Addressing the role of obesity in endometrial cancer risk, prevention, and treatment

Journal of Clinical Oncology

Volumn 34, Issue 35, 2016, Pages 4225-4230

  Onstad, Michaela A ^a   Schmandt, Rosemarie E ^a   Lu, Karen H ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ANTINEOPLASTIC AGENT; ESTROGEN; INSULIN; SOMATOMEDIN C;

CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PREVENTION; CANCER RISK; CANCER SURGERY; CANCER THERAPY; DISEASE ASSOCIATION; ENDOMETRIUM; ENDOMETRIUM CANCER; FEMALE; FEMALE FERTILITY; HUMAN; INFLAMMATION; LIFESTYLE MODIFICATION; META ANALYSIS (TOPIC); OBESITY; OUTCOME ASSESSMENT; PREMENOPAUSE; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW (TOPIC); ADIPOSE TISSUE; COMPLICATION; ENDOMETRIAL NEOPLASMS; METABOLISM; MORTALITY; RISK FACTOR;

ADIPOSE TISSUE; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; OBESITY; RISK FACTORS;

EID: 85002989283     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2016.69.4638     Document Type: Review

References (71)

1. Reeves GK, Pirie K, Beral V, et al: Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study. BMJ 335:1134, 2007
2. Calle EE, Kaaks R: Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579-591, 2004
3. Renehan AG, Tyson M, Egger M, et al: Bodymass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet 371:569-578, 2008
4. World Cancer Research Fund/American Institute for Cancer Research: Continuous Update Project Report. Food: Nutrition, Physical Activity, and the Prevention of Endometrial Cancer. 2013. http://www.dietandcancerreport.org
5. McCullough ML, Patel AV, Patel R, et al: Body mass and endometrial cancer risk by hormone replacement therapy and cancer subtype. Cancer Epidemiol Biomarkers Prev 17:73-79, 2008
6. Calle EE, Rodriguez C, Walker-Thurmond K, et al: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. S. adults. N Engl J Med 348:1625-1638, 2003
7. Von Gruenigen VE, Tian C, Frasure H, et al: Treatment effects, disease recurrence, and survival in obese womenwith early endometrial carcinoma: A Gynecologic Oncology Group study. Cancer 107:2786-2791, 2006
8. Flegal KM, Kruszon-Moran D, Carroll MD, et al: Trends in obesity among adults in the United States, 2005 to 2014. JAMA 315:2284-2291, 2016
9. Sheikh MA, Althouse AD, Freese KE, et al: USA endometrial cancer projections to 2030: Should we be concerned? Future Oncol 10:2561-2568, 2014
10. Soliman PT, Bassett RL, Jr, Wilson EB, et al: Limited public knowledge of obesity and endometrial cancer risk: What women know. Obstet Gynecol 112:835-842, 2008
11. Beavis AL, Cheema S, Holschneider CH, et al: Almost half of women with endometrial cancer or hyperplasia do not know that obesity affects their cancer risk. Gynecol Oncol Rep 13:71-75, 2015
12. Clark LH, Ko EM, Kernodle A, et al: Endometrial cancer survivors' perceptions of provider obesity counseling and attempted behavior change: Are we seizing the moment? Int J Gynecol Cancer 26:318-324, 2016
13. World Cancer Research Fund/American Institute for Cancer Research: Continuous Update Project Report: Food, Nutrition, Physical Activity, and the Prevention of Ovarian Cancer 2014. http://www.dietandcancerreport.org/cup/cup-resources.php
14. Delort L, Kwiatkowski F, Chalabi N, et al: Central adiposity as a major risk factor of ovarian cancer. Anticancer Res 29:5229-5234, 2009
15. Renehan AG, Zwahlen M, Egger M: Adiposity and cancer risk: New mechanistic insights from epidemiology. Nat Rev Cancer 15:484-498, 2015
16. Allott EH, Hursting SD: Obesity and cancer: Mechanistic insights from transdisciplinary studies. Endocr Relat Cancer 22:R365-R386, 2015
17. Park J, Morley TS, Kim M, et al: Obesity and cancer: Mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol 10:455-465, 2014
18. Khandekar MJ, Cohen P, Spiegelman BM: Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 11:886-895, 2011
19. Klopp AH, Zhang Y, Solley T, et al: Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors. Clin Cancer Res 18:771-782, 2012
