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Volumn 101, Issue 2, 2017, Pages 493-500

Natural products from filamentous fungi and production by heterologous expression

Author keywords

Fungi; Gene clusters; Heterologous expression; Natural products; Secondary metabolites

Indexed keywords

AGRICULTURAL CHEMICALS; BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; COST EFFECTIVENESS; FUNGI; GENE EXPRESSION;

EID: 85004115725     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-016-8034-2     Document Type: Review
Times cited : (113)

References (56)
  • 2
    • 85008497521 scopus 로고    scopus 로고
    • Elucidation of the biosynthetic pathway for the diterpene antibiotic pleuromutilin, Manuscript under review
    • Alberti F, Rodriguez Venegas E, Hayes PM, Willis CL, Bailey AM, Foster, GD (2016) Elucidation of the biosynthetic pathway for the diterpene antibiotic pleuromutilin. Manuscript under review
    • (2016) Foster, GD
    • Alberti, F.1    Rodriguez Venegas, E.2    Hayes, P.M.3    Willis, C.L.4    Bailey, A.M.5
  • 3
    • 0017726537 scopus 로고
    • The strobilurins—new antifungal antibiotics from the basidiomycete Strobilurus tenacellus
    • COI: 1:CAS:528:DyaE1cXkvV2msw%3D%3D, PID: 563391
    • Anke T, Oberwinkler F, Steglich W, Schramm G (1977) The strobilurins—new antifungal antibiotics from the basidiomycete Strobilurus tenacellus. J Antibiot 30:806–810
    • (1977) J Antibiot , vol.30 , pp. 806-810
    • Anke, T.1    Oberwinkler, F.2    Steglich, W.3    Schramm, G.4
  • 5
    • 34948833150 scopus 로고    scopus 로고
    • Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis
    • Bailey AM, Cox RJ, Harley K, Lazarus CM, Simpson TJ, Skellam E (2007) Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis. Chem Commun 39:4053–4055
    • (2007) Chem Commun , vol.39 , pp. 4053-4055
    • Bailey, A.M.1    Cox, R.J.2    Harley, K.3    Lazarus, C.M.4    Simpson, T.J.5    Skellam, E.6
  • 8
    • 0029161160 scopus 로고
    • Expression of a fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
    • COI: 1:CAS:528:DyaK2MXnt1SnsrY%3D, PID: 7635840
    • Bedford DJ, Schweizer E, Hopwood DA, Khosla C (1995) Expression of a fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2). J Bacteriol 177:4544–4548
    • (1995) J Bacteriol , vol.177 , pp. 4544-4548
    • Bedford, D.J.1    Schweizer, E.2    Hopwood, D.A.3    Khosla, C.4
  • 9
    • 78650198931 scopus 로고    scopus 로고
    • Fungal secondary metabolites—strategies to activate silent gene clusters
    • COI: 1:CAS:528:DC%2BC3cXhsVGnur7L
    • Brakhage AA, Schroeckh V (2011) Fungal secondary metabolites—strategies to activate silent gene clusters. Fungal Genet Bio 48:15–22
    • (2011) Fungal Genet Bio , vol.48 , pp. 15-22
    • Brakhage, A.A.1    Schroeckh, V.2
  • 11
    • 84958124345 scopus 로고    scopus 로고
    • Production of new cladosporin analogues by reconstitution of the polyketide synthases responsible for the biosynthesis of this antimalarial agent
    • COI: 1:CAS:528:DC%2BC2MXhvFens7fJ
    • Cochrane RVK, Sanichar R, Lambkin GR, Reiz B, Xu W, Tang Y, Vederas JC (2016) Production of new cladosporin analogues by reconstitution of the polyketide synthases responsible for the biosynthesis of this antimalarial agent. Angew Chem Int Ed 55:664–668
    • (2016) Angew Chem Int Ed , vol.55 , pp. 664-668
    • Cochrane, R.V.K.1    Sanichar, R.2    Lambkin, G.R.3    Reiz, B.4    Xu, W.5    Tang, Y.6    Vederas, J.C.7
  • 13
    • 84877786236 scopus 로고    scopus 로고
    • Total synthesis of (+)-pleuromutilin
    • COI: 1:CAS:528:DC%2BC3sXlvFaju7k%3D, PID: 23589420
    • Fazakerley NJ, Helm MD, Procter DJ (2013) Total synthesis of (+)-pleuromutilin. Chem Eur J 19:6718–6723
