Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis

Food Chemistry

Volumn 221, Issue , 2017, Pages 1741-1746

  García Vilas, Javier A ^a,b   Quesada, Ana R ^a,b   Medina, Miguel Ángel ^a,b  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Angiogenesis; Aortic ring assay; Bovine aorta endothelial cells (BAEC); Chorioallantoic membrane (CAM) assay; Hydroxytyrosol; Matrix metalloproteinase (MMP); Tissue inhibitor of metalloproteinase (TIMP); Urokinase type plasminogen activator (uPA)

Indexed keywords

ASSOCIATIVE STORAGE; BLOOD VESSELS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; OLIVE OIL; TISSUE;

ANGIOGENESIS; AORTIC RINGS; BOVINE AORTA ENDOTHELIAL CELLS; CHORIOALLANTOIC MEMBRANE ASSAYS; HYDROXYTYROSOL; MATRIX METALLOPROTEINASES; METALLOPROTEINASES; UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA);

ENDOTHELIAL CELLS;

GELATINASE A; HYDROXYTYROSOL; INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; VIRGIN OLIVE OIL; 3,4-DIHYDROXYPHENYLETHANOL; PHENETHYL ALCOHOL;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; AORTIC ENDOTHELIAL CELL; ARTICLE; CHORIOALLANTOIS; CONTROLLED STUDY; ENDOTHELIUM CELL; EX VIVO STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; IN VIVO STUDY; NONHUMAN; PROTEIN DEGRADATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BOVINE; DRUG EFFECTS; METABOLISM;

ANIMALS; CATTLE; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; NEOVASCULARIZATION, PHYSIOLOGIC; PHENYLETHYL ALCOHOL; PROTEOLYSIS;

EID: 85005921826     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2016.10.111     Document Type: Article

References (30)

