol.64 , Issue.6 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 2
    • 70349084731 scopus 로고    scopus 로고
    • CBTRUS, Hinsdale, IL: Central Brain Tumor Registry of the United States
    • CBTRUS. Primary Brain Tumors in the United States, 2000-2004. Hinsdale, IL: Central Brain Tumor Registry of the United States, 2008
    • (2008) Primary Brain Tumors in the United States, 2000-2004
  • 3
    • 0031042997 scopus 로고    scopus 로고
    • Cerebellar pilocytic astrocytoma: A treatment protocol based upon analysis of 73 cases and a review of the literature
    • DOI 10.1007/s003810050033
    • Dirven CM, Mooij JJ, Molenaar WM. Cerebellar pilocytic astrocytoma: A treatment protocol based upon analysis of 73 cases and a review of the literature. Childs Nerv Syst 1997;13:17-23 (Pubitemid 27104553)
    • (1997) Child's Nervous System , vol.13 , Issue.1 , pp. 17-23
    • Dirven, C.M.F.1    Mooij, J.J.A.2    Molenaar, W.M.3
  • 4
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-68
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 5
    • 52649172327 scopus 로고    scopus 로고
    • Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
    • Bar EE, Lin A, Tihan T, et al. Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. J Neuropathol Exp Neurol 2008; 67:878-87
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 878-887
    • Bar, E.E.1    Lin, A.2    Tihan, T.3
  • 6
    • 68749098096 scopus 로고    scopus 로고
    • Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
    • Jacob K, Albrecht S, Sollier C, et al. Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. Br J Cancer 2009;101:722-33
    • (2009) Br J Cancer , vol.101 , pp. 722-733
    • Jacob, K.1    Albrecht, S.2    Sollier, C.3
  • 7
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 2008;68:8673-77
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 9
    • 66949147222 scopus 로고    scopus 로고
    • Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    • Sievert AJ, Jackson EM, Gai X, et al. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol 2009;19:449-58
    • (2009) Brain Pathol , vol.19 , pp. 449-458
    • Sievert, A.J.1    Jackson, E.M.2    Gai, X.3
  • 10
    • 72049096346 scopus 로고    scopus 로고
    • Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma
    • Yu J, Deshmukh H, Gutmann RJ, et al. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology 2009;73: 1526-31
    • (2009) Neurology , vol.73 , pp. 1526-1531
    • Yu, J.1    Deshmukh, H.2    Gutmann, R.J.3
  • 11
    • 11244344906 scopus 로고    scopus 로고
    • Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    • Dasgupta B, Li W, Perry A, et al. Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res 2005; 65:236-45 (Pubitemid 40070815)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 236-245
    • Dasgupta, B.1    Li, W.2    Perry, A.3    Gutmann, D.H.4
  • 12
    • 67349219657 scopus 로고    scopus 로고
    • Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    • Jones DT, Kocialkowski S, Liu L, et al. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene 2009; 28:2119-23
    • (2009) Oncogene , vol.28 , pp. 2119-2123
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 13
    • 78149467927 scopus 로고    scopus 로고
    • Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
    • Dougherty MJ, Santi M, Brose MS, et al. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol 2010;12:621-30
    • (2010) Neuro Oncol , vol.12 , pp. 621-630
    • Dougherty, M.J.1    Santi, M.2    Brose, M.S.3
  • 14
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAFV600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • Schindler G, Capper D, Meyer J, et al. Analysis of BRAFV600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011;121:397-405
    • (2011) Acta Neuropathol , vol.121 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 16
  • 17
    • 79958087774 scopus 로고    scopus 로고
    • Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
    • Cin H, Meyer C, Herr R, et al. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol 2011;121:763-74
    • (2011) Acta Neuropathol , vol.121 , pp. 763-774
    • Cin, H.1    Meyer, C.2    Herr, R.3
  • 18
    • 79954447261 scopus 로고    scopus 로고
    • PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma
    • Rodriguez EF, Scheithauer BW, Giannini C, et al. PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma. Acta Neuropathol 2011;121: 407-20
    • (2011) Acta Neuropathol , vol.121 , pp. 407-420
    • Rodriguez, E.F.1    Scheithauer, B.W.2    Giannini, C.3
  • 19
    • 79960388615 scopus 로고    scopus 로고
    • BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low grade astrocytoma
    • Hawkins CE, Walker E, Mohamed N, et al. BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low grade astrocytoma. Clin Cancer Res 2011;17:4790-98
    • (2011) Clin Cancer Res , vol.17 , pp. 4790-4798
    • Hawkins, C.E.1    Walker, E.2    Mohamed, N.3
  • 20
    • 78349232314 scopus 로고    scopus 로고
    • MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas: A novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential
    • Jeuken JW, Wesseling P. MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas: A novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential. J Pathol 2010;222:324-28
    • (2010) J Pathol , vol.222 , pp. 324-328
    • Jeuken, J.W.1    Wesseling, P.2
  • 22
    • 66849099801 scopus 로고    scopus 로고
    • Activation of the ERK/ MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas
    • Forshew T, Tatevossian RG, Lawson AR, et al. Activation of the ERK/ MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 2009;218:172-81
    • (2009) J Pathol , vol.218 , pp. 172-181
    • Forshew, T.1    Tatevossian, R.G.2    Lawson, A.R.3
  • 23
    • 79953328752 scopus 로고    scopus 로고
    • RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology
    • Lawson AR, Hindley GF, Forshew T, et al. RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology. Genome Res 2011;21:505-14
    • (2011) Genome Res , vol.21 , pp. 505-514
    • Lawson, A.R.1    Hindley, G.F.2    Forshew, T.3
  • 24
    • 79960397029 scopus 로고    scopus 로고
    • Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas
    • Jacob K, Quang-Khuong DA, Jones DT, et al. Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas. Clin Cancer Res 2011;17:4650-60
    • (2011) Clin Cancer Res , vol.17 , pp. 4650-4660
    • Jacob, K.1    Quang-Khuong, D.A.2    Jones, D.T.3
  • 25
    • 79957880389 scopus 로고    scopus 로고
    • BRAF activation induces transformation and then senescence in human neural stem cells: A pilocytic astrocytoma model
    • Raabe EH, Lim KS, Kim JM, et al. BRAF activation induces transformation and then senescence in human neural stem cells: A pilocytic astrocytoma model. Clin Cancer Res 2011;17:3590-99
    • (2011) Clin Cancer Res , vol.17 , pp. 3590-3599
    • Raabe, E.H.1    Lim, K.S.2    Kim, J.M.3
  • 26
    • 77957275728 scopus 로고    scopus 로고
    • RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort
    • Lawson AR, Tatevossian RG, Phipps KP, et al. RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol 2010;120:271-73
    • (2010) Acta Neuropathol , vol.120 , pp. 271-273
    • Lawson, A.R.1    Tatevossian, R.G.2    Phipps, K.P.3
  • 27
    • 80055084211 scopus 로고    scopus 로고
    • BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults
    • Hasselblatt M, Riesmeier B, Lechtape B, et al. BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults. Neuropathol Appl Neurobiol 2011;37:803-6.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 803-806
    • Hasselblatt, M.1    Riesmeier, B.2    Lechtape, B.3
  • 28
    • 33847068802 scopus 로고    scopus 로고
    • Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    • Sharma MK, Mansur DB, Reifenberger G, et al. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Res 2007;67:890-900
    • (2007) Cancer Res , vol.67 , pp. 890-900
    • Sharma, M.K.1    Mansur, D.B.2    Reifenberger, G.3
  • 30
    • 77953020697 scopus 로고    scopus 로고
    • Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
    • Horbinski C, Hamilton RL, Nikiforov Y, et al. Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol 2010;119:641-49
    • (2010) Acta Neuropathol , vol.119 , pp. 641-649
    • Horbinski, C.1    Hamilton, R.L.2    Nikiforov, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.