Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression

Cancer Biology and Therapy

Volumn 8, Issue 22, 2009, Pages 2126-2135

  Westin, Shannon N ^a   Broaddus, Russell R ^a   Deng, Lei ^a   McCampbell, Adrienne ^a   Lu, Karen H ^a   Lacour, Robin A ^a   Milam, Michael R ^a   Urbauer, Diana L ^a   Mueller, Peter ^a   Pickar, James H ^b   Loose, David S ^c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Biomarkers; Clinical decision making; Endometrial cancer; Estrogen; Tumor recurrence

Indexed keywords

CONJUGATED ESTROGEN; DRUG DERIVATIVE; EQUILIN; EQUILIN SULFATE; ESTRONE; ESTRONE SULFATE; TUMOR MARKER; TUMOR PROTEIN;

ADULT; AGE; AGED; ARTICLE; BIOSYNTHESIS; BODY MASS; CLUSTER ANALYSIS; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECT; ENDOMETRIOID CARCINOMA; ENDOMETRIUM TUMOR; ESTROGEN THERAPY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BODY MASS INDEX; CARCINOMA, ENDOMETRIOID; CLUSTER ANALYSIS; ENDOMETRIAL NEOPLASMS; EQUILIN; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); ESTRONE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROC CURVE; TUMOR MARKERS, BIOLOGICAL;

EID: 77952306546     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.22.9740     Document Type: Article

References (30)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008; 58:71-96. (Pubitemid 351521864)
2. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I. Endometrial cancer. Lancet 2005; 366:491-505. (Pubitemid 41111699)
3. Purdie DM, Green AC. Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynaecol 2001; 15:341-54. (Pubitemid 32631468)
4. Rose PG. Endometrial carcinoma. N Engl J Med 1996; 335:640-9. (Pubitemid 26277956)
5. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients. Cancer 1985; 56:403-12. (Pubitemid 15031667)
6. Shang Y. Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer 2006; 6:360-8.
7. Deng L, Shipley GL, Loose-Mitchell DS, Stancel GM, Broaddus R, Pickar JH, et al. Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium. J Clin Endocrinol Metab 2003; 88:2157-63. (Pubitemid 36553112)
8. R Development Core Team, A language and environment for statistical computing. R Foundation for Statistical Computing 2004.
9. Deng L, Broaddus RR, McCampbell A, Shipley GL, Loose DS, Stancel GM, et al. Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer. Clin Cancer Res 2005; 11:8258-64. (Pubitemid 41746935)
10. Bo WJ, Smith MS. The effect of retinol and retinoic acid on the morphology of the rat uterus. Anat Rec 1966; 156:5-9.
11. Boettger-Tong HL, Stancel GM. Retinoic acid inhibits estrogen-induced uterine stromal and myometrial cell proliferation. Endocrinology 1995; 136:2975-83.
12. Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003; 116:2627-34. (Pubitemid 36857216)
13. Carmon KS, Loose DS. Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol Cancer Res 2008; 6:1017-28.
14. Rutanen EM. Insulin-like growth factors in endometrial function. Gynecol Endocrinol 1998; 12:399-406.
15. Frumovitz M, Slomovitz BM, Singh DK, Broaddus RR, Abrams J, Sun CC, et al. Frozen section analyses as predictors of lymphatic spread in patients with earlystage uterine cancer. J Am Coll Surg 2004; 199:388-93. (Pubitemid 39120053)
16. Lloyd CJ. Using smoothed receiver operating characteristic curve to summarize and compare diagnostic systems. J Amer Stat Assoc 1998; 93:1356-64. (Pubitemid 128385547)
17. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 24:4783-91. (Pubitemid 46630943)
18. Polakis P. Wnt signaling and cancer. Genes Dev 2000; 14:1837-51. (Pubitemid 30639518)
19. Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411:349-54. (Pubitemid 32467044)
20. Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, et al. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci USA 1997; 94:6770-5. (Pubitemid 27281939)
21. Eaton S. Planar polarization of Drosophila and vertebrate epithelia. Curr Opin Cell Biol 1997; 9:860-6. (Pubitemid 27517277)
22. Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, et al. Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab Invest 1999; 79:439-47. (Pubitemid 29190433)
23. Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004; 351:2817-26. (Pubitemid 40051905)
24. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 1987; 60:2035-41. (Pubitemid 17145924)
25. Mohan DS, Samuels MA, Selim MA, Shalodi AD, Ellis RJ, Samuels JR, et al. Long-term outcomes of therapeutic pelvic lymphadenectomy for stage I endometrial adenocarcinoma. Gynecol Oncol 1998; 70:165-71. (Pubitemid 28430923)
26. Cragun JM, Havrilesky LJ, Calingaert B, Synan I, Secord AA, Soper JT, et al. Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer. J Clin Oncol 2005; 23:3668-75.
27. Larson DM, Broste SK, Krawisz BR. Surgery without radiotherapy for primary treatment of endometrial cancer. Obstet Gynecol 1998; 91:355-9. (Pubitemid 28119834)
28. ASTEC Study Group, Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 2009; 373:125-36.
29. Benedetti Panici P, Basile S, Maneschi F, Alberto Lissoni A, Signorelli M, Scambia G, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 2008; 100:1707-16.
30. Case AS, Rocconi RP, Straughn JM Jr, Conner M, Novak L, Wang W, et al. A prospective blinded evaluation of the accuracy of frozen section for the surgical management of endometrial cancer. Obstet Gynecol 2006; 108:1375-9. (Pubitemid 44901010)