20. Pope BD, Warren CR, Parker KK, et al: Microenvironmental control of adipocyte fate and function. Trends Cell Biol 26:745-755, 2016
21. Mihm M, Gangooly S, Muttukrishna S: The normal menstrual cycle in women. Anim Reprod Sci 124:229-236, 2011
22. Davis SR, Lambrinoudaki I, Lumsden M, et al: Menopause. Nat Rev Dis Primers 1:15004, 2015
23. Blakemore J, Naftolin F: Aromatase: Contributions to physiology and disease in women and men. Physiology (Bethesda) 31:258-269, 2016
24. O'Connor KA, Ferrell RJ, Brindle E, et al: Total and unopposed estrogen exposure across stages of the transition to menopause. Cancer Epidemiol Biomarkers Prev 18:828-836, 2009
25. Simpson ER, Mendelson CR: Effect of aging and obesity on aromatase activity of human adipose cells. Am J Clin Nutr 45:290-295, 1987(suppl 1)
26. Bulun SE, Simpson ER: Regulation of aromatase expression in human tissues. Breast Cancer Res Treat 30:19-29, 1994
27. Vicennati V, Garelli S, Rinaldi E, et al: Obesityrelated proliferative diseases: The interaction between adipose tissue and estrogens in post-menopausal women. Horm Mol Biol Clin Investig 21:75-87, 2015
28. Zhao H, Zhou L, Shangguan AJ, et al: Aromatase expression and regulation in breast and endometrial cancer. J Mol Endocrinol 57:R19-R33, 2016
29. Simó R, Sáez-López C, Barbosa-Desongles A, et al: Novel insights in SHBG regulation and clinical implications. Trends Endocrinol Metab 26:376-383, 2015
30. Simó R, Saez-Lopez C, Lecube A, et al: Adiponectin upregulates SHBG production: Molecular mechanisms and potential implications. Endocrinology 155:2820-2830, 2014
31. Deng L, Feng J, Broaddus RR: The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis 1:e32, 2010
32. Westin SN, Broaddus RR, Deng L, et al: Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression. Cancer Biol Ther 8:2126-2135, 2009
33. Thomas C, Gustafsson JA: The different roles of ER subtypes in cancer biology and therapy. Nat Rev Cancer 11:597-608, 2011
34. Cavalieri E, Chakravarti D, Guttenplan J, et al: Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention. Biochim Biophys Acta 1766:63-78, 2006
35. Cavalieri E, Rogan E: The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity. Mol Aspects Med 36:1-55, 2014
36. Cavalieri EL, Rogan EG: Depurinating estrogen-DNA adducts, generators of cancer initiation: Their minimization leads to cancer prevention. Clin Transl Med 5:12, 2016
37. Meyer LA, Broaddus RR, Lu KH: Endometrial cancer and Lynch syndrome: Clinical and pathologic considerations. Cancer Contr 16:14-22, 2009
38. Batte BA, Bruegl AS, Daniels MS, et al: Consequences of universal MSI/IHC in screening endometrial cancer patients for Lynch syndrome. Gynecol Oncol 134:319-325, 2014
39. Tafe LJ, Riggs ER, Tsongalis GJ: Lynch syndrome presenting as endometrial cancer. Clin Chem 60:111-121, 2014
40. Mills AM, Longacre TA: Lynch syndrome: Female genital tract cancer diagnosis and screening. Surg Pathol Clin 9:201-214, 2016
41. DeFronzo RA, Ferrannini E, Groop L, et al: Type 2 diabetes mellitus. Nat Rev Dis Primers 1:15019, 2015
42. Vrachnis N, Iavazzo C, Iliodromiti Z, et al: Diabetes mellitus and gynecologic cancer: Molecular mechanisms, epidemiological, clinical and prognostic perspectives. Arch Gynecol Obstet 293:239-246, 2016
43. Poloz Y, Stambolic V: Obesity and cancer, a case for insulin signaling. Cell Death Dis 6:e2037, 2015
44. Nead KT, Sharp SJ, Thompson DJ, et al: Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis. J Natl Cancer Inst 107:djv178, 2015
45. McCampbell AS, Walker CL, Broaddus RR, et al: Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. Lab Invest 88:615-626, 2008
46. McCampbell AS, Broaddus RR, Loose DS, et al: Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res 12:6373-6378, 2006
47. Lees B, Leath CA, III: The impact of diabetes on gynecologic cancer: Current status and future directions. Curr Obstet Gynecol Rep 4:234-239, 2015
48. Mu N, Zhu Y, Wang Y, et al: Insulin resistance: A significant risk factor of endometrial cancer. Gynecol Oncol 125:751-757, 2012
