Only the two end helixes of eight tandem amphipathic helical domains of human Apo A-I have significant lipid affinity: Implications for HDL assembly

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 16, Issue 2, 1996, Pages 328-338

  Palgunachari, Mayakonda N ^a   Mishra, Vinod K ^a   Lund Katz, Sissel ^b   Phillips, Michael C ^b   Adeyeye, Samuel O ^a   Alluri, Sridevi ^a   Anantharamaiah, G M ^a   Segrest, Jere P ^a  

^a University of Alabama at Birmingham   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

amphipathic helical peptides; cooperative lipid association; helix helix interactions; lipid affinity; protein lipid interactions

Indexed keywords

APOLIPOPROTEIN A1; DIMYRISTOYLPHOSPHATIDYLCHOLINE; HELIX LOOP HELIX PROTEIN; HIGH DENSITY LIPOPROTEIN; LIPOSOME; PHOSPHATIDYLCHOLINE; SYNTHETIC PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; ATHEROSCLEROSIS; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CORONARY ARTERY DISEASE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; HUMAN; MASS SPECTROMETRY; PHASE TRANSITION; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN SYNTHESIS;

EID: 0030047675     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.16.2.328     Document Type: Article

References (50)

1. Rubin EM, Krauss RM, Spangler EA, Verstuyft JG, Clift SM. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein A-I. Nature. 1991;353:265-267.
2. Chajek-Shaul T, Hayek T, Walsh A, Breslow JL. Expression of the human apolipoprotein A-I in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesterol esters. Proc Natl Acad Sci U S A. 1991;88:6731-6735.
3. Schulz JR, Verstuyft, JG, Gong EG, McCall MR, Nichols AV, Rubin EM. Protein composition determines the antiatherogenic property of high density lipoprotein in transgenic mice. Nature. 1993;365:762-764.
4. Warden C, Hedrick CC, Qiao J-H, Castellani LW, Lusis AJ. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science. 1993;261:469-471.
5. Segrest JP, Garber DW, Brouillette CG, Harvey SC, Anantharamaiah GM. The amphipathic α helix: the multifunctional and structural motif in plasma apolipoproteins. Adv Protein Chem. 1994;45:303-369.
6. Brouillette CG, Anantharamaiah GM. Structural models of human apolipoprotein A-I. Biochim Biophys Acta. 1995;1256:103-129.
7. Nakagawa SH, Lau HSH, Kezdy FJ, Kaiser ET. The use of polymer bound oximes for the synthesis of large peptides usable in segment condensation: synthesis of a 44 amino acid peptide model of apolipoprotein A-I. J. Am Chem Soc. 1985;107:7087-7092.
8. Ji Y, Jonas A. Properties of an N-terminal proteolytic fragment of apolipoprotein A-I in solution and reconstituted high density lipoprotein. J Biol Chem. 1995;270:11290-11297.
9. Banka CL, Bonnet DJ, Black AS, Smith RS, Curtis LK. Localization of an apolipoprotcin A-I epitope critical for activation of lecithin:cholesterol acyltransferase. J Biol Chem. 1991;266:23886-23892.
10. Meng Q-H, Calabressi L, Fruchart J-C, Marcel YL. Apolipoprotein A-I conformation in discoidal particles: evidence for alternate structures. Biochemistry. 1993;32:6477-6484.
11. Jonas A, von Eckardstein A, Churgay L, Mantulin WW, Assmann G. Structural and functional properties of natural and chemical variants of apolipoprotein A-I. Biochim Biophys Acta. 1993;1166:202-210.
12. Collet X, Perret B, Simard G, Raffai E, Marcel YL. Differential effects of cholesterol in the immunoreactivities and conformation of apolipoprotein A-I in high density lipoproteins. J Biol Chem. 1991;266:9145-9152.
13. Lins L, Piron S, Conrath K, Vanloo B, Brausser R, Rosseneu M, Baert J. Ruysschaert JM. Enzymatic hydrolysis of reconstituted DMPC-apolipoprotein A-I complexes. Biochim Biophys Acta. 1993;1151:137-142.
