Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes

European Journal of Pharmaceutical Sciences

Volumn 98, Issue , 2017, Pages 51-57

  Royo, Felix ^a   Palomo, Laura ^a   Mleczko, Justyna ^a   Gonzalez, Esperanza ^a   Alonso, Cristina ^b   Martínez, Ibon ^b   Pérez Cormenzana, Miriam ^b   Castro, Azucena ^b   Falcon Perez, Juan M ^a,c  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b OWL Parque Tecnológico de Bizkaia   (Spain)

^c BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

Acetaminophen; Diclofenac; Drug induced liver injury; Exosomes; Extracellular vesicles; Metabolomics; Serum

Indexed keywords

AMINO ACID; DICLOFENAC; LIGNOCERIC ACID; LIPID; PARACETAMOL; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; TAUROURSODEOXYCHOLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EXOSOME; LIVER CELL; LIVER INJURY; MASS SPECTROMETRY; METABOLOME; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SERUM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; MALE; METABOLISM; TOXIC HEPATITIS; WISTAR RAT;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; DICLOFENAC; EXTRACELLULAR VESICLES; HEPATOCYTES; MALE; METABOLOME; RATS, WISTAR; SERUM;

EID: 85005916173     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2016.10.020     Document Type: Article

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