RAS/RAF pathway activation in gliomas: The result of copy number gains rather than activating mutations

Acta Neuropathologica

Volumn 114, Issue 2, 2007, Pages 121-133

  Jeuken, Judith ^a   van de Broecke, Caroline ^b   Gijsen, Sabine ^a   Boots Sprenger, Sandra ^a   Wesseling, Pieter ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

BRAF; Copy number gains; Glioma; Mutation; RAS

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; H RAS PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N RAS PROTEIN; ONCOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RAF PROTEIN; RAS PROTEIN; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE ACTIVATION; GENE MUTATION; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY;

BASE SEQUENCE; BRAIN NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; ENZYME ACTIVATION; GENE DOSAGE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; NUCLEIC ACID HYBRIDIZATION; PHOSPHORYLATION; RAF KINASES; RAS PROTEINS; TISSUE ARRAY ANALYSIS;

EID: 34547100321     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-007-0239-0     Document Type: Article

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