    • (2013) Chem Eur J , vol.19 , pp. 6718-6723
    • Fazakerley, N.J.1    Helm, M.D.2    Procter, D.J.3
  • 14
    • 80054760185 scopus 로고    scopus 로고
    • Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite
    • COI: 1:CAS:528:DC%2BC3MXht1WksL3K, PID: 21899331
    • Fisch KM, Bakeer W, Yakasai AA, Song Z, Pedrick J, Wasil Z, Bailey AM, Lazarus STJ, Cox RJ (2011) Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J Am Chem Soc 133:16635–16641
    • (2011) J Am Chem Soc , vol.133 , pp. 16635-16641
    • Fisch, K.M.1    Bakeer, W.2    Yakasai, A.A.3    Song, Z.4    Pedrick, J.5    Wasil, Z.6    Bailey, A.M.7    Lazarus, S.T.J.8    Cox, R.J.9
  • 15
    • 80053166085 scopus 로고    scopus 로고
    • Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae
    • COI: 1:CAS:528:DC%2BC3MXht12htLjL, PID: 21897020
    • Fujii R, Minami A, Tsukagoshi T, Sato N, Sahara T, Ohgiya S, Gomi K, Oikawa H (2011) Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae. Biosci Biotechnol Biochem 75:1813–1817
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 1813-1817
    • Fujii, R.1    Minami, A.2    Tsukagoshi, T.3    Sato, N.4    Sahara, T.5    Ohgiya, S.6    Gomi, K.7    Oikawa, H.8
  • 16
    • 77956307436 scopus 로고    scopus 로고
    • The antibiotics market
    • COI: 1:CAS:528:DC%2BC3cXhtFSisLjP, PID: 20811374
    • Hamad B (2010) The antibiotics market. Nat Rev Drug Discov 9:675–676
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 675-676
    • Hamad, B.1
  • 18
    • 77955148530 scopus 로고    scopus 로고
    • First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster
    • COI: 1:CAS:528:DC%2BC3cXpt1Clu7o%3D, PID: 20575135
    • Heneghan MN, Yakasai AA, Halo LM, Song Z, Bailey AM, Simpson TJ, Cox RJ, Lazarus CM (2010) First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster. Chembiochem 11:1508–1512
    • (2010) Chembiochem , vol.11 , pp. 1508-1512
    • Heneghan, M.N.1    Yakasai, A.A.2    Halo, L.M.3    Song, Z.4    Bailey, A.M.5    Simpson, T.J.6    Cox, R.J.7    Lazarus, C.M.8
  • 20
    • 33947694781 scopus 로고    scopus 로고
    • Natural products of filamentous fungi: enzymes, genes, and their regulation
    • COI: 1:CAS:528:DC%2BD2sXlt1Oqsrg%3D, PID: 17390002
    • Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24:393–416
    • (2007) Nat Prod Rep , vol.24 , pp. 393-416
    • Hoffmeister, D.1    Keller, N.P.2
  • 22
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • COI: 1:CAS:528:DC%2BD3MXjs1Cgtbo%3D, PID: 11349148
    • Istvan ES, Deisenhofer J (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292:1160–1164
    • (2001) Science , vol.292 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 23
    • 4544292483 scopus 로고    scopus 로고
    • Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts
    • COI: 1:CAS:528:DC%2BD2cXjt1OktLY%3D, PID: 15056900
    • Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K (2004a) Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts. Biosci Biotechnol Biochem 68:656–662
    • (2004) Biosci Biotechnol Biochem , vol.68 , pp. 656-662
    • Jin, F.J.1    Maruyama, J.2    Juvvadi, P.R.3    Arioka, M.4    Kitamoto, K.5
  • 24
    • 4644219707 scopus 로고    scopus 로고
    • Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae
    • COI: 1:CAS:528:DC%2BD2cXnvV2ltLo%3D, PID: 15451104
    • Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K (2004b) Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae. FEMS Microbiol Lett 239:79–85
    • (2004) FEMS Microbiol Lett , vol.239 , pp. 79-85
    • Jin, F.J.1    Maruyama, J.2    Juvvadi, P.R.3    Arioka, M.4    Kitamoto, K.5
  • 25
    • 0031905709 scopus 로고    scopus 로고
    • Production of a polyketide natural product in nonpolyketide producing prokaryotic and eukaryotic hosts
