Persistence of circulating endothelial microparticles in COPD despite smoking cessation

Thorax

Volumn 71, Issue 12, 2016, Pages 1137-1144

  Strulovici Barel, Yael ^a   Staudt, Michelle R ^a   Krause, Anja ^a   Gordon, Cynthia ^a   Tilley, Ann E ^a   Harvey, Ben Gary ^a   Kaner, Robert J ^a   Hollmann, Charleen ^a   Mezey, Jason G ^a,b   Bitter, Hans ^c,d   Pillai, Sreekumar G ^c,e   Hilton, Holly ^c,f   Wolff, Gerhard ^c,g   Stevenson, Christopher S ^c   Visvanathan, Sudha ^c,h   Fine, Jay S ^c,h   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Plant Science Building   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

^d NOVARTIS   (Switzerland)

^e ELI LILLY AND COMPANY   (United States)

^f PPD Labs   (United States)

^g Achillion Pharmaceuticals   (United States)

^h BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN IB ALPHA;

ADULT; APOPTOSIS; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL MICROPARTICLE; FEMALE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; LONGITUDINAL STUDY; LUNG CAPILLARY; MALE; PRIORITY JOURNAL; SMOKING; SMOKING CESSATION; CAPILLARY; CLINICAL TRIAL; DIAGNOSTIC IMAGING; ENDOTHELIUM CELL; FOLLOW UP; LUNG; LUNG FUNCTION TEST; MEMBRANE MICROPARTICLE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; VASCULAR ENDOTHELIUM; VASCULARIZATION; X-RAY COMPUTED TOMOGRAPHY;

ADULT; APOPTOSIS; CAPILLARIES; CELL-DERIVED MICROPARTICLES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; SMOKING CESSATION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 85002931061     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-208274     Document Type: Article

References (42)

1. Global Initiative for Chronic Obstructive Lung Disease. 2011. http://www.goldcopd. com/(accessed 30 Jul 2015
2. Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977; 1: 1645-8
3. McDonough JE, Yuan R, Suzuki M, et al. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 2011; 365: 1567-75
4. Hogg JC, Senior RM. Chronic obstructive pulmonary disease-part 2: pathology and biochemistry of emphysema. Thorax 2002; 57: 830-4
5. Barnes PJ. Mediators of chronic obstructive pulmonary disease. Pharmacol Rev 2004; 56: 515-48
6. Spurzem JR, Rennard SI. Pathogenesis of COPD. Semin Respir Crit Care Med 2005; 26: 142-53
7. Cosio Piqueras MG, Cosio MG. Disease of the airways in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001; 34: 41s-9s
8. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364: 709-21
9. Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 2003; 28: 555-62
10. Plataki M, Tzortzaki E, Rytila P, et al. Apoptotic mechanisms in the pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis 2006; 1: 161-71
11. Rennard SI. Pathogenesis of chronic obstructive pulmonary disease. Pneumonol Alergol Pol 2011; 79: 132-8
12. Gordon C, Gudi K, Krause A, et al. Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. Am J Respir Crit Care Med 2011; 184: 224-32
13. Danilov SM, Gavrilyuk VD, Franke FE, et al. Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. Am J Physiol Lung Cell Mol Physiol 2001; 280: L1335-47
14. Chandra D, Sciurba FC, Gladwin MT. Endothelial chronic destructive pulmonary disease (E-CDPD): is endothelial apoptosis a subphenotype or prequel to COPD? Am J Respir Crit Care Med 2011; 184: 153-5
15. Scanlon PD, Connett JE, Waller LA, et al. Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study. Am J Respir Crit Care Med 2000; 161: 381-90
16. Chironi GN, Boulanger CM, Simon A, et al. Endothelial microparticles in diseases. Cell Tissue Res 2009; 335: 143-51
17. Paige M, Burdick MD, Kim S, et al. Pilot analysis of the plasma metabolite profiles associated with emphysematous Chronic Obstructive Pulmonary Disease phenotype. Biochem Biophys Res Commun 2011; 413: 588-93
18. Strulovici-Barel Y, Omberg L, O?Mahony M, et al. Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke. Am J Respir Crit Care Med 2010; 182: 1524-32
19. Koga H, Sugiyama S, Kugiyama K, et al. Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 2005; 45: 1622-30
20. Tushuizen ME, Nieuwland R, Rustemeijer C, et al. Elevated endothelial microparticles following consecutive meals are associated with vascular endothelial dysfunction in type 2 diabetes. Diabetes Care 2007; 30: 728-30
21. Preston RA, Jy W, Jimenez JJ, et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension 2003; 41: 211-17
22. MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 2001; 429: 195-207
23. Abboud RT, Vimalanathan S. Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema. Int J Tuberc Lung Dis 2008; 12: 361-7
24. Horstman LL, Jy W, Jimenez JJ, et al. Endothelial microparticles as markers of endothelial dysfunction. Front Biosci 2004; 9: 1118-35
25. Jimenez JJ, Jy W, Mauro LM, et al. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 2003; 109: 175-80
26. Werner N, Wassmann S, Ahlers P, et al. Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2006; 26: 112-16
27. Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000; 101: 841-3
28. Simak J, Gelderman MP, Yu H, et al. Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. J Thromb Haemost 2006; 4: 1296-302
29. Amabile N, Guérin AP, Leroyer A, et al. Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol 2005; 16: 3381-8
30. González-Quintero VH, Smarkusky LP, Jiménez JJ, et al. Elevated plasma endothelial microparticles: preeclampsia versus gestational hypertension. Am J Obstet Gynecol 2004; 191: 1418-24
31. Amabile N, Heiss C, Real WM, et al. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med 2008; 177: 1268-75
32. Arteaga RB, Chirinos JA, Soriano AO, et al. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Am J Cardiol 2006; 98: 70-4
33. Chirinos JA, Heresi GA, Velasquez H, et al. Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol 2005; 45: 1467-71
34. Ayers L, Ferry B, Craig S, et al. Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoea. Eur Respir J 2009; 33: 574-80
35. Heiss C, Amabile N, Lee AC, et al. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol 2008; 51: 1760-71
36. Luisetti M, Ma S, Iadarola P, et al. Desmosine as a biomarker of elastin degradation in COPD: current status and future directions. Eur Respir J 2008; 32: 1146-57
37. Comandini A, Rogliani P, Nunziata A, et al. Biomarkers of lung damage associated with tobacco smoke in induced sputum. Respir Med 2009; 103: 1592-613
38. Criner GJ, Cordova F, Sternberg AL, et al. The National Emphysema Treatment Trial (NETT): Part I: Lessons learned about emphysema. Am J Respir Crit Care Med 2011; 184: 763-70
39. Kim V, Han MK, Vance GB, et al. The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest 2011; 140: 626-33
40. Nishimura M, Makita H, Nagai K, et al. Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012; 185: 44-52
41. Salzman SH. Which pulmonary function tests best differentiate between COPD phenotypes? Respir Care 2012; 57: 50-60
42. Agustí A, Celli B. Avoiding confusion in COPD: from risk factors to phenotypes to measures of disease characterisation. Eur Respir J 2011; 38: 749-51