Detection of BRAF V600E mutations in skin metastases of malignant melanoma by monoclonal antibody VE1

Journal of the American Academy of Dermatology

Volumn 67, Issue 3, 2012, Pages 488-491

  Skorokhod, Alexander ^a   Capper, David ^a,b   Von Deimling, Andreas ^a,b   Enk, Alexander ^a   Helmbold, Peter ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY VE1; UNCLASSIFIED DRUG; VALINE; VEMURAFENIB;

CELL INFILTRATION; FALSE NEGATIVE RESULT; GENE MUTATION; GENETIC ANALYSIS; HUMAN; IMMUNOHISTOCHEMISTRY; LETTER; MACROPHAGE; MELANOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PYROSEQUENCING; SKIN METASTASIS;

EID: 84865001178     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2012.03.022     Document Type: Article

References (5)

1. P.B. Chapman, A. Hauschild, C. Robert, J.B. Haanen, P. Ascierto, and J. Larkin Improved survival with vemurafenib in melanoma with BRAF V600E mutation N Engl J Med 364 2011 2507 2516
2. J.H. Lee, J.W. Choi, and Y.S. Kim Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis Br J Dermatol 164 2011 776 784
3. D. Solit, and C.L. Sawyers Drug discovery: how melanomas bypass new therapy Nature 468 2010 902 903
4. D. Capper, M. Preusser, A. Habel, F. Sahm, U. Ackermann, and G. Schindler Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody Acta Neuropathol 122 2011 11 19
5. C. Spittle, M.R. Ward, K.L. Nathanson, P.A. Gimotty, E. Rappaport, and M.S. Brose Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma J Mol Diagn 9 2007 464 471 (Pubitemid 47434113)