    • COI: 1:CAS:528:DyaK1cXmtFWrsA%3D%3D, PID: 9435221
    • Kealey JT, Liu L, Santi DV, Betlach MC, Barr PJ (1998) Production of a polyketide natural product in nonpolyketide producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A 95:505–509
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 505-509
    • Kealey, J.T.1    Liu, L.2    Santi, D.V.3    Betlach, M.C.4    Barr, P.J.5
  • 26
    • 0031079973 scopus 로고    scopus 로고
    • Metabolic pathway gene clusters in filamentous fungi
    • COI: 1:CAS:528:DyaK2sXitlKlsL0%3D
    • Keller NP, Hohn TM (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Bio 21:17–29
    • (1997) Fungal Genet Bio , vol.21 , pp. 17-29
    • Keller, N.P.1    Hohn, T.M.2
  • 27
    • 70449358979 scopus 로고    scopus 로고
    • Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus
    • COI: 1:CAS:528:DC%2BD1MXhsFSit7jM
    • Kilaru S, Collins CM, Hartley AJ, Bailey AM, Foster GD (2009) Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus. Appl Environ Microb 75:7196–7204
    • (2009) Appl Environ Microb , vol.75 , pp. 7196-7204
    • Kilaru, S.1    Collins, C.M.2    Hartley, A.J.3    Bailey, A.M.4    Foster, G.D.5
  • 28
    • 0024723238 scopus 로고
    • Risk assessment of the mycotoxin ochratoxin A
    • COI: 1:STN:280:DyaK3c7itFOrsw%3D%3D, PID: 2692617
    • Kuiper-Goodman T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179–248
    • (1989) Biomed Environ Sci , vol.2 , pp. 179-248
    • Kuiper-Goodman, T.1    Scott, P.M.2
  • 29
    • 84907144112 scopus 로고    scopus 로고
    • Reconstructing fungal natural product biosynthetic pathways
    • COI: 1:CAS:528:DC%2BC2cXhsVSiurrN, PID: 25140842
    • Lazarus CM, Williams K, Bailey AM (2014) Reconstructing fungal natural product biosynthetic pathways. Nat Prod Rep 31(10):1339–1347
    • (2014) Nat Prod Rep , vol.31 , Issue.10 , pp. 1339-1347
    • Lazarus, C.M.1    Williams, K.2    Bailey, A.M.3
  • 31
    • 0036222207 scopus 로고    scopus 로고
    • Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs
    • COI: 1:CAS:528:DC%2BD38Xjs12ktL0%3D, PID: 11956737
    • Manzoni M, Rollini M (2002) Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58:555–564
    • (2002) Appl Microbiol Biotechnol , vol.58 , pp. 555-564
    • Manzoni, M.1    Rollini, M.2
  • 33
    • 84873471350 scopus 로고    scopus 로고
    • Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari
    • COI: 1:CAS:528:DC%2BC3sXls1yitQ%3D%3D, PID: 23307607
    • Munawar A, Marshall JW, Cox RJ, Bailey AM, Lazarus CM (2013) Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari. Chembiochem 14(3):388–394
    • (2013) Chembiochem , vol.14 , Issue.3 , pp. 388-394
    • Munawar, A.1    Marshall, J.W.2    Cox, R.J.3    Bailey, A.M.4    Lazarus, C.M.5
  • 34
    • 84882966238 scopus 로고    scopus 로고
    • Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach
    • COI: 1:CAS:528:DC%2BC3sXhtl2iu7fE, PID: 24009710
    • Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH (2013) Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach. PLoS One 8:e72871
    • (2013) PLoS One , vol.8
    • Nielsen, M.T.1    Nielsen, J.B.2    Anyaogu, D.C.3    Holm, D.K.4    Nielsen, K.F.5    Larsen, T.O.6    Mortensen, U.H.7
  • 35
    • 84887586519 scopus 로고    scopus 로고
    • Gene clustering in plant specialized metabolism
    • PID: 24679264
    • Nützmann H-W, Osbourn A (2014) Gene clustering in plant specialized metabolism. Curr Opin Biotech 26:91–99
    • (2014) Curr Opin Biotech , vol.26 , pp. 91-99
    • Nützmann, H.-W.1    Osbourn, A.2
  • 36
    • 77956767424 scopus 로고    scopus 로고
    • Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation
    • COI: 1:CAS:528:DC%2BC3cXhtFyju7zL, PID: 20739089