14. Sparks DL, Phillips MC, Lund-Katz S. The conformation of apolipoprotein A-I in discoidal and spherical recombinant high density lipoprotein particles. J Biol Chem. 1992;267:25830-25838.
15. Marcel YL, Provost PR, Koa H, Raffai E, Dac NV, Fruchart JC, Rassart E. The epitopes of apolipoprotein A-I define distinct structural domains including a mobile middle region. J Biol Chem. 1991;266:3644-3656.
16. Nolte RT, Atkinson D. Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism. Biophys J. 1992;63:1221-1239.
17. Ponsin G, Hester L, Gotto AM Jr, Pownall H, Sparrow JT. Lipid: peptide association and activation of lecithin:cholesterol acyltransferase: effect of α helicity. J Biol Chem. 1986;261:9202-9205.
18. Sparrow JT, Gotto AM Jr. Phospholipid binding studies with synthetic apolipoprotein fragments. Ann N Y Acad Sci. 1980;348:187-211.
19. Anantharamaiah GM, Jones JL, Brouillette CG, Schmidt CF, Chung BH, Hughes TA, Bhown AS, Segrest JP. Studies of synthetic peptide analogs of the amphipathic helix. J Biol Chem. 1985;260:10248-10262.
20. Kaiser E, Colescott RL, Bossinger CD, Cook PI. Color test for the detection of free terminal amino groups in the solid phase synthesis of peptides. Anal Chem. 1970;34:595-598.
21. Ebert RF. Amino acid analysis by HPLC optimized conditions for chromatography of phenylthiocarbamyl derivative. Anal Biochem. 1986;154:431-435.
22. Forte TM, Nordhausen RW. Electron microscopy of negatively stained lipoproteins. Methods Enzymol. 1986;128:442-457.
23. Mishra VK, Palgunachari MN, Segrest JP, Anantharamaiah GM. Interaction of synthetic peptide analogs of the class A amphipathic helix with lipids: evidence for snorkel hypothesis. J Biol Chem. 1994;269:7185-7191.
24. Morrisett JD, David JSK, Pownall HJ, Gotto AM Jr. Interaction of apolipoprotein (apo Lp-Alanine) with phosphatidylcholine. Biochemistry. 1973;12:1290-1299.
25. Spuhler P, Anantharamaiah GM, Segrest JP, Seelig J. Binding of apolipoprotein A-I model peptides to lipid bilayers: measurement of binding isotherms and peptide-lipid head group interactions. J Biol Chem. 1994;269:23904-23910.
26. Phillips MC, Krebs KE. Surface chemistry of apolipoproteins at the air-water interface. Methods Enzymol. 1986;128:387-403.
27. Ibdah JA, Krebs KE, Phillips MC. The surface properties of apolipoproteins A-I and A-II at the lipid-water interface. Biochim Biophys Acta. 1989;1004:300-308.
28. Anantharamaiah GM, Hughes TA, Iqbal M, Gawish A, Neame PJ, Meadley MF, Segrest JP. Effect of oxidation on the properties of apolipoproteins A-I and A-II. J Lipid Res. 1988;29:309-318.
29. Hughes TA, Moore MA, Neame P, Meadley MF, Chung BH. Rapid quantitative analysis of apolipoproteins by gradient ultracentrifugation and reversed-phase high performance liquid chromatography. J Lipid Res. 1988;229:363-376.
30. Jonas A. Reconstitution of high density lipoproteins. Methods Enzymol. 1986;128:553-582.
31. Narayanaswamy V, Kay CM, Oikawa K. Ryan RO. Structural and binding characteristics of the carboxyl terminal fragment of apolipophorin III from Manduka sexta. Biochemistry. 1994;33:13312-13320.
32. Owens RJ, Anantharamaiah GM, Kalhone JB, Srinivas RV, Compans RW, Segrest JP. Apolipoprotein A-I and its amphipathic helical peptide analogs inhibit human immunodeficiency virus-induced syncytium formation. J Clin Invest. 1990;86:1142-1150.
33. Segrest JP, de Loof H, Dohlman JG, Brouillette CG, Anantharamaiah GK. Amphipathic helix motif: classes and properties. Proteins. 1990;8:103-117.
