Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

Nature Medicine

Volumn 23, Issue 1, 2017, Pages 69-78

  Göllner, Stefanie ^a   Oellerich, Thomas ^b,c   Agrawal Singh, Shuchi ^d   Schenk, Tino ^e,o   Klein, Hans Ulrich ^f,p   Rohde, Christian ^a   Pabst, Caroline ^a   Sauer, Tim ^f,q   Lerdrup, Mads ^d   Tavor, Sigal ^a,g   Stölzel, Friedrich ^h   Herold, Sylvia ^h   Ehninger, Gerhard ^h   Köhler, Gabriele ^a,i,r   Pan, Kuan Ting ^j   Urlaub, Henning ^j,k   Serve, Hubert ^b,c   Dugas, Martin ^f   Spiekermann, Karsten ^c,l   Vick, Binje ^c,m   Jeremias, Irmela ^c,m   Berdel, Wolfgang E ^f   Hansen, Klaus ^d   Zelent, Arthur ⁿ   Wickenhauser, Claudia ^a   Müller, Lutz P ^a   Thiede, Christian ^h   Müller Tidow, Carsten ^a   more..

^a MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^f UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^g Goldyne Savad Inst of Gene Therapy   (Israel)

^h UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

ⁱ UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^j MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^k UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^l LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ UNIVERSITY OF MIAMI   (United States)

^o JENA UNIVERSITY HOSPITAL   (Germany)

^p HARVARD MEDICAL SCHOOL   (United States)

^q ASSUTA MEDICAL CENTER   (Israel)

^r KLINIKUM FULDA   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CYBB PROTEIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTARABINE; CYTOTOXIC AGENT; DAUNORUBICIN; HEAT SHOCK PROTEIN 90; HOX PROTEIN; HOXB7 PROTEIN; LESTAURTINIB; LINIFANIB; MIDOSTAURIN; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN; PROTEIN FOS; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR HOXA9; TRANSCRIPTION FACTOR JUNB; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; EZH2 PROTEIN, HUMAN; GSK126; HISTONE; HOMEODOMAIN PROTEIN; HOXB7 PROTEIN, HUMAN; INDOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDONE DERIVATIVE;

ACUTE MYELOID LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; CANCER COMBINATION CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 7; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESISTANCE; DRUG SENSITIVITY; EVENT FREE SURVIVAL; EX VIVO STUDY; FEMALE; GENE DEREPRESSION; GENE MUTATION; GENE ONTOLOGY; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GRAFT VERSUS HOST REACTION; HIGH THROUGHPUT SEQUENCING; HISTONE METHYLATION; HISTONE TRIMETHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA RELAPSE; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PHENOTYPE; PRIMARY CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RECURRENCE FREE SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER TRANSPLANTATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPRECIPITATION; LEUKEMIA, MYELOID, ACUTE; MALE; METABOLISM; MIDDLE AGED; PROTEIN PROCESSING; PROTEOMICS; TUMOR CELL LINE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BORTEZOMIB; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; CYTARABINE; DRUG RESISTANCE, NEOPLASM; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HISTONES; HOMEODOMAIN PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INDOLES; LEUKEMIA, MYELOID, ACUTE; MALE; MASS SPECTROMETRY; MICE; MIDDLE AGED; NEOPLASM TRANSPLANTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; PYRIDONES; YOUNG ADULT;

EID: 85003864894     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4247     Document Type: Article

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