    • Osbourn A (2010) Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation. Trends Genet 26:449–457
    • (2010) Trends Genet , vol.26 , pp. 449-457
    • Osbourn, A.1
  • 37
    • 84867635716 scopus 로고    scopus 로고
    • A toolkit for heterologous expression of metabolic pathways in Aspergillus oryzae
    • COI: 1:CAS:528:DC%2BC3sXlvVehsQ%3D%3D
    • Pahirulzaman KAK, Williams K, Lazarus CM (2012) A toolkit for heterologous expression of metabolic pathways in Aspergillus oryzae. Method Enzymol 517:241–260
    • (2012) Method Enzymol , vol.517 , pp. 241-260
    • Pahirulzaman, K.A.K.1    Williams, K.2    Lazarus, C.M.3
  • 38
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    • COI: 1:CAS:528:DC%2BD3MXhslSku7c%3D, PID: 11230695
    • Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C (2001) Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 291:1790–1792
    • (2001) Science , vol.291 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 39
    • 0242405686 scopus 로고    scopus 로고
    • Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host
    • COI: 1:CAS:528:DC%2BD3sXptVyktL4%3D
    • Pfeifer BA, Wang CCC, Walsh CT, Khosla C (2003) Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microb 69:6698–6702
    • (2003) Appl Environ Microb , vol.69 , pp. 6698-6702
    • Pfeifer, B.A.1    Wang, C.C.C.2    Walsh, C.T.3    Khosla, C.4
  • 41
    • 33344460613 scopus 로고    scopus 로고
    • Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline
    • COI: 1:CAS:528:DC%2BD28XhvVegs70%3D, PID: 16494875
    • Saikia S, Parker EJ, Koulman A, Scott B (2006) Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline. FEBS Lett 580:1625–1630
    • (2006) FEBS Lett , vol.580 , pp. 1625-1630
    • Saikia, S.1    Parker, E.J.2    Koulman, A.3    Scott, B.4
  • 42
    • 34447125702 scopus 로고    scopus 로고
    • Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases
    • COI: 1:CAS:528:DC%2BD2sXmt1ags70%3D, PID: 17428785
    • Saikia S, Parker EJ, Koulman A, Scott B (2007) Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases. J Biol Chem 282:16829–16837
    • (2007) J Biol Chem , vol.282 , pp. 16829-16837
    • Saikia, S.1    Parker, E.J.2    Koulman, A.3    Scott, B.4
  • 43
    • 57849149449 scopus 로고    scopus 로고
    • Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae
    • COI: 1:CAS:528:DC%2BD1MXhvVymsrY%3D, PID: 19111642
    • Sakai K, Kinoshita H, Shimizu T, Nihira T (2008) Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 106:466–472
    • (2008) J Biosci Bioeng , vol.106 , pp. 466-472
    • Sakai, K.1    Kinoshita, H.2    Shimizu, T.3    Nihira, T.4
  • 44
    • 84922736028 scopus 로고    scopus 로고
    • NextGen microbial natural products discovery
    • PID: 25546172
    • Schmidt-Dannert C (2015) NextGen microbial natural products discovery. Microb Biotechnol 8:26–28
    • (2015) Microb Biotechnol , vol.8 , pp. 26-28
    • Schmidt-Dannert, C.1
  • 46
    • 0038394347 scopus 로고    scopus 로고
    • Trichothecenes in the environment: relevance to human health
    • COI: 1:CAS:528:DC%2BD3sXjs1ahsLo%3D, PID: 12749813
    • Sudakin DL (2003) Trichothecenes in the environment: relevance to human health. Toxicol Lett 143:97–107
    • (2003) Toxicol Lett , vol.143 , pp. 97-107
    • Sudakin, D.L.1
  • 47
    • 0343091497 scopus 로고
    • Cloning and nucleotide sequence of the genomic Taka-amylase A gene of Aspergillus oryzae
    • COI: 1:CAS:528:DyaK3cXkvFKksQ%3D%3D
    • Tada S, Iimura Y, Gomi K, Takahashi K, Hara S, Yoshizawa K (1989) Cloning and nucleotide sequence of the genomic Taka-amylase A gene of Aspergillus oryzae. Agric Biol Chem 53:593–599
    • (1989) Agric Biol Chem , vol.53 , pp. 593-599