34. Jacobs RE, White SH. The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helices. Biochemistry. 1989;28:3421-3437.
35. Tytler EM, Segrest JP, Epand RM, Nie S-Q, Epand RF, Mishra VK, Venkatachalapathi YV, Anantharamaiah GM. Reciprocal effects of apolipoprotein and lytic peptide analogs on membrane: cross-sectional molecular shapes of amphipathic α helices control membrane stability. J Biol Chem. 1993;268:22112-22118.
36. Brasseur R. Differentiation of lipid-associating helices by the use of three dimensional molecular hydrophobicity potential calculations. J Biol Chem. 1991;266:16120-16127.
37. Richardson JS, Richardson DC. In: Fasman GD, ed. Prediction of Protein Structure and the Principles of Protein Conformation. New York, NY: Plenum Press; 1989:1-98.
38. Segrest JP, Jones MK, de Loof H, Brouillette CG, Venkatachalapathi YV, Anantharamaiah GM. The amphipathic helix in exchangeable apolipoproteins: a review of secondary structure and function. J Lipid Res. 1992;33:141-166.
39. Cohn EJ, Edsall JT. Amino acids and peptides as ions and dipolar ions. In: Proteins, Amino Acids and Peptides. New York, NY: Reinhold Publishing Co; 1943:196-216.
40. Lins L, Rosseneu M, Ruysschaert JM, Brausseur R. Mode of assembly of apolipoproteins with lipids: structural determinants of the complexes. In: Rosseneu M, ed. Structure and Function of Apolipoproteins. Boca Raton, Fla: CRC Press; 1992:251-268.
41. Mishra VK, Palgunachari MN, Lund-Katz S, Phillips MC, Segrest JP, Anantharamaiah GM. Effect of the arrangement of tandem repeating units of class A amphipathic helixes on lipid interaction. J Biol Chem. 1995;270:1602-1611.
42. Anantharamaiah GM, Venkatachalapathi YV, Brouillette CG, Segrest JP, Use of synthetic peptide analogues to localize lecithin: cholesterol acyltransferase activating domain in apolipoprotein A-I. Arteriosclerosis. 1990;10:95-105.
43. Wlodawer A, Segrest JP, Chung BH, Chiovetti R, Weinstein JN. High density lipoprotein recombinants: evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Lett. 1979;104:231-235.
44. Rosseneu M, Vanloo B, Lins L, DePawn M, Ruysschaert J-M, Brasseur R. Analysis of the primary and of the secondary structure of the apolipoproteins. In: Rosseneu M, ed. Structure and Function of Apolipoproteins. Boca Raton, Fla: CRC Press; 1992:159-183.
45. Brouillette CG, Jones JL, Ng TC, Kercret H, Chung BH, Segrest JP. Structural studies of apolipoprotein A-I phosphatidylcholine recombinants by high field proton NMR, nondenaturing gradient gel electrophoresis and electron microscopy. Biochemistry. 1984;23:359-367.
46. Dalton MB, Swaney JB. Structural and functional domains of apolipoprotein A-I within high density lipoproteins. J Biol Chem. 1993;268:19274-19283.
47. Chung MC, Segrest JP, Albers JJ, Cone JT, Brouillette CG, Chung BH, Kashyap MA, Glasscock MA, Anantharamaiah GM. Characterization of high density lipoprotein subspecies: structural studies by single vertical spin ultracentrifugation and immunoaffinity chromatography. J Lipid Res. 1987;28:913-929.
48. Schmidt HH-J, Remaley AT, Stonik JA, Ronan R, Wellmann A, Thomas F, Zech LA, Brewer HB Jr, Hoeg JM. Carboxyl-terminal domain truncation alters apolipoprotein A-I in vivo catabolism. J Biol Chem. 1995;270:5469-5475.
49. Hiebsch RR, McGuire KA, Jonas A, Wattenberg BW. A glycosylated apolipoprotein A-I displays alterations in lipoprotein formation: use of glycosylated form to follow intracellular trafficking of apolipoprotein A-I. Personal Communication. 1995.
50. Engelman DM, Steitz TA, Goldman A. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu Rev Biophys Biophys Chem. 1986;15:321-353.