49. Masur K, Vetter C, Hinz A, et al: Diabetogenic glucose and insulin concentrations modulate transcriptome and protein levels involved in tumour cell migration, adhesion and proliferation. Br J Cancer 104:345-352, 2011
50. Ryu TY, Park J, Scherer PE: Hyperglycemia as a risk factor for cancer progression. DiabetesMetab J 38:330-336, 2014
51. Kwon H, Pessin JE: Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) 4:71, 2013
52. Simó R, Barbosa-Desongles A, Sáez-Lopez C, et al: Molecular mechanism of TNFa-induced downregulation of SHBG expression. Mol Endocrinol 26:438-446, 2012
53. Mulholland HG, Murray LJ, Cardwell CR, et al: Dietary glycaemic index, glycaemic load and breast cancer risk: A systematic review and meta-analysis. Br J Cancer 99:1170-1175, 2008
54. Nagle CM, Olsen CM, Ibiebele TI, et al: Glycemic index, glycemic load and endometrial cancer risk: Results from the Australian National Endometrial Cancer study and an updated systematic review and meta-analysis. Eur J Nutr 52:705-715, 2013
55. Filomeno M, Bosetti C, Bidoli E, et al: Mediterranean diet and risk of endometrial cancer: A pooled analysis of three Italian case-control studies. Br J Cancer 112:1816-1821, 2015
56. George SM, Ballard R, Shikany JM, et al: A prospective analysis of diet quality and endometrial cancer among 84, 415 postmenopausal women in the Women's Health Initiative. Ann Epidemiol 25:788-793, 2015
57. Chandran U, Bandera EV, Williams-King MG, et al: Adherence to the dietary guidelines for Americans and endometrial cancer risk. Cancer Causes Control 21:1895-1904, 2010
58. Mai V, Kant AK, Flood A, et al: Diet quality and subsequent cancer incidence and mortality in a prospective cohort of women. Int J Epidemiol 34:54-60, 2005
59. Upala S, Sanguankeo A: Bariatric surgery reduces risk of endometrial cancer. Surg Obes Relat Dis 11:1410, 2015
60. Jernigan AM, Maurer KA, Cooper K, et al: Referring survivors of endometrial cancer and complex atypical hyperplasia to bariatric specialists: A prospective cohort study. Am J Obstet Gynecol 213:350.e1-10, 2015
61. Collaborative Group on Epidemiological Studies on Endometrial Cancer: Endometrial cancer and oral contraceptives: An individual participantmeta-analysis of 27 276 women with endometrial cancer from 36 epidemiological studies. Lancet Oncol 16:1061-1070, 2015
62. Felix AS, Gaudet MM, La Vecchia C, et al: Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium. Int J Cancer 136:E410-E422, 2015
63. Zhou G, Myers R, Li Y, et al: Role of AMPactivated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174, 2001
64. Jalving M, Gietema JA, Lefrandt JD, et al: Metformin: Taking away the candy for cancer? Eur J Cancer 46:2369-2380, 2010
65. Bouwman F, Smits A, Lopes A, et al: The impact of BMI on surgical complications and outcomes in endometrial cancer surgery: An institutional study and systematic reviewof the literature. Gynecol Oncol 139:369-376, 2015
66. Gehrig PA, Cantrell LA, Shafer A, et al: What is the optimal minimally invasive surgical procedure for endometrial cancer staging in the obese and morbidly obese woman? Gynecol Oncol 111:41-45, 2008
67. Acharya S, Esthappan J, Badiyan S, et al: Medically inoperable endometrial cancer in patients with a high body mass index (BMI): Patterns of failure after 3-D image-based high dose rate (HDR) brachytherapy. Radiother Oncol 118:167-172, 2016
68. Schwarz JK, Beriwal S, Esthappan J, et al: Consensus statement for brachytherapy for the treatment of medically inoperable endometrial cancer. Brachytherapy 14:587-599, 2015
69. Gallos ID, Yap J, Rajkhowa M, et al: Regression, relapse, and live birth rates with fertilitysparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: A systematic review and metaanalysis. Am J Obstet Gynecol 207:266.e1-12, 2012
70. Wright JD, Buck AM, Shah M, et al: Safety of ovarian preservation in premenopausal women with endometrial cancer. J Clin Oncol 27:1214-1219, 2009
71. Wright JD, Jorge S, Tergas AI, et al: Utilization and outcomes of ovarian conservation in premenopausalwomenwith endometrial cancer. Obstet Gynecol 127:101-108, 2016