    • Tada, S.1    Iimura, Y.2    Gomi, K.3    Takahashi, K.4    Hara, S.5    Yoshizawa, K.6
  • 49
    • 84908261083 scopus 로고    scopus 로고
    • Rapid reconstitution of biosynthetic machinery for fungal metabolites in Aspergillus oryzae: total biosynthesis of aflatrem
    • COI: 1:CAS:528:DC%2BC2cXht1KhurjI, PID: 25087641
    • Tagami K, Minami A, Fujii R, Liu C, Tanaka M, Gomi K, Dairi T, Oikawa H (2014) Rapid reconstitution of biosynthetic machinery for fungal metabolites in Aspergillus oryzae: total biosynthesis of aflatrem. Chembiochem 15:2076–2080
    • (2014) Chembiochem , vol.15 , pp. 2076-2080
    • Tagami, K.1    Minami, A.2    Fujii, R.3    Liu, C.4    Tanaka, M.5    Gomi, K.6    Dairi, T.7    Oikawa, H.8
  • 50
    • 84946484510 scopus 로고    scopus 로고
    • Heterologous expression of a fungal sterol esterase/lipase in different hosts: effect on solubility, glycosylation and production
    • COI: 1:CAS:528:DC%2BC2MXmsl2rsrg%3D, PID: 25939548
    • Vaquero ME, Barriuso J, Medrano FJ, Prieto A, Martínez MJ (2015) Heterologous expression of a fungal sterol esterase/lipase in different hosts: effect on solubility, glycosylation and production. J Biosci Bioeng 120:637–643
    • (2015) J Biosci Bioeng , vol.120 , pp. 637-643
    • Vaquero, M.E.1    Barriuso, J.2    Medrano, F.J.3    Prieto, A.4    Martínez, M.J.5
  • 51
    • 0028284699 scopus 로고
    • The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
    • COI: 1:CAS:528:DyaK2cXmsVOksrk%3D, PID: 8001164
    • Weber G, Schörgendorfer K, Schneider-Scherzer E, Leitner E (1994) The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26:120–125
    • (1994) Curr Genet , vol.26 , pp. 120-125
    • Weber, G.1    Schörgendorfer, K.2    Schneider-Scherzer, E.3    Leitner, E.4
  • 52
    • 31144445460 scopus 로고    scopus 로고
    • Approaches to functional genomics in filamentous fungi
    • COI: 1:CAS:528:DC%2BD28XlvFSiuw%3D%3D, PID: 16467874
    • Weld RJ, Plummer KM, Carpenter MA, Ridgway HJ (2006) Approaches to functional genomics in filamentous fungi. Cell Res 16:31–44
    • (2006) Cell Res , vol.16 , pp. 31-44
    • Weld, R.J.1    Plummer, K.M.2    Carpenter, M.A.3    Ridgway, H.J.4
  • 53
    • 84895075667 scopus 로고    scopus 로고
    • Strategies for mining fungal natural products
    • Wiemann P, Keller N (2013) Strategies for mining fungal natural products. J Ind Microbiol Biot 41:301–313
    • (2013) J Ind Microbiol Biot , vol.41 , pp. 301-313
    • Wiemann, P.1    Keller, N.2
  • 54
    • 84895107216 scopus 로고    scopus 로고
    • Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans
    • COI: 1:CAS:528:DC%2BC3sXhvFCjt73J
    • Yaegashi J, Oakley B, Wang CC (2014) Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J Ind Microbiol Biot 41:433–442
    • (2014) J Ind Microbiol Biot , vol.41 , pp. 433-442
    • Yaegashi, J.1    Oakley, B.2    Wang, C.C.3
  • 55
    • 85009547782 scopus 로고    scopus 로고
    • Transformation system for Aspergillus oryzae with double auxotrophic mutations niaD and sC
    • COI: 1:CAS:528:DyaK2sXlvFequro%3D
    • Yamada O, Rho LB, Katsuya G (1997) Transformation system for Aspergillus oryzae with double auxotrophic mutations niaD and sC. Biosci Biotechnol Biochem 61:1367–1369
    • (1997) Biosci Biotechnol Biochem , vol.61 , pp. 1367-1369
    • Yamada, O.1    Rho, L.B.2    Katsuya, G.3
  • 56
    • 24944557992 scopus 로고    scopus 로고
    • Regulation of secondary metabolism in filamentous fungi
    • COI: 1:CAS:528:DC%2BD2MXhtVOksrvJ, PID: 16078891
    • Yu JH, Keller N (2005) Regulation of secondary metabolism in filamentous fungi. Annu Rev Phytopathol 43:437–458
    • (2005) Annu Rev Phytopathol , vol.43 , pp. 437-458
    • Yu, J.H.1    Keller, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.