Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

Journal of Pharmaceutical Sciences

Volumn 106, Issue 1, 2017, Pages 168-175

  Matsumoto, Akihiro ^a   Takahashi, Yuki ^a   Nishikawa, Makiya ^a   Sano, Kohei ^a   Morishita, Masaki ^a   Charoenviriyakul, Chonlada ^a   Saji, Hideo ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

clearance; lipids; nanoparticles; pharmacokinetics; phospholipids; physicochemical; static charge

Indexed keywords

(3 IODOBENZOYL)NORBIOTINAMIDE I 125; LIPOSOME; LUCIFERASE LACTADHERIN FUSION PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLSERINE; RADIOPHARMACEUTICAL AGENT; RECOMBINANT PROTEIN; STREPTAVIDIN LACTADHERIN FUSION PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLADDER TISSUE; BLOOD; BONE TISSUE; BRAIN TISSUE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG UPTAKE; EXOSOME; HEART TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE TISSUE; KIDNEY TISSUE; LIPOSOMAL DELIVERY; LIVER TISSUE; LUNG PARENCHYMA; MALE; MEAN RESIDENCE TIME; MELANOMA CELL LINE; MOUSE; NONHUMAN; PARTICLE SIZE; PERITONEUM MACROPHAGE; PHYSICAL CHEMISTRY; PLASMA CLEARANCE; QUANTITATIVE ANALYSIS; SPLEEN TISSUE; STOMACH TISSUE; SURFACE CHARGE; TISSUE DISTRIBUTION; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; METABOLISM; SURFACE PROPERTY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; EXOSOMES; INJECTIONS, INTRAVENOUS; LIPOSOMES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PHOSPHATIDYLSERINES; SURFACE PROPERTIES;

EID: 85002855860     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.07.022     Document Type: Article

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