Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway

European Journal of Pharmacology

Volumn 795, Issue , 2017, Pages 115-123

  Wang, Lan ^a   Wang, Min ^a   Hu, Jing ^b   Shen, Wei ^a   Hu, Junjie ^a   Yao, Yi ^a   Wang, Xifeng ^a   Afzal, Curimbacus M ^a   Ma, Rong ^a   Li, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

3H 1, 2 dithiole 3 thione; Alzheimer's disease; N2a APPswe; Nrf2

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 3H 1,2 DITHIOLE 3 THIONE; AMYLOID BETA PROTEIN; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MALONALDEHYDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 1,2-DITHIOL-3-THIONE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; GLUTATHIONE; NQO1 PROTEIN, MOUSE; PEPTIDE FRAGMENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL INTERFERING RNA; THIOKETONE; THIOPHENE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL SURVIVAL; DEFICIENCY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRACELLULAR SPACE; METABOLISM; MITOCHONDRION; MOLECULARLY TARGETED THERAPY; NUCLEOCYTOPLASMIC TRANSPORT; PATHOLOGY; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CYTOPROTECTION; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLUTATHIONE; HEME OXYGENASE-1; INTRACELLULAR SPACE; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MALONDIALDEHYDE; MICE; MITOCHONDRIA; MOLECULAR TARGETED THERAPY; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIONES; THIOPHENES;

EID: 85003944875     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.12.013     Document Type: Article

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