Endothelial chronic destructive pulmonary disease (E-CDPD): Is endothelial apoptosis a subphenotype or prequel to COPD?

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 2, 2011, Pages 153-155

  Chandra, Divay ^a   Sciurba, Frank C ^a   Gladwin, Mark T ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; EDITORIAL; FORCED EXPIRATORY VOLUME; HUMAN; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; LUNG INJURY; PRIORITY JOURNAL; SMOKING;

APOPTOSIS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FORCED EXPIRATORY VOLUME; HUMANS; LUNG INJURY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 80051559745     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201104-0758ED     Document Type: Editorial

References (16)

1. Gordon C, Gudi K, Krause A, Sackrowitz R, Harvey B-G, Strulovici-Barel Y, Mezey JG, Crystal RG. Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. Am J Respir Crit Care Med 2011;184:224-232.
2. Liebow A. Pulmonary emphysema with special emphasis to vascular changes. Am Rev Respir Dis 1959;80:67-93.
3. Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD. Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest 2006;116:753-759. (Pubitemid 43326884)
4. MacNee W, Wiggs B, Belzberg AS, Hogg JC. The effect of cigarette smoking on neutrophil kinetics in human lungs. N Engl J Med 1989;321:924-928. (Pubitemid 19244050)
5. Stockley RA, Mannino D, Barnes PJ. Burden and pathogenesis of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6:524-526.
6. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of vegf receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000;106:1311-1319.
7. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001;163:737-744. (Pubitemid 32230838)
8. Gladwin MT. Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the no resistance syndrome. J Clin Invest 2006;116:2330-2332. (Pubitemid 44330131)
9. Barr RG, Mesia-Vela S, Austin JH, Basner RC, Keller BM, Reeves AP, Shimbo D, Stevenson L. Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the emphysema and cancer action project (emcap) study. Am J Respir Crit Care Med 2007;176:1200-1207. (Pubitemid 350256473)
10. McAllister DA, Maclay JD, Mills NL, Mair G, Miller J, Anderson D, Newby DE, Murchison JT, Macnee W. Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;176:1208-1214. (Pubitemid 350256474)
11. Barr RG, Bluemke DA, Ahmed FS, Carr JJ, Enright PL, Hoffman EA, Jiang R, Kawut SM, Kronmal RA, Lima JA, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med 2010;362:217-227.
12. Cuttica MJ, Kalhan R, Shlobin OA, Ahmad S, Gladwin M, Machado RF, Barnett SD, Nathan SD. Categorization and impact of pulmonary hypertension in patients with advanced COPD. Respir Med 2010;104:1877-1882.
13. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Lynch DA, Brehm JM, et al. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011;364:897-906.
14. Wilson DO, Weissfeld JL, Balkan A, Schragin JG, Fuhrman CR, Fisher SN, Wilson J, Leader JK, Siegfried JM, Shapiro SD, et al. Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med 2008;178:738-744.
15. Bon J, Fuhrman CR, Weissfeld JL, Duncan SR, Branch RA, Chang CC, Zhang Y, Leader JK, Gur D, Greenspan SL, et al. Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort. Am J Respir Crit Care Med 2011;183:885-890.
16. Leader JK, Fuhrman CR, Bon J, Tan J, Weissfeld J, Wilson DO, Reilly JJ, Gur D, Sciurba FC. Visual emphysema assessment and quantitative CT image analysis [abstract]. Am J Respir Crit Care Med 2010;181:A5539.