1. Baker, M., Robinson, S.D., Lechertier, T., Barber, P.R., Tavora, B., D'Amico, G., Hodivala-Dilke, K., Use of the mouse aortic ring assay to study angiogenesis. Nature Protocols 7:1 (2012), 89–104.
2. Commission Regulation (EU) 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children's development and health. O.J. 2012, L136/1. (2012).
3. De La Cruz, J.P., Ruiz-Moreno, M.I., Guerrero, A., Reyes, J.J., Benitez-Guerrero, A., Espartero, J.L., Gonzalez-Correa, J.A., Differences in the neuroprotective effect of orally administered virgin olive oil (Olea europaea) polyphenols tyrosol and hydroxytyrosol in rats. Journal of Agricultural and Food Chemistry 63:25 (2015), 5957–5963.
4. Fortes, C., García-Vilas, J.A., Quesada, A.R., Medina, M.A., Evaluation of the anti-angiogenic potential of hydroxytyrosol and tyrosol, two bio-active phenolic compounds of extra virgin olive oil, in endothelial cell cultures. Food Chemistry 134 (2012), 134–140.
5. Fuccelli, R., Fabiani, R., Sepporta, M.V., Rosignoli, P., The hydroxytyrosol-dependent increase of TNF-alpha in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation. Toxicology In Vitro 29:5 (2015), 933–937.
6. Gallardo, E., Madrona, A., Palma-Valdes, R., Espartero, J.L., Santiago, M., Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis. Life Sciences 134 (2015), 30–35.
7. García-Vilas, J.A., Quesada, A.R., Medina, M.A., 4-Methylumbelliferone inhibits angiogenesis in vitro and in vivo. Journal of Agricultural and Food Chemistry 61 (2013), 4063–4071.
8. Gospodarowicz, D., Moran, J.S., Mitogenic effect of fibroblast growth factor on early passage cultures of human and murine fibroblasts. The Journal of Cell Biology 66:2 (1975), 451–457.
9. Granados-Principal, S., El-Azem, N., Pamplona, R., Ramirez-Tortosa, C., Pulido-Moran, M., Vera-Ramirez, L.,. Ramirez-Tortosa, M., Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer. Biochemical Pharmacology 90:1 (2014), 25–33.
10. Granner, T., Maloney, S., Antecka, E., Correa, J.A., Burnier, M.N. Jr., 3,4 Dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells. British Journal of Ophthalmology 97:3 (2013), 371–374.
11. Lamy, S., Ouanouki, A., Beliveau, R., Desrosiers, R.R., Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation. Experimental Cell Research 322:1 (2014), 89–98.
12. Lopez de Las Hazas, M.C., Rubio, L., Kotronoulas, A., de la Torre, R., Sola, R., Motilva, M.J., Dose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in rats. Molecular Nutrition & Food Research 59:7 (2015), 1395–1399.
13. Martínez-Poveda, B., García-Vilas, J.A., Cárdenas, C., Melgarejo, E., Quesada, A.R., Medina, M.A., The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro-inflammatory molecules in human endothelial and monocyte cells. PLoS One, 8(1), 2013, e55203.
14. Miró-Casas, E., Covas, M.I., Fitó, M., Farré-Albadalejo, M., Marrugat, J., De la Torre, R., Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans. European Journal of Clinical Nutrition 57 (2003), 186–190.
15. Mnafgui, K., Hajji, R., Derbali, F., Khlif, I., Kraiem, F., Ellefi, H.,. Gharsallah, N., Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat. Cardiovascular Toxicology, 2015.
16. Nicosia, R.F., Ottinetti, A., Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro. Laboratory Investigation 63:1 (1990), 115–122.
17. Owen, R.W., Giacosa, A., Hull, W.E., Haubner, R., Wurtele, G., Spiegelhalder, B., Bartsch, H., Olive-oil consumption and health: The possible role of antioxidants. The Lancet Oncology 1 (2000), 107–112.
18. Persia, F.A., Mariani, M.L., Fogal, T.H., Penissi, A.B., Hydroxytyrosol and oleuropein of olive oil inhibit mast cell degranulation induced by immune and non-immune pathways. Phytomedicine 21:11 (2014), 1400–1405.
19. Ribatti, D., Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis. International Review of Cell Molecular Biology 270 (2008), 181–224.
20. Samuel, S.M., Thirunavukkarasu, M., Penumathsa, S.V., Paul, D., Maulik, N., Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: Switching gears toward survival and longevity. The Journal of Agricultural and Food Chemistry 56:20 (2008), 9692–9698.
21. Scoditti, E., Calabriso, N., Massaro, M., Pellegrino, M., Storelli, C., Martines, G.,. Carluccio, M.A., Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Archives of Biochemical Biophysics 527:2 (2012), 81–89.
22. Scoditti, E., Nestola, A., Massaro, M., Calabriso, N., Storelli, C., De Caterina, R., Carluccio, M.A., Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCalpha and PKCbeta1 inhibition. Atherosclerosis 232:1 (2014), 17–24.
23. Silva, S., Sepodes, B., Rocha, J., Direito, R., Fernandes, A., Brites, D.,. Figueira, M.E., Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. The Journal of Nutritional Biochemistry 26:4 (2015), 360–368.
24. Sirianni, R., Chimento, A., De Luca, A., Casaburi, I., Rizza, P., Onofrio, A.,. Pezzi, V., Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. Molecular Nutrition & Food Research 54:6 (2010), 833–840.
25. Stetler-Stevenson, W.G., Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention. The Journal of Clinical Investigation 103:9 (1999), 1237–1241.
26. Sun, L., Luo, C., Liu, J., Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation. Food & Function 5:8 (2014), 1909–1914.
27. Tutino, V., Orlando, A., Russo, F., Notarnicola, M., Hydroxytyrosol inhibits cannabinoid cb1 receptor gene expression in 3T3-L1 preadipocyte cell line. The Journal of Cellular Physiology 231:2 (2016), 483–489.
28. Zhao, B., Ma, Y., Xu, Z., Wang, J., Wang, F., Wang, D.,. Jiang, H., Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways. Cancer Letters 347:1 (2014), 79–87.
29. Zheng, A., Li, H., Xu, J., Cao, K., Li, H., Pu, W.,. Feng, Z., Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. British Journal of Nutrition 113:11 (2015), 1667–1676.
30. Zoric, N., Horvat, I., Kopjar, N., Vucemilovic, A., Kremer, D., Tomic, S., Kosalec, I., Hydroxytyrosol expresses antifungal activity in vitro. Current Drug Targets 14:9 (2